EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000182934 (Gene tree)
Gene ID: 6734
Gene Symbol: SRPRA
Alias: SRP-alpha|Sralpha|SR-alpha|SRPR
Full Name: SRP receptor subunit alpha
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 6,226 bases
Position: chr11:126,262,919-126,269,144
Accession: 11307
RBP type: canonical RBP
Summary: The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000435508	SRP54	PF00448.22	5.4e-47	1	1
ENSP00000328023	SRP54	PF00448.22	6.1e-47	1	1
ENSP00000435508	SRP54_N	PF02881.19	3.2e-08	1	1
ENSP00000328023	SRP54_N	PF02881.19	3.5e-08	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18441046	The 5e motif of eukaryotic signal recognition particle RNA contains a conserved adenosine for the binding of SRP72.	RNA	2008 Jun	Iakhiaeva E	doi: 10.1261/rna.979508

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000530680	SRPRA-204	558	-	-	- (aa)	-	-
ENST00000531104	SRPRA-205	542	-	-	- (aa)	-	-
ENST00000532259	SRPRA-206	2453	-	ENSP00000435508	610 (aa)	-	P08240
ENST00000332118	SRPRA-201	3069	XM_017018179	ENSP00000328023	638 (aa)	XP_016873668	P08240
ENST00000532268	SRPRA-207	829	-	-	- (aa)	-	-
ENST00000528744	SRPRA-203	856	-	-	- (aa)	-	-
ENST00000527817	SRPRA-202	687	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000182934's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03060	Protein export	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000182934's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000182934	SRPRA	100	68.244	ENSAPOG00000017588	srpra	100	68.502	Acanthochromis_polyacanthus
ENSG00000182934	SRPRA	100	97.179	ENSAMEG00000000117	SRPRA	100	97.179	Ailuropoda_melanoleuca
ENSG00000182934	SRPRA	100	66.362	ENSACIG00000021588	srpra	100	66.514	Amphilophus_citrinellus
ENSG00000182934	SRPRA	100	68.389	ENSAOCG00000018884	srpra	100	69.008	Amphiprion_ocellaris
ENSG00000182934	SRPRA	100	67.884	ENSAPEG00000022286	srpra	100	67.239	Amphiprion_percula
ENSG00000182934	SRPRA	83	86.984	ENSATEG00000023578	srpra	93	86.728	Anabas_testudineus
ENSG00000182934	SRPRA	94	77.997	ENSAPLG00000016079	SRPRA	100	78.161	Anas_platyrhynchos
ENSG00000182934	SRPRA	100	76.888	ENSACAG00000000108	SRPRA	100	77.196	Anolis_carolinensis
ENSG00000182934	SRPRA	100	98.903	ENSANAG00000020346	SRPRA	100	98.903	Aotus_nancymaae
ENSG00000182934	SRPRA	100	67.381	ENSACLG00000000518	srpra	100	67.481	Astatotilapia_calliptera
ENSG00000182934	SRPRA	100	65.839	ENSAMXG00000009975	srpra	100	65.319	Astyanax_mexicanus
ENSG00000182934	SRPRA	100	97.340	ENSBTAG00000014105	SRPRA	100	97.340	Bos_taurus
ENSG00000182934	SRPRA	99	48.097	WBGene00009521	F38A1.8	99	47.945	Caenorhabditis_elegans
ENSG00000182934	SRPRA	100	98.903	ENSCJAG00000008752	SRPRA	100	98.903	Callithrix_jacchus
ENSG00000182934	SRPRA	100	94.828	ENSCAFG00000010474	SRPRA	100	94.828	Canis_familiaris
ENSG00000182934	SRPRA	100	96.865	ENSCAFG00020010608	SRPRA	100	96.865	Canis_lupus_dingo
ENSG00000182934	SRPRA	100	96.557	ENSCHIG00000012423	SRPRA	100	96.557	Capra_hircus
