EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000185238 (Gene tree)
Gene ID: 10196
Gene Symbol: PRMT3
Alias: HRMT1L3
Full Name: protein arginine methyltransferase 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 121,804 bases
Position: chr11:20,387,530-20,509,333
Accession: 30163
RBP type: canonical RBP
Summary: This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000397766	MTS	PF05175.14	9.6e-05	1	1
ENSP00000331879	MTS	PF05175.14	0.00014	1	1
ENSP00000397766	Methyltransf_31	PF13847.6	1e-07	1	1
ENSP00000331879	Methyltransf_31	PF13847.6	1.2e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30577570	Protein Arginine Methyltransferase 3 Enhances Chemoresistance in Pancreatic Cancer by Methylating hnRNPA1 to Increase ABCG2 Expression.	Cancers (Basel)	2018 Dec 20	Hsu MC	doi: 10.3390/cancers11010008.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000331079	PRMT3-202	2653	-	ENSP00000331879	531 (aa)	-	O60678
ENST00000525188	PRMT3-204	681	-	ENSP00000435151	46 (aa)	-	E9PLF6
ENST00000330796	PRMT3-201	2530	-	ENSP00000329586	46 (aa)	-	E9PLF6
ENST00000529592	PRMT3-206	4159	-	-	- (aa)	-	-
ENST00000437750	PRMT3-203	1736	XM_011519836	ENSP00000397766	469 (aa)	XP_011518138	O60678
ENST00000526583	PRMT3-205	532	-	ENSP00000434260	54 (aa)	-	E9PRB4

Gene Model

Click here to download ENSG00000185238's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000185238	Pulse Wave Analysis	4.62e-005	-
ENSG00000185238	Anger	1.718e-005	-
ENSG00000185238	3-hydroxy-1-methylpropylmercapturic acid	4E-7	26053186
ENSG00000185238	Smoking	4E-7	26053186
ENSG00000185238	Marijuana Abuse	1E-7	27028160
ENSG00000185238	Antineoplastic Agents	5E-6	19176441
ENSG00000185238	Precursor Cell Lymphoblastic Leukemia-Lymphoma	5E-6	19176441

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000185238	rs80315173	11	20492179	?	3-hydroxy-1-methylpropylmercapturic acid levels in smokers	26053186	[NR] unit decrease	0.6257	EFO_0004318\|EFO_0007015
ENSG00000185238	rs11025559	11	20422329	A	Pursuit maintenance gain	29064472			EFO_0008433

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000185238's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000185238	PRMT3	98	60.302	ENSAPOG00000022038	prmt3	98	60.531	Acanthochromis_polyacanthus
ENSG00000185238	PRMT3	94	92.200	ENSAMEG00000004679	PRMT3	100	92.200	Ailuropoda_melanoleuca
ENSG00000185238	PRMT3	98	60.302	ENSAOCG00000013816	prmt3	98	60.878	Amphiprion_ocellaris
ENSG00000185238	PRMT3	98	59.887	ENSAPEG00000000139	prmt3	99	60.456	Amphiprion_percula
ENSG00000185238	PRMT3	98	59.176	ENSATEG00000021598	prmt3	98	59.962	Anabas_testudineus
ENSG00000185238	PRMT3	92	76.322	ENSAPLG00000006907	PRMT3	100	76.380	Anas_platyrhynchos
