EuRBPDB

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  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • GWAS
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000181019 (Gene tree)
Gene ID
1728
Gene Symbol
NQO1
Alias
DHQU|QR1|DTD|NMOR1|DIA4
Full Name
NAD(P)H quinone dehydrogenase 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
19,956 bases
Position
chr16:69,706,996-69,726,951
Accession
2874
RBP type
non-canonical RBP
Summary
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
27515817Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation.Free Radic Biol Med2016 OctDi Francesco Adoi: 10.1016/j.freeradbiomed.2016.08.005
7780966An alternatively spliced form of NQO1 (DT-diaphorase) messenger RNA lacking the putative quinone substrate binding site is present in human normal and tumor tissues.Cancer Res1995 Jun 15Gasdaska PY-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000379046NQO1-2021105-ENSP00000368334236 (aa)-P15559
ENST00000379047NQO1-2032527-ENSP00000368335240 (aa)-P15559
ENST00000564043NQO1-206892-ENSP00000455020253 (aa)-H3BNV2
ENST00000320623NQO1-2012912-ENSP00000319788274 (aa)-P15559
ENST00000561500NQO1-205891-ENSP00000456282269 (aa)-H3BRK3
ENST00000569118NQO1-207519--- (aa)--
ENST00000439109NQO1-204924-ENSP00000398330202 (aa)-B4DLR8
Gene Model
Click here to download ENSG00000181019's gene model file
Pathways
Pathway IDPathway NameSource
hsa00130Ubiquinone and other terpenoid-quinone biosynthesisKEGG
hsa05200Pathways in cancerKEGG
hsa05225Hepatocellular carcinomaKEGG
hsa05418Fluid shear stress and atherosclerosisKEGG
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000181019rs18370161669723778TRisk-taking tendency (4-domain principal component model)30643258[0.012-0.022] unit decrease0.017263984EFO_0008579
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000181019's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003723RNA binding22658674.HDAFunction
GO:0003955NAD(P)H dehydrogenase (quinone) activity21873635.IBAFunction
GO:0004128cytochrome-b5 reductase activity, acting on NAD(P)H9579781.TASFunction
GO:0004784superoxide dismutase activity-IEAFunction
GO:0005515protein binding18388957.21636573.IPIFunction
GO:0005737cytoplasm2843525.TASComponent
GO:0005829cytosol21873635.IBAComponent
GO:0005829cytosol10945627.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006521regulation of cellular amino acid metabolic process-TASProcess
GO:0006805xenobiotic metabolic process10393963.TASProcess
GO:0006809nitric oxide biosynthetic process9579781.TASProcess
GO:0007271synaptic transmission, cholinergic9579781.TASProcess
GO:0007568aging-IEAProcess
GO:0007584response to nutrient-IEAProcess
GO:0009055electron transfer activity21873635.IBAFunction
GO:0009636response to toxic substance10393963.TASProcess
GO:0016491oxidoreductase activity21873635.IBAFunction
GO:0019430removal of superoxide radicals-IEAProcess
GO:0022900electron transport chain-IEAProcess
GO:0030425dendrite-IEAComponent
GO:0032355response to estradiol-IEAProcess
GO:0042802identical protein binding25143260.IPIFunction
GO:0043025neuronal cell body-IEAComponent
GO:0043066negative regulation of apoptotic process-IEAProcess
GO:0043086negative regulation of catalytic activity-IEAProcess
GO:0043525positive regulation of neuron apoptotic process-IEAProcess
GO:0045471response to ethanol-IEAProcess
GO:0051602response to electrical stimulus-IEAProcess
GO:0070301cellular response to hydrogen peroxide-IEAProcess
GO:0071248cellular response to metal ion-IEAProcess
GO:1901698response to nitrogen compound-IEAProcess
GO:1904880response to hydrogen sulfide-IEAProcess

