EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000182810 (Gene tree)
Gene ID: 55794
Gene Symbol: DDX28
Alias: MDDX28|FLJ11282
Full Name: DEAD-box helicase 28
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 2,594 bases
Position: chr16:68,021,274-68,023,867
Accession: 17330
RBP type: canonical RBP
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is intronless. It encodes an RNA-dependent ATPase. The encoded protein is localized in the mitochondria and the nucleus, and can be transported between the mitochondria and the nucleus. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000332340	DEAD	PF00270.29	2.5e-33	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25683715	Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis.	Cell Rep	2015 Feb 17	Antonicka H	doi: 10.1016/j.celrep.2015.01.030
15350529	Regulated compartmentalization of the putative DEAD-box helicase MDDX28 within the mitochondria in COS-1 cells.	Exp Cell Res	2004 Oct 1	Valgardsdottir R	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000332395	DDX28-201	2169	-	ENSP00000332340	540 (aa)	-	Q9NUL7

Gene Model

Click here to download ENSG00000182810's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000182810's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000182810	DDX28	80	34.253	ENSG00000213782	DDX47	86	33.790
ENSG00000182810	DDX28	73	30.534	ENSG00000080007	DDX43	56	30.534
ENSG00000182810	DDX28	74	31.762	ENSG00000105671	DDX49	76	31.527
ENSG00000182810	DDX28	70	31.899	ENSG00000118197	DDX59	82	30.102
ENSG00000182810	DDX28	68	31.536	ENSG00000124228	DDX27	57	36.364

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000182810	DDX28	94	48.256	ENSAPOG00000000991	ddx28	89	48.256	Acanthochromis_polyacanthus
ENSG00000182810	DDX28	99	83.457	ENSAMEG00000019426	DDX28	99	83.457	Ailuropoda_melanoleuca
ENSG00000182810	DDX28	93	47.674	ENSACIG00000021615	ddx28	90	47.674	Amphilophus_citrinellus
ENSG00000182810	DDX28	94	48.450	ENSAOCG00000004610	ddx28	89	47.481	Amphiprion_ocellaris
ENSG00000182810	DDX28	94	48.256	ENSAPEG00000002143	ddx28	89	47.287	Amphiprion_percula
ENSG00000182810	DDX28	99	48.155	ENSATEG00000018691	ddx28	94	48.155	Anabas_testudineus
ENSG00000182810	DDX28	95	54.475	ENSACAG00000009755	DDX28	94	54.475	Anolis_carolinensis
ENSG00000182810	DDX28	93	46.498	ENSACLG00000012984	ddx28	89	46.498	Astatotilapia_calliptera
ENSG00000182810	DDX28	94	48.302	ENSAMXG00000005878	ddx28	91	48.302	Astyanax_mexicanus
ENSG00000182810	DDX28	100	85.185	ENSBTAG00000004290	DDX28	99	85.185	Bos_taurus
ENSG00000182810	DDX28	98	83.365	ENSCAFG00000020327	DDX28	99	83.365	Canis_familiaris
ENSG00000182810	DDX28	98	83.365	ENSCAFG00020019785	DDX28	99	83.365	Canis_lupus_dingo
ENSG00000182810	DDX28	97	85.057	ENSCHIG00000009658	DDX28	99	84.444	Capra_hircus
ENSG00000182810	DDX28	99	80.669	ENSCPOG00000013746	DDX28	99	80.669	Cavia_porcellus