ENSG00000185238	PRMT3	98	70.435	ENSACAG00000015533	PRMT3	95	70.099	Anolis_carolinensis
ENSG00000185238	PRMT3	100	97.363	ENSANAG00000024501	PRMT3	100	97.363	Aotus_nancymaae
ENSG00000185238	PRMT3	97	61.686	ENSACLG00000001816	prmt3	98	62.524	Astatotilapia_calliptera
ENSG00000185238	PRMT3	73	59.897	ENSAMXG00000035692	prmt3	90	58.942	Astyanax_mexicanus
ENSG00000185238	PRMT3	100	90.960	ENSBTAG00000013421	PRMT3	100	90.960	Bos_taurus
ENSG00000185238	PRMT3	100	96.798	ENSCJAG00000006650	PRMT3	100	96.798	Callithrix_jacchus
ENSG00000185238	PRMT3	100	90.388	ENSCAFG00000009831	PRMT3	100	94.273	Canis_familiaris
ENSG00000185238	PRMT3	98	91.132	ENSCAFG00020019297	PRMT3	99	91.321	Canis_lupus_dingo
ENSG00000185238	PRMT3	100	91.149	ENSCHIG00000016465	PRMT3	100	91.149	Capra_hircus
ENSG00000185238	PRMT3	72	88.021	ENSTSYG00000011089	PRMT3	98	88.021	Carlito_syrichta
ENSG00000185238	PRMT3	96	84.375	ENSCAPG00000009804	PRMT3	100	83.264	Cavia_aperea
ENSG00000185238	PRMT3	100	91.182	ENSCPOG00000034377	PRMT3	100	91.182	Cavia_porcellus
ENSG00000185238	PRMT3	100	96.422	ENSCCAG00000034565	PRMT3	100	96.422	Cebus_capucinus
ENSG00000185238	PRMT3	100	98.294	ENSCATG00000028575	PRMT3	100	98.294	Cercocebus_atys
ENSG00000185238	PRMT3	94	92.771	ENSCLAG00000001520	PRMT3	100	92.771	Chinchilla_lanigera
ENSG00000185238	PRMT3	100	98.117	ENSCSAG00000005127	PRMT3	100	98.117	Chlorocebus_sabaeus
ENSG00000185238	PRMT3	97	77.519	ENSCPBG00000014034	PRMT3	94	76.217	Chrysemys_picta_bellii
ENSG00000185238	PRMT3	97	43.820	ENSCING00000007831	-	98	44.382	Ciona_intestinalis
ENSG00000185238	PRMT3	100	98.682	ENSCANG00000035787	PRMT3	100	98.682	Colobus_angolensis_palliatus
ENSG00000185238	PRMT3	100	88.701	ENSCGRG00001010387	Prmt3	100	88.701	Cricetulus_griseus_chok1gshd
ENSG00000185238	PRMT3	96	90.392	ENSCGRG00000013148	Prmt3	98	90.392	Cricetulus_griseus_crigri
ENSG00000185238	PRMT3	90	65.952	ENSCSEG00000019404	prmt3	98	60.536	Cynoglossus_semilaevis
ENSG00000185238	PRMT3	90	63.915	ENSCVAG00000004723	prmt3	100	60.000	Cyprinodon_variegatus
ENSG00000185238	PRMT3	97	61.479	ENSDARG00000019791	prmt3	99	61.479	Danio_rerio
ENSG00000185238	PRMT3	96	90.588	ENSDNOG00000016946	PRMT3	99	90.588	Dasypus_novemcinctus
ENSG00000185238	PRMT3	99	90.772	ENSDORG00000005014	Prmt3	100	91.731	Dipodomys_ordii
ENSG00000185238	PRMT3	65	38.511	FBgn0038189	Art6	90	38.511	Drosophila_melanogaster
ENSG00000185238	PRMT3	92	39.673	FBgn0038306	Art3	99	39.673	Drosophila_melanogaster
ENSG00000185238	PRMT3	93	91.533	ENSETEG00000017579	PRMT3	88	92.662	Echinops_telfairi
ENSG00000185238	PRMT3	92	45.708	ENSEBUG00000009867	prmt3	100	45.682	Eptatretus_burgeri
ENSG00000185238	PRMT3	100	88.029	ENSEASG00005013043	PRMT3	100	88.029	Equus_asinus_asinus
