EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000180228 (Gene tree)
Gene ID: 8575
Gene Symbol: PRKRA
Alias: PACT|RAX|HSD14|DYT16
Full Name: protein activator of interferon induced protein kinase EIF2AK2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 20,099 bases
Position: chr2:178,431,414-178,451,512
Accession: 9438
RBP type: canonical RBP
Summary: This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000430604	dsrm	PF00035.26	7.2e-32	1	2
ENSP00000430604	dsrm	PF00035.26	7.2e-32	2	2
ENSP00000393883	dsrm	PF00035.26	9e-32	1	2
ENSP00000393883	dsrm	PF00035.26	9e-32	2	2
ENSP00000318176	dsrm	PF00035.26	1.1e-31	1	2
ENSP00000318176	dsrm	PF00035.26	1.1e-31	2	2
ENSP00000408668	dsrm	PF00035.26	1e-13	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18366743	The evolution of core proteins involved in microRNA biogenesis.	BMC Evol Biol	2008 Mar 25	Murphy D	doi: 10.1186/1471-2148-8-92.
25630541	Dissecting the roles of TRBP and PACT in double-stranded RNA recognition and processing of noncoding RNAs.	Wiley Interdiscip Rev RNA	2015 May-Jun	Heyam A	doi: 10.1002/wrna.1272
24954387	'Black sheep' that don't leave the double-stranded RNA-binding domain fold.	Trends Biochem Sci	2014 Jul	Gleghorn ML	doi: 10.1016/j.tibs.2014.05.003
23550157	RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators.	Proc Natl Acad Sci U S A	2013 Apr 16	Redfern AD	doi: 10.1073/pnas.1301620110
23776147	Processing of virus-derived cytoplasmic primary-microRNAs.	Wiley Interdiscip Rev RNA	2013 Jul-Aug	Shapiro JS	doi: 10.1002/wrna.1169
24522921	Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response.	J Virol	2014 May	Siu KL	doi: 10.1128/JVI.03649-13
23661684	Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing.	Nucleic Acids Res	2013 Jul	Lee HY	doi: 10.1093/nar/gkt361
23531496	Multiple sensors ensure guide strand selection in human RNAi pathways.	RNA	2013 May	Noland CL	doi: 10.1261/rna.037424.112
19106622	The NFAR's (nuclear factors associated with dsRNA): evolutionarily conserved members of the dsRNA binding protein family.	RNA Biol	2009 Jan-Mar	Barber GN	-
17452327	Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA.	J Biol Chem	2007 Jun 15	Kok KH	-
25064266	HIV-1 translation and its regulation by cellular factors PKR and PACT.	Virus Res	2014 Nov 26	Burugu S	doi: 10.1016/j.virusres.2014.07.014
24352449	Arabidopsis double-stranded RNA binding protein DRB3 participates in methylation-mediated defense against geminiviruses.	J Virol	2014 Mar	Raja P	doi: 10.1128/JVI.02305-13
24020926	The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication.	Retrovirology	2013 Sep 11	Clerzius G	doi: 10.1186/1742-4690-10-96.
