EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000181991 (Gene tree)
Gene ID: 64963
Gene Symbol: MRPS11
Alias: FLJ23406|HCC-2|FLJ22512
Full Name: mitochondrial ribosomal protein S11
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 13,321 bases
Position: chr15:88,467,453-88,480,773
Accession: 14050
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000317376	Ribosomal_S11	PF00411.19	2.2e-24	1	1
ENSP00000318054	Ribosomal_S11	PF00411.19	2.7e-19	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000559323	MRPS11-207	2002	-	-	- (aa)	-	-
ENST00000560850	MRPS11-210	458	-	-	- (aa)	-	-
ENST00000558406	MRPS11-204	918	-	-	- (aa)	-	-
ENST00000561262	MRPS11-211	726	-	-	- (aa)	-	-
ENST00000353598	MRPS11-202	766	-	ENSP00000318054	161 (aa)	-	P82912
ENST00000559125	MRPS11-206	453	-	-	- (aa)	-	-
ENST00000560708	MRPS11-209	1060	-	ENSP00000453116	118 (aa)	-	H0YL99
ENST00000325844	MRPS11-201	3644	-	ENSP00000317376	194 (aa)	-	P82912
ENST00000559557	MRPS11-208	447	-	-	- (aa)	-	-
ENST00000557974	MRPS11-203	504	-	-	- (aa)	-	-
ENST00000558548	MRPS11-205	745	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000181991's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000181991's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000181991	MRPS11	84	61.350	ENSAPOG00000018727	mrps11	81	61.350	Acanthochromis_polyacanthus
ENSG00000181991	MRPS11	100	77.665	ENSAMEG00000012776	MRPS11	100	77.665	Ailuropoda_melanoleuca
ENSG00000181991	MRPS11	84	58.896	ENSACIG00000007679	mrps11	99	58.896	Amphilophus_citrinellus
ENSG00000181991	MRPS11	81	63.924	ENSAOCG00000000916	mrps11	66	63.924	Amphiprion_ocellaris
ENSG00000181991	MRPS11	81	63.924	ENSAPEG00000006598	mrps11	81	63.924	Amphiprion_percula
ENSG00000181991	MRPS11	84	61.728	ENSATEG00000005662	mrps11	80	61.728	Anabas_testudineus
ENSG00000181991	MRPS11	65	72.115	ENSAPLG00000012913	MRPS11	91	59.884	Anas_platyrhynchos
ENSG00000181991	MRPS11	84	68.712	ENSACAG00000005360	MRPS11	88	68.712	Anolis_carolinensis
ENSG00000181991	MRPS11	100	86.667	ENSANAG00000035828	MRPS11	100	86.667	Aotus_nancymaae
ENSG00000181991	MRPS11	90	58.286	ENSACLG00000019910	mrps11	89	58.286	Astatotilapia_calliptera
ENSG00000181991	MRPS11	81	59.006	ENSAMXG00000021547	mrps11	79	59.006	Astyanax_mexicanus
ENSG00000181991	MRPS11	100	77.778	ENSBTAG00000019831	MRPS11	100	77.778	Bos_taurus
ENSG00000181991	MRPS11	69	43.704	WBGene00012244	mrps-11	65	43.704	Caenorhabditis_elegans
ENSG00000181991	MRPS11	100	85.641	ENSCJAG00000013012	MRPS11	100	85.641	Callithrix_jacchus
ENSG00000181991	MRPS11	100	75.127	ENSCAFG00000011502	MRPS11	100	75.127	Canis_familiaris
ENSG00000181991	MRPS11	100	75.127	ENSCAFG00020018868	MRPS11	100	75.127	Canis_lupus_dingo
ENSG00000181991	MRPS11	100	78.788	ENSCHIG00000022002	MRPS11	100	78.788	Capra_hircus
ENSG00000181991	MRPS11	100	78.974	ENSTSYG00000011176	MRPS11	100	78.974	Carlito_syrichta
ENSG00000181991	MRPS11	69	85.714	ENSCAPG00000012155	MRPS11	100	85.714	Cavia_aperea
