EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000179950 (Gene tree)
Gene ID: 22827
Gene Symbol: PUF60
Alias: FIR|SIAHBP1|RoBPI
Full Name: poly(U) binding splicing factor 60
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 13,516 bases
Position: chr8:143,816,344-143,829,859
Accession: 17042
RBP type: canonical RBP
Summary: This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000322016	RRM_1	PF00076.22	5.9e-43	1	2
ENSP00000322016	RRM_1	PF00076.22	5.9e-43	2	2
ENSP00000431960	RRM_1	PF00076.22	6.6e-43	1	2
ENSP00000431960	RRM_1	PF00076.22	6.6e-43	2	2
ENSP00000402953	RRM_1	PF00076.22	6.8e-43	1	2
ENSP00000402953	RRM_1	PF00076.22	6.8e-43	2	2
ENSP00000322036	RRM_1	PF00076.22	7.1e-43	1	2
ENSP00000322036	RRM_1	PF00076.22	7.1e-43	2	2
ENSP00000395417	RRM_1	PF00076.22	7.6e-43	1	2
ENSP00000395417	RRM_1	PF00076.22	7.6e-43	2	2
ENSP00000434359	RRM_1	PF00076.22	8.2e-43	1	2
ENSP00000434359	RRM_1	PF00076.22	8.2e-43	2	2
ENSP00000432610	RRM_1	PF00076.22	5e-38	1	2
ENSP00000432610	RRM_1	PF00076.22	5e-38	2	2
ENSP00000436131	RRM_1	PF00076.22	6e-38	1	2
ENSP00000436131	RRM_1	PF00076.22	6e-38	2	2
ENSP00000432091	RRM_1	PF00076.22	1.4e-35	1	2
ENSP00000432091	RRM_1	PF00076.22	1.4e-35	2	2
ENSP00000434863	RRM_1	PF00076.22	3.8e-19	1	1
ENSP00000437309	RRM_1	PF00076.22	7.9e-19	1	1
ENSP00000433403	RRM_1	PF00076.22	5.5e-16	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26362209	The first echinoderm poly-U-binding factor 60 kDa (PUF60) from sea cucumber (Stichopus monotuberculatus): Molecular characterization, inducible expression and involvement of apoptosis.	Fish Shellfish Immunol	2015 Nov	Ren C	doi: 10.1016/j.fsi.2015.09.001
23974796	Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step.	EMBO J	2013 Oct 16	Gumireddy K	doi: 10.1038/emboj.2013.188
10668799	Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins.	RNA	2000 Jan	Bouffard P	-
21285945	JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress.	EMBO J	2011 Mar 2	Liu J	doi: 10.1038/emboj.2011.11
28327570	PUF60 variants cause a syndrome of ID, short stature, microcephaly, coloboma, craniofacial, cardiac, renal and spinal features.	Eur J Hum Genet	2017 May	Low KJ	doi: 10.1038/ejhg.2017.27

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000349157	PUF60-202	1821	XM_011516930	ENSP00000322036	542 (aa)	XP_016868725	Q9UHX1
ENST00000526683	PUF60-208	2412	XM_017013234	ENSP00000434359	559 (aa)	XP_016868723	Q9UHX1
ENST00000527197	PUF60-209	1559	XM_024447107	ENSP00000431960	513 (aa)	-	Q9UHX1
ENST00000531897	PUF60-216	785	-	ENSP00000437309	247 (aa)	-	E9PMU7
ENST00000528999	PUF60-213	431	-	-	- (aa)	-	-
ENST00000533162	PUF60-221	761	-	ENSP00000433403	228 (aa)	-	E9PL19
ENST00000528320	PUF60-212	922	-	-	- (aa)	-	-
ENST00000533362	PUF60-222	616	-	-	- (aa)	-	-
ENST00000532884	PUF60-220	819	-	ENSP00000432091	273 (aa)	-	H0YCP8
ENST00000527584	PUF60-210	547	-	-	- (aa)	-	-
ENST00000529999	PUF60-215	867	-	ENSP00000434863	263 (aa)	-	E9PN18
ENST00000526151	PUF60-206	557	-	-	- (aa)	-	-
ENST00000524570	PUF60-205	1934	-	-	- (aa)	-	-
ENST00000313352	PUF60-201	1804	XM_017013240	ENSP00000322016	499 (aa)	XP_016868729	Q9UHX1
ENST00000453551	PUF60-203	1842	XM_017013239	ENSP00000402953	516 (aa)	XP_016868728	Q9UHX1
ENST00000456095	PUF60-204	1736	XM_024447105	ENSP00000395417	530 (aa)	-	Q9UHX1
ENST00000531951	PUF60-217	973	-	-	- (aa)	-	-
ENST00000527744	PUF60-211	1007	-	ENSP00000436131	336 (aa)	-	H0YEM1
ENST00000526459	PUF60-207	1003	-	ENSP00000432610	322 (aa)	-	E9PQ56
ENST00000529693	PUF60-214	684	-	-	- (aa)	-	-
ENST00000532127	PUF60-219	604	-	-	- (aa)	-	-
