EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000183665 (Gene tree)
Gene ID: 55039
Gene Symbol: TRMT12
Alias: FLJ20772|Trm12|TYW2
Full Name: tRNA methyltransferase 12 homolog
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 11,344 bases
Position: chr8:124,450,807-124,462,150
Accession: 26091
RBP type: canonical RBP
Summary: Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000329858	Met_10	PF02475.16	1.5e-29	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000521443	TRMT12-202	562	-	-	- (aa)	-	-
ENST00000328599	TRMT12-201	2207	-	ENSP00000329858	448 (aa)	-	Q53H54
ENST00000522518	TRMT12-203	822	-	ENSP00000429771	150 (aa)	-	E5RHH6

Gene Model

Click here to download ENSG00000183665's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000183665's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000183665	TRMT12	92	51.090	ENSAPOG00000011979	trmt12	96	51.090	Acanthochromis_polyacanthus
ENSG00000183665	TRMT12	98	87.755	ENSAMEG00000019612	TRMT12	98	87.755	Ailuropoda_melanoleuca
ENSG00000183665	TRMT12	74	68.750	ENSACIG00000012982	trmt12	99	49.631	Amphilophus_citrinellus
ENSG00000183665	TRMT12	91	50.860	ENSAOCG00000020570	trmt12	96	52.163	Amphiprion_ocellaris
ENSG00000183665	TRMT12	91	50.860	ENSAPEG00000006335	trmt12	96	52.163	Amphiprion_percula
ENSG00000183665	TRMT12	92	50.966	ENSATEG00000018316	trmt12	97	50.966	Anabas_testudineus
ENSG00000183665	TRMT12	92	50.121	ENSACLG00000001008	trmt12	96	50.121	Astatotilapia_calliptera
ENSG00000183665	TRMT12	93	51.651	ENSAMXG00000040366	trmt12	97	51.651	Astyanax_mexicanus
ENSG00000183665	TRMT12	99	83.669	ENSBTAG00000020398	TRMT12	97	83.669	Bos_taurus
ENSG00000183665	TRMT12	100	95.238	ENSCJAG00000022174	TRMT12	100	93.527	Callithrix_jacchus
ENSG00000183665	TRMT12	97	87.586	ENSCAFG00000001040	TRMT12	99	87.586	Canis_familiaris
ENSG00000183665	TRMT12	97	87.586	ENSCAFG00020006500	TRMT12	99	87.586	Canis_lupus_dingo
ENSG00000183665	TRMT12	97	85.714	ENSCHIG00000016574	TRMT12	99	85.714	Capra_hircus
ENSG00000183665	TRMT12	98	88.095	ENSCPOG00000026520	TRMT12	100	82.472	Cavia_porcellus
ENSG00000183665	TRMT12	100	96.205	ENSCSAG00000018615	TRMT12	100	96.205	Chlorocebus_sabaeus
ENSG00000183665	TRMT12	86	75.000	ENSCPBG00000014290	TRMT12	95	63.864	Chrysemys_picta_bellii
ENSG00000183665	TRMT12	69	45.253	ENSCING00000019633	-	97	45.253	Ciona_intestinalis
ENSG00000183665	TRMT12	71	47.003	ENSCSAVG00000000415	-	92	47.003	Ciona_savignyi
ENSG00000183665	TRMT12	91	72.973	ENSCGRG00001014834	Trmt12	99	62.500	Cricetulus_griseus_chok1gshd
ENSG00000183665	TRMT12	92	49.395	ENSCSEG00000002675	trmt12	92	49.395	Cynoglossus_semilaevis
ENSG00000183665	TRMT12	93	51.190	ENSCVAG00000005590	trmt12	98	51.069	Cyprinodon_variegatus
ENSG00000183665	TRMT12	92	49.395	ENSDARG00000060338	trmt12	95	52.593	Danio_rerio
ENSG00000183665	TRMT12	99	80.952	ENSETEG00000009373	TRMT12	99	76.957	Echinops_telfairi
ENSG00000183665	TRMT12	98	87.699	ENSEASG00005022441	TRMT12	100	87.699	Equus_asinus_asinus
ENSG00000183665	TRMT12	99	80.090	ENSEEUG00000004844	TRMT12	99	80.090	Erinaceus_europaeus
ENSG00000183665	TRMT12	92	51.202	ENSELUG00000004240	trmt12	99	51.889	Esox_lucius
ENSG00000183665	TRMT12	64	62.369	ENSFALG00000003825	TRMT12	94	70.388	Ficedula_albicollis
ENSG00000183665	TRMT12	98	85.194	ENSFDAG00000016647	TRMT12	100	85.194	Fukomys_damarensis
ENSG00000183665	TRMT12	91	43.521	ENSFHEG00000017338	trmt12	98	43.521	Fundulus_heteroclitus
