EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000182150 (Gene tree)
Gene ID: 375748
Gene Symbol: ERCC6L2
Alias: FLJ37706|RAD26L|C9orf102
Full Name: ERCC excision repair 6 like 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 244,859 bases
Position: chr9:95,875,618-96,120,476
Accession: 26922
RBP type: canonical RBP
Summary: This gene encodes a member of the Snf2 family of helicase-like proteins. The encoded protein may play a role in DNA repair and mitochondrial function. Mutations in this gene have been associated with bone marrow failure syndrome 2. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Apr 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000288985	ResIII	PF04851.15	2.8e-10	1	1
ENSP00000288985	DEAD	PF00270.29	6.3e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000456993	ERCC6L2-205	1822	-	ENSP00000409751	365 (aa)	-	F2Z2R4
ENST00000320486	ERCC6L2-202	2936	XM_011518650	ENSP00000320939	522 (aa)	XP_011516952	H7BXQ9
ENST00000470362	ERCC6L2-207	468	-	-	- (aa)	-	-
ENST00000402838	ERCC6L2-203	546	-	ENSP00000384215	182 (aa)	-	H0Y3T7
ENST00000288985	ERCC6L2-201	4564	XM_011518641	ENSP00000288985	712 (aa)	XP_011516943	Q5T890
ENST00000426805	ERCC6L2-204	498	-	ENSP00000395345	82 (aa)	-	X6RE28
ENST00000466840	ERCC6L2-206	3586	-	-	- (aa)	-	-
ENST00000479391	ERCC6L2-208	2849	-	ENSP00000473877	54 (aa)	-	S4R327

Gene Model

Click here to download ENSG00000182150's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000182150	Blood Pressure	8.7477884E-007	-
ENSG00000182150	Blood Pressure	8.7477884E-007	-
ENSG00000182150	Blood Pressure	8.8302748E-007	-
ENSG00000182150	Blood Pressure	8.7477884E-007	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000182150	rs62562991	9	95973777	G	Monokine induced by gamma interferon levels	27989323	[0.38-0.87] SD units decrease	0.6236	EFO_0008236

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000182150's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000182150	ERCC6L2	100	95.122	ENSAMEG00000011657	ERCC6L2	98	91.240	Ailuropoda_melanoleuca
ENSG00000182150	ERCC6L2	100	85.366	ENSAPLG00000006105	ERCC6L2	98	77.892	Anas_platyrhynchos
ENSG00000182150	ERCC6L2	100	85.366	ENSACAG00000012947	ERCC6L2	100	77.843	Anolis_carolinensis
ENSG00000182150	ERCC6L2	100	68.293	ENSACLG00000015088	ercc6l2	66	63.798	Astatotilapia_calliptera
ENSG00000182150	ERCC6L2	100	100.000	ENSCJAG00000008862	ERCC6L2	100	96.067	Callithrix_jacchus
ENSG00000182150	ERCC6L2	100	93.902	ENSCAFG00000001219	ERCC6L2	70	91.143	Canis_familiaris
ENSG00000182150	ERCC6L2	100	96.341	ENSTSYG00000013871	ERCC6L2	99	92.102	Carlito_syrichta
ENSG00000182150	ERCC6L2	100	96.341	ENSCAPG00000009212	ERCC6L2	100	83.372	Cavia_aperea
ENSG00000182150	ERCC6L2	100	96.341	ENSCPOG00000004544	-	91	90.909	Cavia_porcellus
ENSG00000182150	ERCC6L2	100	98.780	ENSCCAG00000026980	ERCC6L2	100	96.067	Cebus_capucinus
ENSG00000182150	ERCC6L2	100	97.561	ENSCHOG00000006282	ERCC6L2	100	79.073	Choloepus_hoffmanni
