EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000183864 (Gene tree)
Gene ID: 10766
Gene Symbol: TOB2
Alias: TOBL|TOB4|bK223H9|APRO5|TROB2
Full Name: transducer of ERBB2, 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 14,743 bases
Position: chr22:41,433,488-41,448,230
Accession: 11980
RBP type: canonical RBP
Summary: TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000331305	PAM2	PF07145.15	6.8e-12	1	2
ENSP00000331305	PAM2	PF07145.15	6.8e-12	2	2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000327492	TOB2-201	4561	XM_005261315	ENSP00000331305	344 (aa)	XP_005261372	Q14106
ENST00000434408	TOB2-202	777	-	ENSP00000388549	101 (aa)	-	B0QXZ4

Gene Model

Click here to download ENSG00000183864's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000183864's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000183864	TOB2	100	79.208	ENSAPOG00000011510	TOB2	100	57.910	Acanthochromis_polyacanthus
ENSG00000183864	TOB2	100	97.030	ENSAMEG00000018561	TOB2	100	91.014	Ailuropoda_melanoleuca
ENSG00000183864	TOB2	100	79.208	ENSACIG00000009336	TOB2	100	52.991	Amphilophus_citrinellus
ENSG00000183864	TOB2	100	79.208	ENSAOCG00000019128	TOB2	100	59.944	Amphiprion_ocellaris
ENSG00000183864	TOB2	100	79.208	ENSAPEG00000012405	TOB2	100	58.000	Amphiprion_percula
ENSG00000183864	TOB2	100	78.218	ENSATEG00000007981	TOB2	100	58.242	Anabas_testudineus
ENSG00000183864	TOB2	97	86.735	ENSACAG00000004782	TOB2	100	79.598	Anolis_carolinensis
ENSG00000183864	TOB2	100	78.218	ENSACLG00000013836	TOB2	100	56.780	Astatotilapia_calliptera
ENSG00000183864	TOB2	100	75.248	ENSAMXG00000031031	TOB2	100	56.948	Astyanax_mexicanus
ENSG00000183864	TOB2	100	98.020	ENSBTAG00000015109	TOB2	100	94.493	Bos_taurus
ENSG00000183864	TOB2	100	100.000	ENSCJAG00000038649	TOB2	100	98.256	Callithrix_jacchus
ENSG00000183864	TOB2	100	97.030	ENSCAFG00000001092	TOB2	99	83.478	Canis_familiaris
ENSG00000183864	TOB2	100	97.030	ENSCAFG00020001990	TOB2	100	91.594	Canis_lupus_dingo
ENSG00000183864	TOB2	100	98.020	ENSCHIG00000003528	TOB2	100	94.203	Capra_hircus
ENSG00000183864	TOB2	100	98.020	ENSCAPG00000005711	TOB2	100	89.049	Cavia_aperea
ENSG00000183864	TOB2	100	98.020	ENSCPOG00000031873	TOB2	100	88.761	Cavia_porcellus
ENSG00000183864	TOB2	100	99.010	ENSCATG00000021391	TOB2	100	96.802	Cercocebus_atys
ENSG00000183864	TOB2	100	96.040	ENSCLAG00000016670	TOB2	100	88.116	Chinchilla_lanigera
ENSG00000183864	TOB2	100	99.419	ENSCSAG00000019283	TOB2	100	99.419	Chlorocebus_sabaeus
ENSG00000183864	TOB2	100	100.000	ENSCGRG00001010039	Tob2	100	93.043	Cricetulus_griseus_chok1gshd
ENSG00000183864	TOB2	100	100.000	ENSCGRG00000019526	Tob2	100	92.754	Cricetulus_griseus_crigri
ENSG00000183864	TOB2	100	79.208	ENSCSEG00000006692	TOB2	100	59.437	Cynoglossus_semilaevis
ENSG00000183864	TOB2	100	76.238	ENSCVAG00000010698	TOB2	100	56.906	Cyprinodon_variegatus