ENST00000531995	PUF60-218	631	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000179950's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000179950	rs4076877	8	143820544	T	Diastolic blood pressure	28135244	[0.27-0.57] unit decrease	0.4184	EFO_0006336

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000179950's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000179950	PUF60	62	30.263	ENSG00000099622	CIRBP	91	30.263
ENSG00000179950	PUF60	63	33.333	ENSG00000090621	PABPC4	98	30.357
ENSG00000179950	PUF60	64	30.097	ENSG00000197451	HNRNPAB	59	37.736
ENSG00000179950	PUF60	63	33.333	ENSG00000101811	CSTF2	57	33.333
ENSG00000179950	PUF60	65	30.726	ENSG00000151923	TIAL1	91	38.028
ENSG00000179950	PUF60	61	37.500	ENSG00000140488	CELF6	58	32.927
ENSG00000179950	PUF60	62	39.394	ENSG00000100461	RBM23	57	43.243
ENSG00000179950	PUF60	54	36.000	ENSG00000063244	U2AF2	83	37.255
ENSG00000179950	PUF60	65	33.333	ENSG00000101104	PABPC1L	95	32.000
ENSG00000179950	PUF60	62	33.333	ENSG00000254535	PABPC4L	97	31.395
ENSG00000179950	PUF60	62	31.429	ENSG00000143368	SF3B4	65	32.374
ENSG00000179950	PUF60	71	31.469	ENSG00000070756	PABPC1	92	37.500
ENSG00000179950	PUF60	61	38.462	ENSG00000048740	CELF2	50	33.333
ENSG00000179950	PUF60	63	31.447	ENSG00000174740	PABPC5	96	31.356
ENSG00000179950	PUF60	62	30.435	ENSG00000151846	PABPC3	53	30.435
ENSG00000179950	PUF60	59	34.426	ENSG00000164548	TRA2A	51	34.426
ENSG00000179950	PUF60	62	35.714	ENSG00000107105	ELAVL2	75	35.714
ENSG00000179950	PUF60	67	31.522	ENSG00000138668	HNRNPD	82	31.522
ENSG00000179950	PUF60	65	30.168	ENSG00000116001	TIA1	88	31.469
ENSG00000179950	PUF60	62	42.424	ENSG00000131051	RBM39	64	43.182
ENSG00000179950	PUF60	52	30.769	ENSG00000161547	SRSF2	75	30.233
ENSG00000179950	PUF60	61	37.500	ENSG00000159409	CELF3	79	33.684
ENSG00000179950	PUF60	57	39.286	ENSG00000101489	CELF4	70	39.583
ENSG00000179950	PUF60	61	37.500	ENSG00000161082	CELF5	52	33.333

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000179950	PUF60	100	86.180	ENSAPOG00000001713	puf60b	99	85.417	Acanthochromis_polyacanthus
ENSG00000179950	PUF60	100	97.481	ENSAMEG00000006406	PUF60	99	96.953	Ailuropoda_melanoleuca
ENSG00000179950	PUF60	100	77.159	ENSACIG00000003263	-	99	77.586	Amphilophus_citrinellus
ENSG00000179950	PUF60	100	85.413	ENSACIG00000021705	puf60b	100	85.413	Amphilophus_citrinellus
ENSG00000179950	PUF60	100	86.180	ENSAOCG00000005395	puf60b	100	86.180	Amphiprion_ocellaris
ENSG00000179950	PUF60	100	81.923	ENSAOCG00000015558	-	100	81.273	Amphiprion_ocellaris
ENSG00000179950	PUF60	100	75.198	ENSAPEG00000001836	-	99	76.471	Amphiprion_percula
ENSG00000179950	PUF60	100	83.333	ENSAPEG00000011923	puf60b	99	82.583	Amphiprion_percula
ENSG00000179950	PUF60	100	85.988	ENSATEG00000001730	puf60b	99	85.227	Anabas_testudineus
ENSG00000179950	PUF60	100	81.503	ENSATEG00000006303	-	99	81.333	Anabas_testudineus
ENSG00000179950	PUF60	100	98.256	ENSAPLG00000010150	PUF60	100	98.084	Anas_platyrhynchos
ENSG00000179950	PUF60	100	96.917	ENSACAG00000001645	PUF60	98	96.023	Anolis_carolinensis
ENSG00000179950	PUF60	100	99.623	ENSANAG00000018626	PUF60	100	99.623	Aotus_nancymaae
ENSG00000179950	PUF60	58	97.015	ENSACLG00000016311	-	62	96.053	Astatotilapia_calliptera
ENSG00000179950	PUF60	100	85.413	ENSACLG00000004462	puf60b	100	85.413	Astatotilapia_calliptera
ENSG00000179950	PUF60	100	85.799	ENSAMXG00000036570	puf60a	97	85.602	Astyanax_mexicanus
ENSG00000179950	PUF60	100	76.449	ENSAMXG00000041030	puf60b	100	76.735	Astyanax_mexicanus
ENSG00000179950	PUF60	100	99.245	ENSBTAG00000037493	PUF60	100	99.245	Bos_taurus
