EuRBPDB

Description

Ensembl ID: ENSG00000184900 (Gene tree)
Gene ID: 6612
Gene Symbol: SUMO3
Alias: SMT3A|SMT3H1
Full Name: small ubiquitin like modifier 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 13,163 bases
Position: chr21:44,805,617-44,818,779
Accession: 11124
RBP type: non-canonical RBP
Summary: This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000332859	SUMO3-201	1807	-	ENSP00000330343	103 (aa)	-	P55854
ENST00000397893	SUMO3-202	520	-	ENSP00000380990	147 (aa)	-	A8MU27
ENST00000466861	SUMO3-205	753	-	-	- (aa)	-	-
ENST00000411651	SUMO3-204	1921	-	ENSP00000409666	141 (aa)	-	P55854
ENST00000479153	SUMO3-206	1736	-	-	- (aa)	-	-
ENST00000397898	SUMO3-203	1779	-	ENSP00000380995	135 (aa)	-	A8MUA9

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa05418	Fluid shear stress and atherosclerosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000184900	Waist Circumference	9.7080000E-005	-

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000184900	SUMO3	90	96.809	ENSG00000188612	SUMO2	99	100.000	Homo_sapiens
ENSG00000184900	SUMO3	90	96.809	ENSMUSG00000020738	Sumo2	99	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000776	kinetochore	9119407.	TAS	Component
GO:0005515	protein binding	17000644.17099700.18538659.19050011.22878415.25416956.25556234.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	21965678.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0016605	PML body	-	IEA	Component
GO:0016925	protein sumoylation	21873635.	IBA	Process
GO:0016925	protein sumoylation	11889051.16626738.17696781.21965678.24105744.	IDA	Process
GO:0019899	enzyme binding	11889051.16626738.	IPI	Function
GO:0031386	protein tag	21873635.	IBA	Function
GO:0043392	negative regulation of DNA binding	16626738.	IDA	Process
GO:0044389	ubiquitin-like protein ligase binding	21873635.	IBA	Function