ENSG00000182934	SRPRA	81	98.883	ENSTSYG00000005187	SRPRA	97	98.883	Carlito_syrichta
ENSG00000182934	SRPRA	95	89.621	ENSCAPG00000007098	SRPRA	91	98.496	Cavia_aperea
ENSG00000182934	SRPRA	100	97.492	ENSCPOG00000014976	SRPRA	100	97.492	Cavia_porcellus
ENSG00000182934	SRPRA	100	98.746	ENSCCAG00000025602	SRPRA	100	98.746	Cebus_capucinus
ENSG00000182934	SRPRA	100	99.373	ENSCATG00000039354	SRPRA	100	99.373	Cercocebus_atys
ENSG00000182934	SRPRA	100	98.433	ENSCLAG00000016839	SRPRA	100	98.433	Chinchilla_lanigera
ENSG00000182934	SRPRA	100	99.373	ENSCSAG00000002271	SRPRA	100	99.373	Chlorocebus_sabaeus
ENSG00000182934	SRPRA	58	98.980	ENSCHOG00000010015	-	73	98.980	Choloepus_hoffmanni
ENSG00000182934	SRPRA	100	78.034	ENSCPBG00000011128	SRPRA	100	78.495	Chrysemys_picta_bellii
ENSG00000182934	SRPRA	99	59.061	ENSCING00000008954	-	100	59.061	Ciona_intestinalis
ENSG00000182934	SRPRA	99	58.986	ENSCSAVG00000005602	-	100	59.571	Ciona_savignyi
ENSG00000182934	SRPRA	100	98.119	ENSCANG00000032337	SRPRA	100	98.119	Colobus_angolensis_palliatus
ENSG00000182934	SRPRA	100	97.179	ENSCGRG00001017670	Srpr	100	97.179	Cricetulus_griseus_chok1gshd
ENSG00000182934	SRPRA	100	97.179	ENSCGRG00000009892	Srpr	100	97.179	Cricetulus_griseus_crigri
ENSG00000182934	SRPRA	100	67.625	ENSCSEG00000002374	srpra	100	67.474	Cynoglossus_semilaevis
ENSG00000182934	SRPRA	100	67.674	ENSCVAG00000019881	srpra	100	68.445	Cyprinodon_variegatus
ENSG00000182934	SRPRA	100	67.071	ENSDARG00000061124	srpra	100	66.616	Danio_rerio
ENSG00000182934	SRPRA	100	95.659	ENSDNOG00000010821	SRPRA	100	95.659	Dasypus_novemcinctus
ENSG00000182934	SRPRA	100	97.492	ENSDORG00000016719	Srpr	100	97.492	Dipodomys_ordii
ENSG00000182934	SRPRA	99	50.926	FBgn0010391	Gtp-bp	100	51.464	Drosophila_melanogaster
ENSG00000182934	SRPRA	100	92.991	ENSETEG00000013956	SRPRA	100	92.991	Echinops_telfairi
ENSG00000182934	SRPRA	53	80.923	ENSEBUG00000002602	srpra	92	68.916	Eptatretus_burgeri
ENSG00000182934	SRPRA	100	96.244	ENSEASG00005022980	SRPRA	100	95.931	Equus_asinus_asinus
ENSG00000182934	SRPRA	100	96.401	ENSECAG00000014692	SRPRA	100	96.401	Equus_caballus
ENSG00000182934	SRPRA	100	86.916	ENSEEUG00000007920	SRPRA	100	86.137	Erinaceus_europaeus
ENSG00000182934	SRPRA	100	68.702	ENSELUG00000017643	srpra	100	68.389	Esox_lucius
ENSG00000182934	SRPRA	100	97.183	ENSFCAG00000011274	-	100	97.183	Felis_catus
ENSG00000182934	SRPRA	80	96.086	ENSFCAG00000030894	-	99	96.086	Felis_catus
ENSG00000182934	SRPRA	99	74.727	ENSFALG00000005048	SRPRA	99	74.727	Ficedula_albicollis
ENSG00000182934	SRPRA	100	98.589	ENSFDAG00000016229	SRPRA	100	98.589	Fukomys_damarensis
ENSG00000182934	SRPRA	100	66.314	ENSFHEG00000016959	srpra	100	67.069	Fundulus_heteroclitus
ENSG00000182934	SRPRA	100	67.857	ENSGMOG00000013244	srpra	100	68.682	Gadus_morhua
ENSG00000182934	SRPRA	100	78.395	ENSGALG00000030759	SRPRA	100	78.549	Gallus_gallus
ENSG00000182934	SRPRA	100	67.933	ENSGAFG00000000453	srpra	100	68.085	Gambusia_affinis
ENSG00000182934	SRPRA	100	67.231	ENSGACG00000006550	srpra	100	67.231	Gasterosteus_aculeatus
