EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000185624 (Gene tree)
Gene ID: 5034
Gene Symbol: P4HB
Alias: PDIA1|PROHB|DSI|GIT|PDI|PO4HB|P4Hbeta|PO4DB|ERBA2L
Full Name: prolyl 4-hydroxylase subunit beta
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 17,537 bases
Position: chr17:81,843,158-81,860,694
Accession: 8548
RBP type: non-canonical RBP
Summary: This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
8455607	Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen.	Mol Cell Biol	1993 Apr	Gatignol A	-
21357685	Glucose-stimulated translation regulation of insulin by the 5' UTR-binding proteins.	J Biol Chem	2011 Apr 22	Kulkarni SD	doi: 10.1074/jbc.M110.190553
11950970	The rice mutant esp2 greatly accumulates the glutelin precursor and deletes the protein disulfide isomerase.	Plant Physiol	2002 Apr	Takemoto Y	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000476482	P4HB-210	765	-	-	- (aa)	-	-
ENST00000576380	P4HB-222	943	-	ENSP00000460285	200 (aa)	-	I3L398
ENST00000477607	P4HB-211	1110	-	-	- (aa)	-	-
ENST00000478034	P4HB-212	811	-	-	- (aa)	-	-
ENST00000570907	P4HB-214	353	-	ENSP00000461362	117 (aa)	-	I3L4M2
ENST00000415593	P4HB-202	1669	-	ENSP00000388117	274 (aa)	-	H0Y3Z3
ENST00000576541	P4HB-224	571	-	ENSP00000460741	188 (aa)	-	I3L3U6
ENST00000439918	P4HB-203	1502	-	ENSP00000388374	464 (aa)	-	H7BZ94
ENST00000571617	P4HB-216	505	-	ENSP00000458300	148 (aa)	-	I3L0S0
ENST00000576052	P4HB-221	562	-	ENSP00000461791	166 (aa)	-	I3NI03
ENST00000576390	P4HB-223	439	-	ENSP00000461718	106 (aa)	-	I3L514
ENST00000484286	P4HB-213	759	-	-	- (aa)	-	-
ENST00000574914	P4HB-219	571	-	ENSP00000460612	156 (aa)	-	I3L3P5
ENST00000575069	P4HB-220	2453	-	ENSP00000459211	54 (aa)	-	I3L1Y5
ENST00000573778	P4HB-217	688	-	ENSP00000460088	208 (aa)	-	I3L312
ENST00000466567	P4HB-204	872	-	-	- (aa)	-	-
ENST00000574007	P4HB-218	1053	-	-	- (aa)	-	-
ENST00000471535	P4HB-206	579	-	-	- (aa)	-	-
ENST00000467086	P4HB-205	785	-	-	- (aa)	-	-
ENST00000472244	P4HB-207	858	-	-	- (aa)	-	-
ENST00000571507	P4HB-215	493	-	-	- (aa)	-	-
ENST00000331483	P4HB-201	2603	XM_024450777	ENSP00000327801	508 (aa)	XP_024306545	P07237
ENST00000473021	P4HB-208	914	-	-	- (aa)	-	-
ENST00000474712	P4HB-209	390	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000185624's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000185624's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000185624	P4HB	97	94.534	ENSMUSG00000025130	P4hb	90	94.989	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003756	protein disulfide isomerase activity	15720785.	EXP	Function
GO:0003756	protein disulfide isomerase activity	21873635.	IBA	Function
GO:0003756	protein disulfide isomerase activity	15225124.	IDA	Function
GO:0004656	procollagen-proline 4-dioxygenase activity	7753822.	IDA	Function
GO:0005178	integrin binding	21670307.	IPI	Function
GO:0005515	protein binding	12095988.17055437.19942855.20802462.21057456.21670307.23475612.23861867.25108285.26224785.	IPI	Function
GO:0005576	extracellular region	14718574.	NAS	Component
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005783	endoplasmic reticulum	12095988.23152784.23475612.	IDA	Component
GO:0005788	endoplasmic reticulum lumen	-	TAS	Component
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	15308636.	IDA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0006457	protein folding	21873635.	IBA	Process
GO:0009897	external side of plasma membrane	21873635.	IBA	Component
GO:0009897	external side of plasma membrane	21670307.	IDA	Component
GO:0015037	peptide disulfide oxidoreductase activity	16677074.	IDA	Function
GO:0016222	procollagen-proline 4-dioxygenase complex	7753822.	IDA	Component
