EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Paralogs

Orthologs

Description

Ensembl ID: ENSG00000181222 (Gene tree)
Gene ID: 5430
Gene Symbol: POLR2A
Alias: POLRA|RPB1|POLR2
Full Name: RNA polymerase II subunit A
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 30,253 bases
Position: chr17:7,484,366-7,514,618
Accession: 9187
RBP type: canonical RBP
Summary: This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000461879	RNA_pol_Rpb1_2	PF00623.20	1.5e-74	1	1
ENSP00000461879	RNA_pol_Rpb1_3	PF04983.18	4.9e-09	1	1
ENSP00000461879	RNA_pol_Rpb1_1	PF04997.12	2.8e-109	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23478263	Trypanosome cdc2-related kinase 9 controls spliced leader RNA cap4 methylation and phosphorylation of RNA polymerase II subunit RPB1.	Mol Cell Biol	2013 May	Badjatia N	doi: 10.1128/MCB.00156-13
31123282	BRAF inhibition sensitizes melanoma cells to α-amanitin via decreased RNA polymerase II assembly.	Sci Rep	2019 May 23	Frischknecht L	doi: 10.1038/s41598-019-44112-7.
17179178	Functional organization of the Rpb5 subunit shared by the three yeast RNA polymerases.	Nucleic Acids Res	2007	Zaros C	-
9325316	RNA polymerase II subunits 2, 3, and 11 form a core subassembly with DNA binding activity.	J Biol Chem	1997 Oct 10	Kimura M	-
16632472	Structural, biochemical, and dynamic characterizations of the hRPB8 subunit of human RNA polymerases.	J Biol Chem	2006 Jun 30	Kang X	-
19711185	High-resolution protein structure determination starting with a global fold calculated from exact solutions to the RDC equations.	J Biomol NMR	2009 Nov	Zeng J	doi: 10.1007/s10858-009-9366-3
18042645	Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs.	Genome Res	2008 Jan	Barrera LO	-
22649785	The Roles of VHL-Dependent Ubiquitination in Signaling and Cancer.	Front Oncol	2012 Apr 12	Zhang Q	doi: 10.3389/fonc.2012.00035
21288871	Functional relevance of CpG island length for regulation of gene expression.	Genetics	2011 Apr	Elango N	doi: 10.1534/genetics.110.126094
26015065	Systematic enrichment analysis of potentially functional regions for 103 prostate cancer risk-associated loci.	Prostate	2015 Sep	Chen H	doi: 10.1002/pros.23008
29317594	Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex.	Transl Psychiatry	2018 Jan 10	Naik RR	doi: 10.1038/s41398-017-0025-2.
30994454	Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.	Elife	2019 Apr 17	Gao R	doi: 10.7554/eLife.42988.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000576553	POLR2A-206	602	-	-	- (aa)	-	-
ENST00000575547	POLR2A-204	702	-	-	- (aa)	-	-
ENST00000576952	POLR2A-208	532	-	-	- (aa)	-	-
ENST00000574158	POLR2A-203	461	-	-	- (aa)	-	-
ENST00000576718	POLR2A-207	548	-	-	- (aa)	-	-
ENST00000617998	POLR2A-209	6751	-	-	- (aa)	-	-
ENST00000576114	POLR2A-205	245	-	-	- (aa)	-	-
ENST00000572844	POLR2A-201	2083	-	ENSP00000461879	566 (aa)	-	P24928
ENST00000573603	POLR2A-202	648	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000181222's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000181222	rs8753	17	7514323	T	Non-glioblastoma glioma	26424050	[2.39-4.00]	3.09	EFO_0000326
ENSG00000181222	rs6761	17	7514346	?	Protein quantitative trait loci	18464913			EFO_0004696
