EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000184937 (Gene tree)
Gene ID: 7490
Gene Symbol: WT1
Alias: WAGR|WIT-2|AWT1|NPHS4|GUD
Full Name: WT1 transcription factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 47,856 bases
Position: chr11:32,387,775-32,435,630
Accession: 12796
RBP type: canonical RBP
Summary: This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000435307	zf-C2H2	PF00096.26	8.9e-15	1	3
ENSP00000435307	zf-C2H2	PF00096.26	8.9e-15	2	3
ENSP00000435307	zf-C2H2	PF00096.26	8.9e-15	3	3
ENSP00000368370	zf-C2H2	PF00096.26	1.2e-14	1	3
ENSP00000368370	zf-C2H2	PF00096.26	1.2e-14	2	3
ENSP00000368370	zf-C2H2	PF00096.26	1.2e-14	3	3
ENSP00000492269	zf-C2H2	PF00096.26	1.4e-13	1	2
ENSP00000492269	zf-C2H2	PF00096.26	1.4e-13	2	2
ENSP00000415516	zf-C2H2	PF00096.26	1.4e-13	1	2
ENSP00000415516	zf-C2H2	PF00096.26	1.4e-13	2	2
ENSP00000491511	zf-C2H2	PF00096.26	1.7e-13	1	2
ENSP00000491511	zf-C2H2	PF00096.26	1.7e-13	2	2
ENSP00000413452	zf-C2H2	PF00096.26	1.7e-13	1	2
ENSP00000413452	zf-C2H2	PF00096.26	1.7e-13	2	2
ENSP00000491984	zf-C2H2	PF00096.26	1.7e-13	1	2
ENSP00000491984	zf-C2H2	PF00096.26	1.7e-13	2	2
ENSP00000331327	zf-C2H2	PF00096.26	1.7e-13	1	2
ENSP00000331327	zf-C2H2	PF00096.26	1.7e-13	2	2
ENSP00000435624	zf-C2H2	PF00096.26	2e-09	1	2
ENSP00000435624	zf-C2H2	PF00096.26	2e-09	2	2
ENSP00000492269	WT1	PF02165.15	3.6e-156	1	1
ENSP00000415516	WT1	PF02165.15	3.6e-156	1	1
ENSP00000491511	WT1	PF02165.15	1.3e-148	1	2
ENSP00000491511	WT1	PF02165.15	1.3e-148	2	2
ENSP00000413452	WT1	PF02165.15	1.3e-148	1	2
ENSP00000413452	WT1	PF02165.15	1.3e-148	2	2
ENSP00000491984	WT1	PF02165.15	1.3e-148	1	2
ENSP00000491984	WT1	PF02165.15	1.3e-148	2	2
ENSP00000331327	WT1	PF02165.15	1.3e-148	1	2
ENSP00000331327	WT1	PF02165.15	1.3e-148	2	2
ENSP00000435307	WT1	PF02165.15	1e-90	1	1
ENSP00000368370	WT1	PF02165.15	2.7e-84	1	1
ENSP00000435351	WT1	PF02165.15	1.8e-59	1	2
ENSP00000435351	WT1	PF02165.15	1.8e-59	2	2
ENSP00000435624	WT1	PF02165.15	1.6e-24	1	1

Literatures on RNA binding capacity

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Search:

PID	Title	Article	Time	Author	Doi
27417971	Methods to Identify and Validate WT1-RNA Interaction.	Methods Mol Biol	2016	Bharathavikru R	doi: 10.1007/978-1-4939-4023-3_17.
25375204	How mRNA is misspliced in acute myelogenous leukemia (AML)?	Oncotarget	2014 Oct 30	Mohamed AM	-
20885852	WT1 and kidney progenitor cells.	Organogenesis	2010 Apr-Jun	Kreidberg JA	-
12970737	Transcriptional activity of testis-determining factor SRY is modulated by the Wilms' tumor 1 gene product, WT1.	Oncogene	2003 Sep 11	Matsuzawa-Watanabe Y	-
12215008	Regulation of gene expression by WT1 in development and tumorigenesis.	Int J Hematol	2002 Aug	Ellisen LW	-
9512553	Overlapping RNA and DNA binding domains of the wt1 tumor suppressor gene product.	Nucleic Acids Res	1998 Apr 1	Bardeesy N	-
8896454	Regulation of WT1 by phosphorylation: inhibition of DNA binding, alteration of transcriptional activity and cellular translocation.	EMBO J	1996 Oct 15	Ye Y	-
7493135	The emerging molecular genetics of sarcoma translocations.	Diagn Mol Pathol	1995 Sep	Ladanyi M	-
7862627	Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumor.	Proc Natl Acad Sci U S A	1995 Feb 14	Gerald WL	-