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
27840932Expression and correlation of NRF2, KEAP1, NQO-1 and HO-1 in advanced squamous cell carcinoma of the larynx and their association with clinicopathologic features.Mol Med Rep2016 DecLi Cdoi: 10.3892/mmr.2016.5913
20613985NAD(P)H quinone oxidoreductase protects TAp63gamma from proteasomal degradation and regulates TAp63gamma-dependent growth arrest.PLoS One2010 Jun 30Hershkovitz Rokah Odoi: 10.1371/journal.pone.0011401.
28964792Prognostic implication of NQO1 overexpression in hepatocellular carcinoma.Hum Pathol2017 NovLin Ldoi: 10.1016/j.humpath.2017.09.002
24512128Tumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 bioactivatable radiosensitizing drugs in triple-negative breast cancers.Antioxid Redox Signal2014 Jul 10Cao Ldoi: 10.1089/ars.2013.5462
21706157NQO1 expression correlates inversely with NF??B activation in human breast cancer.Breast Cancer Res Treat2012 AprJamshidi Mdoi: 10.1007/s10549-011-1629-5
24830960Genetic polymorphism 609C>T in NAD(P)H:quinone oxidoreductase 1 enhances the risk of proximal colon cancer.J Hum Genet2014 JulFreriksen JJdoi: 10.1038/jhg.2014.38
22393995The NQO1 C609T polymorphism and risk of lung cancer: a meta-analysis.Asian Pac J Cancer Prev2011Liu Y-
22387672NAD(P)H quinone oxidoreductase 1 (NQO1) genetic C609T polymorphism is associated with the risk of digestive tract cancer: a meta-analysis based on 21 case-control studies.Eur J Cancer Prev2012 SepYang FYdoi: 10.1097/CEJ.0b013e32834f7514.
28291250Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.Sci Rep2017 Mar 14Medina-Carmona Edoi: 10.1038/srep44532.
29652514*
%Nutr Cancer2018 May-JunYadav Udoi: 10.1080/01635581.2018.1460674
25125658NQO1 suppresses NF-??B-p300 interaction to regulate inflammatory mediators associated with prostate tumorigenesis.Cancer Res2014 Oct 1Thapa Ddoi: 10.1158/0008-5472.CAN-14-0562
21479364The NQO1*2/*2 polymorphism is associated with poor overall survival in patients following resection of stages II and IIIa non-small cell lung cancer.Oncol Rep2011 JunKolesar JMdoi: 10.3892/or.2011.1249
20966810Superoxide dismutase and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase polymorphisms and pancreatic cancer risk.Pancreas2011 JanMohelnikova-Duchonova Bdoi: 10.1097/MPA.0b013e3181f74ad7.
20091863Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer.Int J Cancer2010 Oct 1Timofeeva Mdoi: 10.1002/ijc.25175.
12694753An association between NQO1 genetic polymorphism and risk of bladder cancer.Mutat Res2003 Apr 20Park SJ-
23458878NQO1 609C>T polymorphism interaction with tobacco smoking and alcohol drinking increases colorectal cancer risk in a Chinese population.Gene2013 May 25Peng XEdoi: 10.1016/j.gene.2013.02.029
21351093Association of superoxide dismutases and NAD(P)H quinone oxidoreductases with prognosis of patients with breast carcinomas.Int J Cancer2012 Jan 15Hubackova Mdoi: 10.1002/ijc.26006
19822020Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.BMC Gastroenterol2009 Oct 13Zhu Fdoi: 10.1186/1471-230X-9-76.
14634213P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1.Proc Natl Acad Sci U S A2003 Dec 9Asher G-
24213850Association between NQO1 Pro187Ser polymorphism and esophageal cancer: a meta-analysis.Tumour Biol2014 MarLiu Kdoi: 10.1007/s13277-013-1273-2
21253823Association of bladder cancer risk with an NAD(P)H:quinone oxidoreductase polymorphism in an ethnic Kashmiri population.Biochem Genet2011 AugPandith AAdoi: 10.1007/s10528-011-9418-8
25880877NQO1 protein expression predicts poor prognosis of non-small cell lung cancers.BMC Cancer2015 Mar 31Li Zdoi: 10.1186/s12885-015-1227-8.
