EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000184575 (Gene tree)
Gene ID: 11260
Gene Symbol: XPOT
Alias: XPO3
Full Name: exportin for tRNA
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 46,778 bases
Position: chr12:64,404,350-64,451,127
Accession: 12826
RBP type: canonical RBP
Summary: This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000327821	Xpo1	PF08389.12	9e-41	1	1
ENSP00000383722	Xpo1	PF08389.12	4.4e-25	1	1
ENSP00000383722	IBN_N	PF03810.19	2.4e-06	1	1
ENSP00000327821	IBN_N	PF03810.19	2.6e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12509441	Exportin-5 mediates nuclear export of minihelix-containing RNAs.	J Biol Chem	2003 Feb 21	Gwizdek C	-
12426392	Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.	EMBO J	2002 Nov 15	Bohnsack MT	-
11911364	Both ran and importins have the ability to function as nuclear mRNA export factors.	RNA	2002 Feb	Yi R	-
18366743	The evolution of core proteins involved in microRNA biogenesis.	BMC Evol Biol	2008 Mar 25	Murphy D	doi: 10.1186/1471-2148-8-92.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000332707	XPOT-201	6414	XM_017018748	ENSP00000327821	962 (aa)	XP_016874237	O43592
ENST00000400935	XPOT-202	984	-	ENSP00000383722	201 (aa)	-	F8WDU6
ENST00000542958	XPOT-206	1321	-	-	- (aa)	-	-
ENST00000541842	XPOT-205	523	-	-	- (aa)	-	-
ENST00000538086	XPOT-203	787	-	ENSP00000444345	63 (aa)	-	F5GZM3
ENST00000540203	XPOT-204	548	-	ENSP00000441376	60 (aa)	-	F5GYW6

Gene Model

Click here to download ENSG00000184575's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000184575's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000184575	XPOT	100	83.333	ENSAPOG00000001362	xpot	99	80.021	Acanthochromis_polyacanthus
ENSG00000184575	XPOT	100	98.753	ENSAMEG00000018109	XPOT	100	98.753	Ailuropoda_melanoleuca
ENSG00000184575	XPOT	100	83.333	ENSACIG00000009016	xpot	100	79.895	Amphilophus_citrinellus
ENSG00000184575	XPOT	100	83.333	ENSAOCG00000005711	xpot	99	79.709	Amphiprion_ocellaris
ENSG00000184575	XPOT	100	83.333	ENSAPEG00000024660	XPOT	99	79.777	Amphiprion_percula
ENSG00000184575	XPOT	100	83.333	ENSAPEG00000024714	xpot	98	79.279	Amphiprion_percula
ENSG00000184575	XPOT	100	81.667	ENSATEG00000000675	xpot	99	80.125	Anabas_testudineus
ENSG00000184575	XPOT	100	93.763	ENSAPLG00000008073	XPOT	100	93.763	Anas_platyrhynchos
ENSG00000184575	XPOT	100	90.333	ENSACAG00000003154	XPOT	100	90.333	Anolis_carolinensis
ENSG00000184575	XPOT	99	83.281	ENSANAG00000032778	-	99	89.061	Aotus_nancymaae
ENSG00000184575	XPOT	100	98.333	ENSANAG00000029914	-	100	80.977	Aotus_nancymaae
ENSG00000184575	XPOT	100	83.333	ENSACLG00000008404	xpot	99	79.396	Astatotilapia_calliptera
ENSG00000184575	XPOT	100	81.667	ENSAMXG00000013542	xpot	99	79.292	Astyanax_mexicanus
ENSG00000184575	XPOT	100	99.064	ENSBTAG00000026962	XPOT	100	99.064	Bos_taurus
ENSG00000184575	XPOT	100	100.000	ENSCJAG00000014762	XPOT	95	99.480	Callithrix_jacchus
ENSG00000184575	XPOT	100	99.272	ENSCAFG00000000352	XPOT	100	99.272	Canis_familiaris
ENSG00000184575	XPOT	100	99.272	ENSCAFG00020019527	XPOT	100	99.272	Canis_lupus_dingo
ENSG00000184575	XPOT	100	99.272	ENSCHIG00000018310	XPOT	100	99.272	Capra_hircus
ENSG00000184575	XPOT	100	97.193	ENSTSYG00000008852	XPOT	100	97.193	Carlito_syrichta
ENSG00000184575	XPOT	100	79.602	ENSCAPG00000001620	XPOT	100	72.709	Cavia_aperea
ENSG00000184575	XPOT	100	98.333	ENSCPOG00000027042	XPOT	100	97.921	Cavia_porcellus
ENSG00000184575	XPOT	100	100.000	ENSCCAG00000035803	XPOT	97	99.457	Cebus_capucinus