ENSG00000185238	PRMT3	100	89.800	ENSECAG00000021124	PRMT3	100	93.833	Equus_caballus
ENSG00000185238	PRMT3	98	57.656	ENSELUG00000010394	prmt3	98	57.656	Esox_lucius
ENSG00000185238	PRMT3	100	93.220	ENSFCAG00000031309	PRMT3	100	93.220	Felis_catus
ENSG00000185238	PRMT3	98	74.292	ENSFALG00000001682	PRMT3	98	71.887	Ficedula_albicollis
ENSG00000185238	PRMT3	99	92.264	ENSFDAG00000013589	PRMT3	100	94.273	Fukomys_damarensis
ENSG00000185238	PRMT3	93	65.217	ENSFHEG00000021475	prmt3	100	61.583	Fundulus_heteroclitus
ENSG00000185238	PRMT3	97	59.728	ENSGMOG00000002570	prmt3	97	59.728	Gadus_morhua
ENSG00000185238	PRMT3	92	76.102	ENSGALG00000003958	PRMT3	100	72.461	Gallus_gallus
ENSG00000185238	PRMT3	89	63.962	ENSGAFG00000014066	prmt3	99	57.547	Gambusia_affinis
ENSG00000185238	PRMT3	97	59.923	ENSGACG00000017094	prmt3	98	59.923	Gasterosteus_aculeatus
ENSG00000185238	PRMT3	93	77.033	ENSGAGG00000004116	PRMT3	92	77.033	Gopherus_agassizii
ENSG00000185238	PRMT3	98	92.514	ENSHGLG00000008724	-	99	92.514	Heterocephalus_glaber_female
ENSG00000185238	PRMT3	99	92.939	ENSHGLG00100010863	-	100	92.939	Heterocephalus_glaber_male
ENSG00000185238	PRMT3	97	58.157	ENSHCOG00000005337	prmt3	98	58.157	Hippocampus_comes
ENSG00000185238	PRMT3	97	56.809	ENSIPUG00000018719	prmt3	98	56.069	Ictalurus_punctatus
ENSG00000185238	PRMT3	100	94.350	ENSSTOG00000011235	PRMT3	100	94.350	Ictidomys_tridecemlineatus
ENSG00000185238	PRMT3	100	86.007	ENSJJAG00000012757	Prmt3	100	86.381	Jaculus_jaculus
ENSG00000185238	PRMT3	98	59.662	ENSKMAG00000020166	prmt3	98	60.227	Kryptolebias_marmoratus
ENSG00000185238	PRMT3	90	67.062	ENSLBEG00000003735	prmt3	98	61.420	Labrus_bergylta
ENSG00000185238	PRMT3	99	63.389	ENSLOCG00000004922	prmt3	100	64.591	Lepisosteus_oculatus
ENSG00000185238	PRMT3	85	92.650	ENSLAFG00000018704	PRMT3	100	92.650	Loxodonta_africana
ENSG00000185238	PRMT3	100	98.305	ENSMFAG00000038053	PRMT3	100	98.294	Macaca_fascicularis
ENSG00000185238	PRMT3	100	97.655	ENSMMUG00000010719	PRMT3	100	97.655	Macaca_mulatta
ENSG00000185238	PRMT3	100	98.305	ENSMNEG00000032665	PRMT3	100	98.081	Macaca_nemestrina
ENSG00000185238	PRMT3	100	98.117	ENSMLEG00000041702	PRMT3	100	98.117	Mandrillus_leucophaeus
ENSG00000185238	PRMT3	90	65.166	ENSMAMG00000015896	prmt3	100	60.000	Mastacembelus_armatus
ENSG00000185238	PRMT3	97	61.686	ENSMZEG00005014447	prmt3	98	62.524	Maylandia_zebra
ENSG00000185238	PRMT3	92	75.406	ENSMGAG00000002195	PRMT3	100	74.220	Meleagris_gallopavo
ENSG00000185238	PRMT3	100	87.947	ENSMAUG00000012296	Prmt3	100	87.947	Mesocricetus_auratus
ENSG00000185238	PRMT3	99	94.194	ENSMICG00000042200	PRMT3	100	91.902	Microcebus_murinus
