EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000183207 (Gene tree)
Gene ID: 10856
Gene Symbol: RUVBL2
Alias: RVB2|TIP48|TIP49b|Reptin52|ECP51|TIH2|INO80J|Rvb2
Full Name: RuvB like AAA ATPase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 22,643 bases
Position: chr19:48,993,353-49,015,995
Accession: 10475
RBP type: non-canonical RBP
Summary: This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23938467	Linking spermatid ribonucleic acid (RNA) binding protein and retrogene diversity to reproductive success.	Mol Cell Proteomics	2013 Nov	Chapman KM	doi: 10.1074/mcp.M113.030585

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000595811	RUVBL2-207	572	-	ENSP00000469760	44 (aa)	-	M0QYD8
ENST00000639391	RUVBL2-213	120	-	ENSP00000492564	39 (aa)	-	A0A1W2PS22
ENST00000595002	RUVBL2-205	546	-	-	- (aa)	-	-
ENST00000596837	RUVBL2-209	682	-	ENSP00000469189	109 (aa)	-	M0QXI6
ENST00000593570	RUVBL2-202	813	-	ENSP00000469488	39 (aa)	-	M0QXZ7
ENST00000598768	RUVBL2-210	497	-	-	- (aa)	-	-
ENST00000221413	RUVBL2-201	1478	-	ENSP00000221413	259 (aa)	-	X6R2L4
ENST00000595090	RUVBL2-206	2009	-	ENSP00000473172	463 (aa)	-	Q9Y230
ENST00000601968	RUVBL2-211	1641	XM_011526330	ENSP00000471524	354 (aa)	XP_011524632	M0R0Y3
ENST00000596247	RUVBL2-208	1563	-	ENSP00000471538	50 (aa)	-	M0R0Z0
ENST00000640699	RUVBL2-214	153	-	ENSP00000492610	50 (aa)	-	A0A1W2PS48
ENST00000594017	RUVBL2-203	959	-	-	- (aa)	-	-
ENST00000627972	RUVBL2-212	1065	-	ENSP00000486242	354 (aa)	-	M0R0Y3
ENST00000594338	RUVBL2-204	1853	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000183207's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000183207	Follicle Stimulating Hormone	4E-8	24049095

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000183207	rs75287599	19	49013883	T	Blood protein levels	29875488	[0.33-0.53] unit decrease	0.43	EFO_0007937
ENSG00000183207	rs79785970	19	49014074	G	Blood protein levels	29875488	[1.03-1.19] unit increase	1.11	EFO_0007937
ENSG00000183207	rs139643250	19	49013889	T	Blood protein levels	29875488	[0.58-0.78] unit decrease	0.68	EFO_0007937
ENSG00000183207	rs3764618	19	48993898	?	Follicule stimulating hormone	24049095			EFO_0004768
ENSG00000183207	rs753307	19	49015227	C	Blood protein levels	28240269	[0.19-0.32] unit increase	0.256	EFO_0008156
ENSG00000183207	rs79502742	19	48997109	G	Blood protein levels	30072576	[NR] unit decrease	0.9031508	EFO_0007937
ENSG00000183207	rs79502742	19	48997109	G	Blood protein levels	30072576	[NR] unit increase	0.7314155	EFO_0007937
ENSG00000183207	rs79502742	19	48997109	G	Blood protein levels	30072576	[0.54-0.65] unit increase	0.594	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000183207's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000183207	RUVBL2	100	79.817	FBgn0040075	rept	94	78.146	Drosophila_melanogaster
ENSG00000183207	RUVBL2	92	57.000	ENSG00000175792	RUVBL1	100	51.908	Homo_sapiens
ENSG00000183207	RUVBL2	100	100.000	ENSMUSG00000003868	Ruvbl2	100	99.568	Mus_musculus
ENSG00000183207	RUVBL2	92	57.000	ENSMUSG00000030079	Ruvbl1	100	47.761	Mus_musculus
ENSG00000183207	RUVBL2	99	78.704	YPL235W	RVB2	94	68.764	Saccharomyces_cerevisiae
ENSG00000183207	RUVBL2	92	53.000	YDR190C	RVB1	94	42.597	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000492	box C/D snoRNP assembly	21873635.	IBA	Process
GO:0000812	Swr1 complex	21873635.	IBA	Component
GO:0000812	Swr1 complex	24463511.	IDA	Component
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	23637611.	IDA	Function
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	23637611.	IDA	Function
GO:0001094	TFIID-class transcription factor complex binding	-	IEA	Function
GO:0003678	DNA helicase activity	10524211.	IDA	Function
