EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000182173 (Gene tree)
Gene ID: 283989
Gene Symbol: TSEN54
Alias: SEN54|SEN54L
Full Name: tRNA splicing endonuclease subunit 54
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 9,033 bases
Position: chr17:75,515,707-75,524,739
Accession: 27561
RBP type: canonical RBP
Summary: This gene encodes a subunit of the tRNA splicing endonuclease complex, which catalyzes the removal of introns from precursor tRNAs. The complex is also implicated in pre-mRNA 3-prime end processing. Mutations in this gene result in pontocerebellar hypoplasia type 2.[provided by RefSeq, Oct 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000327487	tRNA_int_end_N2	PF12928.7	1.8e-17	1	1
ENSP00000406559	tRNA_int_end_N2	PF12928.7	6.1e-07	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000577197	TSEN54-204	650	-	-	- (aa)	-	-
ENST00000580013	TSEN54-207	568	-	-	- (aa)	-	-
ENST00000583173	TSEN54-208	798	-	ENSP00000463619	178 (aa)	-	J3QLM6
ENST00000545228	TSEN54-203	1139	-	ENSP00000438169	259 (aa)	-	J9JIH8
ENST00000583634	TSEN54-210	282	-	-	- (aa)	-	-
ENST00000578415	TSEN54-205	994	-	ENSP00000464335	167 (aa)	-	J3QRQ5
ENST00000583454	TSEN54-209	733	-	-	- (aa)	-	-
ENST00000583818	TSEN54-211	765	-	ENSP00000461928	142 (aa)	-	J3KRC5
ENST00000434205	TSEN54-202	627	-	ENSP00000406559	72 (aa)	-	E7EN92
ENST00000579449	TSEN54-206	786	-	-	- (aa)	-	-
ENST00000333213	TSEN54-201	1944	XM_005257229	ENSP00000327487	526 (aa)	XP_005257286	Q7Z6J9

Gene Model

Click here to download ENSG00000182173's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000182173	Forced Expiratory Volume	2E-6	28166213

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000182173	rs7218675	17	75517104	A	Lung function (FEV1)	28166213	[0.021-0.049] unit decrease	0.035	EFO_0004314
ENSG00000182173	rs62088463	17	75518235	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000182173	rs8064529	17	75523332	?	Lung function (FEV1/FVC)	30595370			EFO_0004713

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000182173's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000182173	TSEN54	100	65.278	ENSAPOG00000009659	tsen54	77	64.773	Acanthochromis_polyacanthus
ENSG00000182173	TSEN54	99	94.286	ENSAMEG00000009414	TSEN54	99	82.075	Ailuropoda_melanoleuca
ENSG00000182173	TSEN54	97	64.286	ENSACIG00000010899	-	87	44.751	Amphilophus_citrinellus
ENSG00000182173	TSEN54	100	65.278	ENSAOCG00000000152	tsen54	95	45.543	Amphiprion_ocellaris
ENSG00000182173	TSEN54	100	63.889	ENSAPEG00000018931	tsen54	94	44.961	Amphiprion_percula
ENSG00000182173	TSEN54	97	61.429	ENSATEG00000019860	tsen54	97	43.570	Anabas_testudineus
ENSG00000182173	TSEN54	100	68.056	ENSAPLG00000009419	TSEN54	100	51.416	Anas_platyrhynchos