23658827	Distinguishable in vitro binding mode of monomeric TRBP and dimeric PACT with siRNA.	PLoS One	2013 May 2	Takahashi T	doi: 10.1371/journal.pone.0063434
29513570	Antiviral activity of double-stranded RNA-binding protein PACT against influenza A virus mediated via suppression of viral RNA polymerase.	FASEB J	2018 Aug	Chan CP	doi: 10.1096/fj.201701361R
25557550	Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis.	Mol Cell	2015 Feb 5	Wilson RC	doi: 10.1016/j.molcel.2014.11.030
16571658	A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing.	Proc Natl Acad Sci U S A	2006 Apr 11	Rowe TM	-
12874289	A novel role for RAX, the cellular activator of PKR, in synergistically stimulating SV40 large T antigen-dependent gene expression.	J Biol Chem	2003 Oct 3	Yang M	-
16466763	Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA.	Virology	2006 May 25	Li S	-
11401490	PACT, a double-stranded RNA binding protein acts as a positive regulator for type I interferon gene induced by Newcastle disease virus.	Biochem Biophys Res Commun	2001 Mar 30	Iwamura T	-
19541653	The double-stranded RNA-binding protein, PACT, is required for postnatal anterior pituitary proliferation.	Proc Natl Acad Sci U S A	2009 Jun 30	Peters GA	doi: 10.1073/pnas.0900735106
18936160	TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress.	Mol Cell Biol	2009 Jan	Daher A	doi: 10.1128/MCB.01030-08
22961479	Expression of microRNA machinery proteins in different types of chronic rhinosinusitis.	Laryngoscope	2012 Dec	Zhang YN	doi: 10.1002/lary.23517
18421256	Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions.	RNA Biol	2008 Apr-Jun	Laraki G	-
22194846	Missense mutation in the second RNA binding domain reveals a role for Prkra (PACT/RAX) during skull development.	PLoS One	2011	Dickerman BK	doi: 10.1371/journal.pone.0028537
22025453	Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA-induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1, and TARBP2 in epithelial skin cancer.	Mol Carcinog	2012 Nov	Sand M	doi: 10.1002/mc.20861
21501829	The double-stranded RNA-binding protein PACT functions as a cellular activator of RIG-I to facilitate innate antiviral response.	Cell Host Microbe	2011 Apr 21	Kok KH	doi: 10.1016/j.chom.2011.03.007.
25110015	Regulation of miRNA strand selection: follow the leader?	Biochem Soc Trans	2014 Aug	Meijer HA	doi: 10.1042/BST20140142.
24067967	Suppression of PACT-induced type I interferon production by herpes simplex virus 1 Us11 protein.	J Virol	2013 Dec	Kew C	doi: 10.1128/JVI.02564-13
24030553	The evolution of microRNA pathway protein components in Cnidaria.	Mol Biol Evol	2013 Dec	Moran Y	doi: 10.1093/molbev/mst159
23511973	The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing.	EMBO J	2013 Apr 17	Stalder L	doi: 10.1038/emboj.2013.52
26414443	The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development.	FEBS J	2015 Dec	Dickerman BK	doi: 10.1111/febs.13533
28634830	The microRNA effector RNA-induced silencing complex in hidradenitis suppurativa: a significant dysregulation within active inflammatory lesions.	Arch Dermatol Res	2017 Sep	Hessam S	doi: 10.1007/s00403-017-1752-1
29032202	PACT is required for MDA5-mediated immunoresponses triggered by Cardiovirus infection via interaction with LGP2.	Biochem Biophys Res Commun	2017 Dec 9	Miyamoto M	doi: 10.1016/j.bbrc.2017.10.048
29045748	Conserved asymmetry underpins homodimerization of Dicer-associated double-stranded RNA-binding proteins.	Nucleic Acids Res	2017 Dec 1	Heyam A	doi: 10.1093/nar/gkx928.
