EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000181026 (Gene tree)
Gene ID: 64782
Gene Symbol: AEN
Alias: FLJ12484|FLJ12562|ISG20L1
Full Name: apoptosis enhancing nuclease
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 27,602 bases
Position: chr15:88,604,681-88,632,282
Accession: 25722
RBP type: canonical RBP
Summary: (Apoptosis Enhancing Nuclease) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and exonuclease activity. An important paralog of this gene is ISG20L2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000331944	RNase_T	PF00929.24	6.7e-16	1	1
ENSP00000453631	RNase_T	PF00929.24	9.1e-08	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000559528	AEN-205	895	-	ENSP00000453631	179 (aa)	-	H0YMJ6
ENST00000557927	AEN-203	5039	-	-	- (aa)	-	-
ENST00000560174	AEN-206	461	-	-	- (aa)	-	-
ENST00000332810	AEN-201	3117	XM_005254966	ENSP00000331944	325 (aa)	XP_005255023	Q8WTP8
ENST00000558327	AEN-204	883	-	-	- (aa)	-	-
ENST00000557787	AEN-202	1242	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000181026's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000181026	Alzheimer Disease	2.4138175E-005	17998437
ENSG00000181026	Sleep	9E-6	27126917

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000181026	rs8024058	15	88621800	A	Night sleep phenotypes	27126917	[0.12-0.3] unit increase	0.2095	EFO_0005271

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000181026's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000181026	AEN	55	61.453	ENSG00000143319	ISG20L2	51	61.453

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000181026	AEN	99	80.745	ENSAMEG00000012798	AEN	100	80.745	Ailuropoda_melanoleuca
ENSG00000181026	AEN	100	93.538	ENSANAG00000026698	AEN	100	93.538	Aotus_nancymaae
ENSG00000181026	AEN	100	80.615	ENSBTAG00000017632	AEN	99	80.615	Bos_taurus
ENSG00000181026	AEN	100	92.308	ENSCJAG00000012988	AEN	100	92.308	Callithrix_jacchus
ENSG00000181026	AEN	100	82.769	ENSCAFG00000011521	AEN	100	82.769	Canis_familiaris
ENSG00000181026	AEN	100	82.462	ENSCAFG00020018839	AEN	100	82.462	Canis_lupus_dingo
ENSG00000181026	AEN	100	79.077	ENSCHIG00000001561	AEN	99	79.077	Capra_hircus
ENSG00000181026	AEN	99	86.420	ENSTSYG00000012416	AEN	99	86.420	Carlito_syrichta
ENSG00000181026	AEN	68	68.468	ENSCAPG00000006550	-	100	68.468	Cavia_aperea
ENSG00000181026	AEN	99	78.154	ENSCPOG00000021693	AEN	99	78.154	Cavia_porcellus
ENSG00000181026	AEN	100	91.385	ENSCCAG00000037160	AEN	100	91.385	Cebus_capucinus
ENSG00000181026	AEN	100	94.462	ENSCATG00000034567	AEN	100	94.462	Cercocebus_atys
ENSG00000181026	AEN	100	76.667	ENSCLAG00000008791	AEN	99	78.638	Chinchilla_lanigera
ENSG00000181026	AEN	100	94.462	ENSCSAG00000017196	AEN	100	94.462	Chlorocebus_sabaeus
ENSG00000181026	AEN	88	51.488	ENSCPBG00000017884	AEN	85	50.148	Chrysemys_picta_bellii
ENSG00000181026	AEN	100	92.923	ENSCANG00000037330	AEN	100	92.923	Colobus_angolensis_palliatus
ENSG00000181026	AEN	99	75.077	ENSCGRG00001021559	Aen	99	75.077	Cricetulus_griseus_chok1gshd
ENSG00000181026	AEN	100	74.847	ENSCGRG00000000641	Aen	99	75.077	Cricetulus_griseus_crigri
ENSG00000181026	AEN	100	79.330	ENSDNOG00000001849	-	100	83.548	Dasypus_novemcinctus
