EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000179526 (Gene tree)
Gene ID: 81858
Gene Symbol: SHARPIN
Alias: DKFZP434N1923|SIPL1
Full Name: SHANK associated RH domain interactor
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 9,492 bases
Position: chr8:144,098,633-144,108,124
Accession: 25321
RBP type: canonical RBP
Summary: SHARPIN (SHANK Associated RH Domain Interactor) is a Protein Coding gene. Diseases associated with SHARPIN include Incontinentia Pigmenti and Branchiootic Syndrome. Among its related pathways are TNF signaling (REACTOME) and Protein-protein interactions at synapses. Gene Ontology (GO) annotations related to this gene include identical protein binding and polyubiquitin modification-dependent protein binding. An important paralog of this gene is RBCK1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000432355	zf-RanBP	PF00641.18	2.1e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000533184	SHARPIN-207	352	-	-	- (aa)	-	-
ENST00000532536	SHARPIN-206	533	-	ENSP00000432355	95 (aa)	-	H0YCU2
ENST00000534435	SHARPIN-210	656	-	-	- (aa)	-	-
ENST00000530216	SHARPIN-204	673	-	-	- (aa)	-	-
ENST00000531375	SHARPIN-205	613	-	-	- (aa)	-	-
ENST00000359551	SHARPIN-201	1687	-	ENSP00000352551	326 (aa)	-	Q9H0F6
ENST00000398712	SHARPIN-202	1765	XM_017013887	ENSP00000381698	387 (aa)	XP_016869376	Q9H0F6
ENST00000534242	SHARPIN-209	933	-	-	- (aa)	-	-
ENST00000533948	SHARPIN-208	981	-	-	- (aa)	-	-
ENST00000525275	SHARPIN-203	521	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000179526's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04217	Necroptosis	KEGG
hsa04621	NOD-like receptor signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000179526	Metabolism	6E-110	24816252

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000179526	rs12550729	8	144100505	T	Blood metabolite levels	24816252	[0.058-0.07] unit increase	0.064	EFO_0005664
ENSG00000179526	rs34173062	8	144103704	A	Neutrophil percentage of granulocytes	27863252	[0.044-0.073] unit decrease	0.05862283	EFO_0007994
ENSG00000179526	rs34173062	8	144103704	A	Eosinophil percentage of granulocytes	27863252	[0.046-0.074] unit increase	0.0599948	EFO_0007996
ENSG00000179526	rs34173062	8	144103704	A	Sum eosinophil basophil counts	27863252	[0.043-0.072] unit increase	0.05751766	EFO_0005090\|EFO_0004842
ENSG00000179526	rs34173062	8	144103704	A	Eosinophil percentage of white cells	27863252	[0.045-0.074] unit increase	0.05961465	EFO_0007991
ENSG00000179526	rs34173062	8	144103704	A	Eosinophil counts	27863252	[0.045-0.074] unit increase	0.05925318	EFO_0004842
ENSG00000179526	rs34173062	8	144103704	?	Respiratory diseases	30595370			EFO_0000684
ENSG00000179526	rs34173062	8	144103704	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000179526's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000179526	SHARPIN	100	85.263	ENSAMEG00000006042	SHARPIN	95	82.173	Ailuropoda_melanoleuca
ENSG00000179526	SHARPIN	88	38.931	ENSACAG00000007245	-	54	40.000	Anolis_carolinensis
ENSG00000179526	SHARPIN	100	80.000	ENSCAFG00000001536	SHARPIN	95	76.880	Canis_familiaris
ENSG00000179526	SHARPIN	100	89.474	ENSCCAG00000036190	SHARPIN	93	91.643	Cebus_capucinus
ENSG00000179526	SHARPIN	97	66.304	ENSDORG00000008469	Sharpin	99	71.386	Dipodomys_ordii
ENSG00000179526	SHARPIN	100	85.263	ENSECAG00000001400	SHARPIN	88	83.242	Equus_caballus
ENSG00000179526	SHARPIN	100	85.263	ENSECAG00000002550	-	86	82.967	Equus_caballus