ENSG00000179950	PUF60	89	49.032	WBGene00004389	rnp-6	83	53.497	Caenorhabditis_elegans
ENSG00000179950	PUF60	100	99.811	ENSCJAG00000021485	PUF60	100	99.811	Callithrix_jacchus
ENSG00000179950	PUF60	100	99.599	ENSCAFG00000001400	PUF60	100	99.448	Canis_familiaris
ENSG00000179950	PUF60	100	99.623	ENSCAFG00020018754	PUF60	100	99.623	Canis_lupus_dingo
ENSG00000179950	PUF60	100	99.225	ENSCHIG00000001618	PUF60	92	99.093	Capra_hircus
ENSG00000179950	PUF60	100	99.612	ENSTSYG00000011912	PUF60	100	99.612	Carlito_syrichta
ENSG00000179950	PUF60	97	99.392	ENSCPOG00000014613	PUF60	99	93.023	Cavia_porcellus
ENSG00000179950	PUF60	100	99.623	ENSCCAG00000007744	PUF60	100	99.623	Cebus_capucinus
ENSG00000179950	PUF60	100	100.000	ENSCATG00000035405	PUF60	100	100.000	Cercocebus_atys
ENSG00000179950	PUF60	100	99.419	ENSCLAG00000009154	PUF60	100	98.582	Chinchilla_lanigera
ENSG00000179950	PUF60	100	100.000	ENSCSAG00000008878	PUF60	100	100.000	Chlorocebus_sabaeus
ENSG00000179950	PUF60	100	98.256	ENSCPBG00000005595	PUF60	99	97.727	Chrysemys_picta_bellii
ENSG00000179950	PUF60	100	48.803	ENSCING00000008436	-	100	49.156	Ciona_intestinalis
ENSG00000179950	PUF60	93	50.554	ENSCING00000002156	-	87	63.043	Ciona_intestinalis
ENSG00000179950	PUF60	97	50.205	ENSCSAVG00000004765	-	97	50.412	Ciona_savignyi
ENSG00000179950	PUF60	97	55.364	ENSCSAVG00000001385	-	99	55.000	Ciona_savignyi
ENSG00000179950	PUF60	96	100.000	ENSCANG00000041843	PUF60	100	100.000	Colobus_angolensis_palliatus
ENSG00000179950	PUF60	100	98.837	ENSCGRG00001017442	Puf60	100	97.872	Cricetulus_griseus_chok1gshd
ENSG00000179950	PUF60	100	98.837	ENSCGRG00000003717	Puf60	99	97.302	Cricetulus_griseus_crigri
ENSG00000179950	PUF60	100	85.221	ENSCSEG00000019887	puf60b	93	84.440	Cynoglossus_semilaevis
ENSG00000179950	PUF60	100	75.099	ENSCSEG00000014845	-	91	75.915	Cynoglossus_semilaevis
ENSG00000179950	PUF60	100	84.645	ENSCVAG00000009386	puf60b	100	85.797	Cyprinodon_variegatus
ENSG00000179950	PUF60	90	80.795	ENSCVAG00000001560	-	98	79.536	Cyprinodon_variegatus
ENSG00000179950	PUF60	100	87.146	ENSDARG00000032175	puf60a	99	94.043	Danio_rerio
ENSG00000179950	PUF60	100	78.759	ENSDARG00000001241	puf60b	99	96.032	Danio_rerio
ENSG00000179950	PUF60	98	83.826	ENSDNOG00000043278	PUF60	98	81.622	Dasypus_novemcinctus
ENSG00000179950	PUF60	100	99.225	ENSDORG00000004585	Puf60	100	99.274	Dipodomys_ordii
ENSG00000179950	PUF60	81	68.321	FBgn0028577	hfp	99	49.644	Drosophila_melanogaster
ENSG00000179950	PUF60	98	72.279	ENSEBUG00000005470	-	88	72.016	Eptatretus_burgeri
ENSG00000179950	PUF60	100	63.176	ENSEBUG00000014291	puf60b	85	65.739	Eptatretus_burgeri
ENSG00000179950	PUF60	100	99.623	ENSEASG00005009695	PUF60	100	99.623	Equus_asinus_asinus
ENSG00000179950	PUF60	100	99.612	ENSECAG00000024681	PUF60	99	99.277	Equus_caballus
ENSG00000179950	PUF60	100	84.038	ENSELUG00000006507	puf60b	100	79.286	Esox_lucius
ENSG00000179950	PUF60	100	85.687	ENSELUG00000018443	-	99	85.602	Esox_lucius
ENSG00000179950	PUF60	100	99.245	ENSFCAG00000001045	PUF60	100	99.245	Felis_catus
ENSG00000179950	PUF60	100	85.465	ENSFALG00000001136	PUF60	99	86.667	Ficedula_albicollis
ENSG00000179950	PUF60	100	99.225	ENSFDAG00000017177	PUF60	100	98.227	Fukomys_damarensis
ENSG00000179950	PUF60	96	79.116	ENSFHEG00000021687	PUF60	100	79.959	Fundulus_heteroclitus
ENSG00000179950	PUF60	100	84.837	ENSFHEG00000020046	puf60b	100	85.988	Fundulus_heteroclitus
ENSG00000179950	PUF60	100	71.673	ENSGMOG00000006392	puf60b	100	70.677	Gadus_morhua
ENSG00000179950	PUF60	87	99.659	ENSGALG00000039901	PUF60	94	97.965	Gallus_gallus