Showing 1 to 9 of 9 entries

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Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000530998	WT1-209	2421	-	ENSP00000435307	288 (aa)	-	P19544
ENST00000526685	WT1-206	718	-	ENSP00000436292	25 (aa)	-	E9PPW3
ENST00000379079	WT1-203	2466	-	ENSP00000368370	302 (aa)	-	P19544
ENST00000379077	WT1-202	3032	-	ENSP00000368368	317 (aa)	-	H0Y3F0
ENST00000639907	WT1-211	1545	-	ENSP00000491511	514 (aa)	-	A0A1W2PPP2
ENST00000640146	WT1-212	1554	-	ENSP00000491984	517 (aa)	-	A0A1W2PR07
ENST00000448076	WT1-204	2114	-	ENSP00000413452	514 (aa)	-	H0Y7K5
ENST00000527882	WT1-208	551	-	ENSP00000435624	178 (aa)	-	H0YED9
ENST00000639563	WT1-210	1494	-	ENSP00000492269	497 (aa)	-	A0A1W2PQQ0
ENST00000332351	WT1-201	3122	-	ENSP00000331327	517 (aa)	-	J3KNN9
ENST00000527775	WT1-207	578	-	ENSP00000435351	131 (aa)	-	E9PKS2
ENST00000452863	WT1-205	2768	-	ENSP00000415516	497 (aa)	-	A0A0A0MT54

Gene Model

Click here to download ENSG00000184937's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05202	Transcriptional misregulation in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000184937	Hernia, Inguinal	4E-14	26686553

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	EFO ID
ENSG00000184937	rs4986811	11	32429547	G	Rubella-specific interleukin-6 secretion	29253144	EFO_0004810\|EFO_0004645
ENSG00000184937	rs5030179	11	32426709	?	Systolic blood pressure	30595370	EFO_0006335
ENSG00000184937	rs7110547	11	32425801	?	Waist-hip ratio	30595370	EFO_0004343