ENSG00000184575	XPOT	95	82.456	ENSCATG00000039901	-	99	73.881	Cercocebus_atys
ENSG00000184575	XPOT	100	100.000	ENSCATG00000037826	XPOT	100	99.896	Cercocebus_atys
ENSG00000184575	XPOT	100	98.333	ENSCLAG00000011382	XPOT	100	98.233	Chinchilla_lanigera
ENSG00000184575	XPOT	100	100.000	ENSCSAG00000004475	XPOT	100	99.896	Chlorocebus_sabaeus
ENSG00000184575	XPOT	66	98.338	ENSCHOG00000000288	-	68	98.338	Choloepus_hoffmanni
ENSG00000184575	XPOT	100	92.931	ENSCPBG00000001003	XPOT	100	92.931	Chrysemys_picta_bellii
ENSG00000184575	XPOT	100	45.000	ENSCSAVG00000001681	-	99	45.106	Ciona_savignyi
ENSG00000184575	XPOT	98	71.095	ENSCANG00000030844	-	100	71.945	Colobus_angolensis_palliatus
ENSG00000184575	XPOT	100	100.000	ENSCANG00000033371	XPOT	100	99.792	Colobus_angolensis_palliatus
ENSG00000184575	XPOT	100	96.667	ENSCGRG00001016835	Xpot	100	95.530	Cricetulus_griseus_chok1gshd
ENSG00000184575	XPOT	100	96.667	ENSCGRG00000000577	Xpot	100	95.016	Cricetulus_griseus_crigri
ENSG00000184575	XPOT	100	81.667	ENSCSEG00000003973	xpot	99	78.356	Cynoglossus_semilaevis
ENSG00000184575	XPOT	100	83.333	ENSCVAG00000020453	xpot	99	79.292	Cyprinodon_variegatus
ENSG00000184575	XPOT	100	81.667	ENSDARG00000099652	xpot	99	78.564	Danio_rerio
ENSG00000184575	XPOT	100	98.129	ENSDORG00000000259	Xpot	100	98.129	Dipodomys_ordii
ENSG00000184575	XPOT	100	91.667	ENSETEG00000002981	-	55	96.957	Echinops_telfairi
ENSG00000184575	XPOT	91	58.804	ENSEBUG00000007650	xpot	99	59.324	Eptatretus_burgeri
ENSG00000184575	XPOT	100	98.233	ENSEASG00005007701	XPOT	98	98.233	Equus_asinus_asinus
ENSG00000184575	XPOT	100	98.233	ENSECAG00000018336	XPOT	94	96.674	Equus_caballus
ENSG00000184575	XPOT	100	98.333	ENSEEUG00000009700	XPOT	86	99.670	Erinaceus_europaeus
ENSG00000184575	XPOT	100	83.333	ENSELUG00000009337	xpot	96	75.824	Esox_lucius
ENSG00000184575	XPOT	100	99.168	ENSFCAG00000012360	XPOT	100	99.168	Felis_catus
ENSG00000184575	XPOT	100	93.763	ENSFALG00000009938	XPOT	100	93.763	Ficedula_albicollis
ENSG00000184575	XPOT	100	98.333	ENSFDAG00000012640	XPOT	99	97.914	Fukomys_damarensis
ENSG00000184575	XPOT	83	78.936	ENSFHEG00000009648	xpot	99	78.936	Fundulus_heteroclitus
ENSG00000184575	XPOT	93	77.372	ENSGMOG00000018888	xpot	93	77.372	Gadus_morhua
ENSG00000184575	XPOT	100	93.867	ENSGALG00000009835	XPOT	100	93.867	Gallus_gallus
ENSG00000184575	XPOT	100	83.333	ENSGAFG00000004150	xpot	99	79.292	Gambusia_affinis
ENSG00000184575	XPOT	99	74.819	ENSGACG00000000589	xpot	99	74.819	Gasterosteus_aculeatus
ENSG00000184575	XPOT	100	92.723	ENSGAGG00000022917	XPOT	100	92.723	Gopherus_agassizii
ENSG00000184575	XPOT	100	94.527	ENSGGOG00000027170	-	95	88.481	Gorilla_gorilla
ENSG00000184575	XPOT	100	100.000	ENSGGOG00000006089	XPOT	100	100.000	Gorilla_gorilla
ENSG00000184575	XPOT	100	83.333	ENSHBUG00000020681	xpot	99	79.501	Haplochromis_burtoni
ENSG00000184575	XPOT	100	98.333	ENSHGLG00000005833	XPOT	99	98.115	Heterocephalus_glaber_female
ENSG00000184575	XPOT	100	98.333	ENSHGLG00100000810	XPOT	100	98.129	Heterocephalus_glaber_male
ENSG00000184575	XPOT	100	78.333	ENSHCOG00000006415	xpot	99	72.320	Hippocampus_comes
ENSG00000184575	XPOT	100	81.667	ENSIPUG00000015271	xpot	99	79.084	Ictalurus_punctatus
ENSG00000184575	XPOT	100	98.960	ENSSTOG00000021805	XPOT	100	98.960	Ictidomys_tridecemlineatus
ENSG00000184575	XPOT	100	98.333	ENSJJAG00000019671	-	99	94.974	Jaculus_jaculus
ENSG00000184575	XPOT	97	91.379	ENSJJAG00000014767	-	100	83.646	Jaculus_jaculus
ENSG00000184575	XPOT	100	85.000	ENSKMAG00000019126	xpot	100	79.583	Kryptolebias_marmoratus
