EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000183576 (Gene tree)
Gene ID: 84193
Gene Symbol: SETD3
Alias: FLJ23027|C14orf154
Full Name: SET domain containing 3, actin histidine methyltransferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 83,673 bases
Position: chr14:99,397,746-99,481,418
Accession: 20493
RBP type: non-canonical RBP
Summary: (SET Domain Containing 3, Actin Histidine Methyltransferase) is a Protein Coding gene. Diseases associated with SETD3 include Renal Cell Carcinoma, Papillary, 1. Among its related pathways are Chromatin organization and Lysine degradation. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and histone methyltransferase activity (H3-K4 specific). An important paralog of this gene is SETD6.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000630307	SETD3-209	1281	-	ENSP00000486445	81 (aa)	-	C9K0W5
ENST00000446066	SETD3-205	1754	-	ENSP00000396870	81 (aa)	-	C9K0W5
ENST00000489770	SETD3-208	855	-	-	- (aa)	-	-
ENST00000331768	SETD3-202	2878	XM_005268127	ENSP00000327436	594 (aa)	XP_005268184	Q86TU7
ENST00000357563	SETD3-203	2191	-	ENSP00000350174	81 (aa)	-	C9K0W5
ENST00000453764	SETD3-206	973	-	ENSP00000398966	81 (aa)	-	C9K0W5
ENST00000453938	SETD3-207	545	-	-	- (aa)	-	-
ENST00000329331	SETD3-201	1330	XM_011537235	ENSP00000327910	296 (aa)	XP_011535537	Q86TU7
ENST00000436070	SETD3-204	2592	-	ENSP00000408602	292 (aa)	-	Q6NXR6

Gene Model

Click here to download ENSG00000183576's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00310	Lysine degradation	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000183576	rs148151659	14	99410185	C	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.35-0.91] unit increase	0.6329	EFO_0007788
ENSG00000183576	rs148151659	14	99410185	C	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.37-0.95] unit increase	0.6594	EFO_0007788
ENSG00000183576	rs148151659	14	99410185	C	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.61-1.35] unit increase	0.9768	EFO_0007788
ENSG00000183576	rs148151659	14	99410185	C	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.58-1.28] unit increase	0.9283	EFO_0007788

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000183576's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000790	nuclear chromatin	21873635.	IBA	Component
GO:0001102	RNA polymerase II activating transcription factor binding	-	IEA	Function
GO:0003713	transcription coactivator activity	21873635.	IBA	Function
GO:0003713	transcription coactivator activity	-	ISS	Function
GO:0003779	actin binding	-	IEA	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	30626964.	IDA	Component
GO:0010452	histone H3-K36 methylation	-	ISS	Process
GO:0016279	protein-lysine N-methyltransferase activity	21873635.	IBA	Function
GO:0018021	peptidyl-histidine methylation	30526847.30626964.	IDA	Process
GO:0018023	peptidyl-lysine trimethylation	21873635.	IBA	Process
GO:0018023	peptidyl-lysine trimethylation	-	ISS	Process
GO:0018026	peptidyl-lysine monomethylation	21873635.	IBA	Process
GO:0018026	peptidyl-lysine monomethylation	-	ISS	Process
GO:0018027	peptidyl-lysine dimethylation	21873635.	IBA	Process
GO:0018027	peptidyl-lysine dimethylation	-	ISS	Process
GO:0018064	protein-histidine N-methyltransferase activity	30526847.30626964.	IDA	Function
GO:0030047	actin modification	30526847.30626964.	IDA	Process
GO:0042800	histone methyltransferase activity (H3-K4 specific)	21873635.	IBA	Function
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0046975	histone methyltransferase activity (H3-K36 specific)	21873635.	IBA	Function
GO:0046975	histone methyltransferase activity (H3-K36 specific)	-	ISS	Function
GO:0051149	positive regulation of muscle cell differentiation	-	IEA	Process
GO:0051568	histone H3-K4 methylation	-	IEA	Process
GO:0070472	regulation of uterine smooth muscle contraction	-	ISS	Process