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000184937's network

CanvasJS.com

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000184937	WT1	100	100.000	ENSAPOG00000000289	wt1a	100	70.588	Acanthochromis_polyacanthus
ENSG00000184937	WT1	100	88.000	ENSAPOG00000011422	wt1b	99	63.820	Acanthochromis_polyacanthus
ENSG00000184937	WT1	100	100.000	ENSAMEG00000006957	WT1	100	91.686	Ailuropoda_melanoleuca
ENSG00000184937	WT1	100	88.000	ENSACIG00000005676	wt1b	99	63.719	Amphilophus_citrinellus
ENSG00000184937	WT1	100	100.000	ENSACIG00000005841	wt1a	100	69.011	Amphilophus_citrinellus
ENSG00000184937	WT1	100	88.000	ENSAOCG00000011027	wt1b	98	64.172	Amphiprion_ocellaris
ENSG00000184937	WT1	78	62.791	ENSAOCG00000002699	wt1a	99	63.178	Amphiprion_ocellaris
ENSG00000184937	WT1	100	100.000	ENSAOCG00000005965	-	96	84.783	Amphiprion_ocellaris
ENSG00000184937	WT1	100	100.000	ENSAPEG00000007652	wt1a	100	70.495	Amphiprion_percula
ENSG00000184937	WT1	100	88.000	ENSAPEG00000007784	wt1b	98	55.580	Amphiprion_percula
ENSG00000184937	WT1	100	100.000	ENSATEG00000009147	wt1a	100	71.910	Anabas_testudineus
ENSG00000184937	WT1	100	84.000	ENSATEG00000022506	wt1b	98	62.812	Anabas_testudineus
ENSG00000184937	WT1	100	100.000	ENSAPLG00000005775	WT1	100	77.112	Anas_platyrhynchos
ENSG00000184937	WT1	100	92.000	ENSACAG00000002480	WT1	100	91.319	Anolis_carolinensis
ENSG00000184937	WT1	100	100.000	ENSANAG00000025090	WT1	100	99.103	Aotus_nancymaae
ENSG00000184937	WT1	100	100.000	ENSACLG00000014317	wt1a	100	69.231	Astatotilapia_calliptera
ENSG00000184937	WT1	100	88.000	ENSACLG00000007937	wt1b	98	64.172	Astatotilapia_calliptera
ENSG00000184937	WT1	100	100.000	ENSAMXG00000039834	wt1a	100	71.882	Astyanax_mexicanus
ENSG00000184937	WT1	100	88.000	ENSAMXG00000039805	wt1b	99	62.700	Astyanax_mexicanus
ENSG00000184937	WT1	100	100.000	ENSBTAG00000047268	WT1	100	96.607	Bos_taurus
ENSG00000184937	WT1	100	100.000	ENSCJAG00000005900	WT1	100	98.886	Callithrix_jacchus
ENSG00000184937	WT1	100	100.000	ENSCAFG00000007426	WT1	100	95.591	Canis_familiaris
ENSG00000184937	WT1	100	100.000	ENSCAFG00020002366	WT1	100	98.845	Canis_lupus_dingo
ENSG00000184937	WT1	100	100.000	ENSCHIG00000013048	WT1	100	99.111	Capra_hircus
ENSG00000184937	WT1	100	100.000	ENSTSYG00000034121	WT1	100	89.073	Carlito_syrichta
ENSG00000184937	WT1	100	100.000	ENSCAPG00000000045	WT1	100	95.775	Cavia_aperea
ENSG00000184937	WT1	100	100.000	ENSCPOG00000033316	WT1	100	95.312	Cavia_porcellus
ENSG00000184937	WT1	100	100.000	ENSCCAG00000024307	WT1	100	99.338	Cebus_capucinus
ENSG00000184937	WT1	100	100.000	ENSCATG00000034786	WT1	100	99.669	Cercocebus_atys
ENSG00000184937	WT1	100	100.000	ENSCLAG00000001374	WT1	100	95.938	Chinchilla_lanigera
ENSG00000184937	WT1	100	100.000	ENSCSAG00000005257	WT1	100	99.688	Chlorocebus_sabaeus
ENSG00000184937	WT1	100	100.000	ENSCHOG00000006244	WT1	85	98.230	Choloepus_hoffmanni
ENSG00000184937	WT1	100	100.000	ENSCPBG00000018273	WT1	82	83.881	Chrysemys_picta_bellii
ENSG00000184937	WT1	100	100.000	ENSCANG00000037566	WT1	100	99.669	Colobus_angolensis_palliatus
ENSG00000184937	WT1	100	100.000	ENSCGRG00001005125	Wt1	100	97.222	Cricetulus_griseus_chok1gshd
ENSG00000184937	WT1	100	100.000	ENSCGRG00000008703	Wt1	100	97.222	Cricetulus_griseus_crigri
ENSG00000184937	WT1	96	70.833	ENSCSEG00000014378	wt1b	97	42.286	Cynoglossus_semilaevis
ENSG00000184937	WT1	100	88.000	ENSCSEG00000021216	wt1a	79	93.750	Cynoglossus_semilaevis
ENSG00000184937	WT1	100	88.000	ENSCVAG00000019529	wt1b	97	61.644	Cyprinodon_variegatus
ENSG00000184937	WT1	100	96.000	ENSCVAG00000002818	wt1a	100	69.752	Cyprinodon_variegatus
ENSG00000184937	WT1	100	84.000	ENSDARG00000007990	wt1b	97	65.438	Danio_rerio
ENSG00000184937	WT1	100	100.000	ENSDARG00000031420	wt1a	100	73.121	Danio_rerio
ENSG00000184937	WT1	100	100.000	ENSDNOG00000003652	WT1	99	94.767	Dasypus_novemcinctus
ENSG00000184937	WT1	100	100.000	ENSDORG00000013725	Wt1	100	98.675	Dipodomys_ordii
ENSG00000184937	WT1	100	100.000	ENSETEG00000000684	WT1	100	94.272	Echinops_telfairi
ENSG00000184937	WT1	100	80.000	ENSEBUG00000013909	wt1a	100	49.460	Eptatretus_burgeri
ENSG00000184937	WT1	100	100.000	ENSEASG00005013477	WT1	100	95.164	Equus_asinus_asinus