GO:0003714	transcription corepressor activity	11080158.	IDA	Function
GO:0004003	ATP-dependent DNA helicase activity	21873635.	IBA	Function
GO:0005515	protein binding	10966108.11080158.16189514.16230350.17636026.18026119.18087039.18358808.19299493.19433865.20371770.20864032.25416956.27705803.29601588.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	10524211.18026119.19433865.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005719	nuclear euchromatin	23637611.	IDA	Component
GO:0005737	cytoplasm	19433865.	IDA	Component
GO:0005813	centrosome	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006281	DNA repair	-	IEA	Process
GO:0006310	DNA recombination	-	IEA	Process
GO:0006338	chromatin remodeling	21873635.	IBA	Process
GO:0006338	chromatin remodeling	23637611.	IMP	Process
GO:0006357	regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0006457	protein folding	10524211.	TAS	Process
GO:0008013	beta-catenin binding	11080158.	IDA	Function
GO:0016020	membrane	-	IEA	Component
GO:0016363	nuclear matrix	-	IEA	Component
GO:0016573	histone acetylation	21873635.	IBA	Process
GO:0016887	ATPase activity	10966108.	IDA	Function
GO:0017025	TBP-class protein binding	11080158.	IDA	Function
GO:0031011	Ino80 complex	21873635.	IBA	Component
GO:0031011	Ino80 complex	18026119.21303910.	IDA	Component
GO:0031490	chromatin DNA binding	23637611.	IDA	Function
GO:0032508	DNA duplex unwinding	-	IEA	Process
GO:0034644	cellular response to UV	18026119.	IMP	Process
GO:0035066	positive regulation of histone acetylation	23637611.	IMP	Process
GO:0035267	NuA4 histone acetyltransferase complex	21873635.	IBA	Component
GO:0035267	NuA4 histone acetyltransferase complex	10966108.14966270.	IDA	Component
GO:0040008	regulation of growth	-	IEA	Process
GO:0042802	identical protein binding	10966108.	IDA	Function
GO:0042802	identical protein binding	10966108.21988832.22748767.	IPI	Function
GO:0042803	protein homodimerization activity	-	IEA	Function
GO:0043141	ATP-dependent 5'-3' DNA helicase activity	-	IEA	Function
GO:0043531	ADP binding	-	IEA	Function
GO:0043967	histone H4 acetylation	14966270.	IDA	Process
GO:0043968	histone H2A acetylation	14966270.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	23637611.	IMP	Process
GO:0051082	unfolded protein binding	10524211.	TAS	Function
GO:0051117	ATPase binding	-	IEA	Function
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0071169	establishment of protein localization to chromatin	23637611.	IMP	Process
GO:0071339	MLL1 complex	15960975.	IDA	Component
GO:0071392	cellular response to estradiol stimulus	23637611.	IMP	Process
GO:0071733	transcriptional activation by promoter-enhancer looping	23637611.	IMP	Process
GO:0071899	negative regulation of estrogen receptor binding	23637611.	IMP	Process
GO:0090090	negative regulation of canonical Wnt signaling pathway	11080158.	IDA	Process
GO:0097255	R2TP complex	21873635.	IBA	Component
GO:0097255	R2TP complex	26711270.	IDA	Component
GO:1903507	negative regulation of nucleic acid-templated transcription	-	IEA	Process
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	HMP	Process
GO:1990904	ribonucleoprotein complex	-	IEA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17657734	Overexpression and role of the ATPase and putative DNA helicase RuvB-like 2 in human hepatocellular carcinoma.	Hepatology	2007 Oct	Rousseau B	-
20346530	In vivo silencing of Reptin blocks the progression of human hepatocellular carcinoma in xenografts and is associated with replicative senescence.	J Hepatol	2010 May	M??nard L	doi: 10.1016/j.jhep.2009.12.029
27999200	Metalloproteinase meprin α regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin.	Oncotarget	2017 Jan 31	Breig O	doi: 10.18632/oncotarget.13975.