ENSG00000181222	rs11658168	17	7502815	A	Heel bone mineral density	30598549	[0.012-0.02] unit decrease	0.0160772	EFO_0009270
ENSG00000181222	rs4354991	17	7488305	?	Mean corpuscular hemoglobin	30595370			EFO_0004527
ENSG00000181222	rs4239258	17	7493724	T	Metastasis in stage I-III microsatellite instability low/stable colorectal cancer (time to event)	30738427	[18.72-515.88]	98.28	EFO_0007675\|EFO_1001480\|EFO_0008336

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000181222's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000181222	POLR2A	96	37.634	ENSG00000148606	POLR3A	81	45.342

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000181222	POLR2A	100	99.823	ENSCJAG00000015157	POLR2A	100	99.823	Callithrix_jacchus
ENSG00000181222	POLR2A	99	99.113	ENSFCAG00000046533	POLR2A	99	99.113	Felis_catus
ENSG00000181222	POLR2A	98	100.000	ENSGGOG00000014800	-	54	100.000	Gorilla_gorilla
ENSG00000181222	POLR2A	98	99.820	ENSMFAG00000007042	-	57	99.820	Macaca_fascicularis
ENSG00000181222	POLR2A	98	99.820	ENSMLEG00000030263	-	57	99.820	Mandrillus_leucophaeus
ENSG00000181222	POLR2A	93	100.000	ENSMAUG00000021055	-	53	100.000	Mesocricetus_auratus
ENSG00000181222	POLR2A	98	99.820	ENSMICG00000013372	-	56	99.820	Microcebus_murinus
ENSG00000181222	POLR2A	95	97.588	ENSOANG00000003303	-	57	97.588	Ornithorhynchus_anatinus
ENSG00000181222	POLR2A	99	99.113	ENSPPRG00000000743	POLR2A	99	99.113	Panthera_pardus
ENSG00000181222	POLR2A	99	95.722	ENSPTIG00000005583	POLR2A	100	95.722	Panthera_tigris_altaica
ENSG00000181222	POLR2A	93	97.913	ENSSPUG00000017777	-	100	97.913	Sphenodon_punctatus

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23349811	p68/DdX5 supports β-catenin & RNAP II during androgen receptor mediated transcription in prostate cancer.	PLoS One	2013	Clark EL	doi: 10.1371/journal.pone.0054150
28027311	Somatic Mutation Patterns in Hemizygous Genomic Regions Unveil Purifying Selection during Tumor Evolution.	PLoS Genet	2016 Dec 27	Van den Eynden J	doi: 10.1371/journal.pgen.1006506
28922562	Association between polymorphisms in microRNA target sites and survival in early-stage non-small cell lung cancer.	Thorac Cancer	2017 Nov	Yoo SS	doi: 10.1111/1759-7714.12478

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr17	7513535	In_Frame_Ins	novel	S1768_P1774dup	0.18
BLCA	chr17	7509063	Silent	novel	V1195V	0.1
BLCA	chr17	7497751	Silent	novel	F361F	0.52
BLCA	chr17	7498082	Missense_Mutation	novel	Q403E	0.63
BLCA	chr17	7496553	Silent	novel	E159E	0.46
BLCA	chr17	7502002	Missense_Mutation	novel	E818Q	0.55
BLCA	chr17	7503674	Missense_Mutation	novel	F1041L	0.14
BLCA	chr17	7511221	Missense_Mutation	novel	E1274Q	0.27
BLCA	chr17	7512218	Nonsense_Mutation	novel	E1456*	0.12
BLCA	chr17	7509040	Missense_Mutation	novel	E1188K	0.49
BLCA	chr17	7502100	Silent	novel	T850T	0.3
BLCA	chr17	7501550	Missense_Mutation	novel	E724K	0.08
BLCA	chr17	7512307	Silent	novel	E1485E	0.46
BLCA	chr17	7497730	Silent	novel	L354L	0.84
BLCA	chr17	7503184	Missense_Mutation	novel	K940N	0.85
BLCA	chr17	7499474	Missense_Mutation	novel	D552N	0.45
BLCA	chr17	7514149	Nonsense_Mutation	novel	S1962*	0.34
BLCA	chr17	7509145	Missense_Mutation	novel	D1223N	0.62
BLCA	chr17	7501698	Missense_Mutation	novel	G773E	0.59
BRCA	chr17	7514401	3'UTR	NA		0.37
