EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000181552 (Gene tree)
Gene ID: 64184
Gene Symbol: EDDM3B
Alias: HE3-BETA|FAM12B
Full Name: epididymal protein 3B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 2,522 bases
Position: chr14:20,768,427-20,770,948
Accession: 19223
RBP type: canonical RBP
Summary: Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg. Post-testicular maturation requires exposure of spermatozoa to the microenvironment of the epididymal lumen. Spermatozoa undergo extensive changes in the epididymis, including enzymatic modifications, loss of pre-existing components and addition of new glycoproteins from epididymal secretions. These modifying proteins and enzymes are synthesized by epithelial cells lining the epididymal duct and secreted apically into the lumen, where they come into contact with, and may be absorbed onto, the sperm membranes. The proteins encoded by the genes in this cluster are synthesized and secreted by epididymal epithelial cells. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000314810	RnaseA	PF00074.20	3.2e-08	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000326783	EDDM3B-201	896	-	ENSP00000314810	147 (aa)	-	P56851

Gene Model

Click here to download ENSG00000181552's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000181552's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000181552	EDDM3B	97	54.545	ENSAMEG00000019906	-	98	54.545	Ailuropoda_melanoleuca
ENSG00000181552	EDDM3B	88	53.846	ENSBTAG00000055081	-	98	53.957	Bos_taurus
ENSG00000181552	EDDM3B	100	87.755	ENSCJAG00000038288	EDDM3B	100	87.755	Callithrix_jacchus
ENSG00000181552	EDDM3B	100	65.986	ENSCJAG00000040222	EDDM3A	100	65.986	Callithrix_jacchus
ENSG00000181552	EDDM3B	97	51.748	ENSCAFG00000005429	-	98	51.748	Canis_familiaris
ENSG00000181552	EDDM3B	97	51.748	ENSCAFG00020014402	-	88	51.748	Canis_lupus_dingo
ENSG00000181552	EDDM3B	100	95.238	ENSCATG00000022830	EDDM3B	100	95.238	Cercocebus_atys
ENSG00000181552	EDDM3B	100	66.667	ENSCSAG00000000348	EDDM3A	100	66.667	Chlorocebus_sabaeus
ENSG00000181552	EDDM3B	100	96.599	ENSCSAG00000000347	EDDM3B	100	96.599	Chlorocebus_sabaeus
ENSG00000181552	EDDM3B	99	55.479	ENSCHOG00000011384	-	99	55.479	Choloepus_hoffmanni
ENSG00000181552	EDDM3B	100	95.238	ENSCANG00000038286	EDDM3B	100	95.238	Colobus_angolensis_palliatus
ENSG00000181552	EDDM3B	99	60.000	ENSCGRG00001015047	Eddm3b	95	60.000	Cricetulus_griseus_chok1gshd
ENSG00000181552	EDDM3B	75	50.909	ENSDNOG00000041158	-	100	50.909	Dasypus_novemcinctus
ENSG00000181552	EDDM3B	99	59.310	ENSDORG00000023401	Eddm3b	95	59.310	Dipodomys_ordii
ENSG00000181552	EDDM3B	95	48.201	ENSETEG00000011239	-	95	48.201	Echinops_telfairi
ENSG00000181552	EDDM3B	97	60.140	ENSEASG00005002956	-	88	60.140	Equus_asinus_asinus
ENSG00000181552	EDDM3B	97	60.140	ENSECAG00000028388	-	88	60.140	Equus_caballus
ENSG00000181552	EDDM3B	99	55.172	ENSEEUG00000004950	-	99	55.172	Erinaceus_europaeus
ENSG00000181552	EDDM3B	97	60.140	ENSFCAG00000013772	-	98	60.140	Felis_catus
ENSG00000181552	EDDM3B	100	97.279	ENSGGOG00000011563	EDDM3B	100	97.279	Gorilla_gorilla
ENSG00000181552	EDDM3B	100	68.027	ENSGGOG00000016754	EDDM3A	100	68.027	Gorilla_gorilla
ENSG00000181552	EDDM3B	99	53.793	ENSLAFG00000001699	-	99	53.793	Loxodonta_africana
