EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000185608 (Gene tree)
Gene ID: 64976
Gene Symbol: MRPL40
Alias: MRP-L22|NLVCF
Full Name: mitochondrial ribosomal protein L40
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 4,176 bases
Position: chr22:19,431,902-19,436,077
Accession: 14491
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000333401	MRP-L28	PF09812.9	1.3e-60	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000333130	MRPL40-201	1387	-	ENSP00000333401	206 (aa)	-	Q9NQ50
ENST00000443660	MRPL40-202	954	-	-	- (aa)	-	-
ENST00000471259	MRPL40-203	942	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000185608's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000185608	Anger	3.94e-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000185608's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000185608	MRPL40	98	50.746	ENSAPOG00000021291	mrpl40	98	50.746	Acanthochromis_polyacanthus
ENSG00000185608	MRPL40	100	75.728	ENSAMEG00000011421	MRPL40	100	75.728	Ailuropoda_melanoleuca
ENSG00000185608	MRPL40	59	56.198	ENSACIG00000006717	MRPL40	94	43.284	Amphilophus_citrinellus
ENSG00000185608	MRPL40	94	54.455	ENSACIG00000006672	mrpl40	100	54.455	Amphilophus_citrinellus
ENSG00000185608	MRPL40	98	51.220	ENSAOCG00000003216	mrpl40	100	51.220	Amphiprion_ocellaris
ENSG00000185608	MRPL40	98	51.220	ENSAPEG00000017401	mrpl40	100	51.220	Amphiprion_percula
ENSG00000185608	MRPL40	73	60.927	ENSATEG00000020753	mrpl40	82	60.714	Anabas_testudineus
ENSG00000185608	MRPL40	88	57.297	ENSAPLG00000004002	MRPL40	92	58.152	Anas_platyrhynchos
ENSG00000185608	MRPL40	98	53.234	ENSACAG00000001053	MRPL40	99	53.234	Anolis_carolinensis
ENSG00000185608	MRPL40	100	88.835	ENSANAG00000026579	MRPL40	100	88.835	Aotus_nancymaae
ENSG00000185608	MRPL40	98	52.239	ENSACLG00000011106	mrpl40	98	52.239	Astatotilapia_calliptera
ENSG00000185608	MRPL40	86	53.672	ENSAMXG00000029691	mrpl40	100	49.510	Astyanax_mexicanus
ENSG00000185608	MRPL40	94	75.258	ENSBTAG00000019891	MRPL40	100	72.816	Bos_taurus
ENSG00000185608	MRPL40	100	88.889	ENSCJAG00000001584	MRPL40	100	88.889	Callithrix_jacchus
ENSG00000185608	MRPL40	100	76.699	ENSCAFG00020007995	MRPL40	100	76.699	Canis_lupus_dingo
ENSG00000185608	MRPL40	77	68.987	ENSCHIG00000026872	-	100	66.471	Capra_hircus
ENSG00000185608	MRPL40	93	72.917	ENSCHIG00000000131	-	100	70.874	Capra_hircus
ENSG00000185608	MRPL40	100	77.184	ENSTSYG00000014747	MRPL40	100	77.184	Carlito_syrichta
ENSG00000185608	MRPL40	69	83.803	ENSCAPG00000012876	MRPL40	99	83.803	Cavia_aperea
ENSG00000185608	MRPL40	99	81.463	ENSCPOG00000026802	MRPL40	100	81.463	Cavia_porcellus
ENSG00000185608	MRPL40	97	88.000	ENSCCAG00000037694	MRPL40	100	88.000	Cebus_capucinus
ENSG00000185608	MRPL40	96	90.909	ENSCATG00000043592	-	98	90.909	Cercocebus_atys
ENSG00000185608	MRPL40	100	91.262	ENSCATG00000031418	-	100	91.262	Cercocebus_atys