21763315	RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer.	FEBS Lett	2011 Aug 4	Flavin P	doi: 10.1016/j.febslet.2011.07.005
16699503	Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis.	Nat Cell Biol	2006 Jun	Kim JH	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr19	49004307	Missense_Mutation	novel	A52T	0.55
BLCA	chr19	48993890	5'UTR	novel		0.21
BLCA	chr19	49011039	Silent	NA	I276I	0.24
BLCA	chr19	49007081	Missense_Mutation	NA	S110F	0.2
BLCA	chr19	49007064	Silent	rs372090262	A104A	0.18
BLCA	chr19	49010496	Silent	rs767682271	F224F	0.09
BLCA	chr19	49004384	Silent	novel	G77G	0.1
BLCA	chr19	49015822	Missense_Mutation	NA	E458K	0.21
BRCA	chr19	49004396	Silent	rs377545771	T81T	0.31
BRCA	chr19	49015857	3'UTR	novel		0.13
BRCA	chr19	48993805	5'UTR	novel		0.27
BRCA	chr19	49014481	Splice_Site	novel	X334_splice	0.18
BRCA	chr19	48993789	5'UTR	novel		0.2
BRCA	chr19	49010037	Missense_Mutation	NA	A212T	0.5
CESC	chr19	48993807	5'UTR	novel		0.32
CESC	chr19	49007140	Missense_Mutation	NA	R130C	0.33
CESC	chr19	49010449	Intron	novel		0.27
CESC	chr19	49015141	Silent	rs779474986	R414R	0.36
CESC	chr19	49007329	Silent	rs766947238	E141E	0.11
CESC	chr19	49010077	Intron	novel		0.47
CHOL	chr19	49015671	Missense_Mutation	novel	L451I	0.16
COAD	chr19	49010037	Missense_Mutation	NA	A212T	0.35
COAD	chr19	49015097	Missense_Mutation	rs767467214	R400C	0.26
COAD	chr19	49010002	Missense_Mutation	novel	G200V	0.06
COAD	chr19	49007046	Silent	rs370116802	T98T	0.19
COAD	chr19	49014514	Silent	rs377518857	H344H	0.39
COAD	chr19	49007136	Silent	rs760854037	G128G	0.18
COAD	chr19	49014488	Missense_Mutation	NA	R336W	0.34
COAD	chr19	49011290	Silent	NA	A327A	0.29
COAD	chr19	49004324	Silent	novel	G57G	0.32
COAD	chr19	49010514	Silent	NA	G230G	0.5
COAD	chr19	48993907	5'UTR	rs766555662		0.19
COAD	chr19	49014583	Silent	rs758668870	T367T	0.18
COAD	chr19	49014536	Missense_Mutation	NA	D352N	0.31
GBM	chr19	48999360	Silent	novel	R18R	0.13
GBM	chr19	49011228	Missense_Mutation	novel	E307K	0.23
GBM	chr19	49014578	Missense_Mutation	novel	D366Y	0.45
GBM	chr19	49015607	Silent	novel	V429V	0.24
GBM	chr19	49015872	3'UTR	novel		0.44
GBM	chr19	49007351	Nonsense_Mutation	NA	R149*	0.42
GBM	chr19	49011253	Missense_Mutation	NA	A315D	0.05
GBM	chr19	49004418	Missense_Mutation	NA	G89S	0.28
HNSC	chr19	49011031	Missense_Mutation	novel	E274Q	0.14
HNSC	chr19	48993815	5'UTR	novel		0.16
HNSC	chr19	49009880	Splice_Region	rs185487314	A189A	0.23
HNSC	chr19	49004402	Missense_Mutation	novel	K83N	0.19
HNSC	chr19	49009859	Silent	novel	L182L	0.07
HNSC	chr19	49010096	Intron	novel		0.55
HNSC	chr19	49011027	Silent	novel	V272V	0.14
KIRC	chr19	49010088	Intron	novel		0.15