ENSG00000181552	EDDM3B	99	51.034	ENSLAFG00000023121	-	99	51.034	Loxodonta_africana
ENSG00000181552	EDDM3B	100	94.558	ENSMMUG00000001656	EDDM3B	100	94.558	Macaca_mulatta
ENSG00000181552	EDDM3B	100	95.918	ENSMLEG00000027313	EDDM3B	100	95.918	Mandrillus_leucophaeus
ENSG00000181552	EDDM3B	80	43.590	ENSMODG00000024492	-	93	41.844	Monodelphis_domestica
ENSG00000181552	EDDM3B	99	55.862	MGP_CAROLIEiJ_G0019218	Eddm3b	95	55.862	Mus_caroli
ENSG00000181552	EDDM3B	99	56.552	ENSMUSG00000072575	Eddm3b	95	56.552	Mus_musculus
ENSG00000181552	EDDM3B	99	56.552	MGP_SPRETEiJ_G0020111	Eddm3b	95	56.552	Mus_spretus
ENSG00000181552	EDDM3B	97	56.643	ENSMPUG00000018383	-	98	56.643	Mustela_putorius_furo
ENSG00000181552	EDDM3B	99	58.904	ENSMLUG00000014174	-	96	58.904	Myotis_lucifugus
ENSG00000181552	EDDM3B	100	95.238	ENSNLEG00000034277	-	100	95.238	Nomascus_leucogenys
ENSG00000181552	EDDM3B	100	96.599	ENSNLEG00000029047	-	100	96.599	Nomascus_leucogenys
ENSG00000181552	EDDM3B	96	42.553	ENSMEUG00000015068	-	100	42.553	Notamacropus_eugenii
ENSG00000181552	EDDM3B	98	52.778	ENSOPRG00000013117	-	99	52.055	Ochotona_princeps
ENSG00000181552	EDDM3B	99	64.138	ENSOCUG00000026377	-	95	64.138	Oryctolagus_cuniculus
ENSG00000181552	EDDM3B	100	69.388	ENSOGAG00000007767	-	100	69.388	Otolemur_garnettii
ENSG00000181552	EDDM3B	100	55.782	ENSOARG00000012827	-	100	55.782	Ovis_aries
ENSG00000181552	EDDM3B	99	56.164	ENSOARG00000012492	-	96	56.164	Ovis_aries
ENSG00000181552	EDDM3B	100	98.639	ENSPPAG00000033003	EDDM3B	100	98.639	Pan_paniscus
ENSG00000181552	EDDM3B	100	68.027	ENSPPAG00000000145	EDDM3A	100	68.027	Pan_paniscus
ENSG00000181552	EDDM3B	97	60.140	ENSPPRG00000020024	-	98	60.140	Panthera_pardus
ENSG00000181552	EDDM3B	97	58.741	ENSPTIG00000004120	-	98	58.741	Panthera_tigris_altaica
ENSG00000181552	EDDM3B	100	68.027	ENSPTRG00000006102	EDDM3A	100	68.027	Pan_troglodytes
ENSG00000181552	EDDM3B	100	98.639	ENSPTRG00000006103	EDDM3B	100	98.639	Pan_troglodytes
ENSG00000181552	EDDM3B	100	96.599	ENSPANG00000007680	EDDM3B	100	96.599	Papio_anubis
ENSG00000181552	EDDM3B	99	55.172	ENSPEMG00000014380	Eddm3b	95	55.172	Peromyscus_maniculatus_bairdii
ENSG00000181552	EDDM3B	84	42.276	ENSPCIG00000028761	-	93	41.497	Phascolarctos_cinereus
ENSG00000181552	EDDM3B	100	97.959	ENSPPYG00000005576	EDDM3B	100	97.959	Pongo_abelii
ENSG00000181552	EDDM3B	100	69.388	ENSPPYG00000005575	EDDM3A	100	69.388	Pongo_abelii
ENSG00000181552	EDDM3B	100	58.503	ENSPVAG00000013560	-	100	58.503	Pteropus_vampyrus
ENSG00000181552	EDDM3B	97	58.741	ENSRNOG00000030110	LOC103693823	98	58.741	Rattus_norvegicus
ENSG00000181552	EDDM3B	97	58.741	ENSRNOG00000054022	LOC103693384	98	58.741	Rattus_norvegicus
ENSG00000181552	EDDM3B	97	58.741	ENSRNOG00000052100	Eddm3b	98	58.741	Rattus_norvegicus
ENSG00000181552	EDDM3B	100	96.599	ENSRROG00000037495	EDDM3B	100	96.599	Rhinopithecus_roxellana
ENSG00000181552	EDDM3B	99	43.448	ENSSHAG00000006060	-	95	43.448	Sarcophilus_harrisii
ENSG00000181552	EDDM3B	99	55.479	ENSSSCG00000021866	EDDM3B	99	55.479	Sus_scrofa
ENSG00000181552	EDDM3B	100	58.503	ENSVPAG00000007373	-	100	58.503	Vicugna_pacos