ENSG00000185608	MRPL40	93	82.199	ENSCLAG00000016629	MRPL40	100	79.612	Chinchilla_lanigera
ENSG00000185608	MRPL40	100	89.320	ENSCSAG00000011593	MRPL40	100	89.320	Chlorocebus_sabaeus
ENSG00000185608	MRPL40	86	70.225	ENSCHOG00000008751	MRPL40	100	70.225	Choloepus_hoffmanni
ENSG00000185608	MRPL40	87	59.218	ENSCPBG00000010618	MRPL40	100	54.327	Chrysemys_picta_bellii
ENSG00000185608	MRPL40	62	36.220	ENSCSAVG00000001505	-	63	36.220	Ciona_savignyi
ENSG00000185608	MRPL40	91	92.553	ENSCANG00000038600	MRPL40	100	92.553	Colobus_angolensis_palliatus
ENSG00000185608	MRPL40	100	76.214	ENSCGRG00001019957	Mrpl40	100	76.214	Cricetulus_griseus_chok1gshd
ENSG00000185608	MRPL40	100	76.214	ENSCGRG00000001245	Mrpl40	100	76.214	Cricetulus_griseus_crigri
ENSG00000185608	MRPL40	76	60.510	ENSCSEG00000019750	mrpl40	68	60.870	Cynoglossus_semilaevis
ENSG00000185608	MRPL40	63	43.077	ENSCSEG00000012296	-	61	47.826	Cynoglossus_semilaevis
ENSG00000185608	MRPL40	91	53.030	ENSCVAG00000018229	mrpl40	97	53.030	Cyprinodon_variegatus
ENSG00000185608	MRPL40	85	50.286	ENSDARG00000043554	mrpl40	100	45.771	Danio_rerio
ENSG00000185608	MRPL40	100	71.359	ENSDNOG00000038360	-	100	71.359	Dasypus_novemcinctus
ENSG00000185608	MRPL40	100	76.214	ENSDORG00000002949	Mrpl40	100	76.214	Dipodomys_ordii
ENSG00000185608	MRPL40	72	39.610	FBgn0037892	mRpL40	66	40.000	Drosophila_melanogaster
ENSG00000185608	MRPL40	91	55.080	ENSETEG00000006816	-	99	55.080	Echinops_telfairi
ENSG00000185608	MRPL40	99	77.941	ENSEASG00005010493	MRPL40	99	77.941	Equus_asinus_asinus
ENSG00000185608	MRPL40	79	81.481	ENSECAG00000009876	MRPL40	97	81.481	Equus_caballus
ENSG00000185608	MRPL40	100	74.757	ENSEEUG00000009268	MRPL40	99	74.757	Erinaceus_europaeus
ENSG00000185608	MRPL40	82	55.952	ENSELUG00000009281	mrpl40	82	55.952	Esox_lucius
ENSG00000185608	MRPL40	100	78.641	ENSFCAG00000002752	MRPL40	100	78.641	Felis_catus
ENSG00000185608	MRPL40	85	55.429	ENSFALG00000007981	MRPL40	93	55.676	Ficedula_albicollis
ENSG00000185608	MRPL40	79	80.864	ENSFDAG00000020940	MRPL40	100	80.864	Fukomys_damarensis
ENSG00000185608	MRPL40	85	60.000	ENSGALG00000053063	MRPL40	53	60.000	Gallus_gallus
ENSG00000185608	MRPL40	77	59.494	ENSGAFG00000000522	mrpl40	77	56.962	Gambusia_affinis
ENSG00000185608	MRPL40	96	55.288	ENSGAGG00000020728	MRPL40	100	55.288	Gopherus_agassizii
ENSG00000185608	MRPL40	100	98.544	ENSGGOG00000012336	MRPL40	100	98.544	Gorilla_gorilla
ENSG00000185608	MRPL40	98	52.239	ENSHBUG00000000404	mrpl40	98	52.239	Haplochromis_burtoni
ENSG00000185608	MRPL40	79	82.099	ENSHGLG00000018525	MRPL40	100	82.099	Heterocephalus_glaber_female
ENSG00000185608	MRPL40	100	78.641	ENSHGLG00100009563	MRPL40	100	78.641	Heterocephalus_glaber_male
ENSG00000185608	MRPL40	98	46.798	ENSHCOG00000005731	mrpl40	100	46.798	Hippocampus_comes
