EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000181381 (Gene tree)
Gene ID: 91351
Gene Symbol: DDX60L
Alias: FLJ31033
Full Name: DExD/H-box 60 like
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 181,052 bases
Position: chr4:168,356,735-168,537,786
Accession: 26429
RBP type: canonical RBP
Summary: This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in cell culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000422202	ResIII	PF04851.15	2.7e-10	1	1
ENSP00000260184	ResIII	PF04851.15	6.1e-10	1	1
ENSP00000422423	ResIII	PF04851.15	6.1e-10	1	1
ENSP00000422202	DEAD	PF00270.29	1.2e-14	1	1
ENSP00000260184	DEAD	PF00270.29	1.8e-14	1	1
ENSP00000422423	DEAD	PF00270.29	1.8e-14	1	1
ENSP00000421026	DEAD	PF00270.29	3.1e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000512371	DDX60L-210	428	-	ENSP00000427386	77 (aa)	-	D6RIU1
ENST00000505150	DDX60L-204	655	-	-	- (aa)	-	-
ENST00000513103	DDX60L-212	507	-	-	- (aa)	-	-
ENST00000503190	DDX60L-202	562	-	-	- (aa)	-	-
ENST00000504793	DDX60L-203	549	-	-	- (aa)	-	-
ENST00000513901	DDX60L-213	623	-	-	- (aa)	-	-
ENST00000512958	DDX60L-211	769	-	-	- (aa)	-	-
ENST00000514748	DDX60L-215	632	-	ENSP00000424396	98 (aa)	-	D6RB62
ENST00000515088	DDX60L-216	2652	-	-	- (aa)	-	-
ENST00000505696	DDX60L-205	588	-	ENSP00000424310	124 (aa)	-	D6RBA2
ENST00000505890	DDX60L-207	4568	-	ENSP00000422202	1308 (aa)	-	Q5H9U9
ENST00000505863	DDX60L-206	2605	-	ENSP00000421026	868 (aa)	-	H0Y8H0
ENST00000510590	DDX60L-208	3509	-	-	- (aa)	-	-
ENST00000514580	DDX60L-214	813	-	ENSP00000422920	195 (aa)	-	H0Y939
ENST00000511577	DDX60L-209	6781	-	ENSP00000422423	1706 (aa)	-	Q5H9U9
ENST00000260184	DDX60L-201	6754	XM_005263341	ENSP00000260184	1706 (aa)	XP_005263398	Q5H9U9

Gene Model

Click here to download ENSG00000181381's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000181381	Blood Pressure	8.5170000E-005	-
ENSG00000181381	Hypertension	2.8164309E-005	-
ENSG00000181381	Liver Cirrhosis	6E-7	20708005
ENSG00000181381	Non-alcoholic Fatty Liver Disease	6E-7	20708005
ENSG00000181381	Energy Intake	8E-6	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000181381	rs1963569	4	168417369	A	Obesity-related traits	23251661	[NR] %energy increase	0.03	EFO_0003939
ENSG00000181381	rs62334125	4	168414135	C	Pursuit maintenance gain	29064472			EFO_0008433
ENSG00000181381	rs2710833	4	168488807	A	Non-alcoholic fatty liver disease histology (AST)	20708005	[NR] unit increase	0.41	EFO_0003095\|EFO_0001422
ENSG00000181381	rs10019193	4	168526369	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000181381's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000181381	DDX60L	95	79.661	ENSG00000137628	DDX60	95	80.531

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000181381	DDX60L	100	91.129	ENSCJAG00000046221	DDX60L	99	85.068	Callithrix_jacchus
ENSG00000181381	DDX60L	100	81.452	ENSTSYG00000013149	DDX60L	100	74.461	Carlito_syrichta
ENSG00000181381	DDX60L	100	91.129	ENSCCAG00000030111	DDX60L	100	84.674	Cebus_capucinus
ENSG00000181381	DDX60L	100	91.472	ENSCATG00000044236	DDX60L	100	91.530	Cercocebus_atys
ENSG00000181381	DDX60L	100	90.816	ENSCSAG00000003149	DDX60L	100	90.888	Chlorocebus_sabaeus
ENSG00000181381	DDX60L	100	91.355	ENSCANG00000028650	DDX60L	100	91.355	Colobus_angolensis_palliatus
ENSG00000181381	DDX60L	100	83.871	ENSEASG00005021597	DDX60L	99	77.230	Equus_asinus_asinus
ENSG00000181381	DDX60L	100	83.871	ENSECAG00000024062	DDX60L	99	74.898	Equus_caballus
ENSG00000181381	DDX60L	100	100.000	ENSGGOG00000014778	DDX60L	100	97.477	Gorilla_gorilla
ENSG00000181381	DDX60L	100	91.414	ENSMFAG00000045327	DDX60L	100	91.414	Macaca_fascicularis
ENSG00000181381	DDX60L	100	91.360	ENSMMUG00000003634	DDX60L	100	91.360	Macaca_mulatta
ENSG00000181381	DDX60L	100	91.540	ENSMNEG00000029554	DDX60L	100	91.540	Macaca_nemestrina
ENSG00000181381	DDX60L	100	91.233	ENSMLEG00000027365	DDX60L	100	91.233	Mandrillus_leucophaeus
ENSG00000181381	DDX60L	100	95.723	ENSNLEG00000006565	DDX60L	100	95.723	Nomascus_leucogenys
ENSG00000181381	DDX60L	100	98.184	ENSPPAG00000014553	DDX60L	99	98.184	Pan_paniscus
ENSG00000181381	DDX60L	100	98.701	ENSPTRG00000016582	DDX60L	100	98.359	Pan_troglodytes
ENSG00000181381	DDX60L	100	91.599	ENSPANG00000017684	DDX60L	100	91.599	Papio_anubis
ENSG00000181381	DDX60L	100	98.701	ENSPPYG00000015185	DDX60L	100	95.431	Pongo_abelii
ENSG00000181381	DDX60L	100	92.742	ENSRBIG00000025614	DDX60L	99	89.142	Rhinopithecus_bieti
ENSG00000181381	DDX60L	100	92.742	ENSRROG00000039658	DDX60L	99	91.706	Rhinopithecus_roxellana
ENSG00000181381	DDX60L	100	91.935	ENSSBOG00000034368	DDX60L	99	85.614	Saimiri_boliviensis_boliviensis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	-	IEA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005524	ATP binding	-	IEA	Function