ENSG00000182173	TSEN54	99	72.857	ENSACAG00000006714	TSEN54	99	50.947	Anolis_carolinensis
ENSG00000182173	TSEN54	100	97.222	ENSANAG00000024061	TSEN54	99	94.286	Aotus_nancymaae
ENSG00000182173	TSEN54	100	66.667	ENSACLG00000019800	tsen54	96	46.139	Astatotilapia_calliptera
ENSG00000182173	TSEN54	100	68.056	ENSAMXG00000006546	tsen54	96	46.654	Astyanax_mexicanus
ENSG00000182173	TSEN54	100	95.833	ENSBTAG00000000824	TSEN54	100	83.239	Bos_taurus
ENSG00000182173	TSEN54	100	97.222	ENSCJAG00000014278	TSEN54	99	93.143	Callithrix_jacchus
ENSG00000182173	TSEN54	100	94.444	ENSCAFG00000004798	TSEN54	100	85.687	Canis_familiaris
ENSG00000182173	TSEN54	100	94.444	ENSCAFG00020000312	TSEN54	100	85.687	Canis_lupus_dingo
ENSG00000182173	TSEN54	100	95.833	ENSCHIG00000019908	TSEN54	100	81.559	Capra_hircus
ENSG00000182173	TSEN54	100	95.833	ENSTSYG00000037439	TSEN54	100	83.516	Carlito_syrichta
ENSG00000182173	TSEN54	100	88.889	ENSCPOG00000004630	-	99	82.486	Cavia_porcellus
ENSG00000182173	TSEN54	100	97.222	ENSCCAG00000036624	TSEN54	99	93.524	Cebus_capucinus
ENSG00000182173	TSEN54	100	98.611	ENSCATG00000042877	TSEN54	99	96.952	Cercocebus_atys
ENSG00000182173	TSEN54	99	92.857	ENSCLAG00000002924	TSEN54	99	84.000	Chinchilla_lanigera
ENSG00000182173	TSEN54	100	98.611	ENSCSAG00000004809	TSEN54	100	96.578	Chlorocebus_sabaeus
ENSG00000182173	TSEN54	100	75.000	ENSCPBG00000028071	TSEN54	99	55.263	Chrysemys_picta_bellii
ENSG00000182173	TSEN54	92	44.286	ENSCING00000018281	-	62	36.923	Ciona_intestinalis
ENSG00000182173	TSEN54	100	98.611	ENSCANG00000028053	TSEN54	100	95.437	Colobus_angolensis_palliatus
ENSG00000182173	TSEN54	99	87.324	ENSCGRG00001020029	Tsen54	100	81.939	Cricetulus_griseus_chok1gshd
ENSG00000182173	TSEN54	99	87.324	ENSCGRG00000016289	Tsen54	100	80.135	Cricetulus_griseus_crigri
ENSG00000182173	TSEN54	100	63.889	ENSCSEG00000020586	tsen54	99	39.030	Cynoglossus_semilaevis
ENSG00000182173	TSEN54	97	65.714	ENSCVAG00000006741	-	79	56.311	Cyprinodon_variegatus
ENSG00000182173	TSEN54	100	66.667	ENSDARG00000036844	tsen54	99	43.427	Danio_rerio
ENSG00000182173	TSEN54	100	93.056	ENSDNOG00000018452	TSEN54	100	82.486	Dasypus_novemcinctus
ENSG00000182173	TSEN54	99	92.857	ENSDORG00000004073	Tsen54	100	83.460	Dipodomys_ordii
ENSG00000182173	TSEN54	90	57.463	ENSEBUG00000005203	TSEN54	95	36.961	Eptatretus_burgeri
ENSG00000182173	TSEN54	100	95.833	ENSEASG00005000579	TSEN54	100	83.992	Equus_asinus_asinus
ENSG00000182173	TSEN54	100	95.833	ENSECAG00000004924	TSEN54	100	83.992	Equus_caballus
ENSG00000182173	TSEN54	100	93.056	ENSEEUG00000008467	TSEN54	100	79.431	Erinaceus_europaeus
ENSG00000182173	TSEN54	100	62.500	ENSELUG00000017703	tsen54	90	42.831	Esox_lucius
ENSG00000182173	TSEN54	100	94.444	ENSFCAG00000023712	TSEN54	99	85.038	Felis_catus