ENSG00000183665	TRMT12	81	61.957	ENSGALG00000006773	TRMT12	78	61.957	Gallus_gallus
ENSG00000183665	TRMT12	79	65.625	ENSGAFG00000020056	trmt12	96	49.637	Gambusia_affinis
ENSG00000183665	TRMT12	92	49.392	ENSGACG00000017351	trmt12	100	49.392	Gasterosteus_aculeatus
ENSG00000183665	TRMT12	91	72.500	ENSGAGG00000006032	TRMT12	99	63.739	Gopherus_agassizii
ENSG00000183665	TRMT12	92	50.121	ENSHBUG00000016412	trmt12	96	50.121	Haplochromis_burtoni
ENSG00000183665	TRMT12	97	85.550	ENSHGLG00000020498	TRMT12	99	85.550	Heterocephalus_glaber_female
ENSG00000183665	TRMT12	97	85.550	ENSHGLG00100020132	TRMT12	99	85.550	Heterocephalus_glaber_male
ENSG00000183665	TRMT12	92	48.668	ENSHCOG00000005050	trmt12	94	52.149	Hippocampus_comes
ENSG00000183665	TRMT12	93	51.442	ENSIPUG00000018011	trmt12	89	51.442	Ictalurus_punctatus
ENSG00000183665	TRMT12	97	86.636	ENSSTOG00000030617	TRMT12	98	86.636	Ictidomys_tridecemlineatus
ENSG00000183665	TRMT12	92	49.519	ENSKMAG00000000891	trmt12	96	49.519	Kryptolebias_marmoratus
ENSG00000183665	TRMT12	53	55.187	ENSLBEG00000017456	-	88	55.187	Labrus_bergylta
ENSG00000183665	TRMT12	92	47.952	ENSLBEG00000028712	trmt12	96	47.952	Labrus_bergylta
ENSG00000183665	TRMT12	95	67.568	ENSLACG00000015869	TRMT12	99	56.404	Latimeria_chalumnae
ENSG00000183665	TRMT12	85	67.568	ENSLOCG00000015290	trmt12	99	54.292	Lepisosteus_oculatus
ENSG00000183665	TRMT12	98	86.333	ENSLAFG00000012519	TRMT12	100	86.333	Loxodonta_africana
ENSG00000183665	TRMT12	99	96.854	ENSMMUG00000015490	TRMT12	100	96.854	Macaca_mulatta
ENSG00000183665	TRMT12	92	50.962	ENSMAMG00000020311	trmt12	97	50.962	Mastacembelus_armatus
ENSG00000183665	TRMT12	92	49.637	ENSMZEG00005007349	trmt12	96	49.637	Maylandia_zebra
ENSG00000183665	TRMT12	95	58.933	ENSMGAG00000004174	TRMT12	95	58.933	Meleagris_gallopavo
ENSG00000183665	TRMT12	91	50.123	ENSMMOG00000000412	trmt12	95	50.123	Mola_mola
ENSG00000183665	TRMT12	99	66.516	ENSMODG00000021403	-	99	66.516	Monodelphis_domestica
ENSG00000183665	TRMT12	95	68.632	ENSMODG00000011798	-	87	68.632	Monodelphis_domestica
ENSG00000183665	TRMT12	78	67.568	ENSMALG00000008668	trmt12	96	51.090	Monopterus_albus
ENSG00000183665	TRMT12	98	80.866	MGP_CAROLIEiJ_G0019820	Trmt12	98	80.866	Mus_caroli
ENSG00000183665	TRMT12	98	81.007	ENSMUSG00000037085	Trmt12	98	81.007	Mus_musculus
ENSG00000183665	TRMT12	98	80.594	MGP_PahariEiJ_G0019829	Trmt12	98	80.594	Mus_pahari
ENSG00000183665	TRMT12	98	80.778	MGP_SPRETEiJ_G0020717	Trmt12	98	80.778	Mus_spretus
ENSG00000183665	TRMT12	98	87.528	ENSMPUG00000019150	TRMT12	99	87.528	Mustela_putorius_furo
ENSG00000183665	TRMT12	94	90.476	ENSMLUG00000003753	TRMT12	100	84.282	Myotis_lucifugus
ENSG00000183665	TRMT12	98	81.321	ENSNGAG00000014548	Trmt12	100	81.321	Nannospalax_galili
ENSG00000183665	TRMT12	92	50.365	ENSNBRG00000021510	trmt12	96	50.365	Neolamprologus_brichardi
ENSG00000183665	TRMT12	98	72.210	ENSOPRG00000008067	TRMT12	98	72.210	Ochotona_princeps
ENSG00000183665	TRMT12	94	88.095	ENSODEG00000018933	TRMT12	100	82.460	Octodon_degus
ENSG00000183665	TRMT12	92	50.605	ENSONIG00000002614	trmt12	96	50.605	Oreochromis_niloticus
ENSG00000183665	TRMT12	91	78.571	ENSOANG00000009987	TRMT12	100	64.516	Ornithorhynchus_anatinus
ENSG00000183665	TRMT12	97	78.440	ENSOCUG00000026379	TRMT12	97	78.440	Oryctolagus_cuniculus
ENSG00000183665	TRMT12	92	50.363	ENSORLG00000001280	trmt12	96	50.847	Oryzias_latipes