ENSG00000179950	PUF60	100	79.441	ENSGAFG00000004334	-	99	78.842	Gambusia_affinis
ENSG00000179950	PUF60	100	84.261	ENSGAFG00000021040	puf60b	100	85.413	Gambusia_affinis
ENSG00000179950	PUF60	100	73.805	ENSGACG00000004717	puf60b	100	72.523	Gasterosteus_aculeatus
ENSG00000179950	PUF60	100	70.600	ENSGACG00000001484	-	100	69.231	Gasterosteus_aculeatus
ENSG00000179950	PUF60	100	98.256	ENSGAGG00000013289	PUF60	93	97.727	Gopherus_agassizii
ENSG00000179950	PUF60	100	100.000	ENSGGOG00000004646	PUF60	100	100.000	Gorilla_gorilla
ENSG00000179950	PUF60	100	85.413	ENSHBUG00000015118	puf60b	100	85.413	Haplochromis_burtoni
ENSG00000179950	PUF60	100	82.540	ENSHBUG00000009634	-	100	82.540	Haplochromis_burtoni
ENSG00000179950	PUF60	100	99.225	ENSHGLG00000006111	PUF60	100	98.227	Heterocephalus_glaber_female
ENSG00000179950	PUF60	100	99.225	ENSHGLG00100012362	PUF60	100	98.227	Heterocephalus_glaber_male
ENSG00000179950	PUF60	100	82.255	ENSHCOG00000015541	puf60b	100	81.550	Hippocampus_comes
ENSG00000179950	PUF60	98	66.601	ENSHCOG00000000378	-	99	64.850	Hippocampus_comes
ENSG00000179950	PUF60	100	78.571	ENSIPUG00000004660	puf60b	99	78.343	Ictalurus_punctatus
ENSG00000179950	PUF60	100	82.806	ENSIPUG00000002453	puf60a	99	83.202	Ictalurus_punctatus
ENSG00000179950	PUF60	100	99.419	ENSSTOG00000025037	PUF60	100	99.284	Ictidomys_tridecemlineatus
ENSG00000179950	PUF60	100	99.031	ENSJJAG00000001076	Puf60	100	98.577	Jaculus_jaculus
ENSG00000179950	PUF60	100	84.837	ENSKMAG00000016745	puf60b	100	85.988	Kryptolebias_marmoratus
ENSG00000179950	PUF60	100	78.261	ENSKMAG00000010106	-	100	75.746	Kryptolebias_marmoratus
ENSG00000179950	PUF60	100	83.493	ENSLBEG00000012505	puf60b	100	83.493	Labrus_bergylta
ENSG00000179950	PUF60	99	84.783	ENSLACG00000005456	PUF60	100	90.710	Latimeria_chalumnae
ENSG00000179950	PUF60	100	91.137	ENSLOCG00000010106	puf60b	100	88.555	Lepisosteus_oculatus
ENSG00000179950	PUF60	100	98.062	ENSLAFG00000022929	PUF60	100	96.057	Loxodonta_africana
ENSG00000179950	PUF60	100	100.000	ENSMFAG00000043373	PUF60	100	100.000	Macaca_fascicularis
ENSG00000179950	PUF60	100	100.000	ENSMMUG00000013558	PUF60	100	100.000	Macaca_mulatta
ENSG00000179950	PUF60	100	100.000	ENSMNEG00000031099	PUF60	100	100.000	Macaca_nemestrina
ENSG00000179950	PUF60	100	100.000	ENSMLEG00000040009	PUF60	100	100.000	Mandrillus_leucophaeus
ENSG00000179950	PUF60	100	85.797	ENSMAMG00000010394	puf60b	100	83.551	Mastacembelus_armatus
ENSG00000179950	PUF60	100	83.109	ENSMAMG00000019476	-	99	81.973	Mastacembelus_armatus
ENSG00000179950	PUF60	100	82.534	ENSMZEG00005019425	-	99	81.784	Maylandia_zebra
ENSG00000179950	PUF60	100	85.413	ENSMZEG00005018515	puf60b	100	85.413	Maylandia_zebra
ENSG00000179950	PUF60	100	98.256	ENSMGAG00000013070	PUF60	99	97.714	Meleagris_gallopavo
ENSG00000179950	PUF60	99	97.345	ENSMAUG00000014267	-	100	97.549	Mesocricetus_auratus
ENSG00000179950	PUF60	100	79.344	ENSMAUG00000018549	-	100	79.344	Mesocricetus_auratus
ENSG00000179950	PUF60	100	99.623	ENSMICG00000012226	PUF60	100	99.623	Microcebus_murinus
ENSG00000179950	PUF60	100	99.031	ENSMOCG00000018780	Puf60	100	98.050	Microtus_ochrogaster
ENSG00000179950	PUF60	100	85.605	ENSMMOG00000004217	puf60b	100	85.605	Mola_mola
ENSG00000179950	PUF60	100	75.800	ENSMMOG00000018059	-	99	76.484	Mola_mola
ENSG00000179950	PUF60	100	99.399	ENSMODG00000009161	PUF60	100	97.601	Monodelphis_domestica
ENSG00000179950	PUF60	100	81.190	ENSMALG00000000200	-	99	79.057	Monopterus_albus
ENSG00000179950	PUF60	100	78.311	ENSMALG00000006797	puf60b	99	77.652	Monopterus_albus