ENSG00000185238	PRMT3	100	90.019	ENSMOCG00000001042	Prmt3	100	90.019	Microtus_ochrogaster
ENSG00000185238	PRMT3	91	57.764	ENSMMOG00000007235	prmt3	100	56.371	Mola_mola
ENSG00000185238	PRMT3	100	83.457	ENSMODG00000009124	PRMT3	100	84.201	Monodelphis_domestica
ENSG00000185238	PRMT3	97	56.167	ENSMALG00000000433	prmt3	100	56.731	Monopterus_albus
ENSG00000185238	PRMT3	100	89.474	MGP_CAROLIEiJ_G0029790	Prmt3	100	89.474	Mus_caroli
ENSG00000185238	PRMT3	100	89.850	ENSMUSG00000030505	Prmt3	100	89.850	Mus_musculus
ENSG00000185238	PRMT3	100	89.850	MGP_PahariEiJ_G0013015	Prmt3	100	89.850	Mus_pahari
ENSG00000185238	PRMT3	100	89.700	MGP_SPRETEiJ_G0030893	Prmt3	100	89.700	Mus_spretus
ENSG00000185238	PRMT3	100	93.597	ENSMPUG00000013923	PRMT3	100	93.597	Mustela_putorius_furo
ENSG00000185238	PRMT3	100	93.032	ENSMLUG00000017571	PRMT3	100	93.032	Myotis_lucifugus
ENSG00000185238	PRMT3	100	88.136	ENSNGAG00000023697	Prmt3	100	88.136	Nannospalax_galili
ENSG00000185238	PRMT3	97	61.686	ENSNBRG00000018024	prmt3	98	62.524	Neolamprologus_brichardi
ENSG00000185238	PRMT3	100	99.360	ENSNLEG00000017813	PRMT3	100	99.360	Nomascus_leucogenys
ENSG00000185238	PRMT3	61	88.889	ENSMEUG00000008316	PRMT3	67	88.889	Notamacropus_eugenii
ENSG00000185238	PRMT3	92	60.161	ENSONIG00000007146	prmt3	97	61.020	Oreochromis_niloticus
ENSG00000185238	PRMT3	96	86.133	ENSOANG00000011286	PRMT3	100	86.133	Ornithorhynchus_anatinus
ENSG00000185238	PRMT3	100	93.032	ENSOCUG00000000750	PRMT3	100	93.032	Oryctolagus_cuniculus
ENSG00000185238	PRMT3	99	57.836	ENSORLG00000000829	prmt3	100	59.339	Oryzias_latipes
ENSG00000185238	PRMT3	99	58.022	ENSORLG00020001676	prmt3	100	59.339	Oryzias_latipes_hni
ENSG00000185238	PRMT3	99	57.836	ENSORLG00015000823	prmt3	100	59.339	Oryzias_latipes_hsok
ENSG00000185238	PRMT3	97	58.046	ENSOMEG00000003641	prmt3	100	59.339	Oryzias_melastigma
ENSG00000185238	PRMT3	100	93.220	ENSOGAG00000008277	PRMT3	100	93.220	Otolemur_garnettii
ENSG00000185238	PRMT3	100	90.584	ENSOARG00000008231	PRMT3	100	90.584	Ovis_aries
ENSG00000185238	PRMT3	100	100.000	ENSPPAG00000042157	PRMT3	100	100.000	Pan_paniscus
ENSG00000185238	PRMT3	100	93.597	ENSPPRG00000001326	PRMT3	100	93.597	Panthera_pardus
ENSG00000185238	PRMT3	98	93.666	ENSPTIG00000016281	PRMT3	98	93.666	Panthera_tigris_altaica
ENSG00000185238	PRMT3	100	100.000	ENSPTRG00000003439	PRMT3	100	100.000	Pan_troglodytes
ENSG00000185238	PRMT3	100	90.772	ENSPANG00000024678	PRMT3	100	90.584	Papio_anubis
ENSG00000185238	PRMT3	89	63.529	ENSPKIG00000022779	prmt3	98	61.145	Paramormyrops_kingsleyae
ENSG00000185238	PRMT3	92	78.190	ENSPSIG00000012339	PRMT3	87	77.339	Pelodiscus_sinensis
ENSG00000185238	PRMT3	90	58.962	ENSPMGG00000020031	prmt3	100	53.586	Periophthalmus_magnuspinnatus
