EuRBPDB

Description

Ensembl ID: ENSG00000184897 (Gene tree)
Gene ID: 8971
Gene Symbol: H1FX
Alias: MGC15959|MGC8350|H1X
Full Name: H1 histone family member X
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 1,507 bases
Position: chr3:129,314,771-129,316,277
Accession: 4722
RBP type: non-canonical RBP
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000333762	H1FX-201	1507	-	ENSP00000329662	213 (aa)	-	Q92522

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000184897	rs4853	3	129314893	T	Menopause (age at onset)	29773799	[0.38-0.58] year increase	0.48	EFO_0004704
ENSG00000184897	rs4853	3	129314893	T	Menopause (age at onset)	29773799			EFO_0004704

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000786	nucleosome	-	IEA	Component
GO:0003690	double-stranded DNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	21873635.	IBA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0006334	nucleosome assembly	-	IEA	Process
GO:0006355	regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0016584	nucleosome positioning	21873635.	IBA	Process
GO:0030261	chromosome condensation	21873635.	IBA	Process
GO:0031492	nucleosomal DNA binding	21873635.	IBA	Function
GO:0031936	negative regulation of chromatin silencing	21873635.	IBA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045910	negative regulation of DNA recombination	21873635.	IBA	Process