ENSG00000182934	SRPRA	100	79.263	ENSGAGG00000021157	SRPRA	100	79.263	Gopherus_agassizii
ENSG00000182934	SRPRA	100	99.843	ENSGGOG00000012962	SRPRA	100	99.843	Gorilla_gorilla
ENSG00000182934	SRPRA	100	67.228	ENSHBUG00000000119	srpra	100	67.328	Haplochromis_burtoni
ENSG00000182934	SRPRA	100	97.492	ENSHGLG00000001597	SRPR	100	97.492	Heterocephalus_glaber_female
ENSG00000182934	SRPRA	100	97.492	ENSHGLG00100006449	SRPR	100	97.492	Heterocephalus_glaber_male
ENSG00000182934	SRPRA	100	68.120	ENSHCOG00000010749	srpra	100	67.761	Hippocampus_comes
ENSG00000182934	SRPRA	98	61.675	ENSIPUG00000000867	srpra	99	64.830	Ictalurus_punctatus
ENSG00000182934	SRPRA	100	98.119	ENSSTOG00000009897	SRPRA	100	98.119	Ictidomys_tridecemlineatus
ENSG00000182934	SRPRA	100	96.865	ENSJJAG00000020272	Srpr	100	96.865	Jaculus_jaculus
ENSG00000182934	SRPRA	100	68.318	ENSKMAG00000002280	srpra	100	68.722	Kryptolebias_marmoratus
ENSG00000182934	SRPRA	100	67.123	ENSLBEG00000009608	srpra	100	68.389	Labrus_bergylta
ENSG00000182934	SRPRA	100	70.543	ENSLACG00000017781	SRPRA	100	70.543	Latimeria_chalumnae
ENSG00000182934	SRPRA	100	67.216	ENSLOCG00000002733	srpra	100	66.867	Lepisosteus_oculatus
ENSG00000182934	SRPRA	100	95.462	ENSLAFG00000010252	SRPRA	100	95.462	Loxodonta_africana
ENSG00000182934	SRPRA	100	99.530	ENSMFAG00000032606	SRPRA	100	99.530	Macaca_fascicularis
ENSG00000182934	SRPRA	100	99.530	ENSMMUG00000007938	SRPRA	100	99.530	Macaca_mulatta
ENSG00000182934	SRPRA	100	99.373	ENSMNEG00000030709	SRPRA	100	99.373	Macaca_nemestrina
ENSG00000182934	SRPRA	100	99.373	ENSMLEG00000043404	SRPRA	100	99.373	Mandrillus_leucophaeus
ENSG00000182934	SRPRA	100	66.918	ENSMAMG00000000473	srpra	100	66.717	Mastacembelus_armatus
ENSG00000182934	SRPRA	100	67.381	ENSMZEG00005013432	srpra	100	67.481	Maylandia_zebra
ENSG00000182934	SRPRA	94	78.053	ENSMGAG00000000732	SRPRA	100	78.218	Meleagris_gallopavo
ENSG00000182934	SRPRA	100	97.492	ENSMAUG00000015648	Srpr	100	97.492	Mesocricetus_auratus
ENSG00000182934	SRPRA	100	97.649	ENSMICG00000015981	SRPRA	100	97.649	Microcebus_murinus
ENSG00000182934	SRPRA	100	97.492	ENSMOCG00000008311	Srpr	100	97.492	Microtus_ochrogaster
ENSG00000182934	SRPRA	100	67.597	ENSMMOG00000005019	srpra	100	67.597	Mola_mola
ENSG00000182934	SRPRA	100	90.454	ENSMODG00000004576	-	100	89.969	Monodelphis_domestica
ENSG00000182934	SRPRA	100	68.085	ENSMALG00000011343	srpra	100	68.389	Monopterus_albus
ENSG00000182934	SRPRA	100	97.179	MGP_CAROLIEiJ_G0031951	Srpr	100	97.179	Mus_caroli
ENSG00000182934	SRPRA	100	97.179	ENSMUSG00000032042	Srpr	100	97.179	Mus_musculus
ENSG00000182934	SRPRA	100	97.335	MGP_PahariEiJ_G0014816	Srpr	100	97.335	Mus_pahari
ENSG00000182934	SRPRA	100	92.687	MGP_SPRETEiJ_G0033075	Srpr	100	92.687	Mus_spretus
ENSG00000182934	SRPRA	100	97.022	ENSMPUG00000006626	SRPRA	100	97.022	Mustela_putorius_furo
ENSG00000182934	SRPRA	100	95.141	ENSMLUG00000017334	SRPRA	100	95.141	Myotis_lucifugus
ENSG00000182934	SRPRA	100	97.022	ENSNGAG00000015686	Srpr	100	97.022	Nannospalax_galili