ENSG00000181552	EDDM3B	97	53.521	ENSVVUG00000009061	-	87	53.521	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003674	molecular_function	-	ND	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005576	extracellular region	-	IEA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr14	20770359	Missense_Mutation	rs528414264	Y70C	0.16	RnaseA
BLCA	chr14	20770148	5'UTR	novel		0.09
BLCA	chr14	20770242	Missense_Mutation	novel	R31I	0.5	RnaseA
BLCA	chr14	20770541	Missense_Mutation	rs141966055	G131R	0.29
BLCA	chr14	20770140	5'UTR	rs760014696		0.4
CESC	chr14	20770378	Missense_Mutation	novel	I76M	0.21	RnaseA
CESC	chr14	20770835	3'UTR	novel		0.34
COAD	chr14	20770828	3'UTR	rs775709940		0.1
ESCA	chr14	20770585	Silent	rs755986649	I145I	0.1
GBM	chr14	20770265	Missense_Mutation	rs201861023	L39V	0.47	RnaseA
GBM	chr14	20770378	Silent	rs754095070	I76I	0.46
KIRC	chr14	20770540	Silent	rs762396483	D130D	0.18
LGG	chr14	20770287	Missense_Mutation	NA	R46T	0.23	RnaseA
LIHC	chr14	20770944	3'UTR	novel		0.37
LUAD	chr14	20770592	Nonstop_Mutation	novel	148Qext18	0.42
LUAD	chr14	20770488	Missense_Mutation	novel	S113I	0.42	RnaseA
LUAD	chr14	20770657	3'UTR	novel		0.3
LUSC	chr14	20770409	Missense_Mutation	NA	D87H	0.55	RnaseA
LUSC	chr14	20770316	Missense_Mutation	novel	E56K	0.61	RnaseA
LUSC	chr14	20770131	Splice_Site	novel		0.1
LUSC	chr14	20770412	Missense_Mutation	novel	R88S	0.42	RnaseA
OV	chr14	20770383	Missense_Mutation	novel	H78L	0.06	RnaseA
OV	chr14	20770174	Nonsense_Mutation	novel	W8*	0.12
OV	chr14	20770683	3'UTR	novel		0.28
OV	chr14	20770226	Missense_Mutation	NA	K26E	0.16
READ	chr14	20770585	Silent	rs755986649	I145I	0.2
READ	chr14	20770754	3'UTR	novel		0.17
SKCM	chr14	20770242	Missense_Mutation	rs751569950	R31K	0.24	RnaseA
SKCM	chr14	20770441	Silent	NA	Q97Q	0.23
SKCM	chr14	20770549	Silent	NA	V133V	0.34
SKCM	chr14	20770229	Missense_Mutation	rs534719745	E27K	0.43
SKCM	chr14	20770661	3'UTR	novel		0.76
STAD	chr14	20770586	Missense_Mutation	rs540262572	G146S	0.41
STAD	chr14	20770674	3'UTR	novel		0.14
TGCT	chr14	20770310	Missense_Mutation	novel	M54V	0.12	RnaseA
THCA	chr14	20770418	Nonsense_Mutation	rs201632508	R90*	0.49	RnaseA
UCEC	chr14	20770168	Missense_Mutation	NA	K6N	0.37
UCEC	chr14	20770540	Silent	rs762396483	D130D	0.31
UCEC	chr14	20770140	5'UTR	rs760014696		0.33
UCEC	chr14	20770726	3'UTR	novel		0.14
UCEC	chr14	20770368	Nonsense_Mutation	NA	W73*	0.48	RnaseA
UCEC	chr14	20770724	3'UTR	novel		0.4
UCEC	chr14	20770916	3'UTR	novel		0.33
UCEC	chr14	20770794	3'UTR	novel		0.34
UCEC	chr14	20770710	3'UTR	novel		0.09
UCEC	chr14	20770520	Nonsense_Mutation	novel	E124*	0.16	RnaseA
UCEC	chr14	20770829	3'UTR	novel		0.26
UCEC	chr14	20770202	Missense_Mutation	novel	L18I	0.27
UCEC	chr14	20770246	Silent	NA	E32E	0.36
UCEC	chr14	20770183	Silent	NA	L11L	0.38
UCEC	chr14	20770140	5'UTR	rs760014696		0.46
UCEC	chr14	20770658	3'UTR	novel		0.08
UCEC	chr14	20770341	Missense_Mutation	novel	S64N	0.36	RnaseA

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	AMP	0.2667	0.056464
ACC	DEL	0.1444	0.19769
CHOL	DEL	0.3611	0.00040262
HNSC	DEL	0.1092	0.0025503
KIRP	DEL	0.1632	0.085174
LUSC	DEL	0.2615	0.0082553
PAAD	DEL	0.0924	0.11332
READ	DEL	0.3697	0.0043084

Survival Analysis

Cancer	P-value	Q-value
BRCA	0.0076	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

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Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742