EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000185272 (Gene tree)
Gene ID: 54033
Gene Symbol: RBM11
Alias: N
Full Name: RNA binding motif protein 11
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 12,267 bases
Position: chr21:14,216,106-14,228,372
Accession: 9897
RBP type: canonical RBP
Summary: (RNA Binding Motif Protein 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBM7.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000383421	RRM_1	PF00076.22	2.4e-14	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27590229	A typical RNA-binding protein gene (AccRBM11) in Apis cerana cerana: characterization of AccRBM11 and its possible involvement in development and stress responses.	Cell Stress Chaperones	2016 Nov	Li G	-
21984414	The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator.	Nucleic Acids Res	2012 Feb	Pedrotti S	doi: 10.1093/nar/gkr819
21559832	Sequence and expression of the chicken membrane-associated phospholipases A1 alpha (LIPH) and beta (LIPI).	Mol Biol Rep	2012 Jan	Hesse M	doi: 10.1007/s11033-011-0796-0

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000400577	RBM11-201	1934	XM_005260997	ENSP00000383421	281 (aa)	XP_005261054	P57052
ENST00000468643	RBM11-203	1992	NR_135311	-	- (aa)	-	-
ENST00000468788	RBM11-204	680	-	-	- (aa)	-	-
ENST00000475864	RBM11-205	668	-	-	- (aa)	-	-
ENST00000495055	RBM11-206	1597	NR_135309	-	- (aa)	-	-
ENST00000461088	RBM11-202	649	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000185272's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000185272	Platelet Function Tests	1.6946400E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000185272's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000185272	RBM11	96	73.381	ENSAMEG00000014371	RBM11	96	73.381	Ailuropoda_melanoleuca
ENSG00000185272	RBM11	55	59.006	ENSACAG00000000550	RBM11	93	44.403	Anolis_carolinensis
ENSG00000185272	RBM11	100	82.206	ENSANAG00000034350	RBM11	100	82.206	Aotus_nancymaae
ENSG00000185272	RBM11	99	72.222	ENSBTAG00000034347	RBM11	67	72.826	Bos_taurus
ENSG00000185272	RBM11	100	81.851	ENSCJAG00000003218	RBM11	100	81.851	Callithrix_jacchus
ENSG00000185272	RBM11	96	73.333	ENSCAFG00000030228	RBM11	95	73.333	Canis_familiaris
ENSG00000185272	RBM11	96	73.333	ENSCAFG00020026541	RBM11	95	73.333	Canis_lupus_dingo
ENSG00000185272	RBM11	99	71.875	ENSCHIG00000019134	RBM11	96	73.022	Capra_hircus
ENSG00000185272	RBM11	96	77.037	ENSTSYG00000003871	RBM11	95	77.037	Carlito_syrichta
ENSG00000185272	RBM11	85	63.445	ENSCAPG00000013590	RBM11	94	63.445	Cavia_aperea
ENSG00000185272	RBM11	96	68.519	ENSCPOG00000005309	RBM11	95	69.259	Cavia_porcellus
ENSG00000185272	RBM11	96	80.370	ENSCCAG00000030608	RBM11	95	80.370	Cebus_capucinus
ENSG00000185272	RBM11	96	94.815	ENSCATG00000043433	RBM11	96	94.815	Cercocebus_atys
ENSG00000185272	RBM11	96	74.815	ENSCLAG00000005374	RBM11	95	74.815	Chinchilla_lanigera