BRCA	chr17	7511431	Missense_Mutation	novel	D1315A	0.06
BRCA	chr17	7508953	Missense_Mutation	novel	C1159R	0.28
BRCA	chr17	7496783	Missense_Mutation	rs139873836	R186Q	0.46	RNA_pol_Rpb1_2
BRCA	chr17	7502540	Missense_Mutation	rs201063777	I865M	0.42
BRCA	chr17	7500951	Silent	novel	E631E	0.33
BRCA	chr17	7513643	Frame_Shift_Ins	novel	*S1794Lfs131**	0.07
BRCA	chr17	7513084	Missense_Mutation	novel	G1607V	0.1
BRCA	chr17	7509142	Missense_Mutation	novel	T1222A	0.93
BRCA	chr17	7500991	Missense_Mutation	novel	L645V	0.06
BRCA	chr17	7503746	Silent	rs745614130	F1065F	0.43
BRCA	chr17	7499575	Intron	novel		0.43
BRCA	chr17	7509031	Missense_Mutation	novel	V1185L	0.11
CESC	chr17	7503125	Missense_Mutation	novel	R921C	0.5
CESC	chr17	7500671	Silent	rs765136696	S568S	0.32
CESC	chr17	7501911	Silent	rs369411244	V787V	0.39
CESC	chr17	7496912	Missense_Mutation	novel	S229L	0.71	RNA_pol_Rpb1_2
CESC	chr17	7497787	Silent	novel	L373L	0.3
CESC	chr17	7503768	Missense_Mutation	novel	E1073Q	0.32
CESC	chr17	7503393	Silent	novel	L979L	0.09
CESC	chr17	7496568	Silent	rs368365915	F164F	0.35
CESC	chr17	7511971	Missense_Mutation	novel	R1421H	0.17
CESC	chr17	7512476	Splice_Site	novel	X1498_splice	0.14
CESC	chr17	7512882	Missense_Mutation	rs754812578	P1572L	0.4
CESC	chr17	7513072	Missense_Mutation	novel	R1603H	0.12
CESC	chr17	7514509	3'UTR	novel		0.31
CESC	chr17	7513495	Missense_Mutation	novel	T1744I	0.18
CESC	chr17	7513137	Missense_Mutation	novel	T1625A	0.37
CESC	chr17	7508423	Missense_Mutation	rs771125580	S1138L	0.07
CESC	chr17	7512325	Silent	rs768349650	P1491P	0.15
CESC	chr17	7484835	Missense_Mutation	novel	G24A	0.4	RNA_pol_Rpb1_2
CESC	chr17	7513604	Silent	novel	S1780S	0.43
CESC	chr17	7498201	Silent	rs146006267	T442T	0.66
COAD	chr17	7512883	Silent	rs199766347	P1572P	0.53
COAD	chr17	7513153	Missense_Mutation	novel	S1630Y	0.4
COAD	chr17	7499400	Frame_Shift_Del	novel	*Q529Rfs32**	0.18
COAD	chr17	7496870	Missense_Mutation	novel	L215R	0.4	RNA_pol_Rpb1_2
COAD	chr17	7503707	Silent	novel	R1052R	0.25
COAD	chr17	7509063	Silent	novel	V1195V	0.34
COAD	chr17	7509588	Missense_Mutation	novel	L1257F	0.41
COAD	chr17	7500999	Silent	novel	T647T	0.35
COAD	chr17	7499400	Frame_Shift_Del	novel	*Q529Rfs32**	0.31
COAD	chr17	7514110	Missense_Mutation	rs775355170	R1949H	0.29
COAD	chr17	7501364	Missense_Mutation	novel	A709V	0.11
COAD	chr17	7497773	Missense_Mutation	novel	P369T	0.44
COAD	chr17	7512482	Missense_Mutation	novel	G1500C	0.48
COAD	chr17	7509041	Missense_Mutation	novel	E1188G	0.29
COAD	chr17	7512901	Silent	novel	S1578S	0.29
COAD	chr17	7498120	Silent	rs769941878	G415G	0.18
COAD	chr17	7513958	Silent	novel	Q1898Q	0.81
COAD	chr17	7511960	Silent	rs774135346	H1417H	0.18
COAD	chr17	7514025	Frame_Shift_Del	novel	*P1922Qfs44**	0.45
COAD	chr17	7495969	Missense_Mutation	novel	I41T	0.09	RNA_pol_Rpb1_2
COAD	chr17	7514193	Missense_Mutation	novel	A1977T	0.39
COAD	chr17	7502007	Silent	novel	S819S	0.07
COAD	chr17	7498121	Missense_Mutation	rs763272826	A416T	0.11
DLBC	chr17	7513036	Missense_Mutation	rs774093039	P1591L	0.31
ESCA	chr17	7511955	Nonsense_Mutation	novel	R1416*	0.17
GBM	chr17	7513900	Frame_Shift_Del	novel	*V1879Afs35**	0.48
GBM	chr17	7514128	Missense_Mutation	novel	T1955K	0.17
GBM	chr17	7496895	Missense_Mutation	novel	E223D	0.2	RNA_pol_Rpb1_2