ENSG00000184937	WT1	100	100.000	ENSECAG00000022308	WT1	70	95.358	Equus_caballus
ENSG00000184937	WT1	100	100.000	ENSEEUG00000007221	WT1	100	99.003	Erinaceus_europaeus
ENSG00000184937	WT1	100	100.000	ENSELUG00000016479	wt1a	100	74.943	Esox_lucius
ENSG00000184937	WT1	100	84.000	ENSELUG00000023224	wt1b	99	63.170	Esox_lucius
ENSG00000184937	WT1	100	100.000	ENSFCAG00000000308	WT1	100	99.669	Felis_catus
ENSG00000184937	WT1	100	100.000	ENSFALG00000010820	WT1	100	80.742	Ficedula_albicollis
ENSG00000184937	WT1	100	100.000	ENSFDAG00000006720	WT1	100	95.486	Fukomys_damarensis
ENSG00000184937	WT1	100	92.000	ENSFHEG00000020493	wt1b	97	62.955	Fundulus_heteroclitus
ENSG00000184937	WT1	100	96.000	ENSFHEG00000022384	wt1a	100	66.216	Fundulus_heteroclitus
ENSG00000184937	WT1	100	84.000	ENSGMOG00000012296	wt1b	100	62.838	Gadus_morhua
ENSG00000184937	WT1	100	100.000	ENSGALG00000012115	WT1	100	87.327	Gallus_gallus
ENSG00000184937	WT1	100	76.000	ENSGAFG00000002346	wt1b	97	62.187	Gambusia_affinis
ENSG00000184937	WT1	100	92.000	ENSGAFG00000021899	wt1a	100	63.964	Gambusia_affinis
ENSG00000184937	WT1	100	100.000	ENSGACG00000003299	wt1a	100	62.533	Gasterosteus_aculeatus
ENSG00000184937	WT1	100	84.000	ENSGACG00000016020	wt1b	100	63.719	Gasterosteus_aculeatus
ENSG00000184937	WT1	100	100.000	ENSGAGG00000000224	WT1	100	81.567	Gopherus_agassizii
ENSG00000184937	WT1	100	100.000	ENSGGOG00000011586	WT1	100	99.669	Gorilla_gorilla
ENSG00000184937	WT1	100	100.000	ENSHBUG00000002527	wt1a	100	69.451	Haplochromis_burtoni
ENSG00000184937	WT1	100	88.000	ENSHBUG00000016837	wt1b	99	64.303	Haplochromis_burtoni
ENSG00000184937	WT1	100	100.000	ENSHGLG00000004253	WT1	100	96.528	Heterocephalus_glaber_female
ENSG00000184937	WT1	100	100.000	ENSHGLG00100012634	WT1	100	96.528	Heterocephalus_glaber_male
ENSG00000184937	WT1	100	88.000	ENSHCOG00000015781	wt1a	100	65.611	Hippocampus_comes
ENSG00000184937	WT1	100	84.000	ENSHCOG00000015039	wt1b	98	61.435	Hippocampus_comes
ENSG00000184937	WT1	100	88.000	ENSIPUG00000012895	wt1b	100	62.100	Ictalurus_punctatus
ENSG00000184937	WT1	100	100.000	ENSIPUG00000010239	wt1	100	72.665	Ictalurus_punctatus
ENSG00000184937	WT1	100	100.000	ENSSTOG00000023716	WT1	100	99.306	Ictidomys_tridecemlineatus
ENSG00000184937	WT1	96	87.500	ENSKMAG00000011114	wt1b	98	60.909	Kryptolebias_marmoratus
ENSG00000184937	WT1	100	96.000	ENSKMAG00000007444	wt1a	100	68.304	Kryptolebias_marmoratus
ENSG00000184937	WT1	100	100.000	ENSLBEG00000015040	wt1a	62	74.299	Labrus_bergylta
ENSG00000184937	WT1	100	80.000	ENSLBEG00000002082	wt1b	98	62.358	Labrus_bergylta
ENSG00000184937	WT1	70	57.500	ENSLBEG00000004013	wt1a	99	56.904	Labrus_bergylta
ENSG00000184937	WT1	100	100.000	ENSLACG00000016378	WT1	99	80.275	Latimeria_chalumnae
ENSG00000184937	WT1	100	100.000	ENSLOCG00000004537	wt1a	100	75.973	Lepisosteus_oculatus
ENSG00000184937	WT1	100	100.000	ENSLAFG00000006160	WT1	100	98.444	Loxodonta_africana
ENSG00000184937	WT1	100	100.000	ENSMFAG00000030746	WT1	100	99.669	Macaca_fascicularis
ENSG00000184937	WT1	100	100.000	ENSMMUG00000009881	WT1	100	99.669	Macaca_mulatta
ENSG00000184937	WT1	100	100.000	ENSMNEG00000010071	WT1	100	99.669	Macaca_nemestrina
ENSG00000184937	WT1	100	100.000	ENSMLEG00000040206	WT1	100	99.669	Mandrillus_leucophaeus
ENSG00000184937	WT1	100	88.000	ENSMAMG00000020379	wt1b	97	63.946	Mastacembelus_armatus
ENSG00000184937	WT1	100	100.000	ENSMAMG00000014896	wt1a	100	71.024	Mastacembelus_armatus
ENSG00000184937	WT1	100	100.000	ENSMZEG00005012633	wt1a	100	69.977	Maylandia_zebra
ENSG00000184937	WT1	100	88.000	ENSMZEG00005011978	wt1b	99	64.172	Maylandia_zebra
ENSG00000184937	WT1	100	100.000	ENSMGAG00000001489	WT1	100	94.086	Meleagris_gallopavo
ENSG00000184937	WT1	100	100.000	ENSMAUG00000008036	Wt1	100	97.222	Mesocricetus_auratus
ENSG00000184937	WT1	100	100.000	ENSMICG00000004097	WT1	100	99.669	Microcebus_murinus
ENSG00000184937	WT1	100	100.000	ENSMOCG00000006225	Wt1	100	97.222	Microtus_ochrogaster
ENSG00000184937	WT1	100	96.000	ENSMMOG00000000597	wt1a	100	67.647	Mola_mola
ENSG00000184937	WT1	100	88.000	ENSMMOG00000016011	wt1b	100	62.670	Mola_mola
ENSG00000184937	WT1	100	100.000	ENSMODG00000009646	WT1	100	89.333	Monodelphis_domestica
