EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000180370 (Gene tree)
Gene ID: 5062
Gene Symbol: PAK2
Alias: PAK65|PAKgamma
Full Name: p21 (RAC1) activated kinase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 92,791 bases
Position: chr3:196,739,857-196,832,647
Accession: 8591
RBP type: non-canonical RBP
Summary: The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000327134	PAK2-201	6139	XM_011512870	ENSP00000314067	524 (aa)	XP_011511172	Q13177
ENST00000426668	PAK2-202	689	-	ENSP00000402927	221 (aa)	-	H7C1X3
ENST00000481344	PAK2-203	371	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000180370's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04010	MAPK signaling pathway	KEGG
hsa04012	ErbB signaling pathway	KEGG
hsa04014	Ras signaling pathway	KEGG
hsa04360	Axon guidance	KEGG
hsa04510	Focal adhesion	KEGG
hsa04660	T cell receptor signaling pathway	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa05170	Human immunodeficiency virus 1 infection	KEGG
hsa05211	Renal cell carcinoma	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000180370	Schizophrenia	9E-6	26198764
ENSG00000180370	Glucose	9E-6	25524916
ENSG00000180370	Insulin Resistance	9E-6	25524916
ENSG00000180370	Alzheimer Disease	5E-6	21116278
ENSG00000180370	Brain	5E-6	21116278

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000180370	rs7626444	3	196778031	C	Monocyte count	27863252	[0.016-0.03] unit decrease	0.02319992	EFO_0005091
ENSG00000180370	rs843532	3	196755340	?	Glucose homeostasis traits	25524916	[0.055-0.525] unit increase	0.29	EFO_0004471\|EFO_0006896
ENSG00000180370	rs2084385	3	196826996	?	Total ventricular volume (Alzheimer's disease interaction)	21116278	[NR] unit increase	0.006	EFO_0000249\|EFO_0006930
ENSG00000180370	rs10446497	3	196819658	G	Schizophrenia	26198764	[NR]	1.0526316	EFO_0000692
ENSG00000180370	rs13092376	3	196789417	C	Lymphocyte counts	27863252	[0.028-0.043] unit decrease	0.03564678	EFO_0004587
ENSG00000180370	rs13434265	3	196762551	T	White blood cell count	27863252	[0.023-0.038] unit decrease	0.0303966	EFO_0004308
ENSG00000180370	rs11294619	3	196784238	T	Plateletcrit	27863252	[0.025-0.04] unit decrease	0.03266217	EFO_0007985
ENSG00000180370	rs11294619	3	196784238	T	Platelet count	27863252	[0.017-0.032] unit decrease	0.02457575	EFO_0004309
ENSG00000180370	rs9872035	3	196767831	C	Atrial fibrillation	29892015	[1.03-1.06]	1.04	EFO_0000275
ENSG00000180370	rs9829778	3	196822218	A	Sum eosinophil basophil counts	27863252	[0.016-0.03] unit increase	0.0230922	EFO_0005090\|EFO_0004842
ENSG00000180370	rs7630852	3	196781680	A	Eosinophil counts	27863252	[0.015-0.029] unit decrease	0.02171766	EFO_0004842
ENSG00000180370	rs13092376	3	196789417	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000180370	rs2089979	3	196774542	?	White blood cell count	30595370			EFO_0004308
ENSG00000180370	rs9829778	3	196822218	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000180370's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002223	stimulatory C-type lectin receptor signaling pathway	-	TAS	Process
GO:0004672	protein kinase activity	10748018.	TAS	Function
GO:0004674	protein serine/threonine kinase activity	11278486.	EXP	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	11121037.11805089.	IDA	Function
GO:0004674	protein serine/threonine kinase activity	-	TAS	Function
GO:0005515	protein binding	10607567.16374509.16527308.16787945.16837009.18716323.19240112.19264842.19435845.20696164.20936779.21516116.21555521.22705156.25416956.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	25468996.	IDA	Component
GO:0005829	cytosol	8625410.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006468	protein phosphorylation	11805089.	IDA	Process