ENSG00000182173	TSEN54	100	68.056	ENSFALG00000001119	TSEN54	99	50.947	Ficedula_albicollis
ENSG00000182173	TSEN54	100	94.444	ENSFDAG00000019090	TSEN54	99	84.222	Fukomys_damarensis
ENSG00000182173	TSEN54	100	63.889	ENSFHEG00000005470	tsen54	96	46.139	Fundulus_heteroclitus
ENSG00000182173	TSEN54	76	58.182	ENSGMOG00000013146	tsen54	99	45.029	Gadus_morhua
ENSG00000182173	TSEN54	99	63.571	ENSGALG00000047163	TSEN54	98	48.024	Gallus_gallus
ENSG00000182173	TSEN54	100	65.278	ENSGAFG00000005111	tsen54	99	46.604	Gambusia_affinis
ENSG00000182173	TSEN54	99	52.632	ENSGACG00000014987	tsen54	99	44.788	Gasterosteus_aculeatus
ENSG00000182173	TSEN54	98	74.820	ENSGAGG00000006825	TSEN54	99	56.030	Gopherus_agassizii
ENSG00000182173	TSEN54	100	100.000	ENSGGOG00000009417	TSEN54	100	99.606	Gorilla_gorilla
ENSG00000182173	TSEN54	100	66.667	ENSHBUG00000018296	tsen54	99	36.574	Haplochromis_burtoni
ENSG00000182173	TSEN54	100	94.444	ENSHGLG00000007979	TSEN54	100	86.122	Heterocephalus_glaber_female
ENSG00000182173	TSEN54	100	94.444	ENSHGLG00100005497	TSEN54	100	85.361	Heterocephalus_glaber_male
ENSG00000182173	TSEN54	99	61.972	ENSHCOG00000007481	tsen54	99	41.898	Hippocampus_comes
ENSG00000182173	TSEN54	97	74.286	ENSIPUG00000000590	tsen54	79	60.714	Ictalurus_punctatus
ENSG00000182173	TSEN54	100	91.667	ENSSTOG00000012883	TSEN54	100	80.418	Ictidomys_tridecemlineatus
ENSG00000182173	TSEN54	99	90.141	ENSJJAG00000007365	Tsen54	100	81.629	Jaculus_jaculus
ENSG00000182173	TSEN54	100	62.500	ENSKMAG00000006944	tsen54	97	45.472	Kryptolebias_marmoratus
ENSG00000182173	TSEN54	100	65.278	ENSLBEG00000004199	tsen54	97	45.049	Labrus_bergylta
ENSG00000182173	TSEN54	99	63.380	ENSLACG00000009497	TSEN54	100	47.692	Latimeria_chalumnae
ENSG00000182173	TSEN54	100	66.667	ENSLOCG00000011191	tsen54	76	66.857	Lepisosteus_oculatus
ENSG00000182173	TSEN54	100	93.056	ENSLAFG00000011655	TSEN54	99	76.749	Loxodonta_africana
ENSG00000182173	TSEN54	100	98.611	ENSMFAG00000000712	TSEN54	100	96.768	Macaca_fascicularis
ENSG00000182173	TSEN54	100	97.222	ENSMMUG00000022123	TSEN54	99	96.610	Macaca_mulatta
ENSG00000182173	TSEN54	100	98.611	ENSMNEG00000029199	TSEN54	100	96.578	Macaca_nemestrina
ENSG00000182173	TSEN54	100	98.611	ENSMLEG00000044168	TSEN54	88	96.460	Mandrillus_leucophaeus
ENSG00000182173	TSEN54	100	62.500	ENSMAMG00000019773	tsen54	98	44.571	Mastacembelus_armatus
ENSG00000182173	TSEN54	100	66.667	ENSMZEG00005000884	tsen54	96	46.139	Maylandia_zebra
ENSG00000182173	TSEN54	100	65.278	ENSMGAG00000009556	TSEN54	99	47.925	Meleagris_gallopavo
ENSG00000182173	TSEN54	99	90.141	ENSMAUG00000016838	Tsen54	100	81.369	Mesocricetus_auratus
ENSG00000182173	TSEN54	100	94.444	ENSMICG00000044012	TSEN54	100	84.221	Microcebus_murinus