ENSG00000183665	TRMT12	92	50.121	ENSORLG00020000708	trmt12	96	50.605	Oryzias_latipes_hni
ENSG00000183665	TRMT12	92	50.605	ENSORLG00015012344	trmt12	96	50.605	Oryzias_latipes_hsok
ENSG00000183665	TRMT12	93	50.120	ENSOMEG00000015267	trmt12	96	50.120	Oryzias_melastigma
ENSG00000183665	TRMT12	98	84.966	ENSOGAG00000015845	TRMT12	100	84.966	Otolemur_garnettii
ENSG00000183665	TRMT12	93	53.444	ENSPKIG00000004640	trmt12	99	53.222	Paramormyrops_kingsleyae
ENSG00000183665	TRMT12	58	67.910	ENSPSIG00000003476	TRMT12	99	67.910	Pelodiscus_sinensis
ENSG00000183665	TRMT12	93	46.506	ENSPMGG00000016356	trmt12	94	46.506	Periophthalmus_magnuspinnatus
ENSG00000183665	TRMT12	98	67.574	ENSPCIG00000002967	TRMT12	91	67.574	Phascolarctos_cinereus
ENSG00000183665	TRMT12	97	48.037	ENSPFOG00000016931	trmt12	99	48.037	Poecilia_formosa
ENSG00000183665	TRMT12	92	48.681	ENSPLAG00000020621	trmt12	96	48.681	Poecilia_latipinna
ENSG00000183665	TRMT12	92	50.121	ENSPMEG00000000818	trmt12	96	50.121	Poecilia_mexicana
ENSG00000183665	TRMT12	79	62.500	ENSPREG00000011621	trmt12	96	49.153	Poecilia_reticulata
ENSG00000183665	TRMT12	100	98.438	ENSPPYG00000018866	TRMT12	100	98.438	Pongo_abelii
ENSG00000183665	TRMT12	99	82.579	ENSPCAG00000000556	TRMT12	99	82.579	Procavia_capensis
ENSG00000183665	TRMT12	100	84.598	ENSPVAG00000009149	TRMT12	100	84.598	Pteropus_vampyrus
ENSG00000183665	TRMT12	91	49.877	ENSPNYG00000010696	trmt12	99	49.877	Pundamilia_nyererei
ENSG00000183665	TRMT12	92	49.763	ENSPNAG00000019028	trmt12	96	49.763	Pygocentrus_nattereri
ENSG00000183665	TRMT12	98	82.232	ENSRNOG00000008978	Trmt12	100	82.232	Rattus_norvegicus
ENSG00000183665	TRMT12	97	66.975	ENSSHAG00000003345	TRMT12	96	66.975	Sarcophilus_harrisii
ENSG00000183665	TRMT12	95	50.698	ENSSFOG00015006090	trmt12	99	50.698	Scleropages_formosus
ENSG00000183665	TRMT12	92	50.605	ENSSMAG00000013247	trmt12	96	50.605	Scophthalmus_maximus
ENSG00000183665	TRMT12	91	52.580	ENSSDUG00000006168	trmt12	96	52.580	Seriola_dumerili
ENSG00000183665	TRMT12	92	52.058	ENSSLDG00000025007	trmt12	96	52.058	Seriola_lalandi_dorsalis
ENSG00000183665	TRMT12	95	60.920	ENSSPUG00000005321	TRMT12	96	60.920	Sphenodon_punctatus
ENSG00000183665	TRMT12	92	50.121	ENSSPAG00000009435	trmt12	93	50.121	Stegastes_partitus
ENSG00000183665	TRMT12	95	55.399	ENSTGUG00000002280	TRMT12	99	55.220	Taeniopygia_guttata
ENSG00000183665	TRMT12	94	49.644	ENSTRUG00000011548	trmt12	95	50.000	Takifugu_rubripes
ENSG00000183665	TRMT12	86	53.247	ENSTNIG00000016866	trmt12	88	53.247	Tetraodon_nigroviridis
ENSG00000183665	TRMT12	97	86.636	ENSUAMG00000002067	TRMT12	99	86.636	Ursus_americanus
ENSG00000183665	TRMT12	99	86.682	ENSVPAG00000006519	TRMT12	99	86.682	Vicugna_pacos
ENSG00000183665	TRMT12	96	85.880	ENSVVUG00000016790	TRMT12	97	85.880	Vulpes_vulpes
ENSG00000183665	TRMT12	95	63.415	ENSXETG00000009641	trmt12	98	54.773	Xenopus_tropicalis
ENSG00000183665	TRMT12	92	49.760	ENSXCOG00000016505	trmt12	99	46.824	Xiphophorus_couchianus
ENSG00000183665	TRMT12	92	49.517	ENSXMAG00000025318	trmt12	96	49.517	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0008175	tRNA methyltransferase activity	21873635.	IBA	Function
GO:0030488	tRNA methylation	21873635.	IBA	Process
GO:0031591	wybutosine biosynthetic process	21873635.	IBA	Process
GO:0102522	tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity	-	IEA	Function