EuRBPDB

Description

Ensembl ID: ENSG00000180182 (Gene tree)
Gene ID: 9282
Gene Symbol: MED14
Alias: EXLM1|CRSP150|TRAP170|RGR1|CSRP|CXorf4|CRSP2
Full Name: mediator complex subunit 14
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 87,817 bases
Position: chrX:40,648,306-40,736,122
Accession: 2370
RBP type: non-canonical RBP
Summary: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000482034	MED14-206	520	-	-	- (aa)	-	-
ENST00000496531	MED14-209	615	-	-	- (aa)	-	-
ENST00000463072	MED14-204	546	-	-	- (aa)	-	-
ENST00000495865	MED14-208	525	-	-	- (aa)	-	-
ENST00000492219	MED14-207	545	-	-	- (aa)	-	-
ENST00000433003	MED14-203	1480	-	ENSP00000411357	331 (aa)	-	H7C3E5
ENST00000472736	MED14-205	500	-	-	- (aa)	-	-
ENST00000324817	MED14-201	7984	XM_005272701	ENSP00000323720	1454 (aa)	XP_005272758	O60244
ENST00000416199	MED14-202	557	-	ENSP00000392586	155 (aa)	-	H7C017

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04919	Thyroid hormone signaling pathway	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000180182	MED14	100	99.094	ENSMUSG00000064127	Med14	99	98.872	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003712	transcription coregulator activity	21873635.	IBA	Function
GO:0003712	transcription coregulator activity	10198638.12218053.	IDA	Function
GO:0003713	transcription coactivator activity	12037571.	IDA	Function
GO:0005515	protein binding	24882805.	IPI	Function
GO:0005634	nucleus	10235267.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0006357	regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	12218053.	IDA	Process
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016592	mediator complex	21873635.	IBA	Component
GO:0016592	mediator complex	10198638.12037571.	IDA	Component
GO:0019827	stem cell population maintenance	-	IEA	Process
GO:0030374	nuclear receptor transcription coactivator activity	10235266.	NAS	Function
GO:0042809	vitamin D receptor binding	10235266.	NAS	Function
GO:0045893	positive regulation of transcription, DNA-templated	10198638.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	12037571.	IDA	Process
GO:0070847	core mediator complex	21873635.	IBA	Component