ENSG00000184937	WT1	100	88.000	ENSMALG00000011899	wt1b	97	64.679	Monopterus_albus
ENSG00000184937	WT1	100	100.000	ENSMALG00000005342	wt1a	99	70.110	Monopterus_albus
ENSG00000184937	WT1	100	100.000	MGP_CAROLIEiJ_G0024034	Wt1	100	98.264	Mus_caroli
ENSG00000184937	WT1	100	100.000	ENSMUSG00000016458	Wt1	100	97.917	Mus_musculus
ENSG00000184937	WT1	100	100.000	MGP_PahariEiJ_G0025472	Wt1	100	97.917	Mus_pahari
ENSG00000184937	WT1	100	100.000	MGP_SPRETEiJ_G0024947	Wt1	100	98.264	Mus_spretus
ENSG00000184937	WT1	100	100.000	ENSMPUG00000011307	WT1	100	98.845	Mustela_putorius_furo
ENSG00000184937	WT1	100	100.000	ENSMLUG00000027523	WT1	100	93.364	Myotis_lucifugus
ENSG00000184937	WT1	100	100.000	ENSNGAG00000022234	Wt1	100	99.306	Nannospalax_galili
ENSG00000184937	WT1	100	88.000	ENSNBRG00000007171	wt1b	99	60.137	Neolamprologus_brichardi
ENSG00000184937	WT1	100	100.000	ENSNLEG00000017890	-	100	99.669	Nomascus_leucogenys
ENSG00000184937	WT1	100	100.000	ENSOPRG00000015709	WT1	100	98.339	Ochotona_princeps
ENSG00000184937	WT1	79	94.779	ENSODEG00000015471	-	100	94.779	Octodon_degus
ENSG00000184937	WT1	100	100.000	ENSONIG00000011043	wt1a	100	69.518	Oreochromis_niloticus
ENSG00000184937	WT1	100	88.000	ENSONIG00000005545	wt1b	98	63.554	Oreochromis_niloticus
ENSG00000184937	WT1	50	67.213	ENSOANG00000031546	-	98	100.000	Ornithorhynchus_anatinus
ENSG00000184937	WT1	100	100.000	ENSOANG00000015147	-	100	94.340	Ornithorhynchus_anatinus
ENSG00000184937	WT1	100	100.000	ENSOCUG00000005882	WT1	100	98.977	Oryctolagus_cuniculus
ENSG00000184937	WT1	100	96.000	ENSORLG00000012424	wt1	100	69.604	Oryzias_latipes
ENSG00000184937	WT1	100	84.000	ENSORLG00000009859	wt1	98	60.820	Oryzias_latipes
ENSG00000184937	WT1	100	96.000	ENSORLG00020018844	wt1	100	69.147	Oryzias_latipes_hni
ENSG00000184937	WT1	100	84.000	ENSORLG00020005212	wt1b	98	61.468	Oryzias_latipes_hni
ENSG00000184937	WT1	100	96.000	ENSORLG00015009813	wt1a	100	69.365	Oryzias_latipes_hsok
ENSG00000184937	WT1	100	84.000	ENSORLG00015003298	wt1b	98	61.048	Oryzias_latipes_hsok
ENSG00000184937	WT1	100	84.000	ENSOMEG00000003946	wt1b	98	61.048	Oryzias_melastigma
ENSG00000184937	WT1	100	96.000	ENSOMEG00000012831	wt1a	100	70.946	Oryzias_melastigma
ENSG00000184937	WT1	100	100.000	ENSOGAG00000007118	WT1	100	97.921	Otolemur_garnettii
ENSG00000184937	WT1	100	100.000	ENSOARG00000016334	WT1	84	96.306	Ovis_aries
ENSG00000184937	WT1	100	100.000	ENSPPAG00000033782	-	100	99.669	Pan_paniscus
ENSG00000184937	WT1	100	100.000	ENSPPRG00000022915	WT1	100	100.000	Panthera_pardus
ENSG00000184937	WT1	100	100.000	ENSPTIG00000007474	WT1	100	91.060	Panthera_tigris_altaica
ENSG00000184937	WT1	100	100.000	ENSPTRG00000003476	WT1	100	99.669	Pan_troglodytes
ENSG00000184937	WT1	100	100.000	ENSPANG00000019482	WT1	100	99.669	Papio_anubis
ENSG00000184937	WT1	100	96.000	ENSPKIG00000023518	wt1a	100	67.342	Paramormyrops_kingsleyae
ENSG00000184937	WT1	100	100.000	ENSPSIG00000013679	WT1	100	87.037	Pelodiscus_sinensis
ENSG00000184937	WT1	100	84.000	ENSPMGG00000000235	wt1b	97	57.658	Periophthalmus_magnuspinnatus
ENSG00000184937	WT1	100	96.000	ENSPMGG00000010507	wt1a	100	68.653	Periophthalmus_magnuspinnatus
ENSG00000184937	WT1	100	100.000	ENSPEMG00000001292	Wt1	100	97.222	Peromyscus_maniculatus_bairdii
ENSG00000184937	WT1	100	88.000	ENSPMAG00000008950	wt1a	100	55.814	Petromyzon_marinus
ENSG00000184937	WT1	100	76.000	ENSPFOG00000017089	wt1b	97	62.415	Poecilia_formosa
ENSG00000184937	WT1	100	92.000	ENSPFOG00000010572	wt1a	99	62.526	Poecilia_formosa
ENSG00000184937	WT1	100	92.000	ENSPLAG00000010715	wt1a	100	68.694	Poecilia_latipinna
ENSG00000184937	WT1	100	76.000	ENSPLAG00000009581	wt1b	97	62.415	Poecilia_latipinna
ENSG00000184937	WT1	100	76.000	ENSPMEG00000010435	wt1b	97	62.415	Poecilia_mexicana
ENSG00000184937	WT1	100	92.000	ENSPMEG00000022279	wt1a	100	68.694	Poecilia_mexicana
ENSG00000184937	WT1	100	92.000	ENSPREG00000001322	wt1a	93	64.740	Poecilia_reticulata
ENSG00000184937	WT1	100	76.000	ENSPREG00000013693	wt1b	84	62.500	Poecilia_reticulata
ENSG00000184937	WT1	100	100.000	ENSPPYG00000029822	-	100	99.688	Pongo_abelii
ENSG00000184937	WT1	100	100.000	ENSPCAG00000002213	WT1	99	93.810	Procavia_capensis