ENSG00000184575	XPOT	100	81.667	ENSLBEG00000000178	xpot	99	78.564	Labrus_bergylta
ENSG00000184575	XPOT	100	85.685	ENSLACG00000014355	XPOT	100	85.685	Latimeria_chalumnae
ENSG00000184575	XPOT	99	84.855	ENSLOCG00000016512	xpot	99	84.855	Lepisosteus_oculatus
ENSG00000184575	XPOT	100	98.333	ENSLAFG00000009829	XPOT	100	98.027	Loxodonta_africana
ENSG00000184575	XPOT	100	100.000	ENSMFAG00000032644	XPOT	100	99.896	Macaca_fascicularis
ENSG00000184575	XPOT	99	75.858	ENSMFAG00000038180	-	99	75.858	Macaca_fascicularis
ENSG00000184575	XPOT	100	100.000	ENSMMUG00000007659	XPOT	100	99.896	Macaca_mulatta
ENSG00000184575	XPOT	98	79.412	ENSMMUG00000021196	-	100	80.618	Macaca_mulatta
ENSG00000184575	XPOT	100	100.000	ENSMNEG00000033875	XPOT	100	99.792	Macaca_nemestrina
ENSG00000184575	XPOT	99	71.904	ENSMNEG00000029730	-	99	71.904	Macaca_nemestrina
ENSG00000184575	XPOT	100	95.842	ENSMLEG00000043977	XPOT	100	95.842	Mandrillus_leucophaeus
ENSG00000184575	XPOT	100	81.667	ENSMAMG00000020690	xpot	99	79.501	Mastacembelus_armatus
ENSG00000184575	XPOT	100	83.333	ENSMZEG00005018955	xpot	99	79.188	Maylandia_zebra
ENSG00000184575	XPOT	100	93.666	ENSMGAG00000010208	XPOT	100	93.666	Meleagris_gallopavo
ENSG00000184575	XPOT	100	96.667	ENSMAUG00000016836	Xpot	99	93.633	Mesocricetus_auratus
ENSG00000184575	XPOT	100	99.168	ENSMICG00000012001	XPOT	100	99.168	Microcebus_murinus
ENSG00000184575	XPOT	100	95.000	ENSMOCG00000014097	Xpot	100	94.808	Microtus_ochrogaster
ENSG00000184575	XPOT	100	81.667	ENSMMOG00000005960	xpot	97	79.372	Mola_mola
ENSG00000184575	XPOT	100	98.333	ENSMODG00000029301	-	98	94.545	Monodelphis_domestica
ENSG00000184575	XPOT	100	80.000	ENSMALG00000007523	xpot	99	79.813	Monopterus_albus
ENSG00000184575	XPOT	100	98.333	MGP_CAROLIEiJ_G0015858	Xpot	100	95.738	Mus_caroli
ENSG00000184575	XPOT	100	98.333	ENSMUSG00000034667	Xpot	100	95.530	Mus_musculus
ENSG00000184575	XPOT	100	96.667	MGP_PahariEiJ_G0031228	Xpot	100	95.119	Mus_pahari
ENSG00000184575	XPOT	100	98.333	MGP_SPRETEiJ_G0016683	Xpot	100	93.354	Mus_spretus
ENSG00000184575	XPOT	100	99.272	ENSMPUG00000017529	XPOT	100	99.272	Mustela_putorius_furo
ENSG00000184575	XPOT	100	99.064	ENSMLUG00000009664	XPOT	100	99.064	Myotis_lucifugus
ENSG00000184575	XPOT	100	97.089	ENSNGAG00000020615	Xpot	99	97.089	Nannospalax_galili
ENSG00000184575	XPOT	100	83.333	ENSNBRG00000017136	xpot	99	79.501	Neolamprologus_brichardi
ENSG00000184575	XPOT	100	100.000	ENSNLEG00000017052	XPOT	100	99.896	Nomascus_leucogenys
ENSG00000184575	XPOT	65	92.683	ENSMEUG00000016032	-	76	82.396	Notamacropus_eugenii
ENSG00000184575	XPOT	100	98.507	ENSOPRG00000013079	XPOT	75	100.000	Ochotona_princeps
ENSG00000184575	XPOT	100	98.333	ENSODEG00000004607	XPOT	99	97.401	Octodon_degus
ENSG00000184575	XPOT	100	83.333	ENSONIG00000007471	xpot	99	79.605	Oreochromis_niloticus
ENSG00000184575	XPOT	100	95.000	ENSOANG00000010932	XPOT	100	94.906	Ornithorhynchus_anatinus
ENSG00000184575	XPOT	100	98.753	ENSOCUG00000012126	XPOT	96	98.753	Oryctolagus_cuniculus
ENSG00000184575	XPOT	100	83.333	ENSORLG00000020105	xpot	99	77.732	Oryzias_latipes
ENSG00000184575	XPOT	100	81.667	ENSORLG00020003770	xpot	99	77.732	Oryzias_latipes_hni
ENSG00000184575	XPOT	100	78.333	ENSORLG00015003002	xpot	99	76.151	Oryzias_latipes_hsok
ENSG00000184575	XPOT	100	80.000	ENSOMEG00000021300	xpot	99	75.549	Oryzias_melastigma
ENSG00000184575	XPOT	100	98.333	ENSOGAG00000004952	XPOT	100	88.877	Otolemur_garnettii
ENSG00000184575	XPOT	100	99.272	ENSOARG00000003504	XPOT	100	99.272	Ovis_aries