ENSG00000182173	TSEN54	99	91.429	ENSMOCG00000021585	Tsen54	100	82.129	Microtus_ochrogaster
ENSG00000182173	TSEN54	100	65.278	ENSMMOG00000020189	tsen54	98	43.725	Mola_mola
ENSG00000182173	TSEN54	100	84.722	ENSMODG00000007438	TSEN54	98	68.587	Monodelphis_domestica
ENSG00000182173	TSEN54	100	62.500	ENSMALG00000020573	tsen54	97	45.698	Monopterus_albus
ENSG00000182173	TSEN54	99	88.732	MGP_CAROLIEiJ_G0017417	Tsen54	100	79.848	Mus_caroli
ENSG00000182173	TSEN54	99	88.732	ENSMUSG00000020781	Tsen54	100	80.418	Mus_musculus
ENSG00000182173	TSEN54	99	88.732	MGP_PahariEiJ_G0018547	Tsen54	100	80.228	Mus_pahari
ENSG00000182173	TSEN54	99	88.732	MGP_SPRETEiJ_G0018262	Tsen54	100	80.418	Mus_spretus
ENSG00000182173	TSEN54	100	94.444	ENSMPUG00000013870	TSEN54	100	83.616	Mustela_putorius_furo
ENSG00000182173	TSEN54	100	94.444	ENSMLUG00000015298	TSEN54	100	80.226	Myotis_lucifugus
ENSG00000182173	TSEN54	100	93.056	ENSNGAG00000015673	Tsen54	100	81.749	Nannospalax_galili
ENSG00000182173	TSEN54	100	100.000	ENSNLEG00000001071	-	99	98.026	Nomascus_leucogenys
ENSG00000182173	TSEN54	76	78.182	ENSMEUG00000011908	TSEN54	100	64.557	Notamacropus_eugenii
ENSG00000182173	TSEN54	100	75.901	ENSOPRG00000012513	TSEN54	100	75.901	Ochotona_princeps
ENSG00000182173	TSEN54	100	91.667	ENSODEG00000010059	-	99	82.486	Octodon_degus
ENSG00000182173	TSEN54	100	65.278	ENSONIG00000009543	tsen54	96	46.169	Oreochromis_niloticus
ENSG00000182173	TSEN54	100	83.333	ENSOANG00000030893	-	65	71.429	Ornithorhynchus_anatinus
ENSG00000182173	TSEN54	100	88.889	ENSOCUG00000009875	TSEN54	99	77.298	Oryctolagus_cuniculus
ENSG00000182173	TSEN54	100	63.889	ENSORLG00000000852	tsen54	98	44.275	Oryzias_latipes
ENSG00000182173	TSEN54	100	63.889	ENSORLG00020018221	tsen54	98	44.847	Oryzias_latipes_hni
ENSG00000182173	TSEN54	100	63.889	ENSORLG00015009413	tsen54	97	53.548	Oryzias_latipes_hsok
ENSG00000182173	TSEN54	100	65.278	ENSOMEG00000014402	tsen54	96	44.697	Oryzias_melastigma
ENSG00000182173	TSEN54	100	80.418	ENSOGAG00000001442	TSEN54	100	80.418	Otolemur_garnettii
ENSG00000182173	TSEN54	100	95.833	ENSOARG00000010361	TSEN54	100	80.525	Ovis_aries
ENSG00000182173	TSEN54	100	100.000	ENSPPAG00000043519	TSEN54	100	99.195	Pan_paniscus
ENSG00000182173	TSEN54	100	93.056	ENSPPRG00000009162	TSEN54	99	84.659	Panthera_pardus
ENSG00000182173	TSEN54	100	93.056	ENSPTIG00000019312	TSEN54	96	83.628	Panthera_tigris_altaica
ENSG00000182173	TSEN54	100	100.000	ENSPTRG00000009646	TSEN54	100	99.620	Pan_troglodytes
ENSG00000182173	TSEN54	100	97.222	ENSPANG00000020133	TSEN54	99	96.381	Papio_anubis
ENSG00000182173	TSEN54	99	69.014	ENSPKIG00000023018	tsen54	100	45.116	Paramormyrops_kingsleyae
ENSG00000182173	TSEN54	100	75.000	ENSPSIG00000012807	TSEN54	99	51.732	Pelodiscus_sinensis