ENSG00000182934	SRPRA	100	67.737	ENSNBRG00000017311	srpra	100	67.841	Neolamprologus_brichardi
ENSG00000182934	SRPRA	95	99.672	ENSNLEG00000007467	SRPRA	100	99.672	Nomascus_leucogenys
ENSG00000182934	SRPRA	94	91.000	ENSMEUG00000004956	SRPRA	100	90.667	Notamacropus_eugenii
ENSG00000182934	SRPRA	100	90.767	ENSOPRG00000013160	SRPRA	100	90.767	Ochotona_princeps
ENSG00000182934	SRPRA	100	96.865	ENSODEG00000004730	SRPRA	100	96.865	Octodon_degus
ENSG00000182934	SRPRA	100	67.381	ENSONIG00000005324	srpra	100	67.481	Oreochromis_niloticus
ENSG00000182934	SRPRA	100	98.746	ENSOCUG00000017057	SRPRA	100	98.746	Oryctolagus_cuniculus
ENSG00000182934	SRPRA	85	86.349	ENSORLG00000014676	srpra	100	68.405	Oryzias_latipes
ENSG00000182934	SRPRA	100	67.638	ENSORLG00020009240	srpra	100	68.405	Oryzias_latipes_hni
ENSG00000182934	SRPRA	100	67.638	ENSORLG00015015405	srpra	100	68.558	Oryzias_latipes_hsok
ENSG00000182934	SRPRA	100	68.210	ENSOMEG00000005872	srpra	100	68.453	Oryzias_melastigma
ENSG00000182934	SRPRA	100	97.649	ENSOGAG00000008926	SRPRA	100	97.649	Otolemur_garnettii
ENSG00000182934	SRPRA	100	92.668	ENSOARG00000012397	SRPRA	100	93.292	Ovis_aries
ENSG00000182934	SRPRA	100	100.000	ENSPPAG00000030813	SRPRA	100	100.000	Pan_paniscus
ENSG00000182934	SRPRA	100	97.183	ENSPPRG00000001542	SRPRA	100	97.183	Panthera_pardus
ENSG00000182934	SRPRA	100	97.027	ENSPTIG00000006989	SRPRA	100	97.027	Panthera_tigris_altaica
ENSG00000182934	SRPRA	100	100.000	ENSPTRG00000028360	SRPRA	100	100.000	Pan_troglodytes
ENSG00000182934	SRPRA	100	99.530	ENSPANG00000010858	SRPRA	100	99.530	Papio_anubis
ENSG00000182934	SRPRA	100	66.409	ENSPKIG00000016106	srpra	100	66.924	Paramormyrops_kingsleyae
ENSG00000182934	SRPRA	94	77.176	ENSPSIG00000012009	SRPRA	100	77.340	Pelodiscus_sinensis
ENSG00000182934	SRPRA	100	68.405	ENSPMGG00000001393	srpra	100	68.405	Periophthalmus_magnuspinnatus
ENSG00000182934	SRPRA	100	97.649	ENSPEMG00000018279	Srpr	100	97.649	Peromyscus_maniculatus_bairdii
ENSG00000182934	SRPRA	99	61.598	ENSPMAG00000009559	srpra	99	61.633	Petromyzon_marinus
ENSG00000182934	SRPRA	100	90.454	ENSPCIG00000010207	SRPRA	100	90.610	Phascolarctos_cinereus
ENSG00000182934	SRPRA	100	67.776	ENSPFOG00000003114	srpra	100	69.335	Poecilia_formosa
ENSG00000182934	SRPRA	100	67.474	ENSPLAG00000007323	srpra	100	69.033	Poecilia_latipinna
ENSG00000182934	SRPRA	100	67.776	ENSPMEG00000015658	srpra	100	69.335	Poecilia_mexicana
ENSG00000182934	SRPRA	100	68.278	ENSPREG00000004937	srpra	100	68.835	Poecilia_reticulata
ENSG00000182934	SRPRA	89	99.387	ENSPPYG00000004045	SRPRA	100	99.387	Pongo_abelii
ENSG00000182934	SRPRA	64	99.225	ENSPCAG00000003801	-	64	99.225	Procavia_capensis
ENSG00000182934	SRPRA	100	97.806	ENSPCOG00000025726	SRPRA	100	97.806	Propithecus_coquereli
ENSG00000182934	SRPRA	100	96.552	ENSPVAG00000000993	SRPRA	100	96.552	Pteropus_vampyrus
ENSG00000182934	SRPRA	100	67.381	ENSPNYG00000012371	srpra	100	67.481	Pundamilia_nyererei
ENSG00000182934	SRPRA	100	64.688	ENSPNAG00000013476	srpra	100	66.616	Pygocentrus_nattereri