GBM	chr17	7497713	Missense_Mutation	novel	R349W	0.37	RNA_pol_Rpb1_2
GBM	chr17	7512210	Missense_Mutation	novel	G1453E	0.34
GBM	chr17	7499111	Missense_Mutation	novel	M470L	0.25
GBM	chr17	7500960	Silent	novel	E634E	0.35
GBM	chr17	7503218	Missense_Mutation	novel	L952V	0.07
GBM	chr17	7511547	Missense_Mutation	novel	P1354T	0.41
GBM	chr17	7499377	Silent	novel	A519A	0.15
GBM	chr17	7500729	Missense_Mutation	novel	G588R	0.09
HNSC	chr17	7500811	Missense_Mutation	novel	S615N	0.93
HNSC	chr17	7509103	Missense_Mutation	novel	P1209S	0.23
HNSC	chr17	7500828	Missense_Mutation	novel	I621V	0.26
HNSC	chr17	7496221	Missense_Mutation	novel	E80Q	0.1	RNA_pol_Rpb1_2
HNSC	chr17	7511460	Missense_Mutation	novel	D1325H	0.11
HNSC	chr17	7499596	Intron	novel		0.29
HNSC	chr17	7503269	Missense_Mutation	novel	I969V	0.21
HNSC	chr17	7512181	Silent	rs201531764	A1443A	0.33
HNSC	chr17	7496307	Silent	novel	R108R	0.16
HNSC	chr17	7498088	Missense_Mutation	novel	L405V	0.07
HNSC	chr17	7495999	Missense_Mutation	novel	R51P	0.23	RNA_pol_Rpb1_2
HNSC	chr17	7513498	Missense_Mutation	novel	S1745N	0.71
HNSC	chr17	7511474	Silent	rs764911266	K1329K	0.23
HNSC	chr17	7513710	Missense_Mutation	novel	P1816A	0.34
KICH	chr17	7497407	Missense_Mutation	rs201628232	R291W	0.1	RNA_pol_Rpb1_2
KIRC	chr17	7502093	Missense_Mutation	novel	I848T	0.12
KIRC	chr17	7499560	Intron	novel		0.5
KIRC	chr17	7513294	Missense_Mutation	novel	S1677N	0.17
KIRC	chr17	7499070	Missense_Mutation	novel	V456G	0.05
KIRC	chr17	7501098	Frame_Shift_Del	novel	*L681Sfs33**	0.27
KIRC	chr17	7513799	Silent	rs564268404	L1845L	0.21
KIRP	chr17	7513941	In_Frame_Del	rs745782731	L1895del	0.19
KIRP	chr17	7496025	Missense_Mutation	novel	P60A	0.34	RNA_pol_Rpb1_2
KIRP	chr17	7501681	Silent	novel	K767K	0.24
LAML	chr17	7496009	Frame_Shift_Ins	novel	*L57Afs10**	0.1	RNA_pol_Rpb1_2
LGG	chr17	7511560	Missense_Mutation	novel	T1358M	0.22
LGG	chr17	7512512	Missense_Mutation	novel	M1510L	0.42
LGG	chr17	7501685	Missense_Mutation	novel	M769V	0.08
LGG	chr17	7496546	Missense_Mutation	novel	G157V	0.08	RNA_pol_Rpb1_2
LGG	chr17	7501959	Missense_Mutation	novel	K803N	0.32
LGG	chr17	7509613	Missense_Mutation	novel	D1265V	0.09
LIHC	chr17	7513731	In_Frame_Del	rs770798456	S1828_P1834del	0.46
LIHC	chr17	7497657	Missense_Mutation	novel	Q330L	0.26	RNA_pol_Rpb1_2
LIHC	chr17	7501567	Silent	rs140982359	P729P	0.36
LIHC	chr17	7501568	Missense_Mutation	novel	G730W	0.37
LUAD	chr17	7501996	Missense_Mutation	novel	G816W	0.68
LUAD	chr17	7502533	Missense_Mutation	novel	R863L	0.12
LUAD	chr17	7502534	Silent	rs148495191	R863R	0.12
LUAD	chr17	7514195	Silent	novel	A1977A	0.58
LUAD	chr17	7501685	Missense_Mutation	novel	M769V	0.19
LUAD	chr17	7508286	Silent	novel	A1092A	0.54
LUAD	chr17	7498098	Frame_Shift_Del	novel	*N410Tfs60**	0.23
LUAD	chr17	7497479	Missense_Mutation	novel	A315S	0.37	RNA_pol_Rpb1_2
LUAD	chr17	7513985	Silent	novel	L1907L	0.18
LUAD	chr17	7512495	Missense_Mutation	novel	G1504V	0.73
LUAD	chr17	7503463	Missense_Mutation	novel	D1003N	0.21
LUAD	chr17	7499056	Silent	novel	C451C	0.73
LUAD	chr17	7513368	Missense_Mutation	novel	T1702S	0.46
LUAD	chr17	7514134	Nonsense_Mutation	novel	S1957*	0.24
LUAD	chr17	7501598	Nonsense_Mutation	novel	V741*	0.06
LUAD	chr17	7501600	Nonsense_Mutation	novel	*V741Rfs2**	0.05