KIRC	chr19	49014483	Splice_Site	NA	X334_splice	0.15
KIRC	chr19	49007126	Missense_Mutation	NA	R125P	0.27
KIRP	chr19	49007080	Missense_Mutation	NA	S110P	0.36
KIRP	chr19	49014564	Missense_Mutation	novel	P361H	0.3
LAML	chr19	49007351	Nonsense_Mutation	NA	R149*	0.16
LGG	chr19	49015578	Missense_Mutation	NA	E420K	0.25
LIHC	chr19	49003314	Missense_Mutation	NA	D35N	0.46
LIHC	chr19	49010492	Missense_Mutation	novel	K223R	0.3
LUAD	chr19	49015596	Missense_Mutation	NA	I426V	0.77
LUAD	chr19	49010478	Intron	novel		0.42
LUAD	chr19	49015816	Splice_Site	NA	X456_splice	0.18
LUAD	chr19	49007314	Missense_Mutation	novel	E136D	0.23
LUAD	chr19	49003289	Silent	novel	S26S	0.34
LUSC	chr19	49011249	Missense_Mutation	rs187501901	R314W	0.47
LUSC	chr19	49010998	Splice_Site	novel	X263_splice	0.27
LUSC	chr19	49010512	Missense_Mutation	novel	G230W	0.16
LUSC	chr19	49010474	Intron	novel		0.56
LUSC	chr19	49007025	Silent	novel	A91A	0.25
OV	chr19	49014524	Missense_Mutation	NA	I348V	0.36
OV	chr19	49011238	Missense_Mutation	NA	S310F	0.36
OV	chr19	48999366	Missense_Mutation	novel	E20D	0.06
OV	chr19	48999367	Missense_Mutation	novel	R21G	0.06
PAAD	chr19	49004350	Missense_Mutation	novel	G66V	0.17
PAAD	chr19	49007141	Missense_Mutation	rs754112742	R130H	0.04
PAAD	chr19	49007320	Silent	rs750573386	I138I	0.1
PAAD	chr19	49010058	Missense_Mutation	novel	G219C	0.19
PRAD	chr19	49004396	Silent	rs377545771	T81T	0.11
PRAD	chr19	49007141	Missense_Mutation	rs754112742	R130H	0.46
PRAD	chr19	49014604	Splice_Site	NA	X374_splice	0.36
READ	chr19	49011309	Nonsense_Mutation	NA	R334*	0.5
READ	chr19	49007024	Missense_Mutation	rs761782658	A91V	0.24
READ	chr19	49009830	Missense_Mutation	NA	D173N	0.15
SARC	chr19	49011094	Splice_Site	novel	X294_splice	0.27
SARC	chr19	49014602	Missense_Mutation	novel	R374W	0.11
SARC	chr19	49010020	Missense_Mutation	novel	G206A	0.56
SKCM	chr19	49004408	Silent	novel	A85A	0.29
SKCM	chr19	49003300	Missense_Mutation	NA	G30E	0.37
SKCM	chr19	48999337	Missense_Mutation	NA	P11S	0.24
SKCM	chr19	48993808	5'UTR	novel		0.36
SKCM	chr19	49004358	Missense_Mutation	NA	A69S	0.29
SKCM	chr19	49011254	Silent	novel	A315A	0.24
SKCM	chr19	49011255	Silent	novel	L316L	0.22
SKCM	chr19	49004371	Missense_Mutation	NA	V73D	0.41
SKCM	chr19	49007341	Silent	novel	I145I	0.57
SKCM	chr19	49007342	Nonsense_Mutation	novel	Q146*	0.57
SKCM	chr19	49007318	Missense_Mutation	NA	I138V	0.14
SKCM	chr19	49009883	Splice_Site	novel	X190_splice	0.38
STAD	chr19	49004384	Silent	novel	G77G	0.36
STAD	chr19	49004309	Silent	novel	A52A	0.13
STAD	chr19	49009813	Missense_Mutation	novel	E167V	0.16
STAD	chr19	49010000	Silent	rs550156979	T199T	0.35
STAD	chr19	49007140	Missense_Mutation	NA	R130C	0.36