ENSG00000182173	TSEN54	91	54.264	ENSPMGG00000019578	tsen54	99	36.253	Periophthalmus_magnuspinnatus
ENSG00000182173	TSEN54	99	90.714	ENSPEMG00000014857	Tsen54	100	82.129	Peromyscus_maniculatus_bairdii
ENSG00000182173	TSEN54	100	65.278	ENSPFOG00000022740	tsen54	99	47.280	Poecilia_formosa
ENSG00000182173	TSEN54	100	65.278	ENSPLAG00000014847	tsen54	99	47.358	Poecilia_latipinna
ENSG00000182173	TSEN54	100	65.278	ENSPMEG00000022876	tsen54	99	47.170	Poecilia_mexicana
ENSG00000182173	TSEN54	100	65.278	ENSPREG00000013090	tsen54	99	45.763	Poecilia_reticulata
ENSG00000182173	TSEN54	100	98.611	ENSPPYG00000008629	TSEN54	100	88.727	Pongo_abelii
ENSG00000182173	TSEN54	100	90.278	ENSPCAG00000002093	TSEN54	99	69.261	Procavia_capensis
ENSG00000182173	TSEN54	100	93.056	ENSPCOG00000027880	TSEN54	99	87.380	Propithecus_coquereli
ENSG00000182173	TSEN54	100	95.833	ENSPVAG00000008446	TSEN54	100	84.934	Pteropus_vampyrus
ENSG00000182173	TSEN54	100	66.667	ENSPNYG00000010217	tsen54	99	44.289	Pundamilia_nyererei
ENSG00000182173	TSEN54	100	69.444	ENSPNAG00000003770	tsen54	81	57.949	Pygocentrus_nattereri
ENSG00000182173	TSEN54	99	88.732	ENSRNOG00000004598	Tsen54	100	81.559	Rattus_norvegicus
ENSG00000182173	TSEN54	100	98.611	ENSRBIG00000043040	TSEN54	100	96.198	Rhinopithecus_bieti
ENSG00000182173	TSEN54	100	98.611	ENSRROG00000030797	TSEN54	100	95.817	Rhinopithecus_roxellana
ENSG00000182173	TSEN54	99	90.667	ENSSBOG00000013543	TSEN54	99	90.667	Saimiri_boliviensis_boliviensis
ENSG00000182173	TSEN54	100	81.944	ENSSHAG00000018127	TSEN54	98	65.672	Sarcophilus_harrisii
ENSG00000182173	TSEN54	100	66.667	ENSSFOG00015004093	tsen54	100	44.138	Scleropages_formosus
ENSG00000182173	TSEN54	97	65.714	ENSSMAG00000012449	tsen54	99	43.629	Scophthalmus_maximus
ENSG00000182173	TSEN54	100	63.889	ENSSDUG00000021506	tsen54	97	45.930	Seriola_dumerili
ENSG00000182173	TSEN54	100	63.889	ENSSLDG00000016303	tsen54	97	45.736	Seriola_lalandi_dorsalis
ENSG00000182173	TSEN54	96	70.073	ENSSPUG00000008988	TSEN54	100	50.000	Sphenodon_punctatus
ENSG00000182173	TSEN54	100	61.111	ENSSPAG00000008047	tsen54	99	41.981	Stegastes_partitus
ENSG00000182173	TSEN54	100	61.111	ENSSPAG00000008098	-	99	44.332	Stegastes_partitus
ENSG00000182173	TSEN54	100	94.444	ENSSSCG00000036852	TSEN54	100	84.934	Sus_scrofa
ENSG00000182173	TSEN54	100	65.278	ENSTGUG00000008548	TSEN54	100	53.319	Taeniopygia_guttata
ENSG00000182173	TSEN54	100	65.278	ENSTRUG00000004230	tsen54	87	61.850	Takifugu_rubripes
ENSG00000182173	TSEN54	100	63.889	ENSTNIG00000011281	tsen54	99	44.423	Tetraodon_nigroviridis
ENSG00000182173	TSEN54	99	94.366	ENSTTRG00000015828	TSEN54	100	84.279	Tursiops_truncatus
ENSG00000182173	TSEN54	100	93.056	ENSUAMG00000010045	TSEN54	99	84.746	Ursus_americanus