ENSG00000181991	MRPS11	100	75.773	ENSCPOG00000014489	MRPS11	100	75.773	Cavia_porcellus
ENSG00000181991	MRPS11	100	81.122	ENSCCAG00000031468	-	100	81.122	Cebus_capucinus
ENSG00000181991	MRPS11	94	79.235	ENSCCAG00000021347	-	95	77.368	Cebus_capucinus
ENSG00000181991	MRPS11	100	89.744	ENSCATG00000016716	MRPS11	100	89.744	Cercocebus_atys
ENSG00000181991	MRPS11	100	73.711	ENSCLAG00000017346	MRPS11	100	73.711	Chinchilla_lanigera
ENSG00000181991	MRPS11	100	88.718	ENSCSAG00000017199	MRPS11	100	88.718	Chlorocebus_sabaeus
ENSG00000181991	MRPS11	100	77.949	ENSCHOG00000009121	MRPS11	99	77.436	Choloepus_hoffmanni
ENSG00000181991	MRPS11	84	66.667	ENSCPBG00000017906	MRPS11	67	66.667	Chrysemys_picta_bellii
ENSG00000181991	MRPS11	100	88.718	ENSCANG00000037910	MRPS11	100	88.718	Colobus_angolensis_palliatus
ENSG00000181991	MRPS11	100	75.258	ENSCGRG00001012765	Mrps11	100	75.258	Cricetulus_griseus_chok1gshd
ENSG00000181991	MRPS11	100	75.258	ENSCGRG00000004167	Mrps11	100	75.258	Cricetulus_griseus_crigri
ENSG00000181991	MRPS11	84	55.215	ENSCSEG00000010615	mrps11	82	55.215	Cynoglossus_semilaevis
ENSG00000181991	MRPS11	69	70.149	ENSCVAG00000013577	mrps11	74	70.149	Cyprinodon_variegatus
ENSG00000181991	MRPS11	84	58.025	ENSDARG00000075129	mrps11	81	58.025	Danio_rerio
ENSG00000181991	MRPS11	84	81.098	ENSDNOG00000005258	MRPS11	85	81.098	Dasypus_novemcinctus
ENSG00000181991	MRPS11	69	83.459	ENSDORG00000024352	Mrps11	100	83.459	Dipodomys_ordii
ENSG00000181991	MRPS11	62	48.333	FBgn0038474	mRpS11	60	48.333	Drosophila_melanogaster
ENSG00000181991	MRPS11	82	51.852	ENSEBUG00000010376	mrps11	93	50.617	Eptatretus_burgeri
ENSG00000181991	MRPS11	100	80.102	ENSEASG00005015369	MRPS11	100	80.102	Equus_asinus_asinus
ENSG00000181991	MRPS11	100	80.102	ENSECAG00000007319	MRPS11	100	80.102	Equus_caballus
ENSG00000181991	MRPS11	86	59.281	ENSELUG00000016452	mrps11	86	66.418	Esox_lucius
ENSG00000181991	MRPS11	100	79.188	ENSFCAG00000014967	MRPS11	100	79.188	Felis_catus
ENSG00000181991	MRPS11	71	64.957	ENSFALG00000010437	MRPS11	99	58.580	Ficedula_albicollis
ENSG00000181991	MRPS11	100	75.258	ENSFDAG00000018915	MRPS11	100	75.258	Fukomys_damarensis
ENSG00000181991	MRPS11	81	61.783	ENSFHEG00000001310	mrps11	79	61.783	Fundulus_heteroclitus
ENSG00000181991	MRPS11	69	67.164	ENSGMOG00000018625	mrps11	100	67.164	Gadus_morhua
ENSG00000181991	MRPS11	82	65.409	ENSGALG00000006777	MRPS11	85	65.409	Gallus_gallus
ENSG00000181991	MRPS11	75	64.828	ENSGAFG00000001720	mrps11	77	63.399	Gambusia_affinis
ENSG00000181991	MRPS11	69	72.932	ENSGACG00000014791	mrps11	99	72.932	Gasterosteus_aculeatus
ENSG00000181991	MRPS11	84	66.667	ENSGAGG00000013556	MRPS11	86	66.667	Gopherus_agassizii
ENSG00000181991	MRPS11	100	99.485	ENSGGOG00000015152	MRPS11	100	99.485	Gorilla_gorilla
ENSG00000181991	MRPS11	95	55.676	ENSHBUG00000019804	mrps11	99	55.676	Haplochromis_burtoni
ENSG00000181991	MRPS11	100	75.258	ENSHGLG00000007732	MRPS11	100	75.258	Heterocephalus_glaber_female