ENSG00000183864	TOB2	100	98.020	ENSDNOG00000016431	TOB2	100	96.232	Dasypus_novemcinctus
ENSG00000183864	TOB2	100	99.010	ENSDORG00000002204	Tob2	100	88.406	Dipodomys_ordii
ENSG00000183864	TOB2	100	99.010	ENSETEG00000010740	TOB2	100	86.533	Echinops_telfairi
ENSG00000183864	TOB2	100	98.020	ENSEASG00005001564	TOB2	100	95.362	Equus_asinus_asinus
ENSG00000183864	TOB2	100	98.020	ENSECAG00000001192	TOB2	100	96.232	Equus_caballus
ENSG00000183864	TOB2	100	96.040	ENSEEUG00000001912	TOB2	100	92.174	Erinaceus_europaeus
ENSG00000183864	TOB2	100	78.218	ENSELUG00000007725	TOB2	100	53.175	Esox_lucius
ENSG00000183864	TOB2	100	98.020	ENSFCAG00000003675	TOB2	100	91.014	Felis_catus
ENSG00000183864	TOB2	100	72.443	ENSFALG00000011965	TOB2	100	72.443	Ficedula_albicollis
ENSG00000183864	TOB2	100	98.020	ENSFDAG00000001578	TOB2	100	89.565	Fukomys_damarensis
ENSG00000183864	TOB2	100	97.030	ENSGALG00000011957	TOB2	100	82.571	Gallus_gallus
ENSG00000183864	TOB2	100	82.178	ENSGAFG00000000508	-	99	57.224	Gambusia_affinis
ENSG00000183864	TOB2	100	79.208	ENSGAFG00000010880	TOB2	100	56.868	Gambusia_affinis
ENSG00000183864	TOB2	100	77.228	ENSGACG00000007621	TOB2	100	57.025	Gasterosteus_aculeatus
ENSG00000183864	TOB2	100	97.030	ENSGAGG00000017489	TOB2	100	81.143	Gopherus_agassizii
ENSG00000183864	TOB2	100	78.218	ENSHBUG00000017701	TOB2	100	56.780	Haplochromis_burtoni
ENSG00000183864	TOB2	100	98.020	ENSHGLG00000009302	TOB2	100	91.594	Heterocephalus_glaber_female
ENSG00000183864	TOB2	100	98.020	ENSHGLG00100008968	TOB2	100	91.594	Heterocephalus_glaber_male
ENSG00000183864	TOB2	100	79.208	ENSHCOG00000006912	TOB2	100	58.611	Hippocampus_comes
ENSG00000183864	TOB2	100	76.238	ENSIPUG00000019765	TOB2	100	53.803	Ictalurus_punctatus
ENSG00000183864	TOB2	97	72.239	ENSSTOG00000003202	-	100	71.343	Ictidomys_tridecemlineatus
ENSG00000183864	TOB2	100	98.020	ENSSTOG00000016206	-	100	95.072	Ictidomys_tridecemlineatus
ENSG00000183864	TOB2	100	100.000	ENSJJAG00000005169	Tob2	100	93.043	Jaculus_jaculus
ENSG00000183864	TOB2	100	79.208	ENSKMAG00000014878	TOB2	100	54.945	Kryptolebias_marmoratus
ENSG00000183864	TOB2	100	80.198	ENSLBEG00000008427	-	84	54.012	Labrus_bergylta
ENSG00000183864	TOB2	100	86.139	ENSLACG00000012403	TOB2	100	68.681	Latimeria_chalumnae
ENSG00000183864	TOB2	100	74.257	ENSLOCG00000011604	TOB2	99	54.286	Lepisosteus_oculatus
ENSG00000183864	TOB2	100	98.020	ENSLAFG00000027484	TOB2	100	94.203	Loxodonta_africana
ENSG00000183864	TOB2	100	99.010	ENSMFAG00000019801	TOB2	100	96.802	Macaca_fascicularis
ENSG00000183864	TOB2	100	99.010	ENSMMUG00000002554	TOB2	100	96.802	Macaca_mulatta
ENSG00000183864	TOB2	100	99.010	ENSMNEG00000020529	TOB2	100	96.802	Macaca_nemestrina
ENSG00000183864	TOB2	100	99.010	ENSMLEG00000011426	TOB2	100	96.802	Mandrillus_leucophaeus
ENSG00000183864	TOB2	100	79.208	ENSMAMG00000007358	TOB2	100	60.167	Mastacembelus_armatus