ENSG00000185608	MRPL40	95	51.531	ENSIPUG00000020288	Mrpl40	91	48.980	Ictalurus_punctatus
ENSG00000185608	MRPL40	95	80.000	ENSSTOG00000002887	MRPL40	95	80.000	Ictidomys_tridecemlineatus
ENSG00000185608	MRPL40	100	78.155	ENSJJAG00000017905	Mrpl40	100	78.155	Jaculus_jaculus
ENSG00000185608	MRPL40	77	63.522	ENSKMAG00000003717	mrpl40	81	61.446	Kryptolebias_marmoratus
ENSG00000185608	MRPL40	83	54.335	ENSLBEG00000025203	mrpl40	74	57.664	Labrus_bergylta
ENSG00000185608	MRPL40	85	55.367	ENSLACG00000015070	MRPL40	97	52.239	Latimeria_chalumnae
ENSG00000185608	MRPL40	98	53.922	ENSLOCG00000001879	mrpl40	100	53.922	Lepisosteus_oculatus
ENSG00000185608	MRPL40	100	80.583	ENSLAFG00000011061	MRPL40	100	80.583	Loxodonta_africana
ENSG00000185608	MRPL40	99	82.266	ENSMFAG00000039890	-	100	81.068	Macaca_fascicularis
ENSG00000185608	MRPL40	100	91.262	ENSMFAG00000032018	-	100	91.262	Macaca_fascicularis
ENSG00000185608	MRPL40	100	87.379	ENSMFAG00000001495	-	98	89.394	Macaca_fascicularis
ENSG00000185608	MRPL40	96	82.234	ENSMMUG00000006218	-	100	82.234	Macaca_mulatta
ENSG00000185608	MRPL40	96	88.832	ENSMMUG00000030886	-	96	88.832	Macaca_mulatta
ENSG00000185608	MRPL40	100	87.864	ENSMNEG00000041171	-	98	89.899	Macaca_nemestrina
ENSG00000185608	MRPL40	100	75.728	ENSMNEG00000040492	-	100	74.272	Macaca_nemestrina
ENSG00000185608	MRPL40	100	89.806	ENSMNEG00000034050	-	100	89.806	Macaca_nemestrina
ENSG00000185608	MRPL40	99	81.281	ENSMLEG00000009022	-	100	80.097	Mandrillus_leucophaeus
ENSG00000185608	MRPL40	91	92.553	ENSMLEG00000030926	-	100	92.553	Mandrillus_leucophaeus
ENSG00000185608	MRPL40	96	90.404	ENSMLEG00000032552	-	98	90.404	Mandrillus_leucophaeus
ENSG00000185608	MRPL40	98	51.244	ENSMAMG00000014249	mrpl40	68	62.319	Mastacembelus_armatus
ENSG00000185608	MRPL40	98	52.239	ENSMZEG00005009853	mrpl40	98	52.239	Maylandia_zebra
ENSG00000185608	MRPL40	71	64.384	ENSMGAG00000001177	MRPL40	90	64.286	Meleagris_gallopavo
ENSG00000185608	MRPL40	100	75.243	ENSMAUG00000015350	Mrpl40	100	75.243	Mesocricetus_auratus
ENSG00000185608	MRPL40	100	80.583	ENSMICG00000046066	MRPL40	100	80.583	Microcebus_murinus
ENSG00000185608	MRPL40	100	74.272	ENSMOCG00000016970	Mrpl40	100	74.272	Microtus_ochrogaster
ENSG00000185608	MRPL40	75	60.645	ENSMMOG00000012861	mrpl40	76	60.714	Mola_mola
ENSG00000185608	MRPL40	84	65.143	ENSMODG00000010070	MRPL40	96	65.143	Monodelphis_domestica
ENSG00000185608	MRPL40	87	50.829	ENSMALG00000020778	mrpl40	94	49.724	Monopterus_albus
ENSG00000185608	MRPL40	100	76.214	MGP_CAROLIEiJ_G0020557	Mrpl40	100	81.481	Mus_caroli
ENSG00000185608	MRPL40	100	75.243	ENSMUSG00000022706	Mrpl40	100	80.864	Mus_musculus
ENSG00000185608	MRPL40	100	77.184	MGP_PahariEiJ_G0016262	Mrpl40	100	81.481	Mus_pahari
ENSG00000185608	MRPL40	100	75.728	MGP_SPRETEiJ_G0021452	Mrpl40	100	80.864	Mus_spretus
ENSG00000185608	MRPL40	100	76.699	ENSMPUG00000003865	MRPL40	100	76.699	Mustela_putorius_furo