GO:0006469	negative regulation of protein kinase activity	10748018.	TAS	Process
GO:0006915	apoptotic process	-	IEA	Process
GO:0007165	signal transduction	7744004.	TAS	Process
GO:0014069	postsynaptic density	-	IEA	Component
GO:0016310	phosphorylation	21555521.	IDA	Process
GO:0016477	cell migration	21873635.	IBA	Process
GO:0018105	peptidyl-serine phosphorylation	11121037.	IDA	Process
GO:0019901	protein kinase binding	11121037.	IPI	Function
GO:0023014	signal transduction by protein phosphorylation	21873635.	IBA	Process
GO:0030296	protein tyrosine kinase activator activity	11121037.	IDA	Function
GO:0031098	stress-activated protein kinase signaling cascade	21873635.	IBA	Process
GO:0031267	small GTPase binding	8625410.	IPI	Function
GO:0031295	T cell costimulation	-	TAS	Process
GO:0032147	activation of protein kinase activity	21873635.	IBA	Process
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	Process
GO:0038095	Fc-epsilon receptor signaling pathway	-	TAS	Process
GO:0040008	regulation of growth	-	IEA	Process
GO:0042802	identical protein binding	16837009.	IPI	Function
GO:0043066	negative regulation of apoptotic process	21555521.	IMP	Process
GO:0043408	regulation of MAPK cascade	21873635.	IBA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046777	protein autophosphorylation	11805089.	IDA	Process
GO:0048010	vascular endothelial growth factor receptor signaling pathway	-	TAS	Process
GO:0048365	Rac GTPase binding	21873635.	IBA	Function
GO:0048365	Rac GTPase binding	8625410.	IPI	Function
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0050690	regulation of defense response to virus by virus	-	TAS	Process
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	11121037.	IDA	Process
GO:0050852	T cell receptor signaling pathway	-	TAS	Process
GO:0060996	dendritic spine development	-	IEA	Process
GO:0061098	positive regulation of protein tyrosine kinase activity	-	IEA	Process
GO:0071407	cellular response to organic cyclic compound	-	IEA	Process
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	19240112.	IMP	Process
GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	21873635.	IBA	Process
GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	21555521.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24621074	Activation of P21-activated protein kinase 2 is an independent prognostic predictor for patients with gastric cancer.	Diagn Pathol	2014 Mar 12	Gao C	doi: 10.1186/1746-1596-9-55.
18411304	Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms.	Mol Cell Biol	2008 Jun	Coniglio SJ	doi: 10.1128/MCB.01532-07
25050916	Motility of select ovarian cancer cell lines: effect of extra-cellular matrix proteins and the involvement of PAK2.	Int J Oncol	2014 Oct	Flate E	doi: 10.3892/ijo.2014.2553
15047871	Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions.	Mol Biol Cell	2004 Jun	Stofega MR	-
24434518	Prostasin may contribute to chemoresistance, repress cancer cells in ovarian cancer, and is involved in the signaling pathways of CASP/PAK2-p34/actin.	Cell Death Dis	2014 Jan 16	Yan BX	doi: 10.1038/cddis.2013.523.
15908432	Binding of activated alpha2-macroglobulin to its cell surface receptor GRP78 in 1-LN prostate cancer cells regulates PAK-2-dependent activation of LIMK.	J Biol Chem	2005 Jul 15	Misra UK	-

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr3	196803138	Missense_Mutation	NA	Q137P	0.69
BLCA	chr3	196782680	Missense_Mutation	novel	P12A	0.06
BLCA	chr3	196782659	Nonsense_Mutation	novel	G5*	0.15
BLCA	chr3	196807818	Missense_Mutation	novel	P205S	0.48
BLCA	chr3	196814566	Missense_Mutation	novel	E351Q	0.53