LUAD	chr17	7501020	Silent	novel	H654H	0.1
LUAD	chr17	7503237	Missense_Mutation	novel	R958P	0.25
LUAD	chr17	7513369	Missense_Mutation	novel	T1702I	0.2
LUSC	chr17	7511879	Silent	rs780224204	G1390G	0.06
LUSC	chr17	7514168	Silent	novel	T1968T	0.35
LUSC	chr17	7513459	Missense_Mutation	novel	P1732L	0.51
LUSC	chr17	7503237	Missense_Mutation	rs565133398	R958Q	0.21
LUSC	chr17	7513645	Nonsense_Mutation	novel	S1794*	0.51
LUSC	chr17	7509544	Missense_Mutation	novel	D1242G	0.38
LUSC	chr17	7509148	Missense_Mutation	novel	R1224W	0.34
LUSC	chr17	7513836	Missense_Mutation	novel	L1858V	0.36
LUSC	chr17	7503777	Missense_Mutation	novel	F1076L	0.39
LUSC	chr17	7512325	Silent	rs768349650	P1491P	0.65
LUSC	chr17	7502043	Silent	novel	L831L	0.38
LUSC	chr17	7511874	Missense_Mutation	novel	D1389H	0.25
LUSC	chr17	7503694	Missense_Mutation	rs755560039	T1048M	0.61
LUSC	chr17	7501613	Missense_Mutation	novel	L745V	0.18
MESO	chr17	7496009	Frame_Shift_Ins	novel	*L57Afs10**	0.17	RNA_pol_Rpb1_2
MESO	chr17	7511925	Missense_Mutation	novel	T1406A	0.05
MESO	chr17	7499573	Intron	novel		0.24
OV	chr17	7511911	Missense_Mutation	novel	L1401W	0.07
OV	chr17	7512877	Silent	novel	G1570G	0.35
OV	chr17	7513810	Missense_Mutation	novel	P1849R	0.77
OV	chr17	7499625	Intron	novel		0.44
OV	chr17	7511903	Missense_Mutation	novel	L1398F	0.36
OV	chr17	7508272	Missense_Mutation	novel	G1088R	0.15
PAAD	chr17	7513679	Silent	novel	S1805S	0.12
PAAD	chr17	7502575	Missense_Mutation	novel	A877V	0.04
PAAD	chr17	7503247	Missense_Mutation	novel	E961D	0.17
PAAD	chr17	7514125	Missense_Mutation	novel	P1954H	0.04
PCPG	chr17	7513717	Missense_Mutation	novel	Y1818C	0.43
PRAD	chr17	7502081	Missense_Mutation	novel	R844H	0.13
PRAD	chr17	7501039	Missense_Mutation	novel	G661S	0.43
READ	chr17	7502022	Missense_Mutation	novel	E824D	0.19
READ	chr17	7513624	Missense_Mutation	novel	S1787F	0.25
READ	chr17	7508466	Silent	novel	E1152E	0.16
READ	chr17	7496055	Missense_Mutation	novel	R70C	0.71	RNA_pol_Rpb1_2
READ	chr17	7495951	Missense_Mutation	novel	S35Y	0.25	RNA_pol_Rpb1_2
READ	chr17	7496568	Silent	rs368365915	F164F	0.33
READ	chr17	7508404	Missense_Mutation	novel	K1132E	0.35
READ	chr17	7513196	Silent	rs200514677	S1644S	0.43
READ	chr17	7513503	Missense_Mutation	novel	N1747D	0.12
SARC	chr17	7502640	Missense_Mutation	novel	E899K	0.73
SKCM	chr17	7513953	Missense_Mutation	novel	P1897S	0.47
SKCM	chr17	7496002	Missense_Mutation	novel	P52L	0.49	RNA_pol_Rpb1_2
SKCM	chr17	7509101	Missense_Mutation	novel	S1208F	0.38
SKCM	chr17	7498132	Silent	novel	I419I	0.4
SKCM	chr17	7513554	Missense_Mutation	novel	P1764S	0.36
SKCM	chr17	7513584	Missense_Mutation	novel	P1774S	0.31
SKCM	chr17	7513083	Missense_Mutation	novel	G1607C	0.25
SKCM	chr17	7501911	Silent	rs369411244	V787V	0.89
SKCM	chr17	7503457	Missense_Mutation	rs754080145	P1001S	0.22
SKCM	chr17	7513155	Missense_Mutation	novel	P1631S	0.27
SKCM	chr17	7513156	Missense_Mutation	novel	P1631L	0.26
SKCM	chr17	7513478	Silent	rs142175837	S1738S	0.27
SKCM	chr17	7513112	Silent	novel	S1616S	0.36
SKCM	chr17	7499106	Missense_Mutation	novel	S468F	0.3
SKCM	chr17	7508419	Missense_Mutation	novel	P1137S	0.21
SKCM	chr17	7501010	Missense_Mutation	novel	S651F	0.35
SKCM	chr17	7514095	Missense_Mutation	novel	L1944P	0.51
SKCM	chr17	7514097	Missense_Mutation	novel	P1945S	0.49