ENSG00000185608	MRPL40	100	75.728	ENSMLUG00000024620	-	100	75.728	Myotis_lucifugus
ENSG00000185608	MRPL40	100	75.728	ENSMLUG00000002456	-	100	75.728	Myotis_lucifugus
ENSG00000185608	MRPL40	90	80.108	ENSNGAG00000000304	Mrpl40	93	79.787	Nannospalax_galili
ENSG00000185608	MRPL40	100	94.660	ENSNLEG00000005372	MRPL40	100	94.660	Nomascus_leucogenys
ENSG00000185608	MRPL40	71	49.660	ENSMEUG00000003868	-	90	49.655	Notamacropus_eugenii
ENSG00000185608	MRPL40	100	56.796	ENSOPRG00000002606	MRPL40	100	56.796	Ochotona_princeps
ENSG00000185608	MRPL40	100	78.155	ENSODEG00000017051	MRPL40	100	78.155	Octodon_degus
ENSG00000185608	MRPL40	98	52.239	ENSONIG00000014393	mrpl40	98	52.239	Oreochromis_niloticus
ENSG00000185608	MRPL40	92	82.105	ENSOCUG00000009859	MRPL40	68	82.105	Oryctolagus_cuniculus
ENSG00000185608	MRPL40	77	63.924	ENSORLG00000002574	mrpl40	77	64.286	Oryzias_latipes
ENSG00000185608	MRPL40	77	63.291	ENSORLG00020005727	mrpl40	77	63.291	Oryzias_latipes_hni
ENSG00000185608	MRPL40	77	62.025	ENSORLG00015015422	mrpl40	77	62.025	Oryzias_latipes_hsok
ENSG00000185608	MRPL40	77	62.658	ENSOMEG00000017632	mrpl40	77	62.658	Oryzias_melastigma
ENSG00000185608	MRPL40	91	81.915	ENSOGAG00000030071	MRPL40	100	81.915	Otolemur_garnettii
ENSG00000185608	MRPL40	94	71.134	ENSOARG00000017561	MRPL40	94	71.134	Ovis_aries
ENSG00000185608	MRPL40	100	98.058	ENSPPAG00000030349	MRPL40	100	98.058	Pan_paniscus
ENSG00000185608	MRPL40	92	82.105	ENSPPRG00000004672	MRPL40	100	78.641	Panthera_pardus
ENSG00000185608	MRPL40	91	82.447	ENSPTIG00000003393	MRPL40	91	82.447	Panthera_tigris_altaica
ENSG00000185608	MRPL40	100	98.058	ENSPTRG00000014061	MRPL40	100	98.058	Pan_troglodytes
ENSG00000185608	MRPL40	100	90.291	ENSPANG00000007370	-	100	90.291	Papio_anubis
ENSG00000185608	MRPL40	96	91.414	ENSPANG00000000595	-	98	91.414	Papio_anubis
ENSG00000185608	MRPL40	97	53.000	ENSPKIG00000024494	mrpl40	98	53.000	Paramormyrops_kingsleyae
ENSG00000185608	MRPL40	81	60.843	ENSPSIG00000003055	MRPL40	100	60.843	Pelodiscus_sinensis
ENSG00000185608	MRPL40	76	56.688	ENSPMGG00000018388	mrpl40	75	55.714	Periophthalmus_magnuspinnatus
ENSG00000185608	MRPL40	100	74.272	ENSPEMG00000017933	Mrpl40	100	74.272	Peromyscus_maniculatus_bairdii
ENSG00000185608	MRPL40	80	64.848	ENSPCIG00000025479	MRPL40	80	64.848	Phascolarctos_cinereus
ENSG00000185608	MRPL40	77	59.627	ENSPFOG00000012506	mrpl40	66	60.714	Poecilia_formosa
ENSG00000185608	MRPL40	77	60.759	ENSPLAG00000017335	mrpl40	67	62.044	Poecilia_latipinna
ENSG00000185608	MRPL40	77	61.392	ENSPMEG00000003881	mrpl40	77	61.392	Poecilia_mexicana
ENSG00000185608	MRPL40	77	61.392	ENSPREG00000011448	mrpl40	77	61.392	Poecilia_reticulata
ENSG00000185608	MRPL40	91	97.872	ENSPPYG00000011578	MRPL40	100	97.872	Pongo_abelii
ENSG00000185608	MRPL40	100	65.049	ENSPCAG00000007834	MRPL40	100	65.049	Procavia_capensis