ENSG00000184575	XPOT	100	100.000	ENSPPAG00000031361	XPOT	100	100.000	Pan_paniscus
ENSG00000184575	XPOT	100	96.667	ENSPPAG00000041601	-	94	83.671	Pan_paniscus
ENSG00000184575	XPOT	100	73.105	ENSPPAG00000040981	-	99	73.105	Pan_paniscus
ENSG00000184575	XPOT	100	99.272	ENSPPRG00000005552	XPOT	100	99.272	Panthera_pardus
ENSG00000184575	XPOT	100	99.272	ENSPTIG00000022072	XPOT	96	99.272	Panthera_tigris_altaica
ENSG00000184575	XPOT	100	71.859	ENSPTRG00000046749	-	99	71.859	Pan_troglodytes
ENSG00000184575	XPOT	100	100.000	ENSPTRG00000005173	XPOT	100	100.000	Pan_troglodytes
ENSG00000184575	XPOT	100	96.667	ENSPTRG00000045368	-	84	86.038	Pan_troglodytes
ENSG00000184575	XPOT	100	71.755	ENSPTRG00000049416	-	99	71.755	Pan_troglodytes
ENSG00000184575	XPOT	100	100.000	ENSPANG00000030915	-	100	96.881	Papio_anubis
ENSG00000184575	XPOT	100	100.000	ENSPANG00000001024	-	100	99.896	Papio_anubis
ENSG00000184575	XPOT	100	86.667	ENSPKIG00000001935	xpot	99	83.247	Paramormyrops_kingsleyae
ENSG00000184575	XPOT	100	93.333	ENSPSIG00000007346	XPOT	100	92.723	Pelodiscus_sinensis
ENSG00000184575	XPOT	100	81.667	ENSPMGG00000016668	xpot	91	77.020	Periophthalmus_magnuspinnatus
ENSG00000184575	XPOT	100	96.667	ENSPEMG00000002538	Xpot	99	94.906	Peromyscus_maniculatus_bairdii
ENSG00000184575	XPOT	100	70.000	ENSPMAG00000000201	xpot	100	65.586	Petromyzon_marinus
ENSG00000184575	XPOT	100	96.667	ENSPCIG00000029686	XPOT	100	96.258	Phascolarctos_cinereus
ENSG00000184575	XPOT	100	83.333	ENSPFOG00000002834	xpot	99	79.501	Poecilia_formosa
ENSG00000184575	XPOT	100	83.333	ENSPLAG00000017684	xpot	99	79.501	Poecilia_latipinna
ENSG00000184575	XPOT	100	83.333	ENSPMEG00000006259	xpot	99	79.605	Poecilia_mexicana
ENSG00000184575	XPOT	100	79.032	ENSPREG00000018505	xpot	99	77.419	Poecilia_reticulata
ENSG00000184575	XPOT	100	99.688	ENSPPYG00000004727	XPOT	100	99.688	Pongo_abelii
ENSG00000184575	XPOT	100	98.333	ENSPCAG00000001574	XPOT	88	98.160	Procavia_capensis
ENSG00000184575	XPOT	100	99.005	ENSPCOG00000028383	XPOT	100	98.551	Propithecus_coquereli
ENSG00000184575	XPOT	100	98.545	ENSPVAG00000008199	XPOT	100	98.545	Pteropus_vampyrus
ENSG00000184575	XPOT	100	83.333	ENSPNYG00000022747	xpot	99	79.501	Pundamilia_nyererei
ENSG00000184575	XPOT	100	80.000	ENSPNAG00000009140	xpot	99	80.125	Pygocentrus_nattereri
ENSG00000184575	XPOT	100	98.333	ENSRNOG00000007088	Xpot	92	92.708	Rattus_norvegicus
ENSG00000184575	XPOT	100	100.000	ENSRBIG00000041353	XPOT	100	99.896	Rhinopithecus_bieti
ENSG00000184575	XPOT	100	79.067	ENSRBIG00000032079	-	100	79.067	Rhinopithecus_bieti
ENSG00000184575	XPOT	100	100.000	ENSRROG00000038276	XPOT	100	99.896	Rhinopithecus_roxellana
ENSG00000184575	XPOT	100	100.000	ENSSBOG00000024782	XPOT	100	99.584	Saimiri_boliviensis_boliviensis
ENSG00000184575	XPOT	100	98.333	ENSSHAG00000007043	XPOT	100	96.570	Sarcophilus_harrisii
ENSG00000184575	XPOT	100	85.000	ENSSFOG00015000827	xpot	99	81.497	Scleropages_formosus
ENSG00000184575	XPOT	100	76.667	ENSSMAG00000005164	xpot	99	77.523	Scophthalmus_maximus
ENSG00000184575	XPOT	100	81.667	ENSSDUG00000012514	xpot	99	80.125	Seriola_dumerili
ENSG00000184575	XPOT	100	81.667	ENSSLDG00000019497	xpot	99	80.021	Seriola_lalandi_dorsalis
ENSG00000184575	XPOT	83	89.085	ENSSARG00000005789	XPOT	88	89.085	Sorex_araneus
ENSG00000184575	XPOT	100	93.333	ENSSPUG00000009837	XPOT	100	90.787	Sphenodon_punctatus
ENSG00000184575	XPOT	100	98.960	ENSSSCG00000000466	XPOT	100	98.960	Sus_scrofa
ENSG00000184575	XPOT	100	93.555	ENSTGUG00000006459	XPOT	100	93.555	Taeniopygia_guttata