29084250	KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation.	PLoS Pathog	2017 Oct 30	Sharma NR	doi: 10.1371/journal.ppat.1006677
29231267	Contribution of the two dsRBM motifs to the double-stranded RNA binding and protein interactions of PACT.	J Cell Biochem	2018 Apr	Chukwurah E	doi: 10.1002/jcb.26561
24715958	The Human dsRNA binding protein PACT is unable to functionally substitute for the Drosophila dsRNA binding protein R2D2.	Version 2	F1000Res	Dickerman BK	doi: 10.12688/f1000research.2-220.v2
26355092	Regulation of PACT-Mediated Protein Kinase Activation by the OV20.0 Protein of Orf Virus.	J Virol	2015 Nov	Tseng YY	doi: 10.1128/JVI.01739-15
11985496	The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR).	Biochem J	2002 Aug 15	Huang X	-
11555640	Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation.	J Biol Chem	2001 Nov 9	Saelens X	-
16424907	The role of PACT in the RNA silencing pathway.	EMBO J	2006 Feb 8	Lee Y	-
11220620	Haplotype-specific sequence encoding the protein kinase, interferon-inducible double-stranded RNA-dependent activator in the human leukocyte antigen class II region.	Immunogenetics	2001	Chida S	-
14747550	African swine fever virus multigene family 360 and 530 genes affect host interferon response.	J Virol	2004 Feb	Afonso CL	-
21726814	siRNA repositioning for guide strand selection by human Dicer complexes.	Mol Cell	2011 Jul 8	Noland CL	doi: 10.1016/j.molcel.2011.05.028.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000487082	PRKRA-211	1211	XM_011512066	ENSP00000430604	288 (aa)	XP_011510368	O75569
ENST00000474793	PRKRA-210	796	-	-	- (aa)	-	-
ENST00000325748	PRKRA-201	1826	-	ENSP00000318176	313 (aa)	-	O75569
ENST00000466165	PRKRA-208	585	-	-	- (aa)	-	-
ENST00000490501	PRKRA-212	1851	-	-	- (aa)	-	-
ENST00000424699	PRKRA-202	1616	-	ENSP00000408029	105 (aa)	-	G5E9Q4
ENST00000448279	PRKRA-204	549	-	ENSP00000388455	95 (aa)	-	F8WEG8
ENST00000460433	PRKRA-206	461	-	-	- (aa)	-	-
ENST00000463882	PRKRA-207	541	-	-	- (aa)	-	-
ENST00000457633	PRKRA-205	942	-	ENSP00000408668	108 (aa)	-	C9JMM3
ENST00000470200	PRKRA-209	550	-	-	- (aa)	-	-
ENST00000432031	PRKRA-203	1344	XM_011512063	ENSP00000393883	302 (aa)	XP_011510365	O75569

Gene Model

Click here to download ENSG00000180228's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000180228	Multiple Sclerosis	3E-7	23472185
ENSG00000180228	Oligoclonal Bands	3E-7	23472185
ENSG00000180228	Dermatitis, Atopic	1E-34	25574825
ENSG00000180228	Psoriasis	1E-34	25574825

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000180228	rs62176107	2	178436244	?	Inflammatory skin disease	25574825			EFO_0000274\|EFO_0000676
ENSG00000180228	rs9283487	2	178431544	?	Multiple sclerosis (OCB status)	23472185	[1.33-1.92]	1.61	EFO_0003885\|EFO_0005206
ENSG00000180228	rs10930831	2	178439249	G	Blood protein levels	30072576	[0.31-0.42] unit decrease	0.365	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000180228's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000180228	PRKRA	97	51.087	ENSG00000139546	TARBP2	98	52.326