STAD	chr19	49011309	Nonsense_Mutation	NA	R334*	0.23
STAD	chr19	49015581	Missense_Mutation	novel	V421M	0.24
STAD	chr19	49007032	Missense_Mutation	NA	L94M	0.51
STAD	chr19	49015686	Splice_Site	novel	X456_splice	0.18
STAD	chr19	49011198	Missense_Mutation	NA	F297V	0.34
STAD	chr19	49007310	Missense_Mutation	rs776647069	T135M	0.31
STAD	chr19	49010023	Missense_Mutation	rs762109573	R207H	0.31
UCEC	chr19	49014582	Missense_Mutation	rs750596061	T367M	0.13
UCEC	chr19	49011054	Silent	novel	A281A	0.29
UCEC	chr19	49011077	Missense_Mutation	NA	A289V	0.46
UCEC	chr19	49015589	Silent	novel	V423V	0.35
UCEC	chr19	49007136	Silent	rs760854037	G128G	0.29
UCEC	chr19	49015660	Missense_Mutation	novel	Q447R	0.62
UCEC	chr19	49004397	Missense_Mutation	NA	G82W	0.32
UCEC	chr19	49015605	Missense_Mutation	NA	V429I	0.22
UCEC	chr19	49010569	Missense_Mutation	rs770719600	V249I	0.17
UCEC	chr19	49004281	Missense_Mutation	NA	S43L	0.5
UCEC	chr19	48993795	5'UTR	novel		0.5
UCEC	chr19	49010391	Intron	novel		0.43
UCEC	chr19	49009802	Silent	novel	L163L	0.26
UCEC	chr19	48999338	Missense_Mutation	rs371296069	P11L	0.41
UCEC	chr19	49009880	Splice_Region	rs185487314	A189A	0.4
UCEC	chr19	49015655	Missense_Mutation	novel	E445D	0.22
UCEC	chr19	48993696	5'UTR	novel		0.6
UCEC	chr19	49014551	Missense_Mutation	rs772738446	V357I	0.51
UCEC	chr19	49015079	Missense_Mutation	novel	G394R	0.29
UCEC	chr19	49015664	Silent	rs757058036	D448D	0.3
UCEC	chr19	49014572	Missense_Mutation	rs760317774	E364K	0.32
UCEC	chr19	49015062	Missense_Mutation	rs779661942	T388M	0.4
UCEC	chr19	49003294	Missense_Mutation	novel	I28T	0.31
UCEC	chr19	49015927	3'UTR	novel		0.38
UCEC	chr19	49011014	Missense_Mutation	novel	I268N	0.29
UCEC	chr19	48993772	5'UTR	novel		0.5
UCEC	chr19	49010005	Missense_Mutation	NA	K201R	0.17
UCEC	chr19	49010048	Silent	rs138614683	Y215Y	0.48

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.0881	0.027508
KIRP	DEL	0.0486	0.054726
LUAD	DEL	0.2539	1.5526e-05
LUSC	DEL	0.2096	1.1877e-06
PAAD	DEL	0.087	0.035089
READ	DEL	0.0909	0.23023
TGCT	DEL	0.2867	0.0046229
UCS	DEL	0.1964	0.12448

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0008	Kaplan-Meier Survival Analysis
SARC	0.0042	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00018	Kaplan-Meier Survival Analysis
HNSC	0.0022	Kaplan-Meier Survival Analysis
SKCM	0.002	Kaplan-Meier Survival Analysis
TGCT	0.02	Kaplan-Meier Survival Analysis
CESC	0.04	Kaplan-Meier Survival Analysis
LIHC	0.0015	Kaplan-Meier Survival Analysis
DLBC	0.034	Kaplan-Meier Survival Analysis
LGG	0.00016	Kaplan-Meier Survival Analysis
LUAD	0.0017	Kaplan-Meier Survival Analysis
UVM	0.007	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742