ENSG00000184575	XPOT	100	75.385	ENSTNIG00000002483	xpot	99	75.698	Tetraodon_nigroviridis
ENSG00000184575	XPOT	100	98.333	ENSTBEG00000009738	XPOT	90	98.485	Tupaia_belangeri
ENSG00000184575	XPOT	100	99.064	ENSTTRG00000016808	XPOT	100	99.064	Tursiops_truncatus
ENSG00000184575	XPOT	100	99.064	ENSUAMG00000017168	XPOT	100	99.064	Ursus_americanus
ENSG00000184575	XPOT	100	99.064	ENSUMAG00000020382	XPOT	100	99.064	Ursus_maritimus
ENSG00000184575	XPOT	99	98.428	ENSVPAG00000004244	XPOT	100	98.428	Vicugna_pacos
ENSG00000184575	XPOT	100	99.272	ENSVVUG00000015001	XPOT	100	99.272	Vulpes_vulpes
ENSG00000184575	XPOT	100	85.181	ENSXETG00000021668	xpot	100	85.181	Xenopus_tropicalis
ENSG00000184575	XPOT	99	76.875	ENSXCOG00000011945	xpot	99	76.875	Xiphophorus_couchianus
ENSG00000184575	XPOT	100	81.667	ENSXMAG00000002827	xpot	99	79.292	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	21873635.	IBA	Function
GO:0000049	tRNA binding	9660920.	IDA	Function
GO:0005643	nuclear pore	21873635.	IBA	Component
GO:0005643	nuclear pore	9660920.	IDA	Component
GO:0005654	nucleoplasm	9660920.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	9660920.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006409	tRNA export from nucleus	9660920.	IDA	Process
GO:0006409	tRNA export from nucleus	-	TAS	Process
GO:0008536	Ran GTPase binding	21873635.	IBA	Function
GO:0016363	nuclear matrix	21873635.	IBA	Component
GO:0071528	tRNA re-export from nucleus	21873635.	IBA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr12	64418975	Frame_Shift_Del	rs762052135	*F126Lfs6**	0.58
ACC	chr12	64420073	Missense_Mutation	novel	A165T	0.09
BLCA	chr12	64433471	Missense_Mutation	novel	E774Q	0.55
BLCA	chr12	64425827	Missense_Mutation	novel	D529N	0.11
BLCA	chr12	64421310	Missense_Mutation	NA	S307G	0.22
BLCA	chr12	64431690	Missense_Mutation	novel	R710Q	0.22
BLCA	chr12	64439259	Nonsense_Mutation	novel	Q917*	0.37
BLCA	chr12	64419092	Missense_Mutation	NA	E163Q	0.09
BLCA	chr12	64439250	Missense_Mutation	NA	E914K	0.13
BLCA	chr12	64421416	Missense_Mutation	novel	D342G	0.4
BLCA	chr12	64420221	Missense_Mutation	novel	S214C	0.07
BLCA	chr12	64439305	Missense_Mutation	novel	E932G	0.15
BLCA	chr12	64420178	Missense_Mutation	novel	E200K	0.15
BRCA	chr12	64420423	Missense_Mutation	NA	E249Q	0.17
BRCA	chr12	64433533	Silent	novel	L794L	0.04
BRCA	chr12	64428089	Missense_Mutation	novel	R569T	0.23
BRCA	chr12	64420423	Missense_Mutation	NA	E249Q	0.14
BRCA	chr12	64410033	5'UTR	novel		0.04
BRCA	chr12	64424687	Missense_Mutation	NA	L424P	0.27
BRCA	chr12	64418972	Missense_Mutation	NA	K123Q	0.15
BRCA	chr12	64428113	Missense_Mutation	novel	S577F	0.08
BRCA	chr12	64414978	Silent	NA	Q44Q	0.15
BRCA	chr12	64434573	Missense_Mutation	novel	I840N	0.1
BRCA	chr12	64431661	Silent	NA	L700L	0.27
BRCA	chr12	64421310	Missense_Mutation	novel	S307C	0.1
BRCA	chr12	64421308	Missense_Mutation	NA	W306S	0.58
BRCA	chr12	64418975	Frame_Shift_Del	rs762052135	*F126Lfs6**	0.4
CESC	chr12	64448283	3'UTR	novel		0.21
CESC	chr12	64418975	Frame_Shift_Del	rs762052135	*F126Lfs6**	0.61
CESC	chr12	64420183	Silent	novel	V201V	0.28
CESC	chr12	64430235	Missense_Mutation	rs746325841	E642K	0.3
CESC	chr12	64430138	Silent	rs754880442	P609P	0.36
CHOL	chr12	64448641	3'UTR	novel		0.23
COAD	chr12	64421422	Missense_Mutation	NA	S344Y	0.21
COAD	chr12	64425863	Missense_Mutation	rs755856854	R541W	0.29
COAD	chr12	64430110	Missense_Mutation	novel	G600E	0.34
COAD	chr12	64430229	Missense_Mutation	novel	D640N	0.8
COAD	chr12	64418079	Silent	novel	L78L	0.1