ENSG00000180228	PRKRA	72	39.130	ENSG00000040341	STAU2	52	32.692
ENSG00000180228	PRKRA	62	31.053	ENSG00000124214	STAU1	58	31.383

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000180228	PRKRA	99	55.245	ENSAPOG00000019819	prkra	96	53.898	Acanthochromis_polyacanthus
ENSG00000180228	PRKRA	100	99.306	ENSAMEG00000000803	PRKRA	100	99.042	Ailuropoda_melanoleuca
ENSG00000180228	PRKRA	99	51.916	ENSACIG00000020131	prkra	98	52.837	Amphilophus_citrinellus
ENSG00000180228	PRKRA	99	52.982	ENSAOCG00000008651	prkra	99	52.982	Amphiprion_ocellaris
ENSG00000180228	PRKRA	99	55.052	ENSAPEG00000022769	prkra	97	52.982	Amphiprion_percula
ENSG00000180228	PRKRA	100	54.861	ENSATEG00000015036	prkra	100	51.757	Anabas_testudineus
ENSG00000180228	PRKRA	100	64.948	ENSACAG00000017232	PRKRA	83	64.626	Anolis_carolinensis
ENSG00000180228	PRKRA	100	100.000	ENSANAG00000019410	PRKRA	100	99.361	Aotus_nancymaae
ENSG00000180228	PRKRA	96	54.710	ENSACLG00000008370	prkra	98	51.333	Astatotilapia_calliptera
ENSG00000180228	PRKRA	97	56.475	ENSAMXG00000034602	prkra	91	56.228	Astyanax_mexicanus
ENSG00000180228	PRKRA	100	98.611	ENSBTAG00000001096	PRKRA	100	98.083	Bos_taurus
ENSG00000180228	PRKRA	100	100.000	ENSCJAG00000021521	PRKRA	100	99.681	Callithrix_jacchus
ENSG00000180228	PRKRA	100	99.653	ENSCAFG00000013850	PRKRA	100	99.361	Canis_familiaris
ENSG00000180228	PRKRA	100	99.048	ENSCAFG00020007071	-	99	99.048	Canis_lupus_dingo
ENSG00000180228	PRKRA	100	98.264	ENSCHIG00000015333	PRKRA	100	97.764	Capra_hircus
ENSG00000180228	PRKRA	100	100.000	ENSTSYG00000009707	PRKRA	100	99.681	Carlito_syrichta
ENSG00000180228	PRKRA	81	78.541	ENSCAPG00000006602	PRKRA	100	78.541	Cavia_aperea
ENSG00000180228	PRKRA	100	99.653	ENSCPOG00000003900	-	100	98.722	Cavia_porcellus
ENSG00000180228	PRKRA	100	91.468	ENSCPOG00000008302	-	96	92.881	Cavia_porcellus
ENSG00000180228	PRKRA	100	100.000	ENSCCAG00000024400	PRKRA	100	99.681	Cebus_capucinus
ENSG00000180228	PRKRA	100	92.361	ENSCATG00000037246	-	98	92.542	Cercocebus_atys
ENSG00000180228	PRKRA	100	100.000	ENSCATG00000032736	PRKRA	100	100.000	Cercocebus_atys
ENSG00000180228	PRKRA	100	99.653	ENSCLAG00000010338	PRKRA	98	99.317	Chinchilla_lanigera
ENSG00000180228	PRKRA	100	94.444	ENSCSAG00000018878	-	98	94.118	Chlorocebus_sabaeus
ENSG00000180228	PRKRA	100	69.204	ENSCPBG00000021934	PRKRA	93	68.942	Chrysemys_picta_bellii
ENSG00000180228	PRKRA	100	92.014	ENSCANG00000037988	-	100	92.014	Colobus_angolensis_palliatus
ENSG00000180228	PRKRA	98	100.000	ENSCANG00000034610	PRKRA	100	100.000	Colobus_angolensis_palliatus
ENSG00000180228	PRKRA	100	99.048	ENSCGRG00001009200	Prkra	79	98.403	Cricetulus_griseus_chok1gshd
ENSG00000180228	PRKRA	100	99.048	ENSCGRG00000002863	Prkra	100	98.403	Cricetulus_griseus_crigri
ENSG00000180228	PRKRA	98	53.191	ENSCSEG00000002954	prkra	85	53.405	Cynoglossus_semilaevis