ENSG00000185238	PRMT3	93	92.677	ENSPEMG00000008087	Prmt3	100	93.487	Peromyscus_maniculatus_bairdii
ENSG00000185238	PRMT3	100	82.868	ENSPCIG00000001135	PRMT3	100	83.799	Phascolarctos_cinereus
ENSG00000185238	PRMT3	89	64.929	ENSPFOG00000003622	prmt3	94	58.857	Poecilia_formosa
ENSG00000185238	PRMT3	89	64.439	ENSPLAG00000002049	prmt3	98	59.615	Poecilia_latipinna
ENSG00000185238	PRMT3	89	64.929	ENSPMEG00000020897	prmt3	94	58.857	Poecilia_mexicana
ENSG00000185238	PRMT3	97	60.155	ENSPREG00000019857	prmt3	94	58.925	Poecilia_reticulata
ENSG00000185238	PRMT3	93	97.500	ENSPPYG00000003420	PRMT3	87	98.333	Pongo_abelii
ENSG00000185238	PRMT3	85	92.191	ENSPVAG00000017711	PRMT3	87	82.143	Pteropus_vampyrus
ENSG00000185238	PRMT3	97	61.686	ENSPNYG00000002362	prmt3	98	62.524	Pundamilia_nyererei
ENSG00000185238	PRMT3	89	63.962	ENSPNAG00000026361	prmt3	98	58.382	Pygocentrus_nattereri
ENSG00000185238	PRMT3	100	89.098	ENSRNOG00000014829	Prmt3	100	89.098	Rattus_norvegicus
ENSG00000185238	PRMT3	100	98.493	ENSRROG00000029850	PRMT3	100	98.493	Rhinopithecus_roxellana
ENSG00000185238	PRMT3	100	96.422	ENSSBOG00000034320	PRMT3	100	96.422	Saimiri_boliviensis_boliviensis
ENSG00000185238	PRMT3	100	84.544	ENSSHAG00000012761	PRMT3	100	84.544	Sarcophilus_harrisii
ENSG00000185238	PRMT3	89	62.201	ENSSFOG00015022824	prmt3	99	56.405	Scleropages_formosus
ENSG00000185238	PRMT3	97	60.078	ENSSMAG00000008265	prmt3	100	59.693	Scophthalmus_maximus
ENSG00000185238	PRMT3	90	64.455	ENSSDUG00000016148	prmt3	98	59.345	Seriola_dumerili
ENSG00000185238	PRMT3	97	59.345	ENSSLDG00000003057	prmt3	98	58.857	Seriola_lalandi_dorsalis
ENSG00000185238	PRMT3	93	88.330	ENSSARG00000005477	PRMT3	100	89.286	Sorex_araneus
ENSG00000185238	PRMT3	96	69.336	ENSSPUG00000012020	PRMT3	100	69.336	Sphenodon_punctatus
ENSG00000185238	PRMT3	61	57.055	ENSSPAG00000020801	prmt3	97	56.105	Stegastes_partitus
ENSG00000185238	PRMT3	100	93.597	ENSSSCG00000013347	PRMT3	100	93.597	Sus_scrofa
ENSG00000185238	PRMT3	92	77.494	ENSTGUG00000015757	PRMT3	100	76.955	Taeniopygia_guttata
ENSG00000185238	PRMT3	93	60.080	ENSTRUG00000015904	prmt3	97	60.080	Takifugu_rubripes
ENSG00000185238	PRMT3	80	95.057	ENSTBEG00000002253	PRMT3	87	95.695	Tupaia_belangeri
ENSG00000185238	PRMT3	86	93.812	ENSTTRG00000007429	PRMT3	100	86.207	Tursiops_truncatus
ENSG00000185238	PRMT3	100	89.077	ENSUAMG00000017344	PRMT3	100	89.077	Ursus_americanus
ENSG00000185238	PRMT3	100	87.947	ENSUMAG00000020026	PRMT3	100	94.053	Ursus_maritimus
ENSG00000185238	PRMT3	85	88.161	ENSVPAG00000012104	PRMT3	100	88.161	Vicugna_pacos
ENSG00000185238	PRMT3	99	89.239	ENSVVUG00000010077	-	99	88.641	Vulpes_vulpes
ENSG00000185238	PRMT3	66	91.262	ENSVVUG00000002395	-	98	91.262	Vulpes_vulpes