COAD	chr12	64420464	Silent	NA	K262K	0.19
COAD	chr12	64430089	Frame_Shift_Del	NA	*F594Lfs9**	0.32
COAD	chr12	64420481	Missense_Mutation	NA	C268S	0.19
COAD	chr12	64430289	Splice_Site	NA	X659_splice	0.13
COAD	chr12	64430078	Silent	NA	S589S	0.33
COAD	chr12	64425138	Missense_Mutation	NA	G470C	0.35
COAD	chr12	64425863	Missense_Mutation	rs755856854	R541W	0.28
COAD	chr12	64434839	Missense_Mutation	NA	H872R	0.21
COAD	chr12	64445080	Missense_Mutation	novel	F937L	0.07
COAD	chr12	64410031	5'UTR	rs757293122		0.32
COAD	chr12	64430115	Frame_Shift_Ins	novel	*L602Hfs4**	0.04
COAD	chr12	64430116	In_Frame_Ins	novel	L602_I603insR	0.03
COAD	chr12	64433582	In_Frame_Ins	novel	S811delinsNIC	0.06
ESCA	chr12	64448647	3'UTR	novel		0.21
ESCA	chr12	64418099	Nonsense_Mutation	novel	S85*	0.35	Xpo1
ESCA	chr12	64430085	Nonsense_Mutation	novel	Q592*	0.1
GBM	chr12	64423039	Missense_Mutation	novel	V372A	0.31
GBM	chr12	64434530	Silent	rs564400072	L826L	0.4
GBM	chr12	64435673	Missense_Mutation	novel	R911Q	0.33
GBM	chr12	64409999	5'UTR	novel		0.16
GBM	chr12	64434624	Splice_Site	novel	X857_splice	0.19
GBM	chr12	64433461	Frame_Shift_Del	novel	*H770Qfs20**	0.03
GBM	chr12	64430179	Missense_Mutation	novel	P623Q	0.09
HNSC	chr12	64424665	Missense_Mutation	rs752226938	Q417E	0.13
HNSC	chr12	64420132	Silent	novel	V184V	0.24
HNSC	chr12	64420217	Missense_Mutation	novel	V213F	0.23
HNSC	chr12	64425145	Frame_Shift_Del	novel	*S473Qfs9**	0.4
HNSC	chr12	64420109	Missense_Mutation	novel	E177K	0.31
HNSC	chr12	64425069	Nonsense_Mutation	novel	E447*	0.29
HNSC	chr12	64434859	Missense_Mutation	novel	L879V	0.39
HNSC	chr12	64425178	Missense_Mutation	novel	R483L	0.03
KIRC	chr12	64434588	Missense_Mutation	NA	C845F	0.14
KIRC	chr12	64433525	Nonsense_Mutation	NA	Q792*	0.35
KIRC	chr12	64434576	Missense_Mutation	novel	A841V	0.26
KIRP	chr12	64414948	Silent	NA	A34A	0.14
KIRP	chr12	64431685	Silent	novel	L708L	0.25
KIRP	chr12	64433446	Missense_Mutation	NA	F765L	0.57
LAML	chr12	64421285	Frame_Shift_Del	novel	*G299Dfs4**	0.05
LAML	chr12	64433534	Missense_Mutation	rs747729622	R795W	0.11
LGG	chr12	64409997	5'UTR	rs373281732		0.15
LGG	chr12	64418091	Silent	rs761074080	T82T	0.33
LGG	chr12	64431767	Missense_Mutation	novel	A736T	0.46
LIHC	chr12	64420393	Missense_Mutation	NA	L239I	0.34
LIHC	chr12	64420074	Missense_Mutation	NA	A165V	0.13
LIHC	chr12	64420076	Missense_Mutation	novel	R166C	0.43
LUAD	chr12	64419015	Frame_Shift_Del	novel	*G138Efs2**	0.17
LUAD	chr12	64421438	Silent	rs777518529	G349G	0.17
LUAD	chr12	64419050	Missense_Mutation	rs759203434	I149V	0.14
LUAD	chr12	64420353	Missense_Mutation	NA	R225S	0.33
LUAD	chr12	64434859	Silent	novel	L879L	0.19
LUAD	chr12	64439282	Silent	novel	L924L	0.29
LUAD	chr12	64420399	Nonsense_Mutation	NA	E241*	0.25
LUAD	chr12	64421373	Frame_Shift_Ins	novel	*K328Sfs6**	0.09
LUAD	chr12	64421364	Missense_Mutation	rs141202142	I325V	0.22
LUAD	chr12	64420487	Missense_Mutation	novel	V270A	0.07
LUAD	chr12	64421406	Missense_Mutation	NA	E339Q	0.27
LUSC	chr12	64418985	Missense_Mutation	novel	D127G	0.33
LUSC	chr12	64420408	Missense_Mutation	novel	C244R	0.16
LUSC	chr12	64420395	Silent	NA	L239L	0.29
LUSC	chr12	64420396	Missense_Mutation	NA	R240W	0.29
LUSC	chr12	64423182	Missense_Mutation	NA	A374S	0.11
LUSC	chr12	64434580	Missense_Mutation	NA	Q842H	0.14
LUSC	chr12	64414961	Missense_Mutation	novel	A39S	0.28	Xpo1
LUSC	chr12	64425413	Missense_Mutation	novel	E510K	0.3
LUSC	chr12	64434808	Missense_Mutation	novel	P862A	0.36
LUSC	chr12	64421334	Missense_Mutation	novel	I315V	0.21
MESO	chr12	64430085	Nonsense_Mutation	novel	Q592*	0.11