ENSG00000179950	PUF60	100	98.837	MGP_CAROLIEiJ_G0019910	Puf60	100	97.872	Mus_caroli
ENSG00000179950	PUF60	100	98.837	ENSMUSG00000002524	Puf60	100	97.872	Mus_musculus
ENSG00000179950	PUF60	100	98.837	MGP_PahariEiJ_G0019920	Puf60	100	97.872	Mus_pahari
ENSG00000179950	PUF60	100	98.837	MGP_SPRETEiJ_G0020812	Puf60	100	97.872	Mus_spretus
ENSG00000179950	PUF60	100	99.225	ENSMPUG00000008137	PUF60	97	98.911	Mustela_putorius_furo
ENSG00000179950	PUF60	100	94.990	ENSMLUG00000013032	-	100	94.542	Myotis_lucifugus
ENSG00000179950	PUF60	100	98.450	ENSMLUG00000000238	-	98	98.367	Myotis_lucifugus
ENSG00000179950	PUF60	100	99.031	ENSNGAG00000000712	Puf60	100	99.031	Nannospalax_galili
ENSG00000179950	PUF60	100	82.726	ENSNBRG00000017223	-	99	81.939	Neolamprologus_brichardi
ENSG00000179950	PUF60	84	92.580	ENSNBRG00000013047	puf60b	97	84.235	Neolamprologus_brichardi
ENSG00000179950	PUF60	100	100.000	ENSNLEG00000002156	PUF60	100	100.000	Nomascus_leucogenys
ENSG00000179950	PUF60	87	99.659	ENSOPRG00000002147	PUF60	75	99.659	Ochotona_princeps
ENSG00000179950	PUF60	98	73.964	ENSODEG00000015513	-	99	71.186	Octodon_degus
ENSG00000179950	PUF60	99	98.230	ENSODEG00000014024	-	100	100.000	Octodon_degus
ENSG00000179950	PUF60	100	85.413	ENSONIG00000006247	puf60b	99	84.659	Oreochromis_niloticus
ENSG00000179950	PUF60	100	82.726	ENSONIG00000014030	-	99	82.008	Oreochromis_niloticus
ENSG00000179950	PUF60	79	99.569	ENSOANG00000006962	PUF60	99	78.405	Ornithorhynchus_anatinus
ENSG00000179950	PUF60	99	78.598	ENSORLG00000028655	-	99	78.707	Oryzias_latipes
ENSG00000179950	PUF60	100	85.221	ENSORLG00000012279	puf60b	100	84.837	Oryzias_latipes
ENSG00000179950	PUF60	100	85.221	ENSORLG00020007333	puf60	100	84.837	Oryzias_latipes_hni
ENSG00000179950	PUF60	99	79.198	ENSORLG00020018144	-	99	78.049	Oryzias_latipes_hni
ENSG00000179950	PUF60	99	79.198	ENSORLG00015016833	-	99	78.172	Oryzias_latipes_hsok
ENSG00000179950	PUF60	100	84.321	ENSORLG00015007718	puf60b	100	84.704	Oryzias_latipes_hsok
ENSG00000179950	PUF60	99	80.357	ENSOMEG00000022185	-	99	78.947	Oryzias_melastigma
ENSG00000179950	PUF60	100	82.895	ENSOMEG00000001643	puf60b	99	83.030	Oryzias_melastigma
ENSG00000179950	PUF60	100	99.419	ENSOGAG00000006259	PUF60	99	98.387	Otolemur_garnettii
ENSG00000179950	PUF60	100	96.705	ENSOARG00000016235	PUF60	99	96.750	Ovis_aries
ENSG00000179950	PUF60	100	100.000	ENSPPAG00000029933	PUF60	100	100.000	Pan_paniscus
ENSG00000179950	PUF60	100	99.245	ENSPPRG00000003257	PUF60	100	99.245	Panthera_pardus
ENSG00000179950	PUF60	100	98.998	ENSPTIG00000009795	PUF60	99	96.935	Panthera_tigris_altaica
ENSG00000179950	PUF60	100	99.821	ENSPTRG00000020670	PUF60	100	99.821	Pan_troglodytes
ENSG00000179950	PUF60	100	99.806	ENSPTRG00000043963	-	99	99.819	Pan_troglodytes
ENSG00000179950	PUF60	100	100.000	ENSPANG00000021936	PUF60	100	100.000	Papio_anubis
ENSG00000179950	PUF60	100	86.561	ENSPKIG00000004295	puf60a	99	92.059	Paramormyrops_kingsleyae
ENSG00000179950	PUF60	100	87.885	ENSPKIG00000012204	puf60b	100	87.885	Paramormyrops_kingsleyae
ENSG00000179950	PUF60	100	98.062	ENSPSIG00000004679	PUF60	99	97.897	Pelodiscus_sinensis
ENSG00000179950	PUF60	100	84.351	ENSPMGG00000013444	puf60b	99	84.351	Periophthalmus_magnuspinnatus
ENSG00000179950	PUF60	100	99.031	ENSPEMG00000008820	Puf60	100	98.050	Peromyscus_maniculatus_bairdii
ENSG00000179950	PUF60	62	87.117	ENSPMAG00000009884	puf60b	100	89.024	Petromyzon_marinus
ENSG00000179950	PUF60	100	99.419	ENSPCIG00000020270	PUF60	99	99.232	Phascolarctos_cinereus
ENSG00000179950	PUF60	100	84.837	ENSPFOG00000019217	puf60b	100	84.630	Poecilia_formosa