ENSG00000185238	PRMT3	94	61.310	ENSXETG00000014186	prmt3	99	60.501	Xenopus_tropicalis
ENSG00000185238	PRMT3	56	61.450	ENSXCOG00000013989	prmt3	89	61.450	Xiphophorus_couchianus
ENSG00000185238	PRMT3	97	58.720	ENSXMAG00000010154	prmt3	100	57.280	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0005515	protein binding	18573314.23912080.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	9642256.	NAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006355	regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0006479	protein methylation	-	TAS	Process
GO:0008168	methyltransferase activity	18573314.	IDA	Function
GO:0008469	histone-arginine N-methyltransferase activity	21873635.	IBA	Function
GO:0016274	protein-arginine N-methyltransferase activity	9642256.	NAS	Function
GO:0016274	protein-arginine N-methyltransferase activity	-	TAS	Function
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	21873635.	IBA	Process
GO:0031397	negative regulation of protein ubiquitination	18573314.	IDA	Process
GO:0034969	histone arginine methylation	21873635.	IBA	Process
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity	21873635.	IBA	Function
GO:0043022	ribosome binding	-	IEA	Function
GO:0046872	metal ion binding	-	IEA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
15334060	DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo.	Oncogene	2004 Oct 14	Singh V	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr11	20389813	Missense_Mutation	novel	M78I	0.07
BRCA	chr11	20392993	Nonsense_Mutation	NA	Q132*	0.14
BRCA	chr11	20395837	Silent	NA	P145P	0.37
BRCA	chr11	20388031	Missense_Mutation	novel	A14V	0.09
BRCA	chr11	20508326	Silent	novel	V503V	0.06
BRCA	chr11	20395874	Missense_Mutation	novel	V158I	0.09
BRCA	chr11	20464470	Missense_Mutation	NA	C424Y	0.12
BRCA	chr11	20508354	Missense_Mutation	rs146465935	R513C	0.51
CHOL	chr11	20426791	Missense_Mutation	novel	T307A	0.38	MTS
CHOL	chr11	20452147	Missense_Mutation	novel	F337L	0.06	MTS
COAD	chr11	20407971	Missense_Mutation	novel	A278T	0.07	MTS
COAD	chr11	20462056	Missense_Mutation	NA	W383C	0.37
COAD	chr11	20494206	Missense_Mutation	NA	W480G	0.34
COAD	chr11	20407993	Missense_Mutation	novel	D285G	0.41	MTS
COAD	chr11	20402958	Nonsense_Mutation	NA	Q249*	0.87
COAD	chr11	20402928	Nonsense_Mutation	rs376995112	R239*	0.15
COAD	chr11	20392942	Missense_Mutation	novel	W115R	0.04
COAD	chr11	20407911	Missense_Mutation	NA	V258I	0.15	MTS
COAD	chr11	20464545	Missense_Mutation	rs765904610	T449M	0.41
ESCA	chr11	20508428	3'UTR	novel		0.26
GBM	chr11	20389777	Missense_Mutation	novel	H66Q	0.09
GBM	chr11	20426859	Silent	NA	E329E	0.22
HNSC	chr11	20464488	Nonsense_Mutation	novel	S430*	0.2