ENSG00000182173	TSEN54	100	93.056	ENSUMAG00000008979	TSEN54	100	81.798	Ursus_maritimus
ENSG00000182173	TSEN54	100	94.444	ENSVVUG00000011411	TSEN54	98	85.049	Vulpes_vulpes
ENSG00000182173	TSEN54	99	67.857	ENSXETG00000012532	tsen54	99	68.333	Xenopus_tropicalis
ENSG00000182173	TSEN54	100	65.278	ENSXCOG00000018245	tsen54	87	60.625	Xiphophorus_couchianus
ENSG00000182173	TSEN54	100	65.278	ENSXMAG00000018818	tsen54	99	46.704	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000213	tRNA-intron endonuclease activity	21873635.	IBA	Function
GO:0000214	tRNA-intron endonuclease complex	21873635.	IBA	Component
GO:0000379	tRNA-type intron splice site recognition and cleavage	21873635.	IBA	Process
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	17495927.	IDA	Process
GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	-	TAS	Process
GO:0006397	mRNA processing	-	IEA	Process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr17	75524398	Missense_Mutation	novel	D523N	0.32
BLCA	chr17	75519026	Missense_Mutation	NA	V167A	0.39
BLCA	chr17	75516840	Nonsense_Mutation	NA	Q51*	0.12
BLCA	chr17	75519009	Silent	novel	L161L	0.47
BLCA	chr17	75523306	Missense_Mutation	novel	Q428H	0.24
BLCA	chr17	75518992	Splice_Region	novel		0.28
BRCA	chr17	75522251	Silent	novel	V390V	0.29
BRCA	chr17	75521490	Missense_Mutation	NA	K201N	0.46
BRCA	chr17	75524436	3'UTR	novel		0.11
BRCA	chr17	75523747	Silent	NA	P466P	0.16
BRCA	chr17	75524389	Silent	NA	L520L	0.13
BRCA	chr17	75523696	Silent	NA	I449I	0.31
BRCA	chr17	75521862	Missense_Mutation	NA	L261M	0.44
BRCA	chr17	75524494	3'UTR	novel		0.33
CESC	chr17	75517045	Frame_Shift_Del	novel	*G87Lfs94**	0.4
CESC	chr17	75523322	Missense_Mutation	novel	D434H	0.07
CESC	chr17	75521474	Missense_Mutation	NA	G196A	0.24
CHOL	chr17	75523736	In_Frame_Del	novel	K463del	0.5
COAD	chr17	75522208	Missense_Mutation	NA	S376F	0.15
COAD	chr17	75518997	Splice_Region	novel	V157V	0.35
COAD	chr17	75518999	Missense_Mutation	novel	F158Y	0.12
COAD	chr17	75517205	Silent	novel	Q110Q	0.32
COAD	chr17	75521788	Missense_Mutation	rs200904080	Q236R	0.38
COAD	chr17	75522158	Silent	rs546665854	A359A	0.31
COAD	chr17	75518997	Splice_Region	novel	V157V	0.16
COAD	chr17	75517162	Missense_Mutation	rs746239982	G96D	0.09
ESCA	chr17	75522081	Missense_Mutation	novel	A334T	0.41
GBM	chr17	75524321	Missense_Mutation	novel	D497A	0.19
GBM	chr17	75519016	Silent	novel	L164L	0.05
KIRC	chr17	75523756	Silent	NA	P469P	0.13
LIHC	chr17	75523733	Nonsense_Mutation	rs201775186	R462*	0.13
LUSC	chr17	75521457	Silent	NA	V190V	0.25
LUSC	chr17	75522161	Silent	NA	A360A	0.55
OV	chr17	75519030	Silent	novel	V168V	0.12
OV	chr17	75524323	Missense_Mutation	NA	V498F	0.23
OV	chr17	75524353	Missense_Mutation	novel	G508C	0.12