ENSG00000181026	AEN	99	66.111	ENSDORG00000015546	Aen	99	69.231	Dipodomys_ordii
ENSG00000181026	AEN	93	69.935	ENSETEG00000006167	AEN	100	72.876	Echinops_telfairi
ENSG00000181026	AEN	100	81.846	ENSEASG00005015361	AEN	100	81.846	Equus_asinus_asinus
ENSG00000181026	AEN	100	81.846	ENSECAG00000037942	AEN	100	81.846	Equus_caballus
ENSG00000181026	AEN	100	63.128	ENSEEUG00000007015	AEN	100	68.647	Erinaceus_europaeus
ENSG00000181026	AEN	99	81.115	ENSFCAG00000023571	AEN	99	81.115	Felis_catus
ENSG00000181026	AEN	88	53.503	ENSFALG00000010440	AEN	84	52.548	Ficedula_albicollis
ENSG00000181026	AEN	100	77.301	ENSFDAG00000009743	AEN	100	76.994	Fukomys_damarensis
ENSG00000181026	AEN	88	50.000	ENSGAGG00000013545	AEN	85	49.706	Gopherus_agassizii
ENSG00000181026	AEN	100	99.441	ENSGGOG00000010180	AEN	100	99.385	Gorilla_gorilla
ENSG00000181026	AEN	66	65.728	ENSHGLG00000008738	-	99	65.728	Heterocephalus_glaber_female
ENSG00000181026	AEN	100	76.380	ENSHGLG00100013826	AEN	100	75.767	Heterocephalus_glaber_male
ENSG00000181026	AEN	68	70.136	ENSSTOG00000011560	-	98	70.136	Ictidomys_tridecemlineatus
ENSG00000181026	AEN	69	66.071	ENSJJAG00000022647	-	99	66.071	Jaculus_jaculus
ENSG00000181026	AEN	100	78.212	ENSLAFG00000015182	AEN	100	81.046	Loxodonta_africana
ENSG00000181026	AEN	100	94.769	ENSMFAG00000001458	AEN	100	94.769	Macaca_fascicularis
ENSG00000181026	AEN	100	94.769	ENSMMUG00000022516	AEN	100	94.769	Macaca_mulatta
ENSG00000181026	AEN	100	95.077	ENSMNEG00000040133	AEN	100	95.077	Macaca_nemestrina
ENSG00000181026	AEN	100	94.769	ENSMLEG00000032850	AEN	100	94.769	Mandrillus_leucophaeus
ENSG00000181026	AEN	99	76.000	ENSMAUG00000000489	Aen	99	76.000	Mesocricetus_auratus
ENSG00000181026	AEN	100	85.276	ENSMICG00000027602	AEN	100	85.276	Microcebus_murinus
ENSG00000181026	AEN	99	75.078	ENSMOCG00000011735	Aen	96	75.701	Microtus_ochrogaster
ENSG00000181026	AEN	97	62.539	ENSMODG00000019584	-	96	61.300	Monodelphis_domestica
ENSG00000181026	AEN	97	74.684	MGP_CAROLIEiJ_G0029872	Aen	100	69.565	Mus_caroli
ENSG00000181026	AEN	99	72.615	ENSMUSG00000030609	Aen	100	69.565	Mus_musculus
ENSG00000181026	AEN	100	73.313	MGP_PahariEiJ_G0013094	Aen	96	73.313	Mus_pahari
ENSG00000181026	AEN	81	73.762	MGP_SPRETEiJ_G0030974	-	95	76.684	Mus_spretus
ENSG00000181026	AEN	100	80.308	ENSMPUG00000015821	AEN	86	80.308	Mustela_putorius_furo
ENSG00000181026	AEN	76	83.806	ENSMLUG00000023065	AEN	99	84.082	Myotis_lucifugus
ENSG00000181026	AEN	97	78.616	ENSNGAG00000011590	Aen	98	78.616	Nannospalax_galili
ENSG00000181026	AEN	100	97.846	ENSNLEG00000032314	AEN	100	97.846	Nomascus_leucogenys
ENSG00000181026	AEN	100	54.839	ENSMEUG00000005303	-	100	60.000	Notamacropus_eugenii
ENSG00000181026	AEN	63	70.588	ENSODEG00000015278	-	95	70.588	Octodon_degus
ENSG00000181026	AEN	99	85.139	ENSOGAG00000029852	AEN	96	84.211	Otolemur_garnettii
ENSG00000181026	AEN	100	77.846	ENSOARG00000010957	AEN	100	77.846	Ovis_aries
ENSG00000181026	AEN	100	99.385	ENSPPAG00000039598	AEN	100	99.385	Pan_paniscus
ENSG00000181026	AEN	99	79.817	ENSPPRG00000022756	AEN	99	79.817	Panthera_pardus
ENSG00000181026	AEN	100	76.536	ENSPTIG00000018966	AEN	72	81.124	Panthera_tigris_altaica