HNSC	chr11	20426810	Missense_Mutation	novel	I313T	0.3	MTS
HNSC	chr11	20402957	Nonsense_Mutation	novel	Y248*	0.33
HNSC	chr11	20462017	Silent	novel	V370V	0.19
HNSC	chr11	20397624	Missense_Mutation	rs142076035	S203L	0.42
HNSC	chr11	20388072	Missense_Mutation	novel	G28R	0.11
HNSC	chr11	20462024	Missense_Mutation	novel	V373M	0.32
KIRC	chr11	20462134	Silent	rs145890543	P409P	0.03
KIRP	chr11	20387564	5'UTR	novel		0.25
LAML	chr11	20462132	Missense_Mutation	novel	P409S	0.04
LAML	chr11	20395952	Frame_Shift_Ins	rs759247233	*M186Nfs22**	0.11
LGG	chr11	20395834	Silent	novel	V144V	0.37
LGG	chr11	20494169	Splice_Region	rs753927636	V467V	0.38
LIHC	chr11	20452139	Missense_Mutation	novel	L335F	0.4	MTS
LUAD	chr11	20464546	Splice_Region	NA	T449T	0.26
LUAD	chr11	20407970	Silent	novel	G277G	0.17
LUAD	chr11	20452203	Missense_Mutation	rs762915485	G356V	0.08	MTS
LUAD	chr11	20407910	Splice_Site	NA	X258_splice	0.3
LUAD	chr11	20462046	Missense_Mutation	NA	I380T	0.3
LUAD	chr11	20508381	Missense_Mutation	novel	N522Y	0.16
LUAD	chr11	20452134	Missense_Mutation	novel	Y333C	0.15	MTS
LUAD	chr11	20395827	Missense_Mutation	novel	V142G	0.18
LUAD	chr11	20494244	Silent	novel	S492S	0.22
LUAD	chr11	20508457	3'UTR	novel		0.1
LUSC	chr11	20494245	Missense_Mutation	NA	V493L	0.55
LUSC	chr11	20407954	Frame_Shift_Ins	novel	*F272Lfs10**	0.07	MTS
LUSC	chr11	20392954	Missense_Mutation	novel	E119Q	0.24
LUSC	chr11	20508295	Splice_Site	novel	X496_splice	0.34
LUSC	chr11	20407925	Silent	novel	V262V	0.2
LUSC	chr11	20462012	Missense_Mutation	NA	A369T	0.27
LUSC	chr11	20493937	Missense_Mutation	NA	D456Y	0.12
LUSC	chr11	20462150	Missense_Mutation	rs551794312	E415Q	0.21
OV	chr11	20389817	Frame_Shift_Ins	novel	*H80Lfs7**	0.08
PAAD	chr11	20395907	Missense_Mutation	novel	A169T	0.17
PAAD	chr11	20508405	Missense_Mutation	novel	L530I	0.05
PRAD	chr11	20493969	Missense_Mutation	novel	R466S	0.12
PRAD	chr11	20402951	Silent	NA	F246F	0.33
PRAD	chr11	20388078	Nonsense_Mutation	NA	E30*	0.1
READ	chr11	20395814	Missense_Mutation	NA	L138I	0.28
READ	chr11	20508396	Missense_Mutation	NA	T527P	0.39
READ	chr11	20426846	Missense_Mutation	novel	V325A	0.41	MTS
SARC	chr11	20392921	Missense_Mutation	novel	S108A	0.23
SKCM	chr11	20508388	Missense_Mutation	NA	S524L	0.2
SKCM	chr11	20462133	Missense_Mutation	rs142036289	P409L	0.28
SKCM	chr11	20464515	Missense_Mutation	NA	T439I	0.31
SKCM	chr11	20395814	Missense_Mutation	NA	L138F	0.25
SKCM	chr11	20464525	Silent	NA	I442I	0.63
SKCM	chr11	20402951	Silent	NA	F246F	0.19
SKCM	chr11	20392923	Silent	NA	S108S	0.2
SKCM	chr11	20508521	3'UTR	novel		0.5
SKCM	chr11	20508522	3'UTR	novel		0.5
SKCM	chr11	20397716	Silent	novel	L234L	0.2