ENSG00000182934	SRPRA	100	97.649	ENSRNOG00000010543	Srpra	100	97.649	Rattus_norvegicus
ENSG00000182934	SRPRA	100	99.216	ENSRBIG00000008702	SRPRA	100	99.216	Rhinopithecus_bieti
ENSG00000182934	SRPRA	100	99.061	ENSRROG00000029494	SRPRA	100	99.061	Rhinopithecus_roxellana
ENSG00000182934	SRPRA	70	38.075	YDR292C	-	76	38.075	Saccharomyces_cerevisiae
ENSG00000182934	SRPRA	100	98.903	ENSSBOG00000035892	SRPRA	100	98.903	Saimiri_boliviensis_boliviensis
ENSG00000182934	SRPRA	94	91.030	ENSSHAG00000009168	SRPRA	100	90.698	Sarcophilus_harrisii
ENSG00000182934	SRPRA	100	65.109	ENSSFOG00015008837	srpra	100	66.303	Scleropages_formosus
ENSG00000182934	SRPRA	100	66.149	ENSSMAG00000002783	srpra	100	66.096	Scophthalmus_maximus
ENSG00000182934	SRPRA	100	67.031	ENSSDUG00000013920	srpra	100	67.031	Seriola_dumerili
ENSG00000182934	SRPRA	100	66.869	ENSSLDG00000008601	srpra	93	67.325	Seriola_lalandi_dorsalis
ENSG00000182934	SRPRA	85	100.000	ENSSARG00000012434	SRPRA	86	100.000	Sorex_araneus
ENSG00000182934	SRPRA	100	77.469	ENSSPUG00000018221	SRPRA	100	77.623	Sphenodon_punctatus
ENSG00000182934	SRPRA	100	66.616	ENSSPAG00000005103	srpra	100	67.830	Stegastes_partitus
ENSG00000182934	SRPRA	100	97.335	ENSSSCG00000015227	SRPRA	100	97.335	Sus_scrofa
ENSG00000182934	SRPRA	94	74.959	ENSTGUG00000000815	SRPRA	100	74.959	Taeniopygia_guttata
ENSG00000182934	SRPRA	100	66.719	ENSTRUG00000006856	srpra	100	67.431	Takifugu_rubripes
ENSG00000182934	SRPRA	100	64.188	ENSTNIG00000010316	srpra	100	65.402	Tetraodon_nigroviridis
ENSG00000182934	SRPRA	100	96.714	ENSTTRG00000001558	SRPRA	100	96.714	Tursiops_truncatus
ENSG00000182934	SRPRA	100	97.027	ENSUAMG00000005510	SRPRA	100	97.027	Ursus_americanus
ENSG00000182934	SRPRA	98	88.158	ENSUMAG00000002269	SRPRA	100	88.158	Ursus_maritimus
ENSG00000182934	SRPRA	72	99.225	ENSVPAG00000001077	SRPRA	75	99.225	Vicugna_pacos
ENSG00000182934	SRPRA	100	97.022	ENSVVUG00000020094	SRPRA	100	97.022	Vulpes_vulpes
ENSG00000182934	SRPRA	100	62.443	ENSXETG00000003920	srpra	100	62.748	Xenopus_tropicalis
ENSG00000182934	SRPRA	84	87.937	ENSXCOG00000001286	srpra	99	86.486	Xiphophorus_couchianus
ENSG00000182934	SRPRA	100	68.397	ENSXMAG00000028401	srpra	100	68.855	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0005047	signal recognition particle binding	21873635.	IBA	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005785	signal recognition particle receptor complex	-	IEA	Component
GO:0005789	endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	2827661.	TAS	Component
GO:0006605	protein targeting	21873635.	IBA	Process
GO:0006613	cotranslational protein targeting to membrane	2827661.	TAS	Process
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	-	IEA	Process
GO:0016020	membrane	21873635.	IBA	Component
GO:0016020	membrane	22375059.	IDA	Component
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process
GO:0045047	protein targeting to ER	21873635.	IBA	Process
GO:0070062	extracellular exosome	19199708.	HDA	Component