BLCA	chr3	196803039	Missense_Mutation	rs776632073	R104Q	0.34
BLCA	chr3	196806603	Missense_Mutation	novel	P165A	0.3
BLCA	chr3	196820502	Missense_Mutation	novel	L429V	0.1
BLCA	chr3	196814464	Missense_Mutation	novel	D317H	0.17
BRCA	chr3	196829146	3'UTR	novel		0.23
BRCA	chr3	196807871	Frame_Shift_Ins	novel	*K223Qfs4**	0.08
BRCA	chr3	196803147	Missense_Mutation	novel	L140P	0.1
BRCA	chr3	196820529	Missense_Mutation	novel	E438K	0.07
BRCA	chr3	196801980	Missense_Mutation	novel	E81K	0.26
BRCA	chr3	196820553	Missense_Mutation	novel	E446K	0.1
BRCA	chr3	196820467	Missense_Mutation	rs774110601	R417Q	0.24
BRCA	chr3	196782749	Missense_Mutation	NA	H35D	0.16
CESC	chr3	196829168	3'UTR	rs561568371		0.29
CESC	chr3	196801950	Missense_Mutation	rs762853247	R71W	0.35
CESC	chr3	196812839	Missense_Mutation	novel	N308T	0.39
CESC	chr3	196818110	Missense_Mutation	novel	I369M	0.07
CESC	chr3	196805351	Splice_Site	NA	X146_splice	0.2
CESC	chr3	196820452	Missense_Mutation	novel	P412L	0.35
CESC	chr3	196814564	Missense_Mutation	NA	R350K	0.22
COAD	chr3	196806665	Silent	rs756843915	P185P	0.25
COAD	chr3	196814497	Frame_Shift_Del	novel	*S330Hfs6**	0.39
COAD	chr3	196806661	Frame_Shift_Del	novel	*P185Rfs14**	0.2
COAD	chr3	196820449	Missense_Mutation	NA	A411V	0.19
COAD	chr3	196818111	Frame_Shift_Del	NA	*S371Vfs67**	0.31
COAD	chr3	196820490	Missense_Mutation	novel	D425N	0.11
COAD	chr3	196827302	Frame_Shift_Del	novel	*R488Gfs13**	0.32
COAD	chr3	196827307	Missense_Mutation	novel	R488G	0.38
DLBC	chr3	196820530	Missense_Mutation	novel	E438G	0.03
GBM	chr3	196820374	Missense_Mutation	novel	D386V	0.1
HNSC	chr3	196827322	Missense_Mutation	novel	E493Q	0.32
HNSC	chr3	196807815	Missense_Mutation	novel	A204T	0.08
HNSC	chr3	196782819	Missense_Mutation	NA	S58L	0.08
HNSC	chr3	196782653	Missense_Mutation	novel	D3H	0.09
HNSC	chr3	196803061	Missense_Mutation	novel	I111M	0.16
HNSC	chr3	196803148	Silent	NA	L140L	0.13
HNSC	chr3	196814497	Frame_Shift_Del	novel	*S330Hfs6**	0.31
HNSC	chr3	196818143	Silent	novel	G380G	0.57
KIRP	chr3	196782635	5'UTR	novel		0.3
LGG	chr3	196820476	Missense_Mutation	NA	Y420C	0.18
LIHC	chr3	196782654	Missense_Mutation	novel	D3A	0.26
LIHC	chr3	196820459	Silent	NA	V414V	0.28
LUAD	chr3	196820416	Missense_Mutation	NA	R400P	0.55
LUAD	chr3	196782694	Silent	NA	V16V	0.09
LUAD	chr3	196782820	Silent	novel	S58S	0.35
LUAD	chr3	196806667	Missense_Mutation	NA	R186L	0.26
LUSC	chr3	196828357	Missense_Mutation	novel	L509F	0.16
LUSC	chr3	196828372	Missense_Mutation	novel	M514I	0.72
LUSC	chr3	196828460	3'UTR	novel		0.55
LUSC	chr3	196820459	Silent	NA	V414V	0.23
LUSC	chr3	196801951	Missense_Mutation	novel	R71Q	0.19
LUSC	chr3	196827307	Missense_Mutation	novel	R488G	0.17
OV	chr3	196818057	Missense_Mutation	novel	C352R	0.06
OV	chr3	196782668	Missense_Mutation	novel	E8K	0.32
OV	chr3	196803089	Missense_Mutation	novel	Q121E	0.12
OV	chr3	196806593	Silent	novel	G161G	0.05
OV	chr3	196807848	Missense_Mutation	novel	A215S	0.18
OV	chr3	196820497	Nonsense_Mutation	novel	W427*	0.05
OV	chr3	196803071	Missense_Mutation	NA	E115Q	0.18
PAAD	chr3	196782762	Missense_Mutation	novel	P39H	0.04
PAAD	chr3	196814495	Missense_Mutation	novel	A327D	0.19
PRAD	chr3	196782699	Missense_Mutation	NA	M18K	0.05
PRAD	chr3	196820416	Missense_Mutation	novel	R400H	0.19
READ	chr3	196814541	Silent	novel	E342E	0.05
READ	chr3	196807832	Silent	novel	S209S	0.08
READ	chr3	196828475	3'UTR	novel		0.13
READ	chr3	196782662	Nonsense_Mutation	novel	E6*	0.4
READ	chr3	196807890	Missense_Mutation	NA	D229N	0.15
SKCM	chr3	196827314	Missense_Mutation	novel	S490L	0.49
SKCM	chr3	196820404	Missense_Mutation	NA	E396G	0.06
SKCM	chr3	196829897	3'UTR	novel		1
SKCM	chr3	196828344	Missense_Mutation	NA	P505L	0.37