ENSG00000179950	PUF60	100	80.732	ENSPFOG00000011118	-	99	79.773	Poecilia_formosa
ENSG00000179950	PUF60	100	80.732	ENSPLAG00000017025	-	92	79.395	Poecilia_latipinna
ENSG00000179950	PUF60	100	84.837	ENSPLAG00000010754	puf60b	100	85.988	Poecilia_latipinna
ENSG00000179950	PUF60	100	80.732	ENSPMEG00000009767	-	92	79.773	Poecilia_mexicana
ENSG00000179950	PUF60	100	84.837	ENSPMEG00000000838	puf60b	100	85.988	Poecilia_mexicana
ENSG00000179950	PUF60	100	82.540	ENSPREG00000005440	puf60b	100	83.730	Poecilia_reticulata
ENSG00000179950	PUF60	99	86.429	ENSPPYG00000018951	-	95	98.321	Pongo_abelii
ENSG00000179950	PUF60	87	99.659	ENSPCAG00000014837	PUF60	100	99.281	Procavia_capensis
ENSG00000179950	PUF60	100	99.434	ENSPCOG00000027981	PUF60	100	99.434	Propithecus_coquereli
ENSG00000179950	PUF60	100	100.000	ENSPVAG00000016167	PUF60	81	100.000	Pteropus_vampyrus
ENSG00000179950	PUF60	100	85.413	ENSPNYG00000002556	puf60b	100	85.413	Pundamilia_nyererei
ENSG00000179950	PUF60	100	82.534	ENSPNYG00000004273	-	99	81.784	Pundamilia_nyererei
ENSG00000179950	PUF60	100	85.799	ENSPNAG00000019909	puf60a	99	85.602	Pygocentrus_nattereri
ENSG00000179950	PUF60	100	80.556	ENSPNAG00000019415	puf60b	91	78.794	Pygocentrus_nattereri
ENSG00000179950	PUF60	100	98.837	ENSRNOG00000009960	Puf60	100	97.806	Rattus_norvegicus
ENSG00000179950	PUF60	100	100.000	ENSRBIG00000035274	PUF60	100	100.000	Rhinopithecus_bieti
ENSG00000179950	PUF60	100	100.000	ENSRROG00000029360	PUF60	100	100.000	Rhinopithecus_roxellana
ENSG00000179950	PUF60	100	98.450	ENSSBOG00000027089	PUF60	99	97.921	Saimiri_boliviensis_boliviensis
ENSG00000179950	PUF60	99	96.707	ENSSHAG00000006668	PUF60	96	96.844	Sarcophilus_harrisii
ENSG00000179950	PUF60	96	86.235	ENSSFOG00015019619	puf60b	99	86.235	Scleropages_formosus
ENSG00000179950	PUF60	100	81.868	ENSSFOG00015019371	puf60a	98	86.922	Scleropages_formosus
ENSG00000179950	PUF60	84	92.580	ENSSMAG00000016381	puf60b	72	94.224	Scophthalmus_maximus
ENSG00000179950	PUF60	100	84.211	ENSSDUG00000009935	puf60b	100	83.302	Seriola_dumerili
ENSG00000179950	PUF60	99	80.888	ENSSDUG00000007048	-	99	79.773	Seriola_dumerili
ENSG00000179950	PUF60	100	85.988	ENSSLDG00000024011	puf60b	100	83.738	Seriola_lalandi_dorsalis
ENSG00000179950	PUF60	100	80.228	ENSSLDG00000007366	-	99	80.645	Seriola_lalandi_dorsalis
ENSG00000179950	PUF60	87	84.983	ENSSPUG00000013518	PUF60	94	85.460	Sphenodon_punctatus
ENSG00000179950	PUF60	100	81.870	ENSSPAG00000020285	-	100	82.443	Stegastes_partitus
ENSG00000179950	PUF60	100	83.364	ENSSPAG00000012144	puf60b	100	83.925	Stegastes_partitus
ENSG00000179950	PUF60	100	99.225	ENSSSCG00000038800	PUF60	100	98.830	Sus_scrofa
ENSG00000179950	PUF60	62	100.000	ENSTGUG00000016423	-	100	100.000	Taeniopygia_guttata
ENSG00000179950	PUF60	100	94.961	ENSTGUG00000012797	-	100	94.828	Taeniopygia_guttata
ENSG00000179950	PUF60	100	79.760	ENSTRUG00000008843	-	100	80.160	Takifugu_rubripes
ENSG00000179950	PUF60	100	84.837	ENSTRUG00000005420	puf60b	100	82.617	Takifugu_rubripes
ENSG00000179950	PUF60	100	84.837	ENSTNIG00000013675	puf60b	100	83.902	Tetraodon_nigroviridis
ENSG00000179950	PUF60	100	78.488	ENSTNIG00000003069	-	100	77.820	Tetraodon_nigroviridis
ENSG00000179950	PUF60	99	83.214	ENSTBEG00000002751	-	99	95.593	Tupaia_belangeri
ENSG00000179950	PUF60	99	72.245	ENSTBEG00000001899	-	100	81.503	Tupaia_belangeri
ENSG00000179950	PUF60	100	98.643	ENSTTRG00000017088	PUF60	100	98.643	Tursiops_truncatus
ENSG00000179950	PUF60	100	99.623	ENSUAMG00000024917	PUF60	100	99.623	Ursus_americanus
ENSG00000179950	PUF60	97	98.471	ENSUMAG00000000272	PUF60	99	94.192	Ursus_maritimus