24219772Pesticides, gene polymorphisms, and bladder cancer among Egyptian agricultural workers.Arch Environ Occup Health2015Amr Sdoi: 10.1080/19338244.2013.853646.
24886060Use of NQO1 status as a selective biomarker for oesophageal squamous cell carcinomas with greater sensitivity to 17-AAG.BMC Cancer2014 May 15Hadley KEdoi: 10.1186/1471-2407-14-334.
23725139NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T gene polymorphism association with digestive tract cancer: a meta-analysis.Asian Pac J Cancer Prev2013Zhu CL-
26838129Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands.Sci Rep2016 Feb 3Medina-Carmona Edoi: 10.1038/srep20331.
21518531[Interaction between polymorphisms in NQO1(C609T) and XRCC1(G28152A) and their correlation with smoking on gastric cancer].Zhonghua Liu Xing Bing Xue Za Zhi2011 JanChen DJ-
21329464Polymorphism of xenobiotic-metabolizing genes and breast cancer susceptibility in North Indian women.Genet Test Mol Biomarkers2011 MaySingh Vdoi: 10.1089/gtmb.2010.0197
24761924Luteolin sensitizes two oxaliplatin-resistant colorectal cancer cell lines to chemotherapeutic drugs via inhibition of the Nrf2 pathway.Asian Pac J Cancer Prev2014Chian S-
20056632Dietary glucosinolate intake, polymorphisms in selected biotransformation enzymes, and risk of prostate cancer.Cancer Epidemiol Biomarkers Prev2010 JanSteinbrecher Adoi: 10.1158/1055-9965.EPI-09-0660.
23852860NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism and lung cancer risk: a meta-analysis.Tumour Biol2013 DecLou Ydoi: 10.1007/s13277-013-0985-7
27039751The C609T (Pro187Ser) Null Polymorphism of the NQO1 Gene Contributes Significantly to Breast Cancer Susceptibility in North Indian Populations: a Case Control Study.Asian Pac J Cancer Prev2016Yadav P-
15498787NQO1 T allele associated with decreased risk of later age at diagnosis lung cancer among never smokers: results from a population-based study.Carcinogenesis2005 FebBock CH-
12777965CYP2E1 and NQO1 genotypes, smoking and bladder cancer.Pharmacogenetics2003 JunChoi JY-
19596483Clinical significance of NQO1 C609T polymorphisms after postoperative radiation therapy in completely resected non-small cell lung cancer.Lung Cancer2010 MaySong SYdoi: 10.1016/j.lungcan.2009.06.009.
23860519The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis.Br J Cancer2013 Sep 3Lajin Bdoi: 10.1038/bjc.2013.357
24884893The NQO1 Pro187Ser polymorphism and breast cancer susceptibility: evidence from an updated meta-analysis.Diagn Pathol2014 May 29Peng Qdoi: 10.1186/1746-1596-9-100.
23054000Genetic variants in metabolizing genes NQO1, NQO2, MTHFR and risk of prostate cancer: a study from North India.Mol Biol Rep2012 DecMandal RKdoi: 10.1007/s11033-012-2023-z
17166422[Relationship between quinone oxidoreductase1 gene ns-cSNP and genetic susceptibility of esophageal cancer].Zhonghua Yu Fang Yi Xue Za Zhi2006 SepZhang WC-
18511948NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer.Nat Genet2008 JulFagerholm Rdoi: 10.1038/ng.155
19628038NAD(P)H:quinone oxidoreductase 1 Arg139Trp and Pro187Ser polymorphisms imbalance estrogen metabolism towards DNA adduct formation in human mammary epithelial cells.J Steroid Biochem Mol Biol2009 OctSingh Sdoi: 10.1016/j.jsbmb.2009.07.003
16532285Increased levels of NAD(P)H: quinone oxidoreductase 1 (NQO1) in pancreatic tissues from smokers and pancreatic adenocarcinomas: A potential biomarker of early damage in the pancreas.Cell Biol Toxicol2006 MarLyn-Cook BD-
18416817ATBF1 and NQO1 as candidate targets for allelic loss at chromosome arm 16q in breast cancer: absence of somatic ATBF1 mutations and no role for the C609T NQO1 polymorphism.BMC Cancer2008 Apr 16Cleton-Jansen AMdoi: 10.1186/1471-2407-8-105.
