EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000185236 (Gene tree)
Gene ID: 9230
Gene Symbol: RAB11B
Alias: H-YPT3
Full Name: RAB11B, member RAS oncogene family
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 14,454 bases
Position: chr19:8,389,981-8,404,434
Accession: 9761
RBP type: canonical RBP
Summary: The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000471148	MMR_HSR1	PF01926.23	7.4e-07	1	1
ENSP00000333547	MMR_HSR1	PF01926.23	1.1e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000600719	RAB11B-204	532	-	ENSP00000473042	46 (aa)	-	M0R377
ENST00000594216	RAB11B-202	894	-	ENSP00000471148	179 (aa)	-	Q15907
ENST00000598706	RAB11B-203	574	-	-	- (aa)	-	-
ENST00000601897	RAB11B-205	577	-	ENSP00000472473	60 (aa)	-	M0R2D0
ENST00000328024	RAB11B-201	1751	-	ENSP00000333547	218 (aa)	-	Q15907

Gene Model

Click here to download ENSG00000185236's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04144	Endocytosis	KEGG
hsa04152	AMPK signaling pathway	KEGG
hsa04962	Vasopressin-regulated water reabsorption	KEGG
hsa05164	Influenza A	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000185236	Platelet Function Tests	4.9300000E-006	-
ENSG00000185236	Blood Pressure	3.1591048E-005	-
ENSG00000185236	Cholesterol, HDL	1E-8	19060906

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000185236	rs2241588	19	8403601	?	Waist-hip ratio	30595370			EFO_0004343

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000185236's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000185236	RAB11B	100	100.000	ENSAMEG00000004955	RAB11B	99	98.630	Ailuropoda_melanoleuca
ENSG00000185236	RAB11B	100	97.826	ENSACIG00000024374	rab11ba	70	97.076	Amphilophus_citrinellus
ENSG00000185236	RAB11B	100	95.652	ENSAOCG00000018050	rab11ba	100	94.495	Amphiprion_ocellaris
ENSG00000185236	RAB11B	100	95.652	ENSAPEG00000009177	rab11ba	100	94.037	Amphiprion_percula
ENSG00000185236	RAB11B	100	97.826	ENSATEG00000023730	rab11ba	100	95.413	Anabas_testudineus
ENSG00000185236	RAB11B	100	100.000	ENSANAG00000037616	RAB11B	100	100.000	Aotus_nancymaae
ENSG00000185236	RAB11B	100	95.652	ENSACLG00000005420	rab11ba	100	93.119	Astatotilapia_calliptera
ENSG00000185236	RAB11B	100	91.304	ENSACLG00000018852	-	92	87.685	Astatotilapia_calliptera
ENSG00000185236	RAB11B	95	92.353	WBGene00004274	rab-11.1	99	80.556	Caenorhabditis_elegans
ENSG00000185236	RAB11B	100	100.000	ENSCJAG00000010778	RAB11B	100	100.000	Callithrix_jacchus
ENSG00000185236	RAB11B	100	100.000	ENSCAFG00000032060	RAB11B	100	100.000	Canis_familiaris
ENSG00000185236	RAB11B	100	100.000	ENSCAFG00020022184	RAB11B	100	100.000	Canis_lupus_dingo
ENSG00000185236	RAB11B	100	100.000	ENSTSYG00000014758	RAB11B	100	100.000	Carlito_syrichta
ENSG00000185236	RAB11B	100	100.000	ENSCPOG00000030154	RAB11B	100	99.541	Cavia_porcellus
ENSG00000185236	RAB11B	100	100.000	ENSCCAG00000031042	RAB11B	100	100.000	Cebus_capucinus
ENSG00000185236	RAB11B	100	100.000	ENSCLAG00000003207	RAB11B	100	100.000	Chinchilla_lanigera
ENSG00000185236	RAB11B	100	100.000	ENSCSAG00000008024	RAB11B	100	100.000	Chlorocebus_sabaeus
ENSG00000185236	RAB11B	100	85.780	ENSCHOG00000013525	RAB11B	100	85.780	Choloepus_hoffmanni