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	7753822.	IDA	Process
GO:0019899	enzyme binding	-	IEA	Function
GO:0034378	chylomicron assembly	-	TAS	Process
GO:0034379	very-low-density lipoprotein particle assembly	-	TAS	Process
GO:0034663	endoplasmic reticulum chaperone complex	-	IEA	Component
GO:0034976	response to endoplasmic reticulum stress	21873635.	IBA	Process
GO:0034976	response to endoplasmic reticulum stress	12095988.	IMP	Process
GO:0035722	interleukin-12-mediated signaling pathway	-	TAS	Process
GO:0038155	interleukin-23-mediated signaling pathway	-	TAS	Process
GO:0042470	melanosome	-	IEA	Component
GO:0043687	post-translational protein modification	-	TAS	Process
GO:0044267	cellular protein metabolic process	-	TAS	Process
GO:0045454	cell redox homeostasis	-	IEA	Process
GO:0046598	positive regulation of viral entry into host cell	21670307.	IMP	Process
GO:0046982	protein heterodimerization activity	23475612.	IDA	Function
GO:0055114	oxidation-reduction process	-	IEA	Process
GO:0070062	extracellular exosome	19199708.	HDA	Component
GO:0071456	cellular response to hypoxia	12095988.	IMP	Process
GO:0098761	cellular response to interleukin-7	-	IEA	Process
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	12095988.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
29904245	Prognostic value of hypoxia-inducible factor-1 alpha and prolyl 4-hydroxylase beta polypeptide overexpression in gastric cancer.	World J Gastroenterol	2018 Jun 14	Zhang J	doi: 10.3748/wjg.v24.i22.2381.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr17	81846578	Nonsense_Mutation	novel	E303*	0.17
BLCA	chr17	81855263	Missense_Mutation	NA	S168F	0.23
BLCA	chr17	81845629	Missense_Mutation	NA	E431Q	0.14
BLCA	chr17	81855501	Silent	novel	A146A	0.48
BLCA	chr17	81859389	Splice_Site	novel	X49_splice	0.16
BLCA	chr17	81844019	Missense_Mutation	NA	E507G	0.58
BLCA	chr17	81859323	Silent	NA	L70L	0.13
BLCA	chr17	81847323	Missense_Mutation	novel	E217K	0.75
BLCA	chr17	81845591	Silent	NA	L443L	0.44
BLCA	chr17	81855515	Missense_Mutation	novel	D142N	0.21
BLCA	chr17	81843926	3'UTR	novel		0.28
BRCA	chr17	81845151	Missense_Mutation	NA	D480V	0.43
BRCA	chr17	81859323	Silent	novel	L70L	0.48
BRCA	chr17	81845959	Missense_Mutation	NA	D363E	0.41
BRCA	chr17	81845885	Missense_Mutation	novel	V388G	0.44
CESC	chr17	81847323	Missense_Mutation	novel	E217Q	0.24
CESC	chr17	81845224	Missense_Mutation	novel	D456H	0.06
COAD	chr17	81846534	Silent	rs765631122	L317L	0.32
COAD	chr17	81855192	Missense_Mutation	novel	V192M	0.26
COAD	chr17	81843825	3'UTR	rs561138949		0.5
COAD	chr17	81845888	Frame_Shift_Del	rs773547908	*N387Tfs118**	0.25
COAD	chr17	81843701	3'UTR	novel		0.5
COAD	chr17	81846626	Missense_Mutation	NA	L287M	0.36
COAD	chr17	81859273	Missense_Mutation	novel	E87V	0.39
COAD	chr17	81845634	Missense_Mutation	novel	A429V	0.14
COAD	chr17	81845143	Splice_Site	NA	X482_splice	0.28
COAD	chr17	81845616	Missense_Mutation	novel	V435G	0.57
COAD	chr17	81845724	Missense_Mutation	novel	H399R	0.2
COAD	chr17	81855273	Missense_Mutation	novel	E165K	0.13
COAD	chr17	81845654	Silent	rs184374096	I422I	0.33
ESCA	chr17	81855586	Missense_Mutation	novel	A118G	0.17
GBM	chr17	81845933	Missense_Mutation	novel	L372P	0.08
GBM	chr17	81855457	Missense_Mutation	novel	F161C	0.31
GBM	chr17	81846612	Silent	rs151018460	I291I	0.17
GBM	chr17	81846996	Missense_Mutation	novel	D269G	0.14
GBM	chr17	81855537	Silent	novel	G134G	0.19
GBM	chr17	81845573	Missense_Mutation	novel	S449R	0.09
GBM	chr17	81846612	Silent	rs151018460	I291I	0.49
GBM	chr17	81855233	Missense_Mutation	novel	A178G	0.09
GBM	chr17	81844030	Silent	novel	A503A	0.07