23883585Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers.Mol Cancer Ther2013 OctBey EAdoi: 10.1158/1535-7163.MCT-12-0962
25608636The association between NQO1 Pro187Ser polymorphism and urinary system cancer susceptibility: a meta-analysis of 22 studies.Cancer Invest2015 MarZhang Ydoi: 10.3109/07357907.2014.998836.
18798003Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans.Cancer Causes Control2009 MarEom SYdoi: 10.1007/s10552-008-9225-7
23749485Association between NQO1 C609T polymorphism and bladder cancer susceptibility: a systemic review and meta-analysis.Tumour Biol2013 OctGong Mdoi: 10.1007/s13277-013-0799-7
15298951Oral contraceptive use and breast cancer risk: modification by NAD(P)H:quinone oxoreductase (NQO1) genetic polymorphisms.Cancer Epidemiol Biomarkers Prev2004 AugFowke JH-
22911602Meta-analysis demonstrates that the NAD(P)H: quinone oxidoreductase 1 (NQO1) gene 609 C>T polymorphism is associated with increased gastric cancer risk in Asians.Genet Mol Res2012 Aug 13Zhang Ydoi: 10.4238/2012.August.13.6.
23497461NQO1 C609T polymorphism and esophageal cancer risk: a HuGE review and meta-analysis.BMC Med Genet2013 Mar 5Yanling Hdoi: 10.1186/1471-2350-14-31.
23468244Association between polymorphisms in apoptotic genes and susceptibility for developing breast cancer in Syrian women.Breast Cancer Res Treat2013 AprLajin Bdoi: 10.1007/s10549-013-2467-4
17619904Human NAD(P)H:quinone oxidoreductase 1 (NQO1) and sulfotransferase 1A1 (SULT1A1) polymorphisms and urothelial cancer risk in Taiwan.J Cancer Res Clin Oncol2008 FebWang YH-
21480392Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk.Mol Carcinog2011 MayGoode ELdoi: 10.1002/mc.20714
25400754Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in limited-stage small cell lung cancer.Int J Clin Exp Pathol2014 Sep 15Kim HC-
23893397Association between NQO1 C609T polymorphism and colorectal cancer risk.Tumour Biol2013 DecWang Ydoi: 10.1007/s13277-013-0993-7
23803694NQO1 prevents radiation-induced aneuploidy by interacting with Aurora-A.Carcinogenesis2013 NovPark MTdoi: 10.1093/carcin/bgt225
22306249Contribution of NAD(P)H quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and risk of colorectal adenoma and colorectal cancer in Caucasians: a meta-analysis.Arch Med Res2012 JanChen Jdoi: 10.1016/j.arcmed.2012.01.005
25079701Gene polymorphisms in the ornithine decarboxylase-polyamine pathway modify gastric cancer risk by interaction with isoflavone concentrations.Gastric Cancer2015 JulCho LYdoi: 10.1007/s10120-014-0396-5
23873104Association between NAD(P)H:quinone oxidoreductase 1 rs1800566 polymorphism and risk of bladder cancer.Tumour Biol2013 DecZhang Hdoi: 10.1007/s13277-013-0909-6
19138946Resveratrol prevents estrogen-DNA adduct formation and neoplastic transformation in MCF-10F cells.Cancer Prev Res (Phila)2008 JulLu Fdoi: 10.1158/1940-6207.CAPR-08-0037.
19360290Association between mitochondrial DNA 4,977 bp deletion and NAD(P)H:quinone oxidoreductase 1 C609T polymorphism in human breast tissues.Oncol Rep2009 MayTseng LM-
25729241Interactive effect of smoking and NQO1 haplotypes on lung cancer risk.J Korean Med Sci2015 MarKim JHdoi: 10.3346/jkms.2015.30.3.221
25602258The association between NQO1 Pro187Ser polymorphism and bladder cancer susceptibility: a meta-analysis of 15 studies.PLoS One2015 Jan 20Yang Sdoi: 10.1371/journal.pone.0116500
24142528Meta-analysis of the association between NQO1 Pro187Ser polymorphism and colorectal cancer in Asians.Tumour Biol2014 MarZhao Hdoi: 10.1007/s13277-013-1280-3
23249637Low expression of NQO1 predicts pathological complete response to neoadjuvant chemotherapy in breast cancer patients treated with TAC regimen.Folia Biol (Praha)2012Grim J-