ENSG00000185236	RAB11B	100	91.304	ENSCING00000009526	-	100	84.475	Ciona_intestinalis
ENSG00000185236	RAB11B	100	100.000	ENSCANG00000040517	RAB11B	100	100.000	Colobus_angolensis_palliatus
ENSG00000185236	RAB11B	100	100.000	ENSCGRG00001013827	Rab11b	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000185236	RAB11B	100	100.000	ENSCGRG00000010967	Rab11b	100	100.000	Cricetulus_griseus_crigri
ENSG00000185236	RAB11B	100	97.826	ENSCSEG00000007121	rab11ba	84	94.495	Cynoglossus_semilaevis
ENSG00000185236	RAB11B	100	100.000	ENSDARG00000041878	rab11ba	100	96.330	Danio_rerio
ENSG00000185236	RAB11B	100	100.000	ENSDNOG00000004134	-	100	98.165	Dasypus_novemcinctus
ENSG00000185236	RAB11B	100	100.000	ENSDNOG00000014618	RAB11B	97	100.000	Dasypus_novemcinctus
ENSG00000185236	RAB11B	100	100.000	ENSDORG00000006304	Rab11b	100	99.083	Dipodomys_ordii
ENSG00000185236	RAB11B	100	97.826	ENSEBUG00000011775	rab11ba	99	94.146	Eptatretus_burgeri
ENSG00000185236	RAB11B	100	86.957	ENSEBUG00000015447	-	100	81.651	Eptatretus_burgeri
ENSG00000185236	RAB11B	80	100.000	ENSEEUG00000009165	-	100	100.000	Erinaceus_europaeus
ENSG00000185236	RAB11B	100	93.478	ENSELUG00000019240	-	99	92.784	Esox_lucius
ENSG00000185236	RAB11B	100	100.000	ENSFCAG00000015216	RAB11B	100	99.541	Felis_catus
ENSG00000185236	RAB11B	100	100.000	ENSFDAG00000019872	RAB11B	100	99.541	Fukomys_damarensis
ENSG00000185236	RAB11B	100	97.826	ENSFHEG00000022642	rab11ba	100	94.037	Fundulus_heteroclitus
ENSG00000185236	RAB11B	100	93.478	ENSGMOG00000007390	rab11ba	99	92.661	Gadus_morhua
ENSG00000185236	RAB11B	100	97.826	ENSGAFG00000005679	rab11ba	100	94.495	Gambusia_affinis
ENSG00000185236	RAB11B	100	100.000	ENSGAGG00000012557	-	100	99.083	Gopherus_agassizii
ENSG00000185236	RAB11B	100	100.000	ENSHGLG00000014984	RAB11B	100	100.000	Heterocephalus_glaber_female
ENSG00000185236	RAB11B	100	100.000	ENSHGLG00100003638	RAB11B	100	99.541	Heterocephalus_glaber_male
ENSG00000185236	RAB11B	100	100.000	ENSSTOG00000031571	RAB11B	100	100.000	Ictidomys_tridecemlineatus
ENSG00000185236	RAB11B	100	100.000	ENSJJAG00000018891	Rab11b	100	100.000	Jaculus_jaculus
ENSG00000185236	RAB11B	100	97.826	ENSKMAG00000006082	-	100	94.954	Kryptolebias_marmoratus
ENSG00000185236	RAB11B	100	95.652	ENSLBEG00000006087	rab11ba	100	94.954	Labrus_bergylta
ENSG00000185236	RAB11B	100	100.000	ENSLACG00000016974	RAB11B	99	99.415	Latimeria_chalumnae
ENSG00000185236	RAB11B	100	100.000	ENSLAFG00000013598	RAB11B	100	100.000	Loxodonta_africana
ENSG00000185236	RAB11B	100	100.000	ENSMNEG00000039759	-	100	100.000	Macaca_nemestrina
ENSG00000185236	RAB11B	100	95.652	ENSMAMG00000018556	rab11ba	100	94.495	Mastacembelus_armatus
ENSG00000185236	RAB11B	100	91.304	ENSMZEG00005019251	-	92	87.685	Maylandia_zebra
ENSG00000185236	RAB11B	100	95.652	ENSMZEG00005010947	rab11ba	100	93.119	Maylandia_zebra
ENSG00000185236	RAB11B	100	100.000	ENSMAUG00000021579	Rab11b	100	99.541	Mesocricetus_auratus
ENSG00000185236	RAB11B	100	100.000	ENSMOCG00000012667	Rab11b	100	99.541	Microtus_ochrogaster
ENSG00000185236	RAB11B	100	93.478	ENSMALG00000021949	rab11ba	100	92.202	Monopterus_albus
ENSG00000185236	RAB11B	100	100.000	MGP_CAROLIEiJ_G0021415	Rab11b	100	100.000	Mus_caroli