ENSG00000181026	AEN	100	99.385	ENSPTRG00000007422	AEN	100	99.385	Pan_troglodytes
ENSG00000181026	AEN	100	95.077	ENSPANG00000005905	AEN	100	95.077	Papio_anubis
ENSG00000181026	AEN	88	56.314	ENSPSIG00000014281	AEN	93	55.290	Pelodiscus_sinensis
ENSG00000181026	AEN	100	75.229	ENSPEMG00000020445	Aen	100	75.229	Peromyscus_maniculatus_bairdii
ENSG00000181026	AEN	97	60.436	ENSPCIG00000006401	-	90	59.875	Phascolarctos_cinereus
ENSG00000181026	AEN	100	97.538	ENSPPYG00000006755	AEN	100	97.538	Pongo_abelii
ENSG00000181026	AEN	100	75.419	ENSPCAG00000015481	AEN	97	61.716	Procavia_capensis
ENSG00000181026	AEN	100	87.385	ENSPCOG00000020924	AEN	100	87.385	Propithecus_coquereli
ENSG00000181026	AEN	100	78.212	ENSPVAG00000007189	AEN	93	84.158	Pteropus_vampyrus
ENSG00000181026	AEN	100	74.847	ENSRNOG00000018421	Aen	96	74.847	Rattus_norvegicus
ENSG00000181026	AEN	100	92.923	ENSRBIG00000031540	AEN	100	92.923	Rhinopithecus_bieti
ENSG00000181026	AEN	100	93.538	ENSRROG00000043282	AEN	100	93.538	Rhinopithecus_roxellana
ENSG00000181026	AEN	100	90.769	ENSSBOG00000021857	AEN	100	90.769	Saimiri_boliviensis_boliviensis
ENSG00000181026	AEN	96	59.688	ENSSHAG00000017070	-	96	59.375	Sarcophilus_harrisii
ENSG00000181026	AEN	100	83.692	ENSSSCG00000005102	AEN	100	83.692	Sus_scrofa
ENSG00000181026	AEN	88	55.446	ENSTGUG00000008335	AEN	98	54.027	Taeniopygia_guttata
ENSG00000181026	AEN	100	78.212	ENSTBEG00000016234	AEN	98	80.189	Tupaia_belangeri
ENSG00000181026	AEN	100	76.536	ENSTTRG00000014668	AEN	92	81.126	Tursiops_truncatus
ENSG00000181026	AEN	54	88.571	ENSUAMG00000019063	-	100	88.571	Ursus_americanus
ENSG00000181026	AEN	100	83.077	ENSVVUG00000012020	AEN	100	83.077	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0004527	exonuclease activity	16171785.18264133.	IDA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	16171785.18264133.	IDA	Component
GO:0005730	nucleolus	18264133.	IDA	Component
GO:0010212	response to ionizing radiation	16171785.	IDA	Process
GO:0031965	nuclear membrane	-	IDA	Component
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	18264133.	IDA	Process
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18264133	p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis.	Oncogene	2008 Jun 19	Kawase T	doi: 10.1038/onc.2008.32

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr15	88626502	Missense_Mutation	NA	A98V	0.28
BLCA	chr15	88629378	Silent	novel	R231R	0.46
BLCA	chr15	88630216	Missense_Mutation	NA	M300I	0.38
BLCA	chr15	88630088	Missense_Mutation	novel	D258H	0.28
BLCA	chr15	88626702	Missense_Mutation	novel	R165W	0.16	RNase_T
BRCA	chr15	88626645	Missense_Mutation	novel	Y146H	0.11	RNase_T
BRCA	chr15	88630266	Missense_Mutation	novel	A317V	0.13
BRCA	chr15	88626562	Missense_Mutation	NA	V118A	0.35	RNase_T
CESC	chr15	88629359	Missense_Mutation	novel	G225D	0.54
CESC	chr15	88630980	3'UTR	novel		0.38
CESC	chr15	88626313	Missense_Mutation	rs139013526	R35L	0.26
COAD	chr15	88630318	3'UTR	novel		0.16
COAD	chr15	88626423	Missense_Mutation	novel	T72A	0.31
COAD	chr15	88626677	Silent	NA	Y156Y	0.56
COAD	chr15	88630304	3'UTR	rs781200131		0.41
COAD	chr15	88629288	Silent	rs138959764	A201A	0.13
