EuRBPDB

Description

Ensembl ID: ENSG00000183495 (Gene tree)
Gene ID: 57634
Gene Symbol: EP400
Alias: CAGH32|KIAA1498|P400|KIAA1818|DKFZP434I225|TNRC12
Full Name: E1A binding protein p400
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 131,183 bases
Position: chr12:131,949,920-132,081,102
Accession: 11958
RBP type: non-canonical RBP
Summary: (E1A Binding Protein P400) is a Protein Coding gene. Diseases associated with EP400 include Ossifying Fibromyxoid Tumor. Among its related pathways are Chromatin organization and DNA Damage/Telomere Stress Induced Senescence. Gene Ontology (GO) annotations related to this gene include chromatin binding and helicase activity. An important paralog of this gene is SRCAP.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21673954	Hepatitis C virus NS3 protein can activate the Notch-signaling pathway through binding to a transcription factor, SRCAP.	PLoS One	2011	Iwai A	doi: 10.1371/journal.pone.0020718
26551076	R loops regulate promoter-proximal chromatin architecture and cellular differentiation.	Nat Struct Mol Biol	2015 Dec	Chen PB	doi: 10.1038/nsmb.3122

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000611739	EP400-207	4314	-	-	- (aa)	-	-
ENST00000333577	EP400-203	3092	-	ENSP00000333602	985 (aa)	-	A0A0A0MR80
ENST00000330386	EP400-201	3908	-	ENSP00000330620	374 (aa)	-	A0A0A0MR70
ENST00000389562	EP400-205	12836	-	ENSP00000374213	3123 (aa)	-	Q96L91
ENST00000389561	EP400-204	12317	-	ENSP00000374212	3123 (aa)	-	Q96L91
ENST00000332482	EP400-202	2588	-	ENSP00000331737	826 (aa)	-	A0A0A0MR72
ENST00000611118	EP400-206	2403	-	-	- (aa)	-	-
ENST00000611841	EP400-208	3129	-	-	- (aa)	-	-
ENST00000616136	EP400-209	3134	-	-	- (aa)	-	-

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000183495	rs12318272	12	132049192	G	Red cell distribution width	28957414	[0.066-0.117] unit decrease	0.0914211	EFO_0005192

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000183495	EP400	95	89.694	ENSMUSG00000029505	Ep400	99	85.507	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000812	Swr1 complex	24463511.	IDA	Component
GO:0003677	DNA binding	-	IEA	Function
GO:0003682	chromatin binding	-	IEA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005515	protein binding	17314511.18413597.21150319.21516116.25416956.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0016607	nuclear speck	-	ISS	Component
GO:0035267	NuA4 histone acetyltransferase complex	14966270.	IDA	Component
GO:0043967	histone H4 acetylation	14966270.	IDA	Process
GO:0043968	histone H2A acetylation	14966270.	IDA	Process
GO:1990405	protein antigen binding	-	IEA	Function