ENSG00000185272	RBM11	72	86.634	ENSCHOG00000007826	RBM11	95	86.634	Choloepus_hoffmanni
ENSG00000185272	RBM11	92	53.731	ENSCPBG00000028340	RBM11	92	53.818	Chrysemys_picta_bellii
ENSG00000185272	RBM11	96	94.444	ENSCANG00000017645	RBM11	96	94.444	Colobus_angolensis_palliatus
ENSG00000185272	RBM11	83	78.112	ENSCANG00000027287	-	95	78.112	Colobus_angolensis_palliatus
ENSG00000185272	RBM11	96	68.889	ENSCGRG00001013426	Rbm11	95	69.630	Cricetulus_griseus_chok1gshd
ENSG00000185272	RBM11	86	65.560	ENSCGRG00000011040	Rbm11	80	66.390	Cricetulus_griseus_crigri
ENSG00000185272	RBM11	96	71.852	ENSDNOG00000044590	RBM11	95	73.978	Dasypus_novemcinctus
ENSG00000185272	RBM11	51	91.667	ENSDORG00000000801	Rbm11	100	91.667	Dipodomys_ordii
ENSG00000185272	RBM11	96	75.556	ENSEASG00005013619	RBM11	95	75.556	Equus_asinus_asinus
ENSG00000185272	RBM11	94	73.384	ENSECAG00000015417	RBM11	69	73.384	Equus_caballus
ENSG00000185272	RBM11	96	74.815	ENSFCAG00000018199	RBM11	95	74.815	Felis_catus
ENSG00000185272	RBM11	85	73.109	ENSFDAG00000012193	RBM11	95	73.109	Fukomys_damarensis
ENSG00000185272	RBM11	92	50.746	ENSGALG00000044391	RBM11	89	50.746	Gallus_gallus
ENSG00000185272	RBM11	65	38.974	ENSGALG00000007017	RBM7	68	38.974	Gallus_gallus
ENSG00000185272	RBM11	92	53.358	ENSGAGG00000010715	RBM11	90	53.455	Gopherus_agassizii
ENSG00000185272	RBM11	100	98.932	ENSGGOG00000025603	RBM11	100	98.932	Gorilla_gorilla
ENSG00000185272	RBM11	96	73.704	ENSHGLG00000013951	RBM11	95	74.444	Heterocephalus_glaber_female
ENSG00000185272	RBM11	96	73.704	ENSHGLG00100007848	RBM11	95	74.444	Heterocephalus_glaber_male
ENSG00000185272	RBM11	96	75.926	ENSSTOG00000034273	RBM11	95	75.926	Ictidomys_tridecemlineatus
ENSG00000185272	RBM11	95	69.663	ENSJJAG00000019251	Rbm11	95	69.259	Jaculus_jaculus
ENSG00000185272	RBM11	72	52.736	ENSLACG00000008381	-	85	52.736	Latimeria_chalumnae
ENSG00000185272	RBM11	70	44.131	ENSLOCG00000009642	-	80	44.131	Lepisosteus_oculatus
ENSG00000185272	RBM11	96	71.481	ENSLAFG00000007082	RBM11	95	71.481	Loxodonta_africana
ENSG00000185272	RBM11	96	94.815	ENSMFAG00000039455	RBM11	96	94.815	Macaca_fascicularis
ENSG00000185272	RBM11	96	95.185	ENSMMUG00000020089	RBM11	96	95.185	Macaca_mulatta
ENSG00000185272	RBM11	96	95.185	ENSMNEG00000030940	RBM11	96	95.185	Macaca_nemestrina
ENSG00000185272	RBM11	96	95.556	ENSMLEG00000028823	RBM11	96	95.556	Mandrillus_leucophaeus
ENSG00000185272	RBM11	96	71.004	ENSMAUG00000008588	Rbm11	95	71.111	Mesocricetus_auratus
ENSG00000185272	RBM11	96	79.259	ENSMICG00000037489	RBM11	95	79.259	Microcebus_murinus
ENSG00000185272	RBM11	96	67.037	ENSMOCG00000004302	Rbm11	95	67.037	Microtus_ochrogaster
ENSG00000185272	RBM11	96	67.037	MGP_CAROLIEiJ_G0020874	Rbm11	95	67.778	Mus_caroli
ENSG00000185272	RBM11	96	67.037	ENSMUSG00000032940	Rbm11	95	67.778	Mus_musculus
ENSG00000185272	RBM11	71	80.500	MGP_PahariEiJ_G0016578	Rbm11	95	66.667	Mus_pahari
ENSG00000185272	RBM11	96	67.407	MGP_SPRETEiJ_G0021780	Rbm11	95	68.148	Mus_spretus