25231218NAD(P)H:quinone oxidoreductase-1 overexpression predicts poor prognosis in small cell lung cancer.Oncol Rep2014 DecCui Xdoi: 10.3892/or.2014.3494
24716985The NAD(P)H: quinine oxidoreductase 1 (NQO1) gene 609 C>T polymorphism is associated with gastric cancer risk: evidence from a case-control study and a meta-analysis.Asian Pac J Cancer Prev2014Hu WG-
20526805Evidence on the association between NQO1 Pro187Ser polymorphism and breast cancer risk in the current studies: a meta-analysis.Breast Cancer Res Treat2011 JanYuan Wdoi: 10.1007/s10549-010-0966-0
24315573Association of polymorphisms in iNOS and NQO1 with bladder cancer risk in cigarette smokers.J Chin Med Assoc2014 FebHuang ZMdoi: 10.1016/j.jcma.2013.10.005
21294640Role of NQO1 609C>T and NQO2-3423G>A polymorphisms in susceptibility to gastric cancer in Kashmir valley.DNA Cell Biol2011 MayMalik MAdoi: 10.1089/dna.2010.1115
21964527C609T polymorphism of NAD(P)H quinone oxidoreductase 1 as a predictive biomarker for response to amrubicin.J Thorac Oncol2011 NovTakakuwa Odoi: 10.1097/JTO.0b013e318229137d.
24035474Genetic polymorphisms in NQO1 and SOD2: interactions with smoking, schistosoma infection, and bladder cancer risk in Egypt.Urol Oncol2014 JanGoerlitz Ddoi: 10.1016/j.urolonc.2013.06.016
24142529NQO1 C609T polymorphism is associated with esophageal cancer risk among Chinese: a meta-analysis.Tumour Biol2014 MarZhao HYdoi: 10.1007/s13277-013-1292-z
21602889The exonuclease activity of hPMC2 is required for transcriptional regulation of the QR gene and repair of estrogen-induced abasic sites.Oncogene2011 Nov 24Krishnamurthy Ndoi: 10.1038/onc.2011.186
24838947Association between NQO1 C609T polymorphism and prostate cancer risk.Tumour Biol2014 AugSun Zdoi: 10.1007/s13277-014-2051-5
22017531Meta-analysis of the NAD(P)H: quinine oxidoreductase 1 gene 609 C>T polymorphism with esophageal cancer risk.DNA Cell Biol2012 AprWang Zdoi: 10.1089/dna.2011.1332
22215148Association of NQO1 rs1800566 polymorphism and the risk of colorectal cancer: a meta-analysis.Int J Colorectal Dis2012 JulDing Rdoi: 10.1007/s00384-011-1396-0
18225579Investigation of NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in prostate cancer.Anticancer Res2007 Nov-DecErgen HA-
24499631Clinical implications of high NQO1 expression in breast cancers.J Exp Clin Cancer Res2014 Feb 5Yang Ydoi: 10.1186/1756-9966-33-14.
17726138Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer.Cancer Epidemiol Biomarkers Prev2007 SepHong CC-
20200430TP53, MDM2, NQO1, and susceptibility to cervical cancer.Cancer Epidemiol Biomarkers Prev2010 MarHu Xdoi: 10.1158/1055-9965.EPI-09-0886
25586669NQO1-induced activation of AMPK contributes to cancer cell death by oxygen-glucose deprivation.Sci Rep2015 Jan 14Lee Hdoi: 10.1038/srep07769.
23110137Lack of association between NADPH quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and lung cancer: a case-control study and a meta-analysis.PLoS One2012Guo Sdoi: 10.1371/journal.pone.0047939
16003741Targeting NAD(P)H:quinone oxidoreductase (NQO1) in pancreatic cancer.Mol Carcinog2005 AugLewis AM-
28748640Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with polycystic ovary syndrome.Clin Endocrinol (Oxf)2017 NovAtiomo Wdoi: 10.1111/cen.13436
30009918Biophysical and functional perturbation analyses at cancer-associated P187 and K240 sites of the multifunctional NADP(H):quinone oxidoreductase 1.Int J Biol Macromol2018 Oct 15Pey ALdoi: 10.1016/j.ijbiomac.2018.07.051
30513573NQO1 is Required for β-Lapachone-Mediated Downregulation of Breast-Cancer Stem-Cell Activity.Int J Mol Sci2018 Nov 30Kim DWdoi: 10.3390/ijms19123813.