ENSG00000185236	RAB11B	100	100.000	ENSMUSG00000077450	Rab11b	100	99.083	Mus_musculus
ENSG00000185236	RAB11B	100	100.000	MGP_PahariEiJ_G0020420	Rab11b	100	100.000	Mus_pahari
ENSG00000185236	RAB11B	100	100.000	MGP_SPRETEiJ_G0022327	Rab11b	100	100.000	Mus_spretus
ENSG00000185236	RAB11B	100	100.000	ENSMPUG00000007263	RAB11B	100	99.541	Mustela_putorius_furo
ENSG00000185236	RAB11B	100	97.826	ENSMLUG00000002308	-	100	95.475	Myotis_lucifugus
ENSG00000185236	RAB11B	100	100.000	ENSNGAG00000015757	Rab11b	100	100.000	Nannospalax_galili
ENSG00000185236	RAB11B	100	97.826	ENSNBRG00000023898	rab11ba	84	93.578	Neolamprologus_brichardi
ENSG00000185236	RAB11B	100	100.000	ENSNLEG00000001733	RAB11B	100	100.000	Nomascus_leucogenys
ENSG00000185236	RAB11B	100	100.000	ENSODEG00000011371	RAB11B	100	100.000	Octodon_degus
ENSG00000185236	RAB11B	100	97.826	ENSONIG00000002535	rab11ba	100	94.037	Oreochromis_niloticus
ENSG00000185236	RAB11B	100	100.000	ENSOCUG00000028208	RAB11B	64	99.375	Oryctolagus_cuniculus
ENSG00000185236	RAB11B	100	97.826	ENSORLG00000015307	rab11ba	99	95.853	Oryzias_latipes
ENSG00000185236	RAB11B	100	97.826	ENSORLG00020020816	rab11ba	99	95.853	Oryzias_latipes_hni
ENSG00000185236	RAB11B	100	97.826	ENSORLG00015016946	rab11ba	81	96.296	Oryzias_latipes_hsok
ENSG00000185236	RAB11B	100	97.826	ENSOMEG00000002581	rab11ba	99	95.853	Oryzias_melastigma
ENSG00000185236	RAB11B	100	100.000	ENSOGAG00000003227	RAB11B	99	100.000	Otolemur_garnettii
ENSG00000185236	RAB11B	100	100.000	ENSOARG00000003801	RAB11B	97	100.000	Ovis_aries
ENSG00000185236	RAB11B	100	100.000	ENSPPRG00000010160	RAB11B	84	100.000	Panthera_pardus
ENSG00000185236	RAB11B	100	100.000	ENSPEMG00000014536	Rab11b	100	100.000	Peromyscus_maniculatus_bairdii
ENSG00000185236	RAB11B	100	86.957	ENSPMAG00000009335	-	100	80.952	Petromyzon_marinus
ENSG00000185236	RAB11B	100	97.826	ENSPFOG00000006159	rab11ba	100	94.954	Poecilia_formosa
ENSG00000185236	RAB11B	100	97.826	ENSPLAG00000014243	rab11ba	100	94.954	Poecilia_latipinna
ENSG00000185236	RAB11B	100	97.826	ENSPMEG00000007917	rab11ba	75	94.954	Poecilia_mexicana
ENSG00000185236	RAB11B	100	97.826	ENSPREG00000006357	rab11ba	78	94.954	Poecilia_reticulata
ENSG00000185236	RAB11B	100	100.000	ENSPPYG00000009504	RAB11B	100	100.000	Pongo_abelii
ENSG00000185236	RAB11B	100	91.284	ENSPCAG00000016118	RAB11B	100	91.284	Procavia_capensis
ENSG00000185236	RAB11B	82	97.945	ENSPCOG00000008655	-	100	97.945	Propithecus_coquereli
ENSG00000185236	RAB11B	100	100.000	ENSPCOG00000028053	RAB11B	100	100.000	Propithecus_coquereli
ENSG00000185236	RAB11B	100	100.000	ENSPVAG00000009645	RAB11B	100	100.000	Pteropus_vampyrus
ENSG00000185236	RAB11B	95	77.907	ENSPNYG00000023810	-	90	78.537	Pundamilia_nyererei
ENSG00000185236	RAB11B	100	95.652	ENSPNYG00000019644	rab11ba	100	93.119	Pundamilia_nyererei
ENSG00000185236	RAB11B	100	100.000	ENSPNAG00000006431	-	100	97.706	Pygocentrus_nattereri
ENSG00000185236	RAB11B	100	100.000	ENSPNAG00000020475	rab11ba	100	97.248	Pygocentrus_nattereri
ENSG00000185236	RAB11B	100	100.000	ENSRNOG00000007648	Rab11b	100	100.000	Rattus_norvegicus