ENSG00000179526	SHARPIN	100	85.263	ENSFCAG00000011548	SHARPIN	93	82.173	Felis_catus
ENSG00000179526	SHARPIN	92	39.348	ENSGALG00000048524	SHARPIN	75	38.667	Gallus_gallus
ENSG00000179526	SHARPIN	100	97.895	ENSGGOG00000027471	SHARPIN	97	97.508	Gorilla_gorilla
ENSG00000179526	SHARPIN	91	72.093	MGP_CAROLIEiJ_G0019922	Sharpin	100	72.093	Mus_caroli
ENSG00000179526	SHARPIN	91	73.256	ENSMUSG00000022552	Sharpin	99	73.256	Mus_musculus
ENSG00000179526	SHARPIN	91	70.930	MGP_PahariEiJ_G0019932	Sharpin	100	70.930	Mus_pahari
ENSG00000179526	SHARPIN	91	73.256	MGP_SPRETEiJ_G0020825	Sharpin	100	73.256	Mus_spretus
ENSG00000179526	SHARPIN	100	85.263	ENSPPRG00000015953	SHARPIN	93	81.337	Panthera_pardus
ENSG00000179526	SHARPIN	100	85.263	ENSPTIG00000016864	SHARPIN	83	79.439	Panthera_tigris_altaica
ENSG00000179526	SHARPIN	58	43.333	ENSSPUG00000017933	SHARPIN	73	42.222	Sphenodon_punctatus
ENSG00000179526	SHARPIN	100	77.895	ENSSSCG00000005914	SHARPIN	87	77.716	Sus_scrofa
ENSG00000179526	SHARPIN	99	85.106	ENSUMAG00000020808	SHARPIN	71	79.608	Ursus_maritimus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004842	ubiquitin-protein transferase activity	21873635.	IBA	Function
GO:0005515	protein binding	21455173.21455180.21455181.21709223.21947080.22158122.23032186.23104095.24141947.27070702.	IPI	Function
GO:0005829	cytosol	20179993.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007005	mitochondrion organization	-	IEA	Process
GO:0007249	I-kappaB kinase/NF-kappaB signaling	-	TAS	Process
GO:0007420	brain development	-	IEA	Process
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	21455173.	IDA	Process
GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	-	TAS	Process
GO:0014069	postsynaptic density	-	IEA	Component
GO:0030054	cell junction	-	IEA	Component
GO:0030262	apoptotic nuclear changes	-	IEA	Process
GO:0030425	dendrite	-	IEA	Component
GO:0031424	keratinization	-	IEA	Process
GO:0031593	polyubiquitin modification-dependent protein binding	21455173.21455181.	IDA	Function
GO:0042802	identical protein binding	-	IEA	Function
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	21873635.	IBA	Process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	21455173.	IDA	Process
GO:0043130	ubiquitin binding	21873635.	IBA	Function
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0050728	negative regulation of inflammatory response	-	ISS	Process
GO:0051260	protein homooligomerization	-	IEA	Process
GO:0071797	LUBAC complex	21873635.	IBA	Component
GO:0071797	LUBAC complex	21455173.21455180.21455181.24726323.27523608.	IDA	Component
GO:0097039	protein linear polyubiquitination	21873635.	IBA	Process
GO:0097039	protein linear polyubiquitination	21455173.21455180.21455181.	IDA	Process
GO:2000348	regulation of CD40 signaling pathway	21455173.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20179993	Newly identified tumor-associated role of human Sharpin.	Mol Cell Biochem	2010 Jul	Jung J	doi: 10.1007/s11010-010-0413-x
28230260	Elevation of SHARPIN Protein Levels in Prostate Adenocarcinomas Promotes Metastasis and Impairs Patient Survivals.	Prostate	2017 May	Huang H	doi: 10.1002/pros.23302
25992689	Elevation of SIPL1 (SHARPIN) Increases Breast Cancer Risk.	PLoS One	2015 May 19	De Melo J	doi: 10.1371/journal.pone.0127546
26506596	A novel gammaretroviral shuttle vector insertional mutagenesis screen identifies SHARPIN as a breast cancer metastasis gene and prognostic biomarker.	Oncotarget	2015 Nov 24	Bii VM	doi: 10.18632/oncotarget.6232.