ENSG00000185608	MRPL40	100	81.068	ENSPCOG00000014413	MRPL40	100	81.068	Propithecus_coquereli
ENSG00000185608	MRPL40	52	73.148	ENSPVAG00000006414	-	52	73.148	Pteropus_vampyrus
ENSG00000185608	MRPL40	98	52.239	ENSPNYG00000008216	mrpl40	98	52.239	Pundamilia_nyererei
ENSG00000185608	MRPL40	98	52.475	ENSPNAG00000000310	mrpl40	100	52.475	Pygocentrus_nattereri
ENSG00000185608	MRPL40	100	76.214	ENSRNOG00000049686	Mrpl40	100	76.214	Rattus_norvegicus
ENSG00000185608	MRPL40	100	91.262	ENSRBIG00000023060	MRPL40	100	91.262	Rhinopithecus_bieti
ENSG00000185608	MRPL40	100	90.291	ENSRROG00000043837	MRPL40	100	90.291	Rhinopithecus_roxellana
ENSG00000185608	MRPL40	100	86.893	ENSSBOG00000031050	MRPL40	100	86.893	Saimiri_boliviensis_boliviensis
ENSG00000185608	MRPL40	77	66.038	ENSSHAG00000010239	MRPL40	99	66.038	Sarcophilus_harrisii
ENSG00000185608	MRPL40	92	54.974	ENSSFOG00015014220	mrpl40	97	54.974	Scleropages_formosus
ENSG00000185608	MRPL40	88	52.381	ENSSMAG00000006340	mrpl40	92	51.323	Scophthalmus_maximus
ENSG00000185608	MRPL40	98	47.761	ENSSDUG00000022994	mrpl40	98	47.761	Seriola_dumerili
ENSG00000185608	MRPL40	98	47.761	ENSSLDG00000009671	mrpl40	98	47.761	Seriola_lalandi_dorsalis
ENSG00000185608	MRPL40	100	79.612	ENSSARG00000003051	MRPL40	100	79.612	Sorex_araneus
ENSG00000185608	MRPL40	98	56.716	ENSSPUG00000015559	MRPL40	100	56.716	Sphenodon_punctatus
ENSG00000185608	MRPL40	96	51.010	ENSSPAG00000015481	mrpl40	97	51.010	Stegastes_partitus
ENSG00000185608	MRPL40	96	74.112	ENSSSCG00000034014	MRPL40	100	72.330	Sus_scrofa
ENSG00000185608	MRPL40	60	60.484	ENSTGUG00000008534	MRPL40	91	60.714	Taeniopygia_guttata
ENSG00000185608	MRPL40	93	52.970	ENSTRUG00000025904	mrpl40	70	62.143	Takifugu_rubripes
ENSG00000185608	MRPL40	92	75.789	ENSTTRG00000014932	MRPL40	100	73.786	Tursiops_truncatus
ENSG00000185608	MRPL40	100	77.184	ENSUAMG00000007667	MRPL40	100	77.184	Ursus_americanus
ENSG00000185608	MRPL40	92	76.190	ENSUMAG00000006804	MRPL40	99	76.190	Ursus_maritimus
ENSG00000185608	MRPL40	90	64.021	ENSVVUG00000020719	-	90	64.021	Vulpes_vulpes
ENSG00000185608	MRPL40	100	75.728	ENSVVUG00000025360	-	100	75.728	Vulpes_vulpes
ENSG00000185608	MRPL40	84	56.322	ENSXETG00000018600	mrpl40	87	56.322	Xenopus_tropicalis
ENSG00000185608	MRPL40	77	59.494	ENSXCOG00000002135	mrpl40	77	57.595	Xiphophorus_couchianus
ENSG00000185608	MRPL40	77	59.494	ENSXMAG00000014595	mrpl40	77	57.595	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	9790763.	TAS	Component
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005761	mitochondrial ribosome	21873635.	IBA	Component
GO:0005761	mitochondrial ribosome	-	ISS	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.28892042.	IDA	Component
GO:0009653	anatomical structure morphogenesis	9790763.	TAS	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process