SKCM	chr17	7513501	Missense_Mutation	rs779849342	P1746L	0.43
SKCM	chr17	7499135	Missense_Mutation	novel	P478S	0.32
SKCM	chr17	7503487	Missense_Mutation	novel	E1011K	0.37
SKCM	chr17	7502080	Missense_Mutation	novel	R844C	0.81
SKCM	chr17	7513522	Missense_Mutation	novel	P1753L	0.82
SKCM	chr17	7498142	Missense_Mutation	novel	N423Y	0.42
SKCM	chr17	7512875	Missense_Mutation	novel	G1570S	0.27
SKCM	chr17	7501026	Silent	novel	S656S	0.11
SKCM	chr17	7511828	Silent	rs764110481	A1373A	0.32
SKCM	chr17	7499291	Missense_Mutation	novel	P491S	0.14
SKCM	chr17	7498168	Silent	novel	F431F	0.45
SKCM	chr17	7497472	Silent	novel	F312F	0.18
SKCM	chr17	7512787	Silent	novel	T1540T	0.32
SKCM	chr17	7497003	Silent	rs142508418	S259S	0.68
SKCM	chr17	7514058	Missense_Mutation	novel	R1932C	0.56
SKCM	chr17	7499482	Silent	rs752556134	F554F	0.29
SKCM	chr17	7496893	Missense_Mutation	novel	E223K	0.41	RNA_pol_Rpb1_2
SKCM	chr17	7512311	Missense_Mutation	novel	P1487S	0.2
SKCM	chr17	7497682	Silent	novel	S338S	0.25
SKCM	chr17	7512223	Missense_Mutation	novel	N1457K	0.33
SKCM	chr17	7503457	Missense_Mutation	rs754080145	P1001S	0.33
SKCM	chr17	7511969	Silent	novel	N1420N	0.69
SKCM	chr17	7512323	Missense_Mutation	novel	P1491T	0.39
SKCM	chr17	7498135	Silent	novel	I420I	0.24
STAD	chr17	7513785	Frame_Shift_Del	novel	*Q1842Nfs72**	0.12
STAD	chr17	7495957	Missense_Mutation	novel	T37M	0.32	RNA_pol_Rpb1_2
STAD	chr17	7496305	Missense_Mutation	novel	R108C	0.19	RNA_pol_Rpb1_2
STAD	chr17	7513072	Missense_Mutation	novel	R1603H	0.25
STAD	chr17	7502571	Missense_Mutation	novel	D876N	0.35
STAD	chr17	7513579	Missense_Mutation	novel	T1772I	0.16
STAD	chr17	7511237	Missense_Mutation	novel	M1279T	0.16
STAD	chr17	7512198	Missense_Mutation	novel	D1449G	0.26
STAD	chr17	7496527	Frame_Shift_Del	novel	*N152Tfs24**	0.1	RNA_pol_Rpb1_2
STAD	chr17	7513689	Missense_Mutation	novel	P1809S	0.35
STAD	chr17	7503409	Missense_Mutation	rs548638112	R985W	0.09
STAD	chr17	7513072	Missense_Mutation	novel	R1603H	0.36
STAD	chr17	7496521	Missense_Mutation	novel	K149E	0.33	RNA_pol_Rpb1_2
STAD	chr17	7513490	Silent	novel	S1742S	0.3
STAD	chr17	7499065	Silent	novel	D454D	0.34
STAD	chr17	7499126	Missense_Mutation	rs775983104	R475C	0.32
STAD	chr17	7513751	Silent	rs370656689	S1829S	0.21
STAD	chr17	7501622	Missense_Mutation	novel	A748T	0.18
STAD	chr17	7496347	Splice_Site	novel	X121_splice	0.28
STAD	chr17	7509122	Missense_Mutation	novel	E1215A	0.23
STAD	chr17	7511500	Missense_Mutation	novel	T1338M	0.14
STAD	chr17	7503264	Missense_Mutation	novel	R967M	0.15
STAD	chr17	7513886	Silent	novel	S1874S	0.13
STAD	chr17	7498121	Missense_Mutation	rs763272826	A416T	0.32
STAD	chr17	7503665	Silent	rs771846320	T1038T	0.13
STAD	chr17	7496880	Silent	novel	P218P	0.33
STAD	chr17	7500660	Missense_Mutation	novel	M565V	0.38
THCA	chr17	7514080	Missense_Mutation	novel	Q1939P	0.1
THCA	chr17	7503729	Missense_Mutation	novel	L1060F	0.15
UCEC	chr17	7496545	Frame_Shift_Del	novel	*E158Rfs18**	0.29	RNA_pol_Rpb1_2
UCEC	chr17	7497771	Frame_Shift_Del	novel	*D370Tfs19**	0.3
UCEC	chr17	7501077	Silent	rs112363039	Q673Q	0.36
UCEC	chr17	7496885	Missense_Mutation	rs756676283	R220Q	0.43	RNA_pol_Rpb1_2
UCEC	chr17	7501964	Missense_Mutation	novel	R805Q	0.38
UCEC	chr17	7512182	Missense_Mutation	novel	A1444T	0.39