28063307	SHARPIN Facilitates p53 Degradation in Breast Cancer Cells.	Neoplasia	2017 Feb	Yang H	doi: 10.1016/j.neo.2016.12.002
29248549	A role of SIPL1/SHARPIN in promoting resistance to hormone therapy in breast cancer.	Biochim Biophys Acta Mol Basis Dis	2018 Mar	Ojo D	doi: 10.1016/j.bbadis.2017.12.018

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr8	144099800	Missense_Mutation	rs777839426	E188K	0.22
BLCA	chr8	144098953	Silent	novel	P363P	0.43
BLCA	chr8	144099188	Nonsense_Mutation	rs201083501	Q314*	0.39
BRCA	chr8	144099705	Missense_Mutation	novel	I219M	0.18
BRCA	chr8	144099386	Silent	NA	V271V	0.13
BRCA	chr8	144099293	Silent	NA	A302A	0.26
BRCA	chr8	144099761	Frame_Shift_Del	novel	*Q193Sfs25**	0.2
BRCA	chr8	144100062	Missense_Mutation	NA	K128N	0.16
CESC	chr8	144099831	Silent	novel	G177G	0.18
CESC	chr8	144098981	Missense_Mutation	NA	C354Y	0.13
CESC	chr8	144103179	Missense_Mutation	NA	G83D	0.23	zf-RanBP
COAD	chr8	144103048	Splice_Region	novel		0.36
COAD	chr8	144099758	Missense_Mutation	rs776988893	R202C	0.33
COAD	chr8	144099142	Frame_Shift_Del	novel	*P329Hfs83**	0.11
COAD	chr8	144103144	Missense_Mutation	novel	G95W	0.12
ESCA	chr8	144099361	Missense_Mutation	novel	E280Q	0.1
GBM	chr8	144098915	Missense_Mutation	novel	P376R	0.25
GBM	chr8	144099416	Silent	rs200626709	L261L	0.2
GBM	chr8	144103163	Missense_Mutation	novel	E88D	0.2
GBM	chr8	144099709	Missense_Mutation	novel	P218H	0.09
HNSC	chr8	144099425	Silent	novel	F258F	0.24
HNSC	chr8	144099126	Silent	novel	P334P	0.07
LAML	chr8	144098874	3'UTR	novel		0.14
LGG	chr8	144098914	Silent	novel	P376P	0.38
LGG	chr8	144099168	Silent	rs555935290	D320D	0.33
LUAD	chr8	144098962	Silent	novel	I360I	0.26
LUAD	chr8	144099423	Missense_Mutation	rs762859512	S259L	0.37
LUSC	chr8	144099154	Missense_Mutation	rs61732529	R325H	0.14
LUSC	chr8	144103182	Frame_Shift_Del	novel	*G83Pfs76**	0.69	zf-RanBP
LUSC	chr8	144099421	Nonsense_Mutation	novel	E260*	0.14
OV	chr8	144098956	Silent	NA	A362A	0.21
OV	chr8	144098987	Nonsense_Mutation	NA	W352*	0.23
PAAD	chr8	144099798	Missense_Mutation	novel	E188D	0.09
PRAD	chr8	144099386	Silent	NA	V271V	0.22
SARC	chr8	144100036	Missense_Mutation	novel	P137L	0.72
SARC	chr8	144099573	Silent	rs778021240	A235A	0.11
SKCM	chr8	144098747	3'UTR	novel		1
SKCM	chr8	144098928	Missense_Mutation	NA	S372C	0.16
STAD	chr8	144103087	Missense_Mutation	novel	V114F	0.12
STAD	chr8	144098990	Missense_Mutation	NA	S351N	0.1
UCEC	chr8	144099591	Silent	novel	A229A	0.08
UCEC	chr8	144099599	Missense_Mutation	novel	D227Y	0.55
UCEC	chr8	144099167	Missense_Mutation	rs200344062	G321R	0.29
UCEC	chr8	144098925	Missense_Mutation	NA	T373P	0.28
UCEC	chr8	144099301	Silent	novel	L300L	0.31
UCEC	chr8	144099374	Silent	NA	C275C	0.32
UCEC	chr8	144099573	Silent	rs778021240	A235A	0.23
UCEC	chr8	144099408	Missense_Mutation	rs375767993	P264L	0.34
UCEC	chr8	144099142	Frame_Shift_Del	novel	*P329Hfs83**	0.24
UCEC	chr8	144099301	Missense_Mutation	novel	L300M	0.21
UCEC	chr8	144103050	Splice_Site	NA	X126_splice	0.25
UCEC	chr8	144099142	Frame_Shift_Del	novel	*P329Hfs83**	0.56
UCEC	chr8	144103079	Silent	rs746401527	V116V	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.25	0.018626
KIRC	AMP	0.1174	0.15559
LGG	DEL	0.0468	0.014004
SARC	AMP	0.2529	0.18425
SKCM	AMP	0.4523	2.8957e-05
TGCT	AMP	0.56	0.13696
UVM	AMP	0.7375	8.8879e-13

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
UCS	0.03	Kaplan-Meier Survival Analysis
COAD	0.033	Kaplan-Meier Survival Analysis
READ	0.032	Kaplan-Meier Survival Analysis
LAML	0.0056	Kaplan-Meier Survival Analysis
GBM	0.032	Kaplan-Meier Survival Analysis
LIHC	0.0054	Kaplan-Meier Survival Analysis
CHOL	0.02	Kaplan-Meier Survival Analysis
UVM	0.014	Kaplan-Meier Survival Analysis
OV	0.01	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742