OV	chr12	64431603	In_Frame_Del	novel	D682_L688del	0.09
OV	chr12	64420481	Missense_Mutation	NA	C268S	0.15
OV	chr12	64430267	Frame_Shift_Ins	novel	*H653Mfs28**	0.04
OV	chr12	64433476	Silent	NA	V775V	0.42
PAAD	chr12	64425056	Silent	novel	R442R	0.18
PAAD	chr12	64448127	Missense_Mutation	novel	P962H	0.17
PCPG	chr12	64424604	Silent	novel	E396E	0.35
PRAD	chr12	64431618	Missense_Mutation	novel	T686K	0.07
READ	chr12	64433584	Silent	rs749009245	S811S	0.3
READ	chr12	64430202	Missense_Mutation	NA	L631V	0.22
READ	chr12	64418920	Silent	rs372746587	A105A	0.24
SARC	chr12	64448177	3'UTR	novel		0.24
SARC	chr12	64430189	Missense_Mutation	novel	E626D	0.47
SKCM	chr12	64434545	Nonsense_Mutation	NA	Q831*	0.23
SKCM	chr12	64420375	Missense_Mutation	NA	H233Y	0.33
SKCM	chr12	64418980	Missense_Mutation	novel	F125L	0.39
SKCM	chr12	64414938	Missense_Mutation	rs765498017	S31F	0.35	Xpo1
SKCM	chr12	64425863	Missense_Mutation	rs755856854	R541W	0.56
SKCM	chr12	64414938	Missense_Mutation	rs765498017	S31F	0.52	Xpo1
SKCM	chr12	64434858	Silent	NA	F878F	0.33
SKCM	chr12	64433500	Missense_Mutation	rs200929597	N783K	0.19
SKCM	chr12	64421252	Silent	NA	F287F	0.29
SKCM	chr12	64439269	Missense_Mutation	novel	Q920L	0.15
SKCM	chr12	64431719	Missense_Mutation	NA	L720F	0.15
SKCM	chr12	64430142	Missense_Mutation	NA	E611K	0.49
SKCM	chr12	64425847	In_Frame_Del	novel	S536_S549del	0.21
SKCM	chr12	64439292	Nonsense_Mutation	NA	Q928*	0.17
SKCM	chr12	64421338	Missense_Mutation	novel	K316R	0.31
SKCM	chr12	64428069	Silent	NA	F562F	0.38
SKCM	chr12	64448187	3'UTR	novel		0.27
SKCM	chr12	64420375	Missense_Mutation	NA	H233Y	0.59
SKCM	chr12	64420483	Missense_Mutation	NA	Q269K	0.51
SKCM	chr12	64419071	Missense_Mutation	novel	R156C	0.37
SKCM	chr12	64420163	Nonsense_Mutation	novel	Q195*	0.21
STAD	chr12	64418910	Missense_Mutation	rs764750955	R102Q	0.19
STAD	chr12	64409996	5'UTR	rs147876387		0.11
STAD	chr12	64433428	Silent	rs757981724	P759P	0.38
STAD	chr12	64423035	Missense_Mutation	rs771084151	N371D	0.22
STAD	chr12	64431605	Missense_Mutation	novel	D682N	0.45
STAD	chr12	64420232	Missense_Mutation	NA	L218V	0.17
STAD	chr12	64418975	Frame_Shift_Del	NA	F126*	0.45
STAD	chr12	64420185	Missense_Mutation	rs775084744	T202M	0.15
STAD	chr12	64425339	Missense_Mutation	NA	L485P	0.48
STAD	chr12	64418975	Frame_Shift_Del	NA	F126*	0.31
STAD	chr12	64435672	Missense_Mutation	rs377275558	R911W	0.28
THCA	chr12	64433430	Missense_Mutation	novel	F760C	0.45
THYM	chr12	64418975	Frame_Shift_Del	rs762052135	*F126Lfs6**	0.36
UCEC	chr12	64424698	Missense_Mutation	rs552782852	R428C	0.31
UCEC	chr12	64416747	Missense_Mutation	NA	K65Q	0.33	Xpo1
UCEC	chr12	64419035	Nonsense_Mutation	novel	R144*	0.27
UCEC	chr12	64418909	Nonsense_Mutation	novel	R102*	0.27
UCEC	chr12	64435672	Missense_Mutation	rs377275558	R911W	0.3
UCEC	chr12	64431719	Missense_Mutation	novel	L720I	0.05
UCEC	chr12	64416748	Missense_Mutation	NA	K65R	0.23	Xpo1
UCEC	chr12	64425903	Missense_Mutation	NA	S554F	0.23
UCEC	chr12	64431792	Missense_Mutation	NA	P744H	0.23
UCEC	chr12	64431757	Nonsense_Mutation	novel	*D733Lfs3**	0.06
UCEC	chr12	64433534	Missense_Mutation	rs747729622	R795W	0.26
UCEC	chr12	64448191	3'UTR	rs367796508		0.11
UCEC	chr12	64431740	Missense_Mutation	novel	S727A	0.21
UCEC	chr12	64418975	Frame_Shift_Del	rs762052135	*F126Lfs6**	0.35
UCEC	chr12	64448647	3'UTR	rs184653732		0.39
UCEC	chr12	64431593	Missense_Mutation	rs765621181	E678K	0.35
UCEC	chr12	64434584	Missense_Mutation	novel	T844A	0.37
UCEC	chr12	64409986	5'UTR	novel		0.29