COAD	chr15	88630070	Missense_Mutation	NA	G252R	0.18
COAD	chr15	88630316	3'UTR	rs756213497		0.41
ESCA	chr15	88626337	Missense_Mutation	novel	R43L	0.43
ESCA	chr15	88630945	3'UTR	novel		0.57
GBM	chr15	88626552	Missense_Mutation	novel	C115G	0.21	RNase_T
HNSC	chr15	88630116	Missense_Mutation	rs201760461	R267Q	0.14
HNSC	chr15	88626338	Silent	novel	R43R	0.83
HNSC	chr15	88626413	Silent	rs780933013	F68F	0.32
LUAD	chr15	88626191	5'UTR	novel		0.31
LUAD	chr15	88626747	Missense_Mutation	novel	E180Q	0.22
LUAD	chr15	88626461	Silent	NA	L84L	0.17
LUAD	chr15	88630077	Nonsense_Mutation	novel	S254*	0.38
LUAD	chr15	88626504	Missense_Mutation	NA	P99S	0.57
LUSC	chr15	88626601	Missense_Mutation	novel	R131L	0.1	RNase_T
LUSC	chr15	88630162	Missense_Mutation	novel	W282C	0.64
LUSC	chr15	88629396	Silent	NA	L237L	0.08
LUSC	chr15	88629267	Silent	novel	A194A	0.15
OV	chr15	88629287	Missense_Mutation	rs368922473	A201V	0.38
PAAD	chr15	88626652	Missense_Mutation	novel	R148K	0.15	RNase_T
PRAD	chr15	88629397	Missense_Mutation	novel	A238T	0.11
SKCM	chr15	88629345	Silent	novel	F220F	0.35
SKCM	chr15	88626258	Missense_Mutation	rs749170954	L17F	0.45
SKCM	chr15	88626769	Intron	novel		0.18
SKCM	chr15	88629300	Silent	NA	V205V	0.1
SKCM	chr15	88626650	Silent	rs35195058	I147I	0.46
STAD	chr15	88629372	Silent	novel	R229R	0.07
STAD	chr15	88626324	Missense_Mutation	rs756247681	R39W	0.3
STAD	chr15	88626371	Silent	NA	S54S	0.34
STAD	chr15	88630059	Missense_Mutation	NA	V248A	0.28
STAD	chr15	88629320	Missense_Mutation	rs561034272	R212Q	0.35
STAD	chr15	88626200	5'UTR	novel		0.2
STAD	chr15	88629267	Silent	rs758372060	A194A	0.19
UCEC	chr15	88626458	Missense_Mutation	novel	C83W	0.42
UCEC	chr15	88626678	Missense_Mutation	rs148606540	R157C	0.29	RNase_T
UCEC	chr15	88629397	Missense_Mutation	novel	A238T	0.32
UCEC	chr15	88626568	Missense_Mutation	rs766037818	T120M	0.36	RNase_T
UCEC	chr15	88631059	3'UTR	novel		0.22
UCEC	chr15	88629246	Silent	NA	G187G	0.42
UCEC	chr15	88630429	3'UTR	novel		0.25
UCEC	chr15	88626657	Missense_Mutation	novel	E150K	0.28	RNase_T
UCEC	chr15	88626626	Silent	novel	G139G	0.17
UCEC	chr15	88626191	5'UTR	novel		0.36
UCEC	chr15	88626788	Intron	novel		0.28
UCEC	chr15	88631094	3'UTR	novel		0.62
UCEC	chr15	88630062	Missense_Mutation	rs766404986	G249D	0.45
UCEC	chr15	88629319	Missense_Mutation	rs763210791	R212W	0.3
UCEC	chr15	88629277	Missense_Mutation	rs756014603	D198N	0.14
UCEC	chr15	88629330	Silent	novel	T215T	0.13
UCEC	chr15	88630298	3'UTR	novel		0.3
UCEC	chr15	88626324	Missense_Mutation	rs756247681	R39W	0.25
UCEC	chr15	88630257	Missense_Mutation	novel	R314K	0.25
UCEC	chr15	88630108	Missense_Mutation	NA	E264D	0.43
UCEC	chr15	88630165	Silent	novel	T283T	0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.2169	0.0058042
LGG	AMP	0.0214	0.19963
LIHC	DEL	0.1703	0.056724
PAAD	AMP	0.0761	0.20695
PAAD	DEL	0.1033	0.13216
SKCM	AMP	0.2452	9.6912e-06

Survival Analysis

Cancer	P-value	Q-value
THYM	0.043	Kaplan-Meier Survival Analysis
KIRC	0.016	Kaplan-Meier Survival Analysis
MESO	0.014	Kaplan-Meier Survival Analysis
SKCM	0.0015	Kaplan-Meier Survival Analysis
UCEC	0.0063	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742