ENSG00000184937	WT1	100	100.000	ENSPCOG00000020436	WT1	100	98.689	Propithecus_coquereli
ENSG00000184937	WT1	100	100.000	ENSPVAG00000006895	WT1	100	99.617	Pteropus_vampyrus
ENSG00000184937	WT1	100	88.000	ENSPNYG00000018035	wt1b	99	60.137	Pundamilia_nyererei
ENSG00000184937	WT1	100	100.000	ENSPNYG00000009087	wt1a	100	67.120	Pundamilia_nyererei
ENSG00000184937	WT1	100	88.000	ENSPNAG00000019996	wt1b	98	63.182	Pygocentrus_nattereri
ENSG00000184937	WT1	100	100.000	ENSPNAG00000007577	wt1a	100	73.349	Pygocentrus_nattereri
ENSG00000184937	WT1	100	100.000	ENSRNOG00000013074	Wt1	100	97.550	Rattus_norvegicus
ENSG00000184937	WT1	100	100.000	ENSRBIG00000039095	WT1	100	98.689	Rhinopithecus_bieti
ENSG00000184937	WT1	100	100.000	ENSRROG00000021147	WT1	100	98.689	Rhinopithecus_roxellana
ENSG00000184937	WT1	100	100.000	ENSSBOG00000020662	WT1	100	99.200	Saimiri_boliviensis_boliviensis
ENSG00000184937	WT1	100	100.000	ENSSHAG00000017390	WT1	95	95.789	Sarcophilus_harrisii
ENSG00000184937	WT1	100	100.000	ENSSFOG00015022275	wt1a	100	65.766	Scleropages_formosus
ENSG00000184937	WT1	100	100.000	ENSSMAG00000016064	wt1a	100	68.996	Scophthalmus_maximus
ENSG00000184937	WT1	100	88.000	ENSSMAG00000002419	wt1b	99	63.571	Scophthalmus_maximus
ENSG00000184937	WT1	100	88.000	ENSSDUG00000020629	wt1b	98	63.739	Seriola_dumerili
ENSG00000184937	WT1	100	100.000	ENSSDUG00000004388	wt1a	100	72.072	Seriola_dumerili
ENSG00000184937	WT1	100	88.000	ENSSLDG00000025654	wt1b	98	63.964	Seriola_lalandi_dorsalis
ENSG00000184937	WT1	100	100.000	ENSSLDG00000007801	wt1a	100	71.847	Seriola_lalandi_dorsalis
ENSG00000184937	WT1	100	100.000	ENSSARG00000000207	WT1	100	98.007	Sorex_araneus
ENSG00000184937	WT1	100	100.000	ENSSPUG00000004548	WT1	100	85.484	Sphenodon_punctatus
ENSG00000184937	WT1	100	88.000	ENSSPAG00000005131	wt1b	98	65.079	Stegastes_partitus
ENSG00000184937	WT1	100	100.000	ENSSPAG00000017648	wt1a	100	64.978	Stegastes_partitus
ENSG00000184937	WT1	100	100.000	ENSSSCG00000013316	WT1	100	98.605	Sus_scrofa
ENSG00000184937	WT1	100	100.000	ENSTGUG00000004906	WT1	100	86.636	Taeniopygia_guttata
ENSG00000184937	WT1	100	92.000	ENSTRUG00000003418	-	100	58.427	Takifugu_rubripes
ENSG00000184937	WT1	100	84.000	ENSTRUG00000006559	wt1b	98	59.637	Takifugu_rubripes
ENSG00000184937	WT1	100	84.000	ENSTNIG00000013806	wt1b	100	60.544	Tetraodon_nigroviridis
ENSG00000184937	WT1	100	92.000	ENSTNIG00000007794	wt1a	100	65.237	Tetraodon_nigroviridis
ENSG00000184937	WT1	100	100.000	ENSTBEG00000007282	-	100	80.986	Tupaia_belangeri
ENSG00000184937	WT1	100	100.000	ENSTTRG00000012819	WT1	100	98.810	Tursiops_truncatus
ENSG00000184937	WT1	100	100.000	ENSUAMG00000018139	WT1	100	98.689	Ursus_americanus
ENSG00000184937	WT1	100	100.000	ENSUMAG00000019514	WT1	100	93.811	Ursus_maritimus
ENSG00000184937	WT1	100	100.000	ENSVPAG00000007788	WT1	100	98.671	Vicugna_pacos
ENSG00000184937	WT1	100	100.000	ENSVVUG00000016328	WT1	100	99.556	Vulpes_vulpes
ENSG00000184937	WT1	100	100.000	ENSXETG00000008172	wt1	100	68.018	Xenopus_tropicalis
ENSG00000184937	WT1	100	92.000	ENSXCOG00000020638	wt1a	100	69.128	Xiphophorus_couchianus
ENSG00000184937	WT1	100	92.000	ENSXMAG00000029371	wt1a	100	69.128	Xiphophorus_maculatus
ENSG00000184937	WT1	100	76.000	ENSXMAG00000014221	wt1b	97	62.642	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	7585606.	IDA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	23042785.	IMP	Process
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	21873635.	IBA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	ISM	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	19274049.	NAS	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	23042785.	IDA	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	-	ISS	Function
GO:0001570	vasculogenesis	-	ISS	Process
GO:0001657	ureteric bud development	-	ISS	Process
GO:0001658	branching involved in ureteric bud morphogenesis	10101119.	IGI	Process
GO:0001822	kidney development	11912180.	IGI	Process
GO:0003156	regulation of animal organ formation	-	ISS	Process
GO:0003700	DNA-binding transcription factor activity	-	ISS	Function
GO:0003700	DNA-binding transcription factor activity	7862533.8393820.	NAS	Function