ENSG00000182150	ERCC6L2	100	100.000	ENSCANG00000039934	ERCC6L2	99	95.927	Colobus_angolensis_palliatus
ENSG00000182150	ERCC6L2	100	96.341	ENSCGRG00001022738	Ercc6l2	99	89.016	Cricetulus_griseus_chok1gshd
ENSG00000182150	ERCC6L2	100	96.341	ENSCGRG00000015854	Ercc6l2	66	92.377	Cricetulus_griseus_crigri
ENSG00000182150	ERCC6L2	100	93.902	ENSDORG00000010788	Ercc6l2	93	92.111	Dipodomys_ordii
ENSG00000182150	ERCC6L2	100	92.683	ENSETEG00000010686	ERCC6L2	100	85.232	Echinops_telfairi
ENSG00000182150	ERCC6L2	100	73.315	ENSEEUG00000009341	ERCC6L2	100	73.315	Erinaceus_europaeus
ENSG00000182150	ERCC6L2	100	85.366	ENSFALG00000003400	ERCC6L2	63	78.686	Ficedula_albicollis
ENSG00000182150	ERCC6L2	100	95.122	ENSFDAG00000000805	ERCC6L2	100	89.220	Fukomys_damarensis
ENSG00000182150	ERCC6L2	100	70.732	ENSGMOG00000007751	ercc6l2	61	66.341	Gadus_morhua
ENSG00000182150	ERCC6L2	100	71.951	ENSGACG00000006992	ercc6l2	56	68.893	Gasterosteus_aculeatus
ENSG00000182150	ERCC6L2	100	100.000	ENSGGOG00000002705	ERCC6L2	100	98.876	Gorilla_gorilla
ENSG00000182150	ERCC6L2	73	98.333	ENSHGLG00000009488	ERCC6L2	93	92.818	Heterocephalus_glaber_female
ENSG00000182150	ERCC6L2	100	95.122	ENSJJAG00000018150	Ercc6l2	100	88.730	Jaculus_jaculus
ENSG00000182150	ERCC6L2	100	93.902	ENSLAFG00000013092	ERCC6L2	100	89.189	Loxodonta_africana
ENSG00000182150	ERCC6L2	100	100.000	ENSMNEG00000035630	ERCC6L2	100	95.927	Macaca_nemestrina
ENSG00000182150	ERCC6L2	100	98.780	ENSMLEG00000019530	ERCC6L2	100	96.489	Mandrillus_leucophaeus
ENSG00000182150	ERCC6L2	100	95.122	ENSMAUG00000004820	-	66	92.196	Mesocricetus_auratus
ENSG00000182150	ERCC6L2	100	97.561	ENSMICG00000029160	ERCC6L2	100	94.109	Microcebus_murinus
ENSG00000182150	ERCC6L2	100	97.561	ENSMOCG00000019362	-	92	90.909	Microtus_ochrogaster
ENSG00000182150	ERCC6L2	100	68.293	ENSMMOG00000001419	ercc6l2	59	61.994	Mola_mola
ENSG00000182150	ERCC6L2	100	71.951	ENSMALG00000016933	ercc6l2	60	69.181	Monopterus_albus
ENSG00000182150	ERCC6L2	100	96.341	MGP_CAROLIEiJ_G0018635	-	100	89.158	Mus_caroli
ENSG00000182150	ERCC6L2	100	96.341	ENSMUSG00000021470	Ercc6l2	100	89.158	Mus_musculus
ENSG00000182150	ERCC6L2	100	96.341	MGP_PahariEiJ_G0019699	-	100	90.157	Mus_pahari
ENSG00000182150	ERCC6L2	100	96.341	MGP_SPRETEiJ_G0019515	-	100	89.444	Mus_spretus
ENSG00000182150	ERCC6L2	100	95.122	ENSMPUG00000006738	ERCC6L2	68	90.358	Mustela_putorius_furo
ENSG00000182150	ERCC6L2	100	97.561	ENSMLUG00000000845	ERCC6L2	99	89.607	Myotis_lucifugus
ENSG00000182150	ERCC6L2	100	97.561	ENSNGAG00000016174	Ercc6l2	99	90.442	Nannospalax_galili
ENSG00000182150	ERCC6L2	100	100.000	ENSNLEG00000016784	ERCC6L2	100	97.753	Nomascus_leucogenys
ENSG00000182150	ERCC6L2	100	97.561	ENSOPRG00000011647	ERCC6L2	100	90.032	Ochotona_princeps
ENSG00000182150	ERCC6L2	100	96.341	ENSODEG00000016588	ERCC6L2	98	92.308	Octodon_degus
ENSG00000182150	ERCC6L2	100	69.512	ENSONIG00000015139	ercc6l2	100	62.714	Oreochromis_niloticus