OV	chr17	75523700	Missense_Mutation	NA	D451H	0.33
OV	chr17	75519001	Missense_Mutation	novel	S159G	0.11
OV	chr17	75521498	Missense_Mutation	NA	S204T	0.59
OV	chr17	75524394	Silent	novel	P521P	0.04
OV	chr17	75524396	Frame_Shift_Ins	novel	*D523Kfs38**	0.03
OV	chr17	75519014	Missense_Mutation	novel	R163M	0.07
PAAD	chr17	75516776	Silent	novel	R29R	0.07
PAAD	chr17	75521446	Missense_Mutation	novel	D187N	0.17
PAAD	chr17	75522064	Missense_Mutation	novel	A328V	0.14
PRAD	chr17	75522030	Missense_Mutation	rs201125812	A317S	0.36
SARC	chr17	75522268	Missense_Mutation	NA	R396Q	0.4
SKCM	chr17	75522082	Missense_Mutation	NA	A334V	0.44
SKCM	chr17	75521779	Missense_Mutation	novel	P233L	0.53
SKCM	chr17	75523762	Silent	novel	A471A	0.65
SKCM	chr17	75522094	Missense_Mutation	novel	C338F	0.4
SKCM	chr17	75524472	3'UTR	novel		0.67
SKCM	chr17	75521768	Silent	NA	S229S	0.4
SKCM	chr17	75524381	Missense_Mutation	NA	D517G	0.11
STAD	chr17	75521509	Missense_Mutation	rs147165460	R208W	0.13
STAD	chr17	75517632	Missense_Mutation	novel	T149A	0.07
STAD	chr17	75524318	Missense_Mutation	novel	G496V	0.32
THYM	chr17	75522030	Missense_Mutation	rs201125812	A317T	0.23
UCEC	chr17	75522162	Nonsense_Mutation	NA	Q361*	0.31
UCEC	chr17	75521453	Missense_Mutation	novel	S189I	0.41
UCEC	chr17	75524333	Missense_Mutation	novel	I501S	0.04
UCEC	chr17	75524730	3'UTR	novel		0.42
UCEC	chr17	75519031	Nonsense_Mutation	rs199962683	R169*	0.11
UCEC	chr17	75524725	3'UTR	novel		0.16
UCEC	chr17	75521800	Missense_Mutation	novel	C240Y	0.2
UCEC	chr17	75517581	Missense_Mutation	novel	D132Y	0.29
UCEC	chr17	75524441	3'UTR	NA		0.29
UCEC	chr17	75521411	Missense_Mutation	novel	S175Y	0.29
UCEC	chr17	75522152	Silent	rs371212469	A357A	0.41
UCEC	chr17	75523770	Missense_Mutation	novel	C474Y	0.13

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3946	0.00012456
CESC	AMP	0.2	2.0209e-05
GBM	AMP	0.0936	0.0035457
KIRP	AMP	0.6701	0.14801
LGG	AMP	0.0702	1.52e-05
LUSC	AMP	0.3553	0.001059
SARC	AMP	0.2451	0.032181
SKCM	AMP	0.297	7.0388e-08
THCA	DEL	0.002	0.221
UVM	AMP	0.1625	0.054583

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00061	Kaplan-Meier Survival Analysis
STAD	0.00051	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
HNSC	0.0026	Kaplan-Meier Survival Analysis
PRAD	0.0046	Kaplan-Meier Survival Analysis
LUSC	0.047	Kaplan-Meier Survival Analysis
BRCA	0.027	Kaplan-Meier Survival Analysis
PAAD	0.00011	Kaplan-Meier Survival Analysis
BLCA	0.027	Kaplan-Meier Survival Analysis
CESC	0.001	Kaplan-Meier Survival Analysis
LAML	0.047	Kaplan-Meier Survival Analysis
UCEC	0.03	Kaplan-Meier Survival Analysis
LIHC	0.00013	Kaplan-Meier Survival Analysis
LGG	0.0089	Kaplan-Meier Survival Analysis
THCA	0.035	Kaplan-Meier Survival Analysis
LUAD	0.03	Kaplan-Meier Survival Analysis