ENSG00000179950	PUF60	100	99.612	ENSVVUG00000022527	PUF60	100	99.612	Vulpes_vulpes
ENSG00000179950	PUF60	100	94.389	ENSXETG00000012469	puf60	99	94.246	Xenopus_tropicalis
ENSG00000179950	PUF60	100	84.325	ENSXCOG00000012355	puf60b	100	85.516	Xiphophorus_couchianus
ENSG00000179950	PUF60	100	84.837	ENSXMAG00000001862	puf60b	100	85.988	Xiphophorus_maculatus
ENSG00000179950	PUF60	100	81.038	ENSXMAG00000010507	-	99	79.528	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	16169070.16189514.16713569.18255255.21078624.21516116.21988832.22365833.25416956.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006915	apoptotic process	-	IEA	Process
GO:0030054	cell junction	-	IDA	Component
GO:0042802	identical protein binding	16189514.21516116.22365833.25416956.	IPI	Function
GO:0045296	cadherin binding	25468996.	HDA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23113893	SAP155-mediated c-myc suppressor far-upstream element-binding protein-interacting repressor splicing variants are activated in colon cancer tissues.	Cancer Sci	2013 Feb	Kajiwara T	doi: 10.1111/cas.12058
26177862	Concomitant expression of far upstream element (FUSE) binding protein (FBP) interacting repressor (FIR) and its splice variants induce migration and invasion of non-small cell lung cancer (NSCLC) cells.	J Pathol	2015 Nov	M??ller B	doi: 10.1002/path.4588
22496461	SAP155-mediated splicing of FUSE-binding protein-interacting repressor serves as a molecular switch for c-myc gene expression.	Mol Cancer Res	2012 Jun	Matsushita K	doi: 10.1158/1541-7786.MCR-11-0462
27756887	Anti-FIRs (PUF60) auto-antibodies are detected in the sera of early-stage colon cancer patients.	Oncotarget	2016 Dec 13	Kobayashi S	doi: 10.18632/oncotarget.12696.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr8	143816476	3'UTR	novel		0.14
BLCA	chr8	143818004	Missense_Mutation	novel	F225L	0.18	RRM_1
BLCA	chr8	143817103	Missense_Mutation	NA	S396L	0.13
BLCA	chr8	143818266	Missense_Mutation	novel	Y177C	0.59	RRM_1
BLCA	chr8	143817103	Missense_Mutation	NA	S396L	0.14
BLCA	chr8	143818409	Silent	novel	I158I	0.29
BLCA	chr8	143816818	Missense_Mutation	novel	S461C	0.45
BLCA	chr8	143816553	Silent	NA	Q549Q	0.63
BRCA	chr8	143818196	Silent	NA	I200I	0.19
CESC	chr8	143816407	3'UTR	novel		0.13
CESC	chr8	143816557	Missense_Mutation	novel	D548G	0.15
CESC	chr8	143818229	Missense_Mutation	NA	Q189H	0.42	RRM_1
CESC	chr8	143816604	Silent	rs772030514	L532L	0.2
CESC	chr8	143822555	Intron	novel		0.41
COAD	chr8	143817114	Silent	NA	V392V	0.17
COAD	chr8	143817118	Missense_Mutation	NA	P391L	0.17
COAD	chr8	143824339	Missense_Mutation	novel	A29T	0.36
COAD	chr8	143818390	Missense_Mutation	rs756023794	V165I	0.16
COAD	chr8	143816937	Silent	novel	V451V	0.24
COAD	chr8	143817381	Missense_Mutation	NA	G365D	0.3
COAD	chr8	143818206	Frame_Shift_Del	novel	*G197Afs12**	0.08	RRM_1
COAD	chr8	143817446	Silent	rs368804058	A343A	0.06
COAD	chr8	143816510	3'UTR	novel		0.09
COAD	chr8	143817454	Missense_Mutation	novel	G341R	0.1
COAD	chr8	143818483	In_Frame_Del	novel	A124_V133del	0.06
COAD	chr8	143817128	Missense_Mutation	NA	P388S	0.14
COAD	chr8	143816731	Missense_Mutation	novel	F490S	0.39
COAD	chr8	143817991	Missense_Mutation	NA	V230M	0.21
ESCA	chr8	143817999	Missense_Mutation	novel	R227H	0.23	RRM_1
ESCA	chr8	143816506	3'UTR	novel		0.29
ESCA	chr8	143822486	Intron	novel		0.34
GBM	chr8	143817063	Silent	novel	T409T	0.36
HNSC	chr8	143820679	Nonsense_Mutation	novel	S112*	0.25
HNSC	chr8	143818013	Silent	novel	A222A	0.09
HNSC	chr8	143817056	Missense_Mutation	NA	L412V	0.18
KIRP	chr8	143820669	Silent	NA	Q115Q	0.42