ENSG00000185236	RAB11B	100	100.000	ENSSBOG00000035094	RAB11B	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000185236	RAB11B	100	97.826	ENSSDUG00000002965	rab11ba	100	94.954	Seriola_dumerili
ENSG00000185236	RAB11B	100	97.826	ENSSLDG00000005221	rab11ba	100	94.954	Seriola_lalandi_dorsalis
ENSG00000185236	RAB11B	100	95.652	ENSSPAG00000017313	rab11ba	100	94.037	Stegastes_partitus
ENSG00000185236	RAB11B	100	100.000	ENSSSCG00000013600	RAB11B	100	100.000	Sus_scrofa
ENSG00000185236	RAB11B	72	100.000	ENSTBEG00000014750	-	100	100.000	Tupaia_belangeri
ENSG00000185236	RAB11B	100	100.000	ENSTTRG00000009758	RAB11B	100	100.000	Tursiops_truncatus
ENSG00000185236	RAB11B	94	80.488	ENSUMAG00000014594	RAB11B	97	80.488	Ursus_maritimus
ENSG00000185236	RAB11B	100	100.000	ENSVVUG00000025210	RAB11B	100	100.000	Vulpes_vulpes
ENSG00000185236	RAB11B	100	97.826	ENSXETG00000021890	rab11b.2	99	95.413	Xenopus_tropicalis
ENSG00000185236	RAB11B	74	97.744	ENSXCOG00000009194	-	98	97.744	Xiphophorus_couchianus
ENSG00000185236	RAB11B	100	97.826	ENSXMAG00000013416	rab11ba	100	94.495	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001881	receptor recycling	-	ISS	Process
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0003924	GTPase activity	16545962.	IDA	Function
GO:0005515	protein binding	20717956.21976701.22613832.23572552.25556234.26005850.	IPI	Function
GO:0005525	GTP binding	16545962.	IDA	Function
GO:0005768	endosome	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0006887	exocytosis	21873635.	IBA	Process
GO:0008021	synaptic vesicle	-	ISS	Component
GO:0019003	GDP binding	16545962.	IDA	Function
GO:0030054	cell junction	-	IEA	Component
GO:0030670	phagocytic vesicle membrane	-	IEA	Component
GO:0031489	myosin V binding	24006491.	IPI	Function
GO:0032402	melanosome transport	-	ISS	Process
GO:0032482	Rab protein signal transduction	21873635.	IBA	Process
GO:0033572	transferrin transport	-	ISS	Process
GO:0035773	insulin secretion involved in cellular response to glucose stimulus	-	ISS	Process
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0044070	regulation of anion transport	19244346.	IMP	Process
GO:0045054	constitutive secretory pathway	21873635.	IBA	Process
GO:0045054	constitutive secretory pathway	14627637.	IMP	Process
GO:0045055	regulated exocytosis	21873635.	IBA	Process
GO:0045055	regulated exocytosis	-	ISS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045335	phagocytic vesicle	21255211.	IDA	Component
GO:0055037	recycling endosome	21873635.	IBA	Component
GO:0055037	recycling endosome	-	ISS	Component
GO:0055038	recycling endosome membrane	-	TAS	Component
GO:0070062	extracellular exosome	20458337.23533145.	HDA	Component
GO:0071468	cellular response to acidic pH	20717956.	IDA	Process
GO:0090150	establishment of protein localization to membrane	24006491.	IMP	Process
GO:0098993	anchored component of synaptic vesicle membrane	-	IEA	Component
GO:0150093	amyloid-beta clearance by transcytosis	26005850.	IGI	Process
GO:1990126	retrograde transport, endosome to plasma membrane	19244346.	IMP	Process
GO:2000008	regulation of protein localization to cell surface	20717956.	IMP	Process
GO:2001135	regulation of endocytic recycling	-	ISS	Process