UCEC	chr17	7500829	Missense_Mutation	novel	I621T	0.03
UCEC	chr17	7498201	Silent	novel	T442T	0.45
UCEC	chr17	7503294	Splice_Site	novel	X976_splice	0.39
UCEC	chr17	7513363	Missense_Mutation	novel	S1700L	0.39
UCEC	chr17	7511320	Splice_Site	novel	X1306_splice	0.25
UCEC	chr17	7498152	Missense_Mutation	novel	R426H	0.47
UCEC	chr17	7503672	Missense_Mutation	novel	F1041V	0.22
UCEC	chr17	7508456	Missense_Mutation	novel	R1149Q	0.46
UCEC	chr17	7513502	Silent	rs145007034	P1746P	0.43
UCEC	chr17	7499399	Frame_Shift_Ins	novel	*Q529Pfs31**	0.44
UCEC	chr17	7499385	Missense_Mutation	novel	P522H	0.36
UCEC	chr17	7513348	Missense_Mutation	rs749911689	T1695M	0.35
UCEC	chr17	7499489	Missense_Mutation	novel	R557W	0.32
UCEC	chr17	7503441	Silent	rs766259489	H995H	0.42
UCEC	chr17	7509548	Missense_Mutation	novel	L1243F	0.1
UCEC	chr17	7496555	Missense_Mutation	novel	M160R	0.06	RNA_pol_Rpb1_2
UCEC	chr17	7513890	Missense_Mutation	rs766202800	R1876C	0.25
UCEC	chr17	7502621	Silent	rs746718678	G892G	0.13
UCEC	chr17	7511265	Silent	novel	I1288I	0.1
UCEC	chr17	7512286	Silent	novel	E1478E	0.2
UCEC	chr17	7496301	Silent	novel	V106V	0.36
UCEC	chr17	7497358	Splice_Region	novel	D274D	0.46
UCEC	chr17	7500676	Missense_Mutation	novel	W570L	0.33
UCEC	chr17	7501039	Missense_Mutation	novel	G661S	0.21
UCEC	chr17	7508462	Missense_Mutation	novel	A1151G	0.48
UCEC	chr17	7496868	Silent	novel	I214I	0.09
UCEC	chr17	7497670	Silent	novel	R334R	0.33
UCEC	chr17	7498151	Missense_Mutation	novel	R426C	0.45
UCEC	chr17	7508464	Missense_Mutation	novel	E1152K	0.25
UCEC	chr17	7497806	Missense_Mutation	novel	V380M	0.32
UCEC	chr17	7496286	Silent	novel	V101V	0.12
UCEC	chr17	7514587	3'UTR	novel		0.3
UCEC	chr17	7499575	Intron	novel		0.35
UCEC	chr17	7495961	Missense_Mutation	novel	E38D	0.38	RNA_pol_Rpb1_2
UCEC	chr17	7513478	Silent	rs142175837	S1738S	0.25
UCEC	chr17	7499400	Frame_Shift_Del	novel	*Q529Rfs32**	0.44
UCEC	chr17	7499400	Frame_Shift_Del	novel	*Q529Rfs32**	0.39
UCEC	chr17	7512182	Missense_Mutation	novel	A1444T	0.14
UCEC	chr17	7499457	Missense_Mutation	rs759150226	R546H	0.36
UCEC	chr17	7503470	Missense_Mutation	novel	H1005R	0.42
UCEC	chr17	7503665	Silent	rs771846320	T1038T	0.37
UCEC	chr17	7512182	Missense_Mutation	novel	A1444T	0.51
UCEC	chr17	7513617	Missense_Mutation	novel	P1785S	0.4
UCEC	chr17	7514067	Frame_Shift_Del	novel	*P1936Qfs30**	0.3
UCEC	chr17	7497829	Silent	novel	N387N	0.27
UCEC	chr17	7503252	Missense_Mutation	novel	R963Q	0.53
UCEC	chr17	7503452	Missense_Mutation	novel	R999H	0.37
UCEC	chr17	7512181	Silent	rs201531764	A1443A	0.32
UCEC	chr17	7502574	Missense_Mutation	rs764559155	A877T	0.23
UCEC	chr17	7500999	Silent	rs768814281	T647T	0.24
UCEC	chr17	7509055	Missense_Mutation	novel	V1193M	0.15
UCEC	chr17	7496539	Missense_Mutation	novel	E155K	0.43	RNA_pol_Rpb1_2
UCEC	chr17	7511862	Missense_Mutation	novel	V1385I	0.33
UCEC	chr17	7512490	Missense_Mutation	novel	F1502L	0.38
UCEC	chr17	7513502	Silent	rs145007034	P1746P	0.42
UCEC	chr17	7509565	Missense_Mutation	novel	D1249G	0.37
UCEC	chr17	7511520	Missense_Mutation	rs142714917	R1345W	0.18
UCEC	chr17	7512182	Missense_Mutation	novel	A1444T	0.07
UCEC	chr17	7501963	Missense_Mutation	novel	R805W	0.31
UCEC	chr17	7503126	Missense_Mutation	rs200835893	R921H	0.27
UCEC	chr17	7503746	Silent	rs745614130	F1065F	0.38