ENSG00000185272	RBM11	98	75.182	ENSMPUG00000010691	RBM11	98	74.815	Mustela_putorius_furo
ENSG00000185272	RBM11	72	81.818	ENSMLUG00000005721	RBM11	96	68.705	Myotis_lucifugus
ENSG00000185272	RBM11	96	69.630	ENSNGAG00000011146	Rbm11	95	70.370	Nannospalax_galili
ENSG00000185272	RBM11	100	97.153	ENSNLEG00000001741	RBM11	100	97.153	Nomascus_leucogenys
ENSG00000185272	RBM11	55	91.463	ENSMEUG00000003535	-	68	91.463	Notamacropus_eugenii
ENSG00000185272	RBM11	62	62.222	ENSOANG00000008231	-	92	53.600	Ornithorhynchus_anatinus
ENSG00000185272	RBM11	96	75.556	ENSOCUG00000010409	RBM11	95	75.556	Oryctolagus_cuniculus
ENSG00000185272	RBM11	72	90.099	ENSOGAG00000005760	RBM11	100	90.099	Otolemur_garnettii
ENSG00000185272	RBM11	99	72.569	ENSOARG00000016446	RBM11	96	73.022	Ovis_aries
ENSG00000185272	RBM11	100	99.644	ENSPPAG00000037461	RBM11	100	99.644	Pan_paniscus
ENSG00000185272	RBM11	96	74.815	ENSPPRG00000002935	RBM11	95	74.815	Panthera_pardus
ENSG00000185272	RBM11	96	74.815	ENSPTIG00000016278	RBM11	95	74.815	Panthera_tigris_altaica
ENSG00000185272	RBM11	100	99.644	ENSPTRG00000013786	RBM11	100	99.644	Pan_troglodytes
ENSG00000185272	RBM11	96	94.815	ENSPANG00000024393	RBM11	96	94.815	Papio_anubis
ENSG00000185272	RBM11	96	69.630	ENSPEMG00000016731	Rbm11	95	69.630	Peromyscus_maniculatus_bairdii
ENSG00000185272	RBM11	94	49.434	ENSPCIG00000013003	-	93	49.248	Phascolarctos_cinereus
ENSG00000185272	RBM11	100	98.221	ENSPPYG00000011285	RBM11	100	98.221	Pongo_abelii
ENSG00000185272	RBM11	51	88.889	ENSPCAG00000008368	-	100	88.889	Procavia_capensis
ENSG00000185272	RBM11	96	79.259	ENSPCOG00000024136	RBM11	95	79.259	Propithecus_coquereli
ENSG00000185272	RBM11	89	71.888	ENSPVAG00000013858	RBM11	95	71.429	Pteropus_vampyrus
ENSG00000185272	RBM11	71	84.000	ENSRNOG00000029147	Rbm11	95	68.519	Rattus_norvegicus
ENSG00000185272	RBM11	96	94.815	ENSRBIG00000036380	RBM11	96	94.815	Rhinopithecus_bieti
ENSG00000185272	RBM11	96	94.444	ENSRROG00000029863	RBM11	96	94.444	Rhinopithecus_roxellana
ENSG00000185272	RBM11	100	81.139	ENSSBOG00000029034	RBM11	100	81.139	Saimiri_boliviensis_boliviensis
ENSG00000185272	RBM11	95	52.632	ENSSHAG00000013296	-	96	52.632	Sarcophilus_harrisii
ENSG00000185272	RBM11	96	70.741	ENSSARG00000001717	RBM11	95	71.481	Sorex_araneus
ENSG00000185272	RBM11	69	57.353	ENSSPUG00000011684	RBM11	87	49.632	Sphenodon_punctatus
ENSG00000185272	RBM11	99	74.910	ENSSSCG00000037517	RBM11	96	74.815	Sus_scrofa
ENSG00000185272	RBM11	88	71.255	ENSTBEG00000004121	RBM11	94	71.915	Tupaia_belangeri
ENSG00000185272	RBM11	99	76.344	ENSTTRG00000007410	RBM11	96	76.667	Tursiops_truncatus
ENSG00000185272	RBM11	96	74.815	ENSUAMG00000027022	RBM11	95	74.815	Ursus_americanus
ENSG00000185272	RBM11	90	74.603	ENSVPAG00000000673	RBM11	95	74.486	Vicugna_pacos
ENSG00000185272	RBM11	96	72.963	ENSVVUG00000023818	RBM11	69	72.963	Vulpes_vulpes
ENSG00000185272	RBM11	93	40.909	ENSXETG00000005847	rbm11	91	40.909	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	21984414.	IDA	Process