GO:0003723	RNA binding	-	IEA	Function
GO:0005515	protein binding	7720589.8119964.9178767.9553041.14701728.16934801.21390327.25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	1662794.7588596.8306891.14701728.15961562.16934801.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	-	ISS	Process
GO:0006355	regulation of transcription, DNA-templated	7862533.8393820.	NAS	Process
GO:0006357	regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0006357	regulation of transcription by RNA polymerase II	-	ISS	Process
GO:0007281	germ cell development	-	ISS	Process
GO:0007356	thorax and anterior abdomen determination	-	ISS	Process
GO:0007507	heart development	10101119.	IGI	Process
GO:0007530	sex determination	9815658.	IDA	Process
GO:0008270	zinc ion binding	15518539.25258363.	IDA	Function
GO:0008285	negative regulation of cell proliferation	21873635.	IBA	Process
GO:0008285	negative regulation of cell proliferation	9553041.9765217.	IDA	Process
GO:0008380	RNA splicing	-	ISS	Process
GO:0008406	gonad development	-	ISS	Process
GO:0008584	male gonad development	17848411.	IEP	Process
GO:0009888	tissue development	-	ISS	Process
GO:0010385	double-stranded methylated DNA binding	25258363.	IDA	Function
GO:0010628	positive regulation of gene expression	23042785.	IMP	Process
GO:0016607	nuclear speck	9553041.16934801.	IDA	Component
GO:0030308	negative regulation of cell growth	9553041.9765217.	IDA	Process
GO:0030325	adrenal gland development	10101119.	IGI	Process
GO:0030539	male genitalia development	-	ISS	Process
GO:0030855	epithelial cell differentiation	-	ISS	Process
GO:0032835	glomerulus development	10101119.	IGI	Process
GO:0032836	glomerular basement membrane development	19205749.	IMP	Process
GO:0035802	adrenal cortex formation	-	ISS	Process
GO:0043010	camera-type eye development	-	ISS	Process
GO:0043066	negative regulation of apoptotic process	21873635.	IBA	Process
GO:0043066	negative regulation of apoptotic process	10101119.	IGI	Process
GO:0043565	sequence-specific DNA binding	1662794.7720589.8119964.25258363.	IDA	Function
GO:0044212	transcription regulatory region DNA binding	1332065.7585606.7588596.9815658.16467207.23042785.	IDA	Function
GO:0044729	hemi-methylated DNA-binding	25258363.	IDA	Function
GO:0045892	negative regulation of transcription, DNA-templated	1332065.7585606.7720589.8119964.12802290.14701728.19050011.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	8132626.9178767.9553041.9765217.12802290.14701728.16467207.21390327.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	11912180.	IGI	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	23042785.	IDA	Process
GO:0060231	mesenchymal to epithelial transition	-	ISS	Process
GO:0060421	positive regulation of heart growth	-	ISS	Process
GO:0060539	diaphragm development	-	ISS	Process
GO:0060923	cardiac muscle cell fate commitment	-	ISS	Process
GO:0061032	visceral serous pericardium development	10101119.	IGI	Process
GO:0070742	C2H2 zinc finger domain binding	8119964.	IPI	Function
GO:0071320	cellular response to cAMP	21873635.	IBA	Process
GO:0071320	cellular response to cAMP	15961562.	IEP	Process
GO:0071371	cellular response to gonadotropin stimulus	21873635.	IBA	Process
GO:0071371	cellular response to gonadotropin stimulus	15961562.	IDA	Process
GO:0072075	metanephric mesenchyme development	-	ISS	Process
GO:0072112	glomerular visceral epithelial cell differentiation	21873635.	IBA	Process
GO:0072112	glomerular visceral epithelial cell differentiation	-	ISS	Process
GO:0072166	posterior mesonephric tubule development	-	ISS	Process
GO:0072207	metanephric epithelium development	7856737.	IEP	Process
GO:0072284	metanephric S-shaped body morphogenesis	10101119.	IGI	Process
GO:0072302	negative regulation of metanephric glomerular mesangial cell proliferation	-	ISS	Process
GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	23042785.	IMP	Process
GO:1905643	positive regulation of DNA methylation	23042785.	IMP	Process
GO:2000020	positive regulation of male gonad development	-	ISS	Process
GO:2000195	negative regulation of female gonad development	-	ISS	Process
GO:2001076	positive regulation of metanephric ureteric bud development	-	ISS	Process