UCEC	chr17	7497771	Frame_Shift_Del	novel	*D370Tfs19**	0.37
UCEC	chr17	7511284	Missense_Mutation	novel	D1295Y	0.46
UCEC	chr17	7513467	Missense_Mutation	novel	S1735A	0.37
UCEC	chr17	7514417	3'UTR	novel		0.33
UCEC	chr17	7511257	Missense_Mutation	novel	R1286C	0.43
UCEC	chr17	7503159	Missense_Mutation	rs773630296	R932H	0.24
UCEC	chr17	7496868	Silent	novel	I214I	0.31
UCEC	chr17	7498095	Missense_Mutation	rs141769858	R407H	0.52
UCEC	chr17	7500778	Missense_Mutation	rs764504201	R604H	0.35
UCEC	chr17	7513800	Missense_Mutation	novel	L1846I	0.14
UCEC	chr17	7499400	Frame_Shift_Del	novel	*Q529Rfs32**	0.53
UCEC	chr17	7499477	Missense_Mutation	novel	V553I	0.31
UCEC	chr17	7500660	Missense_Mutation	novel	M565V	0.23
UCEC	chr17	7503237	Missense_Mutation	rs565133398	R958Q	0.44
UCEC	chr17	7511554	Missense_Mutation	rs772421579	R1356H	0.3
UCEC	chr17	7496496	Silent	novel	R140R	0.07
UCEC	chr17	7498121	Missense_Mutation	rs763272826	A416T	0.24
UCEC	chr17	7500778	Missense_Mutation	rs764504201	R604H	0.29
UCEC	chr17	7501607	Missense_Mutation	novel	R743C	0.32
UCEC	chr17	7502068	Missense_Mutation	novel	A840T	0.2
UCEC	chr17	7498209	Missense_Mutation	novel	K445R	0.44
UCEC	chr17	7514291	3'UTR	novel		0.09
UCEC	chr17	7514293	3'UTR	novel		0.07
UCEC	chr17	7496010	Frame_Shift_Del	novel	L57*	0.14	RNA_pol_Rpb1_2
UCEC	chr17	7511919	Missense_Mutation	novel	T1404A	0.13
UCEC	chr17	7508269	Missense_Mutation	novel	V1087M	0.4
UCEC	chr17	7499400	Frame_Shift_Del	novel	*Q529Rfs32**	0.28
UCEC	chr17	7498085	Nonsense_Mutation	novel	E404*	0.3
UCEC	chr17	7496825	Missense_Mutation	novel	A200V	0.2	RNA_pol_Rpb1_2
UCEC	chr17	7497451	Missense_Mutation	novel	E305D	0.33	RNA_pol_Rpb1_2
UCEC	chr17	7497806	Missense_Mutation	novel	V380M	0.21
UCEC	chr17	7499457	Missense_Mutation	rs759150226	R546H	0.34
UCEC	chr17	7502576	Silent	novel	A877A	0.14
UCEC	chr17	7511456	Silent	rs143101629	T1323T	0.28
UCEC	chr17	7512481	Silent	rs748257528	T1499T	0.44
UCEC	chr17	7503491	Splice_Site	novel	X1012_splice	0.46
UCEC	chr17	7496796	Missense_Mutation	novel	R190S	0.14	RNA_pol_Rpb1_2
UCEC	chr17	7496583	Silent	novel	P169P	0.05
UCEC	chr17	7496877	Silent	novel	S217S	0.09
UCEC	chr17	7497407	Missense_Mutation	rs201628232	R291W	0.27	RNA_pol_Rpb1_2
UCEC	chr17	7499121	Missense_Mutation	rs201184176	R473Q	0.26
UCEC	chr17	7501352	Missense_Mutation	novel	T705N	0.28
UCEC	chr17	7511505	Missense_Mutation	novel	G1340S	0.22
UCEC	chr17	7495944	Nonsense_Mutation	rs767064007	R33*	0.24	RNA_pol_Rpb1_2
UCEC	chr17	7503231	Missense_Mutation	novel	F956C	0.39
UCEC	chr17	7513927	Missense_Mutation	novel	N1888T	0.38
UCEC	chr17	7503200	Missense_Mutation	novel	A946T	0.35
UCS	chr17	7511566	Missense_Mutation	rs769104202	N1360S	0.85
UCS	chr17	7513836	Missense_Mutation	novel	L1858F	0.4
UCS	chr17	7500999	Silent	rs768814281	T647T	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.2083	0.18166
LAML	DEL	0.0733	0.12511
LIHC	DEL	0.5757	3.9592e-10
THCA	DEL	0.016	0.221

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.012	Kaplan-Meier Survival Analysis
SKCM	0.00011	Kaplan-Meier Survival Analysis
PRAD	0.025	Kaplan-Meier Survival Analysis
LIHC	0.014	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Paralogs

Orthologs

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742