SKCM	chr3	196828338	Missense_Mutation	NA	A503V	0.15
SKCM	chr3	196827255	Silent	NA	S470S	0.37
SKCM	chr3	196806604	Missense_Mutation	NA	P165L	0.34
SKCM	chr3	196827246	Missense_Mutation	NA	E467D	0.1
SKCM	chr3	196812842	Missense_Mutation	NA	F309Y	0.36
SKCM	chr3	196806678	Missense_Mutation	NA	T190A	0.16
STAD	chr3	196828409	3'UTR	novel		0.26
STAD	chr3	196810638	Frame_Shift_Del	novel	*I255Lfs36**	0.16
STAD	chr3	196812218	Splice_Site	NA	X258_splice	0.12
STAD	chr3	196814497	Frame_Shift_Del	novel	*S330Hfs6**	0.08
STAD	chr3	196807826	Silent	rs758114223	G207G	0.09
STAD	chr3	196820567	Missense_Mutation	novel	R450S	0.36
STAD	chr3	196827281	Missense_Mutation	rs759691640	R479Q	0.48
STAD	chr3	196782627	Splice_Region	novel		0.36
STAD	chr3	196803086	Missense_Mutation	NA	P120S	0.49
STAD	chr3	196820502	Missense_Mutation	novel	L429M	0.45
STAD	chr3	196827308	Frame_Shift_Del	novel	*G489Vfs12**	0.18
STAD	chr3	196806629	Missense_Mutation	rs565026135	D173E	0.15
STAD	chr3	196827236	Missense_Mutation	NA	Q464R	0.14
STAD	chr3	196812238	Missense_Mutation	NA	T265A	0.22
STAD	chr3	196820415	Missense_Mutation	novel	R400C	0.27
UCEC	chr3	196806680	Silent	rs141767764	T190T	0.31
UCEC	chr3	196829162	3'UTR	novel		0.35
UCEC	chr3	196829331	3'UTR	novel		0.42
UCEC	chr3	196803077	Missense_Mutation	NA	K117Q	0.2
UCEC	chr3	196828436	3'UTR	novel		0.2
UCEC	chr3	196829087	3'UTR	rs4638940		0.41
UCEC	chr3	196812806	Missense_Mutation	novel	V297A	0.21
UCEC	chr3	196814485	Missense_Mutation	novel	E324Q	0.18
UCEC	chr3	196820513	Missense_Mutation	NA	M432I	0.15
UCEC	chr3	196803159	Missense_Mutation	novel	P144H	0.2
UCEC	chr3	196812741	Splice_Region	NA	V275V	0.38
UCEC	chr3	196812840	Missense_Mutation	novel	N308K	0.5
UCEC	chr3	196828528	3'UTR	novel		0.1
UCEC	chr3	196807855	Missense_Mutation	novel	S217Y	0.53
UCEC	chr3	196827225	Silent	novel	T460T	0.17
UCEC	chr3	196828854	3'UTR	novel		0.32
UCEC	chr3	196810618	Frame_Shift_Ins	novel	*Y249Ifs5**	0.38
UCEC	chr3	196827202	Missense_Mutation	novel	Y453H	0.39
UCEC	chr3	196782762	Missense_Mutation	novel	P39H	0.46
UCEC	chr3	196801942	Missense_Mutation	novel	E68G	0.44
UCEC	chr3	196803159	Missense_Mutation	novel	P144L	0.11
UCEC	chr3	196828687	3'UTR	novel		0.25
UCEC	chr3	196782731	Missense_Mutation	novel	D29N	0.35
UCEC	chr3	196806680	Silent	rs141767764	T190T	0.4
UCEC	chr3	196829333	3'UTR	novel		0.21
UCEC	chr3	196829201	3'UTR	novel		0.34
UCEC	chr3	196829427	3'UTR	novel		0.42
UCEC	chr3	196810644	Missense_Mutation	novel	I255S	0.11
UCEC	chr3	196829087	3'UTR	rs4638940		0.38
UCEC	chr3	196827280	Nonsense_Mutation	novel	R479*	0.11
UCEC	chr3	196829087	3'UTR	rs4638940		0.28
UCEC	chr3	196802019	Missense_Mutation	NA	E94K	0.44
UCEC	chr3	196828429	3'UTR	novel		0.48
UCEC	chr3	196828584	3'UTR	novel		0.1
UCEC	chr3	196820489	Silent	rs201099222	V424V	0.2

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.4338	0.0018563
GBM	DEL	0.0832	3.2518e-06
KIRC	AMP	0.1174	2.0306e-05
KIRP	AMP	0.3194	0.15981
LGG	DEL	0.0858	4.7283e-05
LUAD	DEL	0.1899	0.010111
PAAD	AMP	0.1141	0.16151
PRAD	DEL	0.061	0.17738
SARC	DEL	0.179	0.0086757

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0011	Kaplan-Meier Survival Analysis
KIRC	0.0023	Kaplan-Meier Survival Analysis
MESO	0.0016	Kaplan-Meier Survival Analysis
ACC	0.041	Kaplan-Meier Survival Analysis
SKCM	0.00075	Kaplan-Meier Survival Analysis
PRAD	0.0039	Kaplan-Meier Survival Analysis
KIRP	0.0011	Kaplan-Meier Survival Analysis
PAAD	0.00021	Kaplan-Meier Survival Analysis
KICH	0.011	Kaplan-Meier Survival Analysis
UCEC	0.027	Kaplan-Meier Survival Analysis
LIHC	0.0025	Kaplan-Meier Survival Analysis
LGG	0.014	Kaplan-Meier Survival Analysis
LUAD	0.0067	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742