ENSG00000182810	DDX28	99	95.167	ENSCSAG00000018472	DDX28	99	95.167	Chlorocebus_sabaeus
ENSG00000182810	DDX28	87	59.746	ENSCPBG00000012105	DDX28	86	59.770	Chrysemys_picta_bellii
ENSG00000182810	DDX28	67	38.992	ENSCSAVG00000006341	-	93	37.401	Ciona_savignyi
ENSG00000182810	DDX28	97	81.298	ENSCGRG00001024412	Ddx28	100	81.489	Cricetulus_griseus_chok1gshd
ENSG00000182810	DDX28	95	47.318	ENSCSEG00000011651	ddx28	91	46.768	Cynoglossus_semilaevis
ENSG00000182810	DDX28	94	49.414	ENSCVAG00000004044	ddx28	90	49.414	Cyprinodon_variegatus
ENSG00000182810	DDX28	95	48.952	ENSDARG00000060411	ddx28	92	48.952	Danio_rerio
ENSG00000182810	DDX28	68	87.500	ENSDNOG00000033593	DDX28	99	87.500	Dasypus_novemcinctus
ENSG00000182810	DDX28	99	80.855	ENSDORG00000028868	Ddx28	99	80.855	Dipodomys_ordii
ENSG00000182810	DDX28	88	35.185	FBgn0086130	Dbp21E2	87	35.041	Drosophila_melanogaster
ENSG00000182810	DDX28	99	81.784	ENSETEG00000001062	-	99	81.784	Echinops_telfairi
ENSG00000182810	DDX28	77	43.229	ENSEBUG00000004791	ddx28	80	43.523	Eptatretus_burgeri
ENSG00000182810	DDX28	100	85.370	ENSEASG00005020387	DDX28	100	85.370	Equus_asinus_asinus
ENSG00000182810	DDX28	100	85.926	ENSECAG00000006451	DDX28	100	85.926	Equus_caballus
ENSG00000182810	DDX28	79	75.524	ENSEEUG00000005017	DDX28	99	75.524	Erinaceus_europaeus
ENSG00000182810	DDX28	93	49.513	ENSELUG00000005302	ddx28	97	49.323	Esox_lucius
ENSG00000182810	DDX28	99	85.130	ENSFCAG00000012858	DDX28	99	85.130	Felis_catus
ENSG00000182810	DDX28	94	49.515	ENSFHEG00000012573	ddx28	91	49.515	Fundulus_heteroclitus
ENSG00000182810	DDX28	95	46.947	ENSGMOG00000017045	ddx28	97	46.565	Gadus_morhua
ENSG00000182810	DDX28	94	51.619	ENSGALG00000048700	DDX28	90	50.372	Gallus_gallus
ENSG00000182810	DDX28	94	48.343	ENSGAFG00000009249	ddx28	89	48.343	Gambusia_affinis
ENSG00000182810	DDX28	99	47.541	ENSGACG00000016367	ddx28	99	47.541	Gasterosteus_aculeatus
ENSG00000182810	DDX28	80	57.339	ENSGAGG00000004565	DDX28	94	57.339	Gopherus_agassizii
ENSG00000182810	DDX28	100	99.074	ENSGGOG00000001220	DDX28	100	99.074	Gorilla_gorilla
ENSG00000182810	DDX28	93	48.249	ENSHBUG00000001016	ddx28	90	48.249	Haplochromis_burtoni
ENSG00000182810	DDX28	94	46.628	ENSHCOG00000017590	ddx28	92	46.628	Hippocampus_comes
ENSG00000182810	DDX28	96	48.008	ENSIPUG00000017350	Ddx28	91	48.008	Ictalurus_punctatus
ENSG00000182810	DDX28	99	81.784	ENSSTOG00000002064	DDX28	99	81.784	Ictidomys_tridecemlineatus
ENSG00000182810	DDX28	99	80.741	ENSJJAG00000012460	-	99	80.741	Jaculus_jaculus
ENSG00000182810	DDX28	97	46.241	ENSKMAG00000018183	ddx28	93	46.429	Kryptolebias_marmoratus
ENSG00000182810	DDX28	96	49.049	ENSLBEG00000006072	ddx28	92	48.289	Labrus_bergylta
ENSG00000182810	DDX28	93	53.150	ENSLACG00000005578	DDX28	87	53.150	Latimeria_chalumnae