ENSG00000180228	PRKRA	98	51.399	ENSCVAG00000002749	prkra	91	51.748	Cyprinodon_variegatus
ENSG00000180228	PRKRA	97	50.865	ENSDARG00000076718	prkra	97	50.865	Danio_rerio
ENSG00000180228	PRKRA	100	99.306	ENSDNOG00000019701	PRKRA	100	98.403	Dasypus_novemcinctus
ENSG00000180228	PRKRA	100	96.190	ENSDORG00000013338	Prkra	100	96.166	Dipodomys_ordii
ENSG00000180228	PRKRA	100	89.623	ENSETEG00000010357	PRKRA	100	91.176	Echinops_telfairi
ENSG00000180228	PRKRA	100	99.653	ENSEASG00005022436	PRKRA	100	99.361	Equus_asinus_asinus
ENSG00000180228	PRKRA	100	99.653	ENSECAG00000024263	PRKRA	100	99.361	Equus_caballus
ENSG00000180228	PRKRA	100	87.220	ENSEEUG00000000476	PRKRA	100	87.220	Erinaceus_europaeus
ENSG00000180228	PRKRA	98	54.209	ENSELUG00000023321	prkra	100	50.765	Esox_lucius
ENSG00000180228	PRKRA	100	99.653	ENSFCAG00000031042	PRKRA	100	99.361	Felis_catus
ENSG00000180228	PRKRA	100	98.264	ENSFDAG00000012882	PRKRA	100	97.682	Fukomys_damarensis
ENSG00000180228	PRKRA	77	50.685	ENSFHEG00000007229	-	89	50.685	Fundulus_heteroclitus
ENSG00000180228	PRKRA	97	50.000	ENSGMOG00000004021	prkra	94	50.000	Gadus_morhua
ENSG00000180228	PRKRA	98	51.748	ENSGAFG00000004418	prkra	91	52.098	Gambusia_affinis
ENSG00000180228	PRKRA	98	54.417	ENSGACG00000004394	prkra	92	54.417	Gasterosteus_aculeatus
ENSG00000180228	PRKRA	100	69.204	ENSGAGG00000010791	PRKRA	93	68.942	Gopherus_agassizii
ENSG00000180228	PRKRA	100	100.000	ENSGGOG00000005754	PRKRA	100	99.681	Gorilla_gorilla
ENSG00000180228	PRKRA	96	54.710	ENSHBUG00000020169	prkra	98	51.333	Haplochromis_burtoni
ENSG00000180228	PRKRA	100	85.764	ENSHGLG00000002194	-	98	83.766	Heterocephalus_glaber_female
ENSG00000180228	PRKRA	100	98.095	ENSHGLG00000010663	PRKRA	100	97.125	Heterocephalus_glaber_female
ENSG00000180228	PRKRA	100	97.569	ENSHGLG00100013982	-	100	97.595	Heterocephalus_glaber_male
ENSG00000180228	PRKRA	100	85.764	ENSHGLG00100004391	-	98	83.766	Heterocephalus_glaber_male
ENSG00000180228	PRKRA	98	51.049	ENSHCOG00000000168	prkra	91	51.049	Hippocampus_comes
ENSG00000180228	PRKRA	98	54.804	ENSIPUG00000019396	prkra	95	54.804	Ictalurus_punctatus
ENSG00000180228	PRKRA	100	98.958	ENSSTOG00000006156	PRKRA	100	98.722	Ictidomys_tridecemlineatus
ENSG00000180228	PRKRA	100	98.264	ENSJJAG00000013031	Prkra	100	98.083	Jaculus_jaculus
ENSG00000180228	PRKRA	98	52.759	ENSKMAG00000016206	prkra	91	52.759	Kryptolebias_marmoratus
ENSG00000180228	PRKRA	98	54.895	ENSLBEG00000017208	prkra	99	51.118	Labrus_bergylta
ENSG00000180228	PRKRA	100	66.090	ENSLACG00000002855	PRKRA	100	63.057	Latimeria_chalumnae
ENSG00000180228	PRKRA	99	58.020	ENSLOCG00000006829	prkra	99	55.660	Lepisosteus_oculatus
ENSG00000180228	PRKRA	92	98.851	ENSLAFG00000026940	PRKRA	100	97.951	Loxodonta_africana
ENSG00000180228	PRKRA	100	100.000	ENSMFAG00000040213	PRKRA	100	100.000	Macaca_fascicularis
ENSG00000180228	PRKRA	100	100.000	ENSMMUG00000002185	PRKRA	100	99.669	Macaca_mulatta