ENSG00000181991	MRPS11	100	75.258	ENSHGLG00100010255	MRPS11	100	75.258	Heterocephalus_glaber_male
ENSG00000181991	MRPS11	68	63.910	ENSHCOG00000001347	mrps11	83	66.165	Hippocampus_comes
ENSG00000181991	MRPS11	84	60.843	ENSIPUG00000022494	MRPS11	82	60.843	Ictalurus_punctatus
ENSG00000181991	MRPS11	84	76.543	ENSSTOG00000021237	MRPS11	98	77.160	Ictidomys_tridecemlineatus
ENSG00000181991	MRPS11	100	70.051	ENSJJAG00000000570	Mrps11	100	70.051	Jaculus_jaculus
ENSG00000181991	MRPS11	81	62.658	ENSKMAG00000000890	mrps11	80	62.658	Kryptolebias_marmoratus
ENSG00000181991	MRPS11	84	59.877	ENSLBEG00000023307	mrps11	83	59.877	Labrus_bergylta
ENSG00000181991	MRPS11	84	61.350	ENSLACG00000007480	MRPS11	82	61.350	Latimeria_chalumnae
ENSG00000181991	MRPS11	82	63.354	ENSLOCG00000014531	mrps11	82	60.819	Lepisosteus_oculatus
ENSG00000181991	MRPS11	100	74.742	ENSLAFG00000030086	MRPS11	100	74.742	Loxodonta_africana
ENSG00000181991	MRPS11	100	89.231	ENSMFAG00000001006	MRPS11	100	89.231	Macaca_fascicularis
ENSG00000181991	MRPS11	100	89.231	ENSMMUG00000013659	MRPS11	100	89.231	Macaca_mulatta
ENSG00000181991	MRPS11	100	89.744	ENSMNEG00000039978	MRPS11	100	89.744	Macaca_nemestrina
ENSG00000181991	MRPS11	100	89.231	ENSMLEG00000037050	MRPS11	100	89.231	Mandrillus_leucophaeus
ENSG00000181991	MRPS11	86	57.229	ENSMAMG00000006581	mrps11	84	57.229	Mastacembelus_armatus
ENSG00000181991	MRPS11	84	61.111	ENSMZEG00005005157	mrps11	84	58.286	Maylandia_zebra
ENSG00000181991	MRPS11	82	63.522	ENSMGAG00000008763	MRPS11	94	63.522	Meleagris_gallopavo
ENSG00000181991	MRPS11	100	74.742	ENSMAUG00000006622	Mrps11	100	74.742	Mesocricetus_auratus
ENSG00000181991	MRPS11	100	81.026	ENSMICG00000015830	MRPS11	100	81.026	Microcebus_murinus
ENSG00000181991	MRPS11	100	74.227	ENSMOCG00000020525	Mrps11	100	74.227	Microtus_ochrogaster
ENSG00000181991	MRPS11	78	59.603	ENSMMOG00000015779	mrps11	95	59.603	Mola_mola
ENSG00000181991	MRPS11	100	62.312	ENSMODG00000019589	MRPS11	100	62.312	Monodelphis_domestica
ENSG00000181991	MRPS11	80	65.031	ENSMALG00000012248	mrps11	92	57.143	Monopterus_albus
ENSG00000181991	MRPS11	100	72.165	MGP_CAROLIEiJ_G0029870	Mrps11	100	72.165	Mus_caroli
ENSG00000181991	MRPS11	100	71.649	ENSMUSG00000030611	Mrps11	100	71.649	Mus_musculus
ENSG00000181991	MRPS11	100	72.165	MGP_PahariEiJ_G0013092	Mrps11	100	72.165	Mus_pahari
ENSG00000181991	MRPS11	100	71.134	MGP_SPRETEiJ_G0030972	Mrps11	100	71.134	Mus_spretus
ENSG00000181991	MRPS11	100	78.680	ENSMPUG00000015823	MRPS11	100	78.680	Mustela_putorius_furo
ENSG00000181991	MRPS11	100	50.000	ENSMLUG00000009637	MRPS11	100	51.980	Myotis_lucifugus
ENSG00000181991	MRPS11	100	75.773	ENSNGAG00000010433	Mrps11	100	75.773	Nannospalax_galili
ENSG00000181991	MRPS11	90	58.286	ENSNBRG00000006581	mrps11	87	58.286	Neolamprologus_brichardi
ENSG00000181991	MRPS11	100	94.330	ENSNLEG00000034839	MRPS11	100	94.330	Nomascus_leucogenys