ENSG00000183864	TOB2	100	78.218	ENSMZEG00005003307	TOB2	100	56.780	Maylandia_zebra
ENSG00000183864	TOB2	100	97.030	ENSMGAG00000015716	TOB2	100	82.286	Meleagris_gallopavo
ENSG00000183864	TOB2	100	99.010	ENSMAUG00000007650	Tob2	100	91.304	Mesocricetus_auratus
ENSG00000183864	TOB2	100	99.010	ENSMICG00000044468	TOB2	100	95.072	Microcebus_murinus
ENSG00000183864	TOB2	100	100.000	ENSMOCG00000021112	Tob2	100	91.304	Microtus_ochrogaster
ENSG00000183864	TOB2	100	78.218	ENSMMOG00000002701	TOB2	100	59.341	Mola_mola
ENSG00000183864	TOB2	100	79.208	ENSMALG00000013340	TOB2	100	54.318	Monopterus_albus
ENSG00000183864	TOB2	100	98.020	MGP_CAROLIEiJ_G0020060	Tob2	100	89.565	Mus_caroli
ENSG00000183864	TOB2	100	98.020	ENSMUSG00000048546	Tob2	100	89.565	Mus_musculus
ENSG00000183864	TOB2	100	98.020	MGP_PahariEiJ_G0020062	Tob2	100	89.275	Mus_pahari
ENSG00000183864	TOB2	100	98.020	MGP_SPRETEiJ_G0020961	Tob2	100	89.565	Mus_spretus
ENSG00000183864	TOB2	100	97.030	ENSMPUG00000019594	TOB2	100	90.145	Mustela_putorius_furo
ENSG00000183864	TOB2	100	98.020	ENSMLUG00000002462	TOB2	99	92.754	Myotis_lucifugus
ENSG00000183864	TOB2	100	97.030	ENSNGAG00000008266	Tob2	100	91.014	Nannospalax_galili
ENSG00000183864	TOB2	100	78.218	ENSNBRG00000003831	TOB2	100	55.014	Neolamprologus_brichardi
ENSG00000183864	TOB2	100	94.059	ENSMEUG00000002011	TOB2	100	82.759	Notamacropus_eugenii
ENSG00000183864	TOB2	100	97.030	ENSODEG00000020030	TOB2	100	89.275	Octodon_degus
ENSG00000183864	TOB2	100	79.208	ENSONIG00000008481	TOB2	99	59.341	Oreochromis_niloticus
ENSG00000183864	TOB2	100	94.059	ENSOANG00000009031	TOB2	98	85.366	Ornithorhynchus_anatinus
ENSG00000183864	TOB2	100	96.040	ENSOCUG00000027909	TOB2	100	89.855	Oryctolagus_cuniculus
ENSG00000183864	TOB2	100	76.238	ENSORLG00000014151	TOB2	100	55.714	Oryzias_latipes
ENSG00000183864	TOB2	100	77.228	ENSORLG00020007791	TOB2	100	56.000	Oryzias_latipes_hni
ENSG00000183864	TOB2	100	77.228	ENSORLG00015019053	TOB2	100	56.000	Oryzias_latipes_hsok
ENSG00000183864	TOB2	100	78.218	ENSOMEG00000005730	TOB2	100	55.932	Oryzias_melastigma
ENSG00000183864	TOB2	100	99.010	ENSOGAG00000008831	TOB2	99	96.221	Otolemur_garnettii
ENSG00000183864	TOB2	100	98.020	ENSOARG00000025175	TOB2	100	90.145	Ovis_aries
ENSG00000183864	TOB2	100	98.020	ENSPPRG00000021427	TOB2	100	91.594	Panthera_pardus
ENSG00000183864	TOB2	100	98.020	ENSPTIG00000004228	TOB2	99	77.971	Panthera_tigris_altaica
ENSG00000183864	TOB2	100	99.010	ENSPANG00000009655	TOB2	100	96.802	Papio_anubis
ENSG00000183864	TOB2	100	73.267	ENSPKIG00000003127	TOB2	78	45.538	Paramormyrops_kingsleyae
ENSG00000183864	TOB2	100	79.208	ENSPKIG00000008630	TOB2	100	55.307	Paramormyrops_kingsleyae
ENSG00000183864	TOB2	100	97.030	ENSPSIG00000007002	TOB2	100	81.714	Pelodiscus_sinensis
ENSG00000183864	TOB2	100	79.208	ENSPMGG00000018033	TOB2	100	56.944	Periophthalmus_magnuspinnatus