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr16697264965'UTRnovel0.1
BRCAchr16697108363'UTRnovel0.09
CESCchr1669711239Nonsense_MutationnovelQ188*0.2
CESCchr1669718488SilentnovelF18F0.39
CESCchr1669711149Missense_MutationNAE218K0.15
COADchr1669711170Missense_Mutationrs114112422R211C0.18
COADchr1669718494Silentrs376474672T16T0.25
COADchr1669715067In_Frame_InsNAL104dup0.13
COADchr1669710981Missense_MutationnovelK274E0.07
ESCAchr1669718145Missense_MutationnovelA94V0.72
GBMchr1669715016Missense_MutationNAI122K0.35
GBMchr1669718426Missense_MutationnovelE39V0.03
GBMchr1669711075Missense_MutationnovelE242D0.1
GBMchr1669718472Missense_MutationnovelE24Q0.27
GBMchr1669718473SilentnovelK23K0.23
HNSCchr16697109523'UTRrs31912140.18
HNSCchr1669711224Missense_MutationnovelI193V0.29
HNSCchr1669711282Splice_SitenovelX174_splice0.43
KIRCchr16697108473'UTRnovel0.29
LIHCchr1669718415Missense_MutationnovelY43D0.47
LUADchr1669711033SilentnovelV256V0.08
LUADchr1669710979SilentNAK274K0.29
LUSCchr1669714967SilentNAF138F0.13
OVchr1669714981Missense_MutationnovelD134Y0.16
OVchr1669718420In_Frame_DelNAE36_S40del0.42
OVchr1669718432Missense_MutationnovelV37E0.16
OVchr1669718455SilentnovelA29A0.23
PAADchr16697265205'UTRnovel0.06
PRADchr1669711248Missense_MutationnovelL185I0.11
READchr16697108473'UTRnovel0.45
READchr1669718249SilentNAK59K0.51
SKCMchr1669718407Missense_MutationNAM45I0.18
STADchr1669711272Missense_MutationNAL177V0.14
STADchr16697108793'UTRnovel0.16
STADchr1669718226Missense_MutationNAQ67P0.24
STADchr1669718457Missense_MutationNAA29T0.12
UCECchr1669711199Missense_Mutationrs766847268R201Q0.35
UCECchr1669714989Missense_MutationNAA131V0.25
UCECchr16697107983'UTRnovel0.39
UCECchr1669713082Missense_MutationNAM155I0.19
UCECchr1669718234Silentrs757353713A64A0.19
UCECchr1669711042SilentNAG253G0.41
UCECchr1669718416SilentNAL42L0.4
UCECchr1669711162Missense_MutationnovelE213D0.4
UCECchr1669711199Missense_Mutationrs766847268R201Q0.31
UCECchr16697108373'UTRnovel0.33
UCECchr1669711199Missense_Mutationrs766847268R201Q0.55
UCECchr1669711122Missense_MutationnovelS227G0.31
UCECchr16697265785'UTRnovel0.12
UCECchr16697108373'UTRnovel0.2
UCECchr16697108363'UTRnovel0.3
UCECchr1669711199Missense_Mutationrs766847268R201Q0.5
UCECchr16697109443'UTRnovel0.3
UCECchr1669711199Missense_Mutationrs766847268R201Q0.31

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
BLCAAMP0.18870.063591
CHOLDEL0.16670.23475
LAMLDEL0.02620.0010312
TGCTAMP0.11330.035574
UCECDEL0.27094.7164e-05

Survival Analysis
CancerP-value Q-value
SARC0.013

Kaplan-Meier Survival Analysis

ACC0.00013

Kaplan-Meier Survival Analysis

HNSC0.00021

Kaplan-Meier Survival Analysis

SKCM0.01

Kaplan-Meier Survival Analysis

ESCA0.026

Kaplan-Meier Survival Analysis

KIRP0.00013

Kaplan-Meier Survival Analysis

PAAD0.035

Kaplan-Meier Survival Analysis

CESC0.0085

Kaplan-Meier Survival Analysis

UCEC0.021

Kaplan-Meier Survival Analysis

LIHC0.011

Kaplan-Meier Survival Analysis

LGG0.0023

Kaplan-Meier Survival Analysis

UVM0.00012

Kaplan-Meier Survival Analysis

OV0.021

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


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