ENSG00000180228	PRKRA	98	89.247	ENSMNEG00000030245	-	98	86.230	Macaca_nemestrina
ENSG00000180228	PRKRA	100	100.000	ENSMNEG00000031681	PRKRA	100	100.000	Macaca_nemestrina
ENSG00000180228	PRKRA	100	100.000	ENSMLEG00000019578	PRKRA	100	100.000	Mandrillus_leucophaeus
ENSG00000180228	PRKRA	93	94.796	ENSMLEG00000031889	-	99	94.265	Mandrillus_leucophaeus
ENSG00000180228	PRKRA	99	54.035	ENSMAMG00000006591	prkra	92	54.035	Mastacembelus_armatus
ENSG00000180228	PRKRA	93	44.898	ENSMZEG00005004467	prkra	86	46.457	Maylandia_zebra
ENSG00000180228	PRKRA	100	99.048	ENSMAUG00000019631	Prkra	100	98.722	Mesocricetus_auratus
ENSG00000180228	PRKRA	100	100.000	ENSMICG00000009883	PRKRA	100	99.361	Microcebus_murinus
ENSG00000180228	PRKRA	100	98.264	ENSMOCG00000004548	Prkra	100	97.764	Microtus_ochrogaster
ENSG00000180228	PRKRA	98	49.320	ENSMMOG00000000434	prkra	97	49.320	Mola_mola
ENSG00000180228	PRKRA	100	81.597	ENSMODG00000009823	PRKRA	100	79.553	Monodelphis_domestica
ENSG00000180228	PRKRA	100	55.137	ENSMALG00000010225	prkra	94	52.681	Monopterus_albus
ENSG00000180228	PRKRA	100	98.611	MGP_CAROLIEiJ_G0023688	Prkra	100	98.083	Mus_caroli
ENSG00000180228	PRKRA	100	98.611	ENSMUSG00000002731	Prkra	100	98.083	Mus_musculus
ENSG00000180228	PRKRA	100	98.611	MGP_PahariEiJ_G0025139	Prkra	100	98.083	Mus_pahari
ENSG00000180228	PRKRA	100	98.264	MGP_SPRETEiJ_G0024609	Prkra	100	97.764	Mus_spretus
ENSG00000180228	PRKRA	100	99.653	ENSMPUG00000003180	PRKRA	100	99.361	Mustela_putorius_furo
ENSG00000180228	PRKRA	85	91.358	ENSMLUG00000024042	-	100	75.779	Myotis_lucifugus
ENSG00000180228	PRKRA	100	98.264	ENSMLUG00000005810	-	100	97.764	Myotis_lucifugus
ENSG00000180228	PRKRA	100	99.306	ENSNGAG00000021816	Prkra	100	98.083	Nannospalax_galili
ENSG00000180228	PRKRA	96	55.435	ENSNBRG00000010819	prkra	98	52.000	Neolamprologus_brichardi
ENSG00000180228	PRKRA	100	100.000	ENSNLEG00000006120	-	100	100.000	Nomascus_leucogenys
ENSG00000180228	PRKRA	100	74.653	ENSMEUG00000002625	PRKRA	100	74.914	Notamacropus_eugenii
ENSG00000180228	PRKRA	99	78.526	ENSOPRG00000007575	PRKRA	100	78.526	Ochotona_princeps
ENSG00000180228	PRKRA	100	84.775	ENSODEG00000007930	-	98	84.746	Octodon_degus
ENSG00000180228	PRKRA	100	99.048	ENSODEG00000008743	-	100	98.722	Octodon_degus
ENSG00000180228	PRKRA	96	54.710	ENSONIG00000008579	prkra	96	54.710	Oreochromis_niloticus
ENSG00000180228	PRKRA	100	65.278	ENSOANG00000008630	-	100	62.025	Ornithorhynchus_anatinus
ENSG00000180228	PRKRA	100	98.264	ENSOCUG00000005489	PRKRA	100	97.125	Oryctolagus_cuniculus
ENSG00000180228	PRKRA	99	54.054	ENSORLG00000017598	prkra	91	54.237	Oryzias_latipes
ENSG00000180228	PRKRA	99	54.054	ENSORLG00020020348	prkra	91	54.237	Oryzias_latipes_hni
ENSG00000180228	PRKRA	99	53.559	ENSORLG00015014417	prkra	91	53.741	Oryzias_latipes_hsok
ENSG00000180228	PRKRA	98	55.749	ENSOMEG00000005162	prkra	94	54.027	Oryzias_melastigma