GO:0003727	single-stranded RNA binding	21873635.	IBA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	21984414.	IDA	Component
GO:0005654	nucleoplasm	21984414.	IDA	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0007275	multicellular organism development	-	IEA	Process
GO:0008266	poly(U) RNA binding	21984414.	IDA	Function
GO:0008380	RNA splicing	-	IEA	Process
GO:0016607	nuclear speck	21984414.	IDA	Component
GO:0030154	cell differentiation	-	IEA	Process
GO:0034599	cellular response to oxidative stress	21984414.	IDA	Process
GO:0042803	protein homodimerization activity	21984414.	IDA	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr21	14226969	Silent	NA	L174L	0.22
BRCA	chr21	14216238	Missense_Mutation	NA	E18Q	0.16	RRM_1
BRCA	chr21	14216189	Translation_Start_Site	novel	M1?	0.04
BRCA	chr21	14224507	Missense_Mutation	novel	L134F	0.21
BRCA	chr21	14216157	5'Flank	novel		0.11
BRCA	chr21	14216238	Missense_Mutation	NA	E18Q	0.2	RRM_1
CESC	chr21	14219695	Frame_Shift_Del	novel	*G77Efs29**	0.29	RRM_1
CESC	chr21	14224511	Nonsense_Mutation	NA	Q136*	0.54
COAD	chr21	14227256	Frame_Shift_Del	novel	*K271Sfs17**	0.16
COAD	chr21	14227342	3'UTR	rs775095856		0.17
ESCA	chr21	14221153	Missense_Mutation	novel	N106H	0.71
ESCA	chr21	14224507	Silent	novel	L134L	0.37
GBM	chr21	14227277	Missense_Mutation	novel	K277T	0.29
HNSC	chr21	14227191	Missense_Mutation	novel	K248N	0.19
KIRC	chr21	14227264	Nonsense_Mutation	rs201431914	R273*	0.32
KIRP	chr21	14226982	Missense_Mutation	NA	D179Y	0.46
LAML	chr21	14227190	Missense_Mutation	novel	K248M	0.12
LIHC	chr21	14227033	Missense_Mutation	NA	D196Y	0.22
LUAD	chr21	14219647	Nonsense_Mutation	novel	E61*	0.24	RRM_1
LUAD	chr21	14227433	3'UTR	novel		0.6
LUAD	chr21	14224436	Splice_Site	NA	X111_splice	0.5
LUSC	chr21	14219714	Missense_Mutation	NA	Q83L	0.17
LUSC	chr21	14226920	Missense_Mutation	novel	Y158C	0.17
LUSC	chr21	14219621	Missense_Mutation	NA	F52S	0.65	RRM_1
LUSC	chr21	14227160	Missense_Mutation	NA	D238G	0.2
LUSC	chr21	14219583	Silent	NA	V39V	0.24
LUSC	chr21	14216252	Silent	novel	R22R	0.21
OV	chr21	14227503	3'UTR	novel		0.71
OV	chr21	14227116	Silent	novel	E223E	0.29
PAAD	chr21	14219681	Missense_Mutation	novel	G72V	0.13	RRM_1
READ	chr21	14219686	Missense_Mutation	rs763112579	R74C	0.32	RRM_1
READ	chr21	14227187	Missense_Mutation	rs767760971	R247Q	0.26
SARC	chr21	14224391	Intron	novel		0.14
SARC	chr21	14227066	Missense_Mutation	novel	P207S	0.38
SKCM	chr21	14226922	Missense_Mutation	NA	E159K	0.36
SKCM	chr21	14219696	Missense_Mutation	NA	G77E	0.46	RRM_1
SKCM	chr21	14226900	Silent	novel	P151P	0.28
SKCM	chr21	14226901	Missense_Mutation	novel	V152M	0.29
SKCM	chr21	14227308	3'UTR	novel		0.19
SKCM	chr21	14227336	3'UTR	novel		0.38
SKCM	chr21	14219686	Missense_Mutation	rs763112579	R74C	0.32	RRM_1
SKCM	chr21	14219686	Missense_Mutation	rs763112579	R74C	0.21	RRM_1
SKCM	chr21	14227187	Missense_Mutation	rs767760971	R247Q	0.36