LGG	chr8	143816681	Nonsense_Mutation	novel	E507*	0.23
LIHC	chr8	143816985	Silent	rs372944670	S435S	0.08
LIHC	chr8	143817407	Silent	NA	P356P	0.45
LIHC	chr8	143818384	Missense_Mutation	novel	M167V	0.6
LUAD	chr8	143816699	Missense_Mutation	novel	E501K	0.05
LUAD	chr8	143820683	Missense_Mutation	novel	L111F	0.08
LUAD	chr8	143820717	Splice_Site	novel	X100_splice	0.29
LUSC	chr8	143816733	Missense_Mutation	NA	K489N	0.1
OV	chr8	143820677	Missense_Mutation	novel	P113A	0.3
PAAD	chr8	143817778	Silent	rs373613651	Y274Y	0.23
SARC	chr8	143821827	Silent	novel	A66A	0.29
SKCM	chr8	143818238	Silent	novel	A186A	0.5
SKCM	chr8	143818239	Missense_Mutation	novel	A186V	0.5	RRM_1
SKCM	chr8	143816476	3'UTR	rs766011402		0.31
SKCM	chr8	143817646	Silent	NA	L318L	0.35
SKCM	chr8	143816505	3'UTR	rs775734628		0.24
SKCM	chr8	143818004	Silent	NA	F225F	0.27
SKCM	chr8	143816748	Frame_Shift_Del	novel	*T484Rfs40**	0.47
STAD	chr8	143817638	Missense_Mutation	novel	A321V	0.07
STAD	chr8	143817992	Silent	rs764497081	Y229Y	0.1
STAD	chr8	143820683	Missense_Mutation	novel	L111F	0.4
STAD	chr8	143816714	Missense_Mutation	NA	V496I	0.1
STAD	chr8	143817662	Missense_Mutation	novel	A313V	0.08
STAD	chr8	143820713	Missense_Mutation	NA	A101T	0.11
STAD	chr8	143817947	Silent	rs373238114	S244S	0.15
STAD	chr8	143816717	Missense_Mutation	NA	R495S	0.17
STAD	chr8	143818216	Frame_Shift_Ins	novel	M194*	0.15	RRM_1
STAD	chr8	143821857	Silent	novel	L56L	0.3
STAD	chr8	143818464	Missense_Mutation	NA	L140P	0.36
THCA	chr8	143816496	3'UTR	novel		0.55
UCEC	chr8	143816581	Missense_Mutation	NA	R540H	0.3
UCEC	chr8	143817775	Missense_Mutation	NA	E275D	0.38
UCEC	chr8	143817447	Missense_Mutation	NA	A343V	0.2
UCEC	chr8	143816626	Missense_Mutation	novel	T525I	0.21
UCEC	chr8	143816778	Silent	rs781009221	D474D	0.18
UCEC	chr8	143822499	Intron	novel		0.23
UCEC	chr8	143816985	Silent	rs372944670	S435S	0.3
UCEC	chr8	143816497	3'UTR	novel		0.63
UCEC	chr8	143821661	Missense_Mutation	novel	S78N	0.43
UCEC	chr8	143817468	Splice_Site	novel	X337_splice	0.42
UCEC	chr8	143818512	Missense_Mutation	rs749670489	A124V	0.26
UCEC	chr8	143817635	Missense_Mutation	novel	A322G	0.28
UCEC	chr8	143821621	Missense_Mutation	novel	Q91H	0.58
UCEC	chr8	143818408	Missense_Mutation	novel	D159N	0.38
UCEC	chr8	143821674	Missense_Mutation	novel	A74T	0.1
UCEC	chr8	143816397	3'UTR	novel		0.27
UCEC	chr8	143816679	Missense_Mutation	novel	E507D	0.23
UCEC	chr8	143817904	Silent	novel	R259R	0.07
UCEC	chr8	143821687	Splice_Site	novel	X70_splice	0.09
UCEC	chr8	143816603	Missense_Mutation	novel	N533D	0.2
UCEC	chr8	143816668	Missense_Mutation	NA	I511S	0.42
UCEC	chr8	143818458	Missense_Mutation	novel	E142G	0.17
UCEC	chr8	143816697	Missense_Mutation	NA	E501D	0.28
UCEC	chr8	143822702	Intron	novel		0.33
UCEC	chr8	143817350	Missense_Mutation	novel	Q375H	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.25	0.018626
KIRC	AMP	0.1193	0.15559
LGG	DEL	0.0468	0.014004
SARC	AMP	0.2607	0.18425
SKCM	AMP	0.455	2.8957e-05
TGCT	AMP	0.56	0.13696
UVM	AMP	0.7375	8.8879e-13

Survival Analysis

Cancer	P-value	Q-value
SARC	0.026	Kaplan-Meier Survival Analysis
ACC	0.00082	Kaplan-Meier Survival Analysis
HNSC	0.046	Kaplan-Meier Survival Analysis
LUSC	0.049	Kaplan-Meier Survival Analysis
LAML	0.0043	Kaplan-Meier Survival Analysis
GBM	0.029	Kaplan-Meier Survival Analysis
LIHC	0.0084	Kaplan-Meier Survival Analysis
DLBC	0.027	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.029	Kaplan-Meier Survival Analysis
UVM	0.011	Kaplan-Meier Survival Analysis
OV	0.016	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742