ENSG00000182810	DDX28	94	51.751	ENSLOCG00000017604	ddx28	91	50.482	Lepisosteus_oculatus
ENSG00000182810	DDX28	100	84.815	ENSLAFG00000031239	DDX28	100	84.815	Loxodonta_africana
ENSG00000182810	DDX28	99	94.238	ENSMMUG00000010836	DDX28	99	94.238	Macaca_mulatta
ENSG00000182810	DDX28	94	49.035	ENSMAMG00000020220	ddx28	90	49.035	Mastacembelus_armatus
ENSG00000182810	DDX28	93	48.638	ENSMZEG00005009292	ddx28	90	48.638	Maylandia_zebra
ENSG00000182810	DDX28	96	71.346	ENSMICG00000012346	-	99	71.429	Microcebus_murinus
ENSG00000182810	DDX28	99	80.855	ENSMOCG00000009815	Ddx28	99	80.855	Microtus_ochrogaster
ENSG00000182810	DDX28	95	48.767	ENSMMOG00000000270	ddx28	92	48.767	Mola_mola
ENSG00000182810	DDX28	96	70.600	ENSMODG00000005303	DDX28	98	68.959	Monodelphis_domestica
ENSG00000182810	DDX28	95	48.289	ENSMALG00000008864	ddx28	90	48.289	Monopterus_albus
ENSG00000182810	DDX28	99	80.483	MGP_CAROLIEiJ_G0031510	Ddx28	99	80.483	Mus_caroli
ENSG00000182810	DDX28	99	80.855	ENSMUSG00000045538	Ddx28	99	80.855	Mus_musculus
ENSG00000182810	DDX28	99	81.413	MGP_PahariEiJ_G0023110	Ddx28	99	81.413	Mus_pahari
ENSG00000182810	DDX28	99	80.669	MGP_SPRETEiJ_G0032628	Ddx28	99	80.669	Mus_spretus
ENSG00000182810	DDX28	75	82.382	ENSMPUG00000006915	DDX28	100	82.382	Mustela_putorius_furo
ENSG00000182810	DDX28	98	81.698	ENSMLUG00000005899	DDX28	98	81.698	Myotis_lucifugus
ENSG00000182810	DDX28	99	79.926	ENSNGAG00000015762	Ddx28	99	80.112	Nannospalax_galili
ENSG00000182810	DDX28	93	48.438	ENSNBRG00000001337	ddx28	91	48.438	Neolamprologus_brichardi
ENSG00000182810	DDX28	93	48.638	ENSONIG00000020597	ddx28	90	48.638	Oreochromis_niloticus
ENSG00000182810	DDX28	52	65.018	ENSOANG00000003551	-	98	65.018	Ornithorhynchus_anatinus
ENSG00000182810	DDX28	99	82.682	ENSOCUG00000023074	DDX28	99	82.682	Oryctolagus_cuniculus
ENSG00000182810	DDX28	94	49.031	ENSORLG00000011968	ddx28	92	49.031	Oryzias_latipes
ENSG00000182810	DDX28	94	48.837	ENSORLG00020001951	ddx28	93	48.837	Oryzias_latipes_hni
ENSG00000182810	DDX28	94	48.256	ENSORLG00015023030	ddx28	93	48.256	Oryzias_latipes_hsok
ENSG00000182810	DDX28	94	49.027	ENSOMEG00000012445	ddx28	90	49.027	Oryzias_melastigma
ENSG00000182810	DDX28	97	83.871	ENSOGAG00000016895	DDX28	99	83.673	Otolemur_garnettii
ENSG00000182810	DDX28	82	82.921	ENSOARG00000003313	DDX28	100	82.921	Ovis_aries
ENSG00000182810	DDX28	100	94.815	ENSPPAG00000036971	DDX28	100	94.815	Pan_paniscus
ENSG00000182810	DDX28	99	85.874	ENSPPRG00000018322	DDX28	99	85.874	Panthera_pardus
ENSG00000182810	DDX28	99	82.528	ENSPTIG00000006444	DDX28	99	82.528	Panthera_tigris_altaica
ENSG00000182810	DDX28	100	98.704	ENSPTRG00000008258	DDX28	100	98.704	Pan_troglodytes
ENSG00000182810	DDX28	93	49.612	ENSPKIG00000021200	ddx28	93	49.225	Paramormyrops_kingsleyae
ENSG00000182810	DDX28	55	62.416	ENSPSIG00000001127	DDX28	97	62.416	Pelodiscus_sinensis