SKCM	chr21	14219719	Nonsense_Mutation	rs775462880	R85*	0.29
SKCM	chr21	14227271	Frame_Shift_Ins	novel	K276*	0.17
STAD	chr21	14216215	Missense_Mutation	novel	R10M	0.2
STAD	chr21	14219649	Missense_Mutation	NA	E61D	0.1	RRM_1
STAD	chr21	14227204	Missense_Mutation	NA	T253A	0.04
STAD	chr21	14227341	3'UTR	novel		0.31
STAD	chr21	14227260	Silent	novel	K271K	0.2
THCA	chr21	14227433	3'UTR	novel		0.43
UCEC	chr21	14227393	3'UTR	novel		0.45
UCEC	chr21	14227063	Missense_Mutation	NA	L206F	0.36
UCEC	chr21	14227394	3'UTR	novel		0.3
UCEC	chr21	14227264	Nonsense_Mutation	rs201431914	R273*	0.43
UCEC	chr21	14219686	Missense_Mutation	rs763112579	R74C	0.5	RRM_1
UCEC	chr21	14219657	Missense_Mutation	NA	S64Y	0.23	RRM_1
UCEC	chr21	14227245	Silent	novel	N266N	0.44
UCEC	chr21	14219564	Missense_Mutation	rs528749430	A33V	0.3	RRM_1
UCEC	chr21	14226934	Missense_Mutation	novel	P163S	0.06
UCEC	chr21	14216209	Missense_Mutation	NA	A8V	0.16
UCEC	chr21	14219656	Missense_Mutation	novel	S64P	0.39	RRM_1
UCEC	chr21	14219647	Nonsense_Mutation	novel	E61*	0.23	RRM_1
UCEC	chr21	14221103	Missense_Mutation	novel	S89Y	0.43
UCEC	chr21	14227245	Silent	novel	N266N	0.25
UCEC	chr21	14224437	Splice_Site	novel	X111_splice	0.18
UCEC	chr21	14227259	Missense_Mutation	rs762833076	K271R	0.1
UCEC	chr21	14224525	Silent	novel	L140L	0.26
UCEC	chr21	14219651	Missense_Mutation	rs759324505	S62L	0.42	RRM_1
UCEC	chr21	14227235	Missense_Mutation	novel	N263S	0.29
UCEC	chr21	14227066	Missense_Mutation	NA	P207T	0.23
UCEC	chr21	14227150	Nonsense_Mutation	NA	Q235*	0.3
UCEC	chr21	14224506	Missense_Mutation	novel	L134S	0.29
UCEC	chr21	14219618	Frame_Shift_Ins	novel	*G53Wfs6**	0.25	RRM_1
UCEC	chr21	14221106	Missense_Mutation	rs200021740	R90H	0.09
UCEC	chr21	14227229	Missense_Mutation	novel	D261G	0.32
UCEC	chr21	14227240	Missense_Mutation	novel	G265C	0.33
UCEC	chr21	14227312	3'UTR	novel		0.42
UCEC	chr21	14227343	3'UTR	novel		0.43
UCEC	chr21	14226883	Missense_Mutation	NA	W146R	0.17
UCEC	chr21	14227228	Missense_Mutation	NA	D261Y	0.3
UCEC	chr21	14216247	Missense_Mutation	novel	V21I	0.33	RRM_1

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1593	0.19516
COAD	DEL	0.2639	9.899e-05
ESCA	DEL	0.4728	0.00084599
GBM	DEL	0.0659	0.11207
LUAD	DEL	0.2267	7.0035e-07
LUSC	DEL	0.3812	0.0021004
PAAD	DEL	0.2065	0.10872
SARC	DEL	0.1401	0.11643
STAD	DEL	0.3175	1.2217e-07

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0064	Kaplan-Meier Survival Analysis
ACC	0.018	Kaplan-Meier Survival Analysis
UCS	0.034	Kaplan-Meier Survival Analysis
BRCA	0.016	Kaplan-Meier Survival Analysis
PAAD	0.0001	Kaplan-Meier Survival Analysis
BLCA	0.0071	Kaplan-Meier Survival Analysis
READ	0.023	Kaplan-Meier Survival Analysis
KICH	0.018	Kaplan-Meier Survival Analysis
UCEC	0.0039	Kaplan-Meier Survival Analysis
LIHC	0.012	Kaplan-Meier Survival Analysis
LGG	0.0049	Kaplan-Meier Survival Analysis
UVM	0.014	Kaplan-Meier Survival Analysis
OV	0.014	Kaplan-Meier Survival Analysis