ENSG00000183864	TOB2	100	91.089	ENSPCIG00000026533	TOB2	85	81.921	Phascolarctos_cinereus
ENSG00000183864	TOB2	97	79.592	ENSPFOG00000020913	TOB2	99	50.122	Poecilia_formosa
ENSG00000183864	TOB2	100	79.208	ENSPLAG00000017429	TOB2	100	55.618	Poecilia_latipinna
ENSG00000183864	TOB2	100	79.208	ENSPMEG00000018241	TOB2	100	55.618	Poecilia_mexicana
ENSG00000183864	TOB2	100	79.208	ENSPREG00000017632	TOB2	100	55.337	Poecilia_reticulata
ENSG00000183864	TOB2	100	100.000	ENSPPYG00000011869	TOB2	100	99.709	Pongo_abelii
ENSG00000183864	TOB2	100	98.020	ENSPVAG00000001161	TOB2	100	95.072	Pteropus_vampyrus
ENSG00000183864	TOB2	100	78.218	ENSPNYG00000024071	TOB2	100	56.780	Pundamilia_nyererei
ENSG00000183864	TOB2	100	75.248	ENSPNAG00000007174	TOB2	100	55.874	Pygocentrus_nattereri
ENSG00000183864	TOB2	100	98.020	ENSRNOG00000050500	Tob2	100	91.040	Rattus_norvegicus
ENSG00000183864	TOB2	100	97.030	ENSSHAG00000009821	TOB2	90	94.330	Sarcophilus_harrisii
ENSG00000183864	TOB2	100	80.198	ENSSFOG00015011501	TOB2	92	50.237	Scleropages_formosus
ENSG00000183864	TOB2	100	77.228	ENSSMAG00000005849	TOB2	100	57.407	Scophthalmus_maximus
ENSG00000183864	TOB2	100	79.208	ENSSDUG00000014888	TOB2	100	48.926	Seriola_dumerili
ENSG00000183864	TOB2	100	79.208	ENSSLDG00000018271	TOB2	100	48.926	Seriola_lalandi_dorsalis
ENSG00000183864	TOB2	100	79.208	ENSSPAG00000017858	TOB2	100	59.218	Stegastes_partitus
ENSG00000183864	TOB2	100	98.020	ENSSSCG00000037958	TOB2	100	89.577	Sus_scrofa
ENSG00000183864	TOB2	100	97.030	ENSTGUG00000009941	TOB2	100	82.102	Taeniopygia_guttata
ENSG00000183864	TOB2	100	78.218	ENSTRUG00000020606	TOB2	100	51.566	Takifugu_rubripes
ENSG00000183864	TOB2	100	76.238	ENSTNIG00000002073	-	100	56.389	Tetraodon_nigroviridis
ENSG00000183864	TOB2	100	99.010	ENSTBEG00000010846	TOB2	100	91.304	Tupaia_belangeri
ENSG00000183864	TOB2	100	98.020	ENSTTRG00000003366	TOB2	100	91.570	Tursiops_truncatus
ENSG00000183864	TOB2	100	97.030	ENSUAMG00000026206	TOB2	100	91.014	Ursus_americanus
ENSG00000183864	TOB2	100	97.030	ENSVVUG00000003649	TOB2	100	91.014	Vulpes_vulpes
ENSG00000183864	TOB2	100	79.208	ENSXCOG00000016016	TOB2	100	57.022	Xiphophorus_couchianus
ENSG00000183864	TOB2	100	79.208	ENSXMAG00000021999	TOB2	100	57.022	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003714	transcription corepressor activity	21873635.	IBA	Function
GO:0005515	protein binding	19838187.23340509.25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0007292	female gamete generation	10602502.	TAS	Process
GO:0008285	negative regulation of cell proliferation	-	IEA	Process
GO:0010468	regulation of gene expression	21873635.	IBA	Process
GO:0042809	vitamin D receptor binding	-	IEA	Function
GO:0045671	negative regulation of osteoclast differentiation	-	IEA	Process
GO:0045778	positive regulation of ossification	-	IEA	Process
GO:1903507	negative regulation of nucleic acid-templated transcription	-	IEA	Process