ENSG00000181991	MRPS11	100	68.557	ENSOPRG00000008247	MRPS11	100	68.557	Ochotona_princeps
ENSG00000181991	MRPS11	100	73.196	ENSODEG00000014618	MRPS11	100	73.196	Octodon_degus
ENSG00000181991	MRPS11	91	57.386	ENSONIG00000003016	mrps11	81	57.386	Oreochromis_niloticus
ENSG00000181991	MRPS11	81	66.412	ENSOANG00000015559	MRPS11	90	73.050	Ornithorhynchus_anatinus
ENSG00000181991	MRPS11	100	72.449	ENSOCUG00000025921	MRPS11	100	72.449	Oryctolagus_cuniculus
ENSG00000181991	MRPS11	90	58.286	ENSORLG00000014573	mrps11	81	61.350	Oryzias_latipes
ENSG00000181991	MRPS11	84	61.963	ENSORLG00020019097	mrps11	81	61.350	Oryzias_latipes_hni
ENSG00000181991	MRPS11	84	60.736	ENSORLG00015017121	mrps11	81	60.736	Oryzias_latipes_hsok
ENSG00000181991	MRPS11	81	63.522	ENSOMEG00000017915	mrps11	81	63.522	Oryzias_melastigma
ENSG00000181991	MRPS11	89	80.925	ENSOGAG00000004739	MRPS11	100	80.925	Otolemur_garnettii
ENSG00000181991	MRPS11	100	78.788	ENSOARG00000010899	MRPS11	100	78.788	Ovis_aries
ENSG00000181991	MRPS11	100	98.969	ENSPPAG00000028073	MRPS11	100	98.969	Pan_paniscus
ENSG00000181991	MRPS11	100	79.188	ENSPPRG00000001535	MRPS11	100	79.188	Panthera_pardus
ENSG00000181991	MRPS11	100	79.188	ENSPTIG00000020641	MRPS11	100	79.188	Panthera_tigris_altaica
ENSG00000181991	MRPS11	100	98.969	ENSPTRG00000007420	MRPS11	100	98.969	Pan_troglodytes
ENSG00000181991	MRPS11	100	88.205	ENSPANG00000011753	MRPS11	100	88.205	Papio_anubis
ENSG00000181991	MRPS11	65	57.143	ENSPKIG00000014626	-	65	55.469	Paramormyrops_kingsleyae
ENSG00000181991	MRPS11	84	65.269	ENSPSIG00000014576	MRPS11	81	65.269	Pelodiscus_sinensis
ENSG00000181991	MRPS11	96	56.150	ENSPMGG00000023147	mrps11	90	56.150	Periophthalmus_magnuspinnatus
ENSG00000181991	MRPS11	100	75.258	ENSPEMG00000012996	Mrps11	100	75.258	Peromyscus_maniculatus_bairdii
ENSG00000181991	MRPS11	74	61.806	ENSPMAG00000008136	mrps11	81	61.806	Petromyzon_marinus
ENSG00000181991	MRPS11	75	66.207	ENSPFOG00000017576	mrps11	75	66.207	Poecilia_formosa
ENSG00000181991	MRPS11	75	66.207	ENSPLAG00000016343	mrps11	75	66.207	Poecilia_latipinna
ENSG00000181991	MRPS11	75	66.207	ENSPMEG00000003695	mrps11	75	66.207	Poecilia_mexicana
ENSG00000181991	MRPS11	75	66.207	ENSPREG00000004767	mrps11	75	66.207	Poecilia_reticulata
ENSG00000181991	MRPS11	100	93.814	ENSPPYG00000006751	MRPS11	100	93.814	Pongo_abelii
ENSG00000181991	MRPS11	100	56.410	ENSPCAG00000003032	MRPS11	100	56.410	Procavia_capensis
ENSG00000181991	MRPS11	100	81.026	ENSPCOG00000019243	MRPS11	100	81.026	Propithecus_coquereli
ENSG00000181991	MRPS11	100	76.382	ENSPVAG00000001594	MRPS11	100	76.382	Pteropus_vampyrus
ENSG00000181991	MRPS11	90	57.714	ENSPNYG00000008428	mrps11	87	57.714	Pundamilia_nyererei
ENSG00000181991	MRPS11	84	62.651	ENSPNAG00000002759	mrps11	87	62.651	Pygocentrus_nattereri
ENSG00000181991	MRPS11	100	74.227	ENSRNOG00000018531	Mrps11	100	74.227	Rattus_norvegicus
ENSG00000181991	MRPS11	100	69.744	ENSRNOG00000003080	AABR07021945.1	100	69.744	Rattus_norvegicus