Cancer associated literatures

Show entries

Search:

PID	Title	Article	Time	Author	Doi
29291617	Methylation Status of Transcriptional Modulatory Genes Associated with Colorectal Cancer in Northeast China.	Gut Liver	2018 Mar 15	Gao HL	doi: 10.5009/gnl17163.
28677722	Regulation of retinoic acid synthetic enzymes by WT1 and HDAC inhibitors in 293 cells.	Int J Mol Med	2017 Sep	Li Y	doi: 10.3892/ijmm.2017.3051
29016617	MicroRNA-193a inhibits breast cancer proliferation and metastasis by downregulating WT1.	PLoS One	2017 Oct 10	Xie F	doi: 10.1371/journal.pone.0185565
28345629	WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel.	Sci Rep	2017 Mar 27	Artibani M	doi: 10.1038/srep45255.
28498419	miR-590 regulates WT1 during proliferation of G401 cells.	Mol Med Rep	2017 Jul	Hong L	doi: 10.3892/mmr.2017.6561
27922671	Differential detection of cytoplasmic Wilms tumor 1 expression by immunohistochemistry, western blotting and mRNA quantification.	Int J Oncol	2017 Jan	Maki T	doi: 10.3892/ijo.2016.3786
29024629	The role of WT1 isoforms in vasculogenic mimicry and metastatic potential of human triple negative breast cancer cells.	Biochem Biophys Res Commun	2017 Dec 9	Bissanum R	doi: 10.1016/j.bbrc.2017.10.043
29040381	The CUG-translated WT1, not AUG-WT1, is an oncogene.	Carcinogenesis	2017 Dec 7	Lee KY	doi: 10.1093/carcin/bgx108.
28400619	Dysfunction of the WT1-MEG3 signaling promotes AML leukemogenesis via p53-dependent and -independent pathways.	Leukemia	2017 Dec	Lyu Y	doi: 10.1038/leu.2017.116
27062662	Wilms' tumor 1 protein expression in endometrial adenocarcinoma and endometrial intra-epithelial neoplasia.	J Obstet Gynaecol Res	2016 Jul	Atik Y	doi: 10.1111/jog.12981

Showing 1 to 10 of 104 entries

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Differential Expression

Expression in 33 cancers

Mutations

Show entries

Search:

Cancer	Chr	Position	Mutation Type	dbSNP	Allele Freq
UCEC	chr11	32387983	3'UTR	novel	0.37
UCEC	chr11	32387998	3'UTR	novel	0.21
UCEC	chr11	32388026	3'UTR	novel	0.12
UCEC	chr11	32388078	3'UTR	novel	0.31
UCEC	chr11	32388149	3'UTR	novel	0.39
UCEC	chr11	32388203	3'UTR	novel	0.45
UCEC	chr11	32388291	3'UTR	novel	0.3
UCEC	chr11	32388307	3'UTR	novel	0.55
BRCA	chr11	32388338	3'UTR	novel	0.45
UCEC	chr11	32388409	3'UTR	novel	0.35

Showing 1 to 10 of 287 entries

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Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ESCA	AMP	0.1848	0.018342
TGCT	DEL	0.58	0.21504

Survival Analysis

Cancer	P-value	Q-value
THYM	0.016	Kaplan-Meier Survival Analysis
KIRC	0.00015	Kaplan-Meier Survival Analysis
STAD	0.018	Kaplan-Meier Survival Analysis
SARC	0.014	Kaplan-Meier Survival Analysis
MESO	0.00021	Kaplan-Meier Survival Analysis
ACC	0.0001	Kaplan-Meier Survival Analysis
HNSC	0.012	Kaplan-Meier Survival Analysis
LUSC	0.019	Kaplan-Meier Survival Analysis
BRCA	0.0018	Kaplan-Meier Survival Analysis
KIRP	0.01	Kaplan-Meier Survival Analysis
COAD	0.0086	Kaplan-Meier Survival Analysis
BLCA	0.018	Kaplan-Meier Survival Analysis
READ	0.015	Kaplan-Meier Survival Analysis
LAML	0.0046	Kaplan-Meier Survival Analysis
KICH	0.032	Kaplan-Meier Survival Analysis
UCEC	0.03	Kaplan-Meier Survival Analysis
LIHC	0.0015	Kaplan-Meier Survival Analysis
LGG	0.00012	Kaplan-Meier Survival Analysis
THCA	0.014	Kaplan-Meier Survival Analysis
LUAD	0.036	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742