STAD	chr11	20392936	Missense_Mutation	novel	V113L	0.13
STAD	chr11	20402940	Missense_Mutation	NA	Y243H	0.09
STAD	chr11	20494231	Frame_Shift_Del	novel	*K489Nfs11**	0.1
STAD	chr11	20388113	Frame_Shift_Del	novel	*H43Tfs50**	0.15
STAD	chr11	20494231	Frame_Shift_Del	novel	*K489Nfs11**	0.31
STAD	chr11	20452138	Missense_Mutation	NA	F334L	0.13	MTS
STAD	chr11	20402928	Nonsense_Mutation	rs376995112	R239*	0.25
STAD	chr11	20494231	Frame_Shift_Del	novel	*K489Nfs11**	0.1
STAD	chr11	20494185	Missense_Mutation	NA	P473S	0.11
UCEC	chr11	20462152	Frame_Shift_Ins	NA	*C417Lfs4**	0.25
UCEC	chr11	20389774	Silent	NA	S65S	0.36
UCEC	chr11	20388023	Silent	novel	G11G	0.61
UCEC	chr11	20392897	Missense_Mutation	novel	N100D	0.33
UCEC	chr11	20508405	Missense_Mutation	novel	L530F	0.35
UCEC	chr11	20462155	Silent	novel	P416P	0.55
UCEC	chr11	20494173	Missense_Mutation	rs370312922	F469L	0.34
UCEC	chr11	20397625	Silent	NA	S203S	0.33
UCEC	chr11	20392243	Missense_Mutation	novel	N94H	0.35
UCEC	chr11	20395956	Missense_Mutation	novel	K185T	0.33
UCEC	chr11	20407913	Splice_Region	novel	V258V	0.14
UCEC	chr11	20462043	Missense_Mutation	NA	R379I	0.39
UCEC	chr11	20388101	Silent	novel	D37D	0.36
UCEC	chr11	20392947	Missense_Mutation	novel	E116D	0.22
UCEC	chr11	20461978	Splice_Site	novel	X358_splice	0.4
UCEC	chr11	20452203	Missense_Mutation	novel	G356A	0.27	MTS
UCEC	chr11	20392243	Missense_Mutation	novel	N94H	0.2
UCEC	chr11	20388052	Missense_Mutation	novel	L21P	0.33
UCEC	chr11	20407973	Silent	rs144727080	A278A	0.31
UCEC	chr11	20397608	Missense_Mutation	rs772412365	D198Y	0.13
UCEC	chr11	20397640	Silent	novel	V208V	0.23
UCEC	chr11	20464476	Missense_Mutation	rs772412108	T426M	0.33
UCEC	chr11	20426824	Missense_Mutation	NA	L318I	0.33	MTS
UCEC	chr11	20462043	Missense_Mutation	NA	R379I	0.39
UCEC	chr11	20407972	Missense_Mutation	rs767722630	A278V	0.29	MTS
UCEC	chr11	20494205	Missense_Mutation	novel	H479Q	0.46
UCS	chr11	20464476	Missense_Mutation	novel	T426R	0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.278	0.02701
ESCA	AMP	0.1576	0.018342
PCPG	AMP	0.0247	0.23196
TGCT	DEL	0.5467	0.21504

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0025	Kaplan-Meier Survival Analysis
MESO	0.038	Kaplan-Meier Survival Analysis
UCS	0.012	Kaplan-Meier Survival Analysis
HNSC	0.047	Kaplan-Meier Survival Analysis
SKCM	0.0095	Kaplan-Meier Survival Analysis
BRCA	0.018	Kaplan-Meier Survival Analysis
PAAD	0.00028	Kaplan-Meier Survival Analysis
READ	0.036	Kaplan-Meier Survival Analysis
KICH	0.03	Kaplan-Meier Survival Analysis
GBM	0.012	Kaplan-Meier Survival Analysis
LIHC	0.00034	Kaplan-Meier Survival Analysis
THCA	0.039	Kaplan-Meier Survival Analysis
UVM	0.0084	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742