ENSG00000182150	ERCC6L2	100	98.780	ENSOCUG00000000442	-	98	92.868	Oryctolagus_cuniculus
ENSG00000182150	ERCC6L2	100	68.293	ENSORLG00000004287	ercc6l2	58	69.005	Oryzias_latipes
ENSG00000182150	ERCC6L2	100	68.293	ENSORLG00015010250	ercc6l2	58	69.168	Oryzias_latipes_hsok
ENSG00000182150	ERCC6L2	100	100.000	ENSOGAG00000003146	ERCC6L2	66	95.254	Otolemur_garnettii
ENSG00000182150	ERCC6L2	100	97.561	ENSOARG00000008546	ERCC6L2	71	92.143	Ovis_aries
ENSG00000182150	ERCC6L2	100	100.000	ENSPPAG00000035061	ERCC6L2	100	99.579	Pan_paniscus
ENSG00000182150	ERCC6L2	100	95.122	ENSPPRG00000019238	ERCC6L2	99	91.292	Panthera_pardus
ENSG00000182150	ERCC6L2	100	95.122	ENSPTIG00000009148	ERCC6L2	99	90.871	Panthera_tigris_altaica
ENSG00000182150	ERCC6L2	100	99.438	ENSPTRG00000048689	ERCC6L2	100	99.438	Pan_troglodytes
ENSG00000182150	ERCC6L2	100	90.244	ENSPSIG00000010627	ERCC6L2	100	81.924	Pelodiscus_sinensis
ENSG00000182150	ERCC6L2	100	95.122	ENSPEMG00000006631	-	66	92.196	Peromyscus_maniculatus_bairdii
ENSG00000182150	ERCC6L2	100	93.902	ENSPCIG00000020095	-	58	85.255	Phascolarctos_cinereus
ENSG00000182150	ERCC6L2	100	98.780	ENSPCOG00000026714	ERCC6L2	100	88.640	Propithecus_coquereli
ENSG00000182150	ERCC6L2	100	96.341	ENSPVAG00000003926	ERCC6L2	99	83.966	Pteropus_vampyrus
ENSG00000182150	ERCC6L2	100	68.293	ENSPNYG00000015347	ercc6l2	63	63.839	Pundamilia_nyererei
ENSG00000182150	ERCC6L2	100	100.000	ENSRBIG00000018434	ERCC6L2	100	92.416	Rhinopithecus_bieti
ENSG00000182150	ERCC6L2	100	100.000	ENSRROG00000029000	ERCC6L2	100	96.208	Rhinopithecus_roxellana
ENSG00000182150	ERCC6L2	99	71.951	ENSSHAG00000000781	-	100	84.238	Sarcophilus_harrisii
ENSG00000182150	ERCC6L2	100	69.512	ENSSLDG00000018663	ercc6l2	56	68.078	Seriola_lalandi_dorsalis
ENSG00000182150	ERCC6L2	100	84.146	ENSSPUG00000004336	ERCC6L2	54	76.312	Sphenodon_punctatus
ENSG00000182150	ERCC6L2	100	67.073	ENSSPAG00000004484	ercc6l2	60	62.841	Stegastes_partitus
ENSG00000182150	ERCC6L2	100	85.366	ENSTGUG00000000524	ERCC6L2	100	78.248	Taeniopygia_guttata
ENSG00000182150	ERCC6L2	100	70.732	ENSTRUG00000014634	ercc6l2	66	61.615	Takifugu_rubripes
ENSG00000182150	ERCC6L2	99	96.296	ENSTBEG00000014213	ERCC6L2	87	92.746	Tupaia_belangeri
ENSG00000182150	ERCC6L2	100	86.115	ENSTTRG00000005372	ERCC6L2	100	86.115	Tursiops_truncatus
ENSG00000182150	ERCC6L2	100	98.780	ENSVPAG00000004701	ERCC6L2	100	93.365	Vicugna_pacos
ENSG00000182150	ERCC6L2	100	86.585	ENSXETG00000014835	ercc6l2	63	72.647	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	-	IEA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	24507776.	IMP	Component
GO:0005737	cytoplasm	24507776.	IMP	Component
GO:0005739	mitochondrion	24507776.	IMP	Component
GO:0005813	centrosome	20873783.	IDA	Component
GO:0019901	protein kinase binding	20873783.	IPI	Function
GO:0032991	protein-containing complex	20873783.	IDA	Component
GO:0034614	cellular response to reactive oxygen species	24507776.	IMP	Process
GO:0036297	interstrand cross-link repair	24507776.	IMP	Process