ENSG00000181991	MRPS11	100	89.231	ENSRBIG00000035902	MRPS11	100	89.231	Rhinopithecus_bieti
ENSG00000181991	MRPS11	100	89.231	ENSRROG00000032838	MRPS11	100	89.231	Rhinopithecus_roxellana
ENSG00000181991	MRPS11	100	86.154	ENSSBOG00000032874	MRPS11	100	86.154	Saimiri_boliviensis_boliviensis
ENSG00000181991	MRPS11	63	82.178	ENSSHAG00000000058	-	83	80.000	Sarcophilus_harrisii
ENSG00000181991	MRPS11	90	57.297	ENSSFOG00015023615	mrps11	70	69.630	Scleropages_formosus
ENSG00000181991	MRPS11	84	58.896	ENSSMAG00000010954	mrps11	84	58.896	Scophthalmus_maximus
ENSG00000181991	MRPS11	84	60.494	ENSSDUG00000008450	mrps11	89	60.494	Seriola_dumerili
ENSG00000181991	MRPS11	84	60.494	ENSSLDG00000015652	mrps11	80	60.494	Seriola_lalandi_dorsalis
ENSG00000181991	MRPS11	82	65.409	ENSSPUG00000012009	MRPS11	88	65.409	Sphenodon_punctatus
ENSG00000181991	MRPS11	84	60.123	ENSSPAG00000017107	mrps11	80	59.259	Stegastes_partitus
ENSG00000181991	MRPS11	100	77.157	ENSSSCG00000037343	MRPS11	100	77.157	Sus_scrofa
ENSG00000181991	MRPS11	71	64.103	ENSTGUG00000008345	MRPS11	97	69.048	Taeniopygia_guttata
ENSG00000181991	MRPS11	84	60.736	ENSTRUG00000020346	mrps11	82	60.736	Takifugu_rubripes
ENSG00000181991	MRPS11	84	61.963	ENSTNIG00000011909	mrps11	74	61.963	Tetraodon_nigroviridis
ENSG00000181991	MRPS11	89	76.437	ENSTTRG00000008703	MRPS11	100	76.437	Tursiops_truncatus
ENSG00000181991	MRPS11	100	77.665	ENSUAMG00000019059	MRPS11	100	77.665	Ursus_americanus
ENSG00000181991	MRPS11	100	77.949	ENSUMAG00000006261	MRPS11	100	77.949	Ursus_maritimus
ENSG00000181991	MRPS11	82	59.259	ENSVPAG00000004713	-	100	59.259	Vicugna_pacos
ENSG00000181991	MRPS11	100	76.142	ENSVVUG00000012046	-	100	76.142	Vulpes_vulpes
ENSG00000181991	MRPS11	95	58.763	ENSXETG00000007593	mrps11	98	58.763	Xenopus_tropicalis
ENSG00000181991	MRPS11	85	61.818	ENSXCOG00000018085	mrps11	93	65.359	Xiphophorus_couchianus
ENSG00000181991	MRPS11	75	66.207	ENSXMAG00000011607	mrps11	75	66.207	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000028	ribosomal small subunit assembly	21873635.	IBA	Process
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	21873635.	IBA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0003735	structural constituent of ribosome	11402041.	ISS	Function
GO:0005739	mitochondrion	-	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005763	mitochondrial small ribosomal subunit	21873635.	IBA	Component
GO:0005763	mitochondrial small ribosomal subunit	21531335.25838379.	IDA	Component
GO:0005763	mitochondrial small ribosomal subunit	-	ISS	Component
GO:0006412	translation	21873635.	IBA	Process
GO:0032543	mitochondrial translation	11402041.	ISS	Process
GO:0042769	DNA damage response, detection of DNA damage	15300802.	NAS	Process
GO:0048027	mRNA 5'-UTR binding	21873635.	IBA	Function
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process
GO:0070181	small ribosomal subunit rRNA binding	21873635.	IBA	Function