ENSG00000180228	PRKRA	100	99.306	ENSOGAG00000013971	PRKRA	100	99.042	Otolemur_garnettii
ENSG00000180228	PRKRA	100	98.611	ENSOARG00000017321	PRKRA	100	98.083	Ovis_aries
ENSG00000180228	PRKRA	100	100.000	ENSPPAG00000043306	PRKRA	100	100.000	Pan_paniscus
ENSG00000180228	PRKRA	100	99.653	ENSPPRG00000011982	-	100	99.361	Panthera_pardus
ENSG00000180228	PRKRA	100	99.653	ENSPTIG00000010369	PRKRA	100	99.653	Panthera_tigris_altaica
ENSG00000180228	PRKRA	100	100.000	ENSPTRG00000012688	PRKRA	100	100.000	Pan_troglodytes
ENSG00000180228	PRKRA	93	94.424	ENSPANG00000035264	-	98	93.151	Papio_anubis
ENSG00000180228	PRKRA	100	100.000	ENSPANG00000001046	PRKRA	100	100.000	Papio_anubis
ENSG00000180228	PRKRA	98	55.594	ENSPKIG00000022368	prkra	96	53.642	Paramormyrops_kingsleyae
ENSG00000180228	PRKRA	100	68.512	ENSPSIG00000002848	PRKRA	100	68.512	Pelodiscus_sinensis
ENSG00000180228	PRKRA	93	54.545	ENSPMGG00000000868	-	92	54.545	Periophthalmus_magnuspinnatus
ENSG00000180228	PRKRA	100	99.048	ENSPEMG00000011967	Prkra	100	97.764	Peromyscus_maniculatus_bairdii
ENSG00000180228	PRKRA	100	82.639	ENSPCIG00000025371	PRKRA	72	81.169	Phascolarctos_cinereus
ENSG00000180228	PRKRA	98	51.399	ENSPFOG00000015000	prkra	90	51.748	Poecilia_formosa
ENSG00000180228	PRKRA	98	51.049	ENSPLAG00000021726	prkra	91	51.399	Poecilia_latipinna
ENSG00000180228	PRKRA	98	51.399	ENSPMEG00000006172	prkra	90	51.748	Poecilia_mexicana
ENSG00000180228	PRKRA	98	50.699	ENSPREG00000005680	prkra	91	51.049	Poecilia_reticulata
ENSG00000180228	PRKRA	100	100.000	ENSPPYG00000012976	PRKRA	100	99.681	Pongo_abelii
ENSG00000180228	PRKRA	100	100.000	ENSPCOG00000018812	PRKRA	100	99.681	Propithecus_coquereli
ENSG00000180228	PRKRA	100	98.095	ENSPVAG00000017505	PRKRA	100	88.818	Pteropus_vampyrus
ENSG00000180228	PRKRA	96	54.348	ENSPNYG00000008795	prkra	98	51.000	Pundamilia_nyererei
ENSG00000180228	PRKRA	98	52.249	ENSPNAG00000021962	prkra	90	52.249	Pygocentrus_nattereri
ENSG00000180228	PRKRA	100	98.611	ENSRNOG00000011195	Prkra	100	98.083	Rattus_norvegicus
ENSG00000180228	PRKRA	100	95.486	ENSRBIG00000042015	-	99	94.966	Rhinopithecus_bieti
ENSG00000180228	PRKRA	100	100.000	ENSRBIG00000035301	PRKRA	100	99.681	Rhinopithecus_bieti
ENSG00000180228	PRKRA	100	100.000	ENSRROG00000035389	PRKRA	100	99.681	Rhinopithecus_roxellana
ENSG00000180228	PRKRA	100	99.653	ENSSBOG00000012105	PRKRA	100	99.361	Saimiri_boliviensis_boliviensis
ENSG00000180228	PRKRA	100	81.250	ENSSHAG00000009949	PRKRA	100	81.443	Sarcophilus_harrisii
ENSG00000180228	PRKRA	98	52.465	ENSSFOG00015002157	prkra	90	52.465	Scleropages_formosus
ENSG00000180228	PRKRA	97	54.639	ENSSMAG00000015615	prkra	87	52.733	Scophthalmus_maximus
ENSG00000180228	PRKRA	99	55.088	ENSSDUG00000000636	prkra	92	55.088	Seriola_dumerili
ENSG00000180228	PRKRA	99	52.281	ENSSLDG00000000652	prkra	88	52.281	Seriola_lalandi_dorsalis
ENSG00000180228	PRKRA	100	97.222	ENSSARG00000003080	PRKRA	100	95.541	Sorex_araneus
ENSG00000180228	PRKRA	99	67.133	ENSSPUG00000006140	PRKRA	84	67.123	Sphenodon_punctatus