UCEC	chr12	64425138	Missense_Mutation	NA	G470C	0.3
UCEC	chr12	64448245	3'UTR	novel		0.45
UCEC	chr12	64448246	3'UTR	novel		0.45
UCEC	chr12	64433445	Missense_Mutation	novel	F765S	0.27
UCEC	chr12	64420515	Silent	novel	I279I	0.14
UCEC	chr12	64421275	Missense_Mutation	novel	V295A	0.34
UCEC	chr12	64425367	Silent	novel	Q494Q	0.26
UCEC	chr12	64431689	Nonsense_Mutation	novel	R710*	0.48
UCEC	chr12	64431588	Missense_Mutation	NA	C676Y	0.36
UCEC	chr12	64414936	Missense_Mutation	NA	I30M	0.33	Xpo1
UCEC	chr12	64433467	Missense_Mutation	novel	I772M	0.5
UCEC	chr12	64448636	3'UTR	novel		0.32
UCEC	chr12	64448458	3'UTR	novel		0.5
UCEC	chr12	64418975	Frame_Shift_Del	rs762052135	*F126Lfs6**	0.37
UCEC	chr12	64418095	In_Frame_Ins	novel	I84delinsSSDL	0.07	Xpo1
UCEC	chr12	64419035	Nonsense_Mutation	novel	R144*	0.23
UCEC	chr12	64430089	Missense_Mutation	novel	L593R	0.37
UCEC	chr12	64418909	Nonsense_Mutation	novel	R102*	0.31
UCEC	chr12	64409978	5'UTR	novel		0.26
UCEC	chr12	64431773	Missense_Mutation	novel	D738Y	0.45
UCEC	chr12	64418975	Frame_Shift_Del	rs762052135	*F126Lfs6**	0.45
UCEC	chr12	64428081	Silent	novel	I566I	0.39
UCEC	chr12	64448180	3'UTR	novel		0.54
UCEC	chr12	64430169	Missense_Mutation	novel	L620M	0.07
UCEC	chr12	64433584	Silent	rs749009245	S811S	0.23
UCEC	chr12	64448574	3'UTR	novel		0.18
UCEC	chr12	64418975	Frame_Shift_Del	rs762052135	*F126Lfs6**	0.55
UCEC	chr12	64439316	Splice_Site	NA	X935_splice	0.04
UCEC	chr12	64430277	Missense_Mutation	novel	G656R	0.09
UCEC	chr12	64430167	Missense_Mutation	novel	N619T	0.26
UCEC	chr12	64414990	Splice_Site	NA	X48_splice	0.29
UCEC	chr12	64424614	Missense_Mutation	rs770607826	M400V	0.26
UCEC	chr12	64433452	Silent	novel	P767P	0.18
UCEC	chr12	64439270	Silent	novel	Q920Q	0.14
UCEC	chr12	64448410	3'UTR	novel		0.14
UCEC	chr12	64418975	Frame_Shift_Del	rs762052135	*F126Lfs6**	0.39
UCEC	chr12	64418975	Frame_Shift_Del	rs762052135	*F126Lfs6**	0.32
UCEC	chr12	64410031	5'UTR	rs757293122		0.55
UCEC	chr12	64439312	Missense_Mutation	NA	I934M	0.53
UCEC	chr12	64421422	Missense_Mutation	NA	S344Y	0.21
UCEC	chr12	64435663	Missense_Mutation	NA	H908N	0.25
UCEC	chr12	64419036	Missense_Mutation	novel	R144Q	0.32
UCEC	chr12	64410023	5'UTR	novel		0.17
UCEC	chr12	64419048	Missense_Mutation	novel	A148G	0.04
UCEC	chr12	64421368	Missense_Mutation	novel	E326A	0.36
UCEC	chr12	64425419	Missense_Mutation	novel	F512V	0.14
UCEC	chr12	64431652	Missense_Mutation	novel	K697N	0.19
UCEC	chr12	64416707	Silent	NA	H51H	0.27
UCEC	chr12	64424611	Missense_Mutation	novel	A399T	0.29
UCEC	chr12	64431722	Missense_Mutation	novel	P721S	0.51
UCEC	chr12	64433531	Missense_Mutation	novel	L794M	0.35
UCEC	chr12	64439285	Silent	novel	P925P	0.3
UCEC	chr12	64428064	Missense_Mutation	NA	P561T	0.31

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.0444	0.20414
DLBC	AMP	0.2083	0.085003
GBM	DEL	0.1092	0.0052524
READ	DEL	0.0909	0.064633

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00013	Kaplan-Meier Survival Analysis
SARC	0.0016	Kaplan-Meier Survival Analysis
MESO	0.00011	Kaplan-Meier Survival Analysis
ACC	0.019	Kaplan-Meier Survival Analysis
SKCM	0.029	Kaplan-Meier Survival Analysis
BRCA	0.0039	Kaplan-Meier Survival Analysis
KIRP	0.00011	Kaplan-Meier Survival Analysis
BLCA	0.0029	Kaplan-Meier Survival Analysis
LAML	0.024	Kaplan-Meier Survival Analysis
KICH	0.00068	Kaplan-Meier Survival Analysis
UCEC	0.012	Kaplan-Meier Survival Analysis
GBM	0.046	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
UVM	0.0036	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742