ENSG00000182810	DDX28	92	44.882	ENSPMGG00000007908	ddx28	88	44.882	Periophthalmus_magnuspinnatus
ENSG00000182810	DDX28	99	80.185	ENSPEMG00000003395	Ddx28	99	80.185	Peromyscus_maniculatus_bairdii
ENSG00000182810	DDX28	52	50.355	ENSPMAG00000006983	DDX28	93	50.355	Petromyzon_marinus
ENSG00000182810	DDX28	94	47.969	ENSPFOG00000020952	ddx28	89	47.969	Poecilia_formosa
ENSG00000182810	DDX28	94	47.969	ENSPFOG00000020838	DDX28	90	47.969	Poecilia_formosa
ENSG00000182810	DDX28	94	47.969	ENSPLAG00000016292	ddx28	89	47.969	Poecilia_latipinna
ENSG00000182810	DDX28	94	47.969	ENSPMEG00000011311	ddx28	88	47.969	Poecilia_mexicana
ENSG00000182810	DDX28	94	48.148	ENSPREG00000002899	ddx28	88	48.148	Poecilia_reticulata
ENSG00000182810	DDX28	99	97.955	ENSPPYG00000007481	DDX28	100	97.955	Pongo_abelii
ENSG00000182810	DDX28	100	85.767	ENSPCOG00000024632	DDX28	100	85.767	Propithecus_coquereli
ENSG00000182810	DDX28	93	48.638	ENSPNYG00000018804	ddx28	90	48.638	Pundamilia_nyererei
ENSG00000182810	DDX28	94	49.231	ENSPNAG00000014597	ddx28	95	49.231	Pygocentrus_nattereri
ENSG00000182810	DDX28	99	78.625	ENSRNOG00000019817	Ddx28	99	78.625	Rattus_norvegicus
ENSG00000182810	DDX28	93	49.807	ENSSFOG00015010181	ddx28	92	49.228	Scleropages_formosus
ENSG00000182810	DDX28	91	49.701	ENSSMAG00000006831	ddx28	92	48.497	Scophthalmus_maximus
ENSG00000182810	DDX28	94	47.490	ENSSDUG00000003257	ddx28	89	46.911	Seriola_dumerili
ENSG00000182810	DDX28	94	47.379	ENSSLDG00000004513	ddx28	89	46.796	Seriola_lalandi_dorsalis
ENSG00000182810	DDX28	100	81.111	ENSSARG00000014169	DDX28	100	81.111	Sorex_araneus
ENSG00000182810	DDX28	95	47.893	ENSSPAG00000000988	ddx28	91	47.126	Stegastes_partitus
ENSG00000182810	DDX28	100	86.111	ENSSSCG00000026038	DDX28	100	86.111	Sus_scrofa
ENSG00000182810	DDX28	93	47.929	ENSTRUG00000007815	ddx28	92	48.323	Takifugu_rubripes
ENSG00000182810	DDX28	93	48.915	ENSTNIG00000011352	ddx28	99	47.929	Tetraodon_nigroviridis
ENSG00000182810	DDX28	87	87.671	ENSTBEG00000017695	DDX28	87	87.671	Tupaia_belangeri
ENSG00000182810	DDX28	99	85.316	ENSUAMG00000016116	DDX28	99	85.316	Ursus_americanus
ENSG00000182810	DDX28	81	86.437	ENSUMAG00000019200	DDX28	89	86.437	Ursus_maritimus
ENSG00000182810	DDX28	81	80.594	ENSVVUG00000012876	DDX28	87	80.594	Vulpes_vulpes
ENSG00000182810	DDX28	93	49.405	ENSXETG00000005435	ddx28	98	49.405	Xenopus_tropicalis
ENSG00000182810	DDX28	94	48.549	ENSXCOG00000012364	ddx28	90	48.549	Xiphophorus_couchianus
ENSG00000182810	DDX28	96	47.575	ENSXMAG00000019603	ddx28	95	47.575	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0019843	rRNA binding	25683715.	IDA	Function
GO:0035770	ribonucleoprotein granule	25683715.	IDA	Component
GO:0042645	mitochondrial nucleoid	18063578.25683715.	IDA	Component
GO:1902775	mitochondrial large ribosomal subunit assembly	25683715.	IMP	Process