ENSG00000180228	PRKRA	99	54.035	ENSSPAG00000021062	prkra	98	50.820	Stegastes_partitus
ENSG00000180228	PRKRA	100	99.653	ENSSSCG00000038254	PRKRA	100	99.361	Sus_scrofa
ENSG00000180228	PRKRA	98	51.228	ENSTRUG00000021336	prkra	100	48.254	Takifugu_rubripes
ENSG00000180228	PRKRA	99	50.350	ENSTNIG00000016963	prkra	100	49.045	Tetraodon_nigroviridis
ENSG00000180228	PRKRA	100	97.444	ENSTBEG00000006494	PRKRA	100	97.444	Tupaia_belangeri
ENSG00000180228	PRKRA	100	99.048	ENSTTRG00000009700	PRKRA	100	99.617	Tursiops_truncatus
ENSG00000180228	PRKRA	100	97.143	ENSUAMG00000010644	-	99	97.143	Ursus_americanus
ENSG00000180228	PRKRA	100	99.306	ENSUMAG00000016566	PRKRA	100	99.306	Ursus_maritimus
ENSG00000180228	PRKRA	100	89.236	ENSVPAG00000003485	PRKRA	100	89.347	Vicugna_pacos
ENSG00000180228	PRKRA	100	99.653	ENSVVUG00000010032	PRKRA	100	99.338	Vulpes_vulpes
ENSG00000180228	PRKRA	95	45.556	ENSXCOG00000019261	-	95	45.556	Xiphophorus_couchianus
ENSG00000180228	PRKRA	98	51.399	ENSXMAG00000027764	prkra	91	51.748	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003725	double-stranded RNA binding	23661684.	IDA	Function
GO:0005515	protein binding	16424907.17452327.18096616.20064372.21516116.21858095.21900206.21903422.21994455.22810585.23455922.23661684.23853584.23870315.25416956.25910212.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	17452327.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006468	protein phosphorylation	-	IEA	Process
GO:0006955	immune response	9687506.	TAS	Process
GO:0008047	enzyme activator activity	-	IEA	Function
GO:0008285	negative regulation of cell proliferation	9687506.	TAS	Process
GO:0009615	response to virus	9687506.	TAS	Process
GO:0010586	miRNA metabolic process	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016032	viral process	-	IEA	Process
GO:0019899	enzyme binding	23661684.	IPI	Function
GO:0030422	production of siRNA involved in RNA interference	17452327.	IDA	Process
GO:0030422	production of siRNA involved in RNA interference	-	TAS	Process
GO:0031054	pre-miRNA processing	16424907.23661684.	IDA	Process
GO:0034599	cellular response to oxidative stress	-	IEA	Process
GO:0035196	production of miRNAs involved in gene silencing by miRNA	23661684.	IDA	Process
GO:0042473	outer ear morphogenesis	-	IEA	Process
GO:0042474	middle ear morphogenesis	-	IEA	Process
GO:0042802	identical protein binding	16169070.21900206.25416956.	IPI	Function
GO:0042803	protein homodimerization activity	17452327.	IPI	Function
GO:0043085	positive regulation of catalytic activity	-	IEA	Process
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0048705	skeletal system morphogenesis	-	IEA	Process
GO:0050821	protein stabilization	16424907.	IMP	Process
GO:0070578	RISC-loading complex	23661684.	IDA	Component
GO:0070883	pre-miRNA binding	23661684.	IDA	Function
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	-	IEA	Process