GBM	chr17	81845631	Missense_Mutation	novel	N430S	0.21
HNSC	chr17	81855171	Missense_Mutation	NA	D199H	0.25
HNSC	chr17	81855193	Silent	rs141223466	D191D	0.3
HNSC	chr17	81843801	3'UTR	novel		0.43
HNSC	chr17	81846480	Silent	rs201567654	T335T	0.26
KICH	chr17	81844014	Frame_Shift_Del	novel	*509I	0.29
LGG	chr17	81845174	Silent	rs201834939	S472S	0.43
LIHC	chr17	81860488	5'UTR	novel		0.11
LUAD	chr17	81846483	Silent	NA	L334L	0.17
LUAD	chr17	81847333	Silent	novel	R213R	0.14
LUAD	chr17	81859388	Splice_Site	NA	X49_splice	0.19
LUAD	chr17	81855193	Silent	rs141223466	D191D	0.28
LUAD	chr17	81859286	Missense_Mutation	novel	D83H	0.07
LUAD	chr17	81844048	Missense_Mutation	novel	E497D	0.21
LUAD	chr17	81845564	Missense_Mutation	NA	R452S	0.24
LUAD	chr17	81845595	Missense_Mutation	novel	T442I	0.21
LUAD	chr17	81855160	Silent	NA	G202G	0.15
LUSC	chr17	81846543	Silent	rs199705471	A314A	0.21
LUSC	chr17	81847283	Missense_Mutation	rs773105281	K230R	0.24
LUSC	chr17	81845563	Missense_Mutation	NA	T453A	0.3
LUSC	chr17	81844077	Missense_Mutation	NA	E488Q	0.27
LUSC	chr17	81844073	Missense_Mutation	rs148124283	E489A	0.22
LUSC	chr17	81844074	Nonsense_Mutation	NA	E489*	0.23
LUSC	chr17	81845657	Silent	NA	V421V	0.21
OV	chr17	81855274	Silent	novel	V164V	0.04
OV	chr17	81843971	3'UTR	novel		0.14
OV	chr17	81855203	Missense_Mutation	NA	S188F	0.05
OV	chr17	81855483	Silent	novel	S152S	0.05
OV	chr17	81855484	Missense_Mutation	rs771212950	S152F	0.05
OV	chr17	81855142	Missense_Mutation	novel	K208N	0.06
OV	chr17	81855535	Missense_Mutation	novel	P135R	0.33
OV	chr17	81859181	Missense_Mutation	novel	A118T	0.06
OV	chr17	81846587	Missense_Mutation	novel	R300C	0.18
OV	chr17	81847053	Missense_Mutation	novel	G250A	0.11
PAAD	chr17	81843987	3'UTR	novel		0.33
PRAD	chr17	81845910	Missense_Mutation	rs759952074	V380M	0.46
READ	chr17	81855540	Silent	rs370423809	T133T	0.34
SKCM	chr17	81845619	Missense_Mutation	NA	A434V	0.45
SKCM	chr17	81843860	3'UTR	novel		0.41
SKCM	chr17	81843859	3'UTR	rs201910369		0.54
SKCM	chr17	81845228	Splice_Region	NA	V454V	0.09
SKCM	chr17	81855206	Missense_Mutation	NA	T187I	0.07
SKCM	chr17	81846468	Silent	novel	I339I	0.6
SKCM	chr17	81846498	Silent	rs747026364	P329P	0.46
SKCM	chr17	81846510	Silent	NA	T325T	0.05
SKCM	chr17	81847243	Splice_Region	NA	Q243Q	0.32
SKCM	chr17	81847313	Missense_Mutation	NA	V220A	0.13
STAD	chr17	81845888	Frame_Shift_Del	rs773547908	*N387Tfs118**	0.27
STAD	chr17	81845561	Splice_Region	NA	T453T	0.33
STAD	chr17	81855172	Silent	novel	L198L	0.27
STAD	chr17	81844009	3'UTR	rs370688004		0.16
STAD	chr17	81845888	Frame_Shift_Del	rs773547908	*N387Tfs118**	0.33
STAD	chr17	81845207	Silent	NA	R461R	0.26
STAD	chr17	81845573	Silent	novel	S449S	0.15
STAD	chr17	81846586	Missense_Mutation	NA	R300H	0.15
STAD	chr17	81855492	Silent	novel	L149L	0.13
STAD	chr17	81845888	Frame_Shift_Del	rs773547908	*N387Tfs118**	0.32
STAD	chr17	81845888	Frame_Shift_Del	rs773547908	*N387Tfs118**	0.33
STAD	chr17	81846508	Missense_Mutation	NA	K326R	0.1
STAD	chr17	81843890	3'UTR	novel		0.27
STAD	chr17	81845681	Silent	rs200433403	T413T	0.19
STAD	chr17	81846536	Missense_Mutation	NA	L317F	0.12
THCA	chr17	81846524	Missense_Mutation	NA	E321Q	0.25
THYM	chr17	81846536	Missense_Mutation	novel	L317I	0.13
UCEC	chr17	81847249	Silent	rs142657365	T241T	0.46
UCEC	chr17	81859221	Missense_Mutation	NA	F104L	0.21
UCEC	chr17	81845640	Missense_Mutation	rs371414493	S427L	0.34
UCEC	chr17	81847064	Silent	NA	P246P	0.43
UCEC	chr17	81843932	3'UTR	novel		0.5
UCEC	chr17	81859299	Silent	novel	R78R	0.44
UCEC	chr17	81845872	Missense_Mutation	novel	F392L	0.26
UCEC	chr17	81845203	Missense_Mutation	rs757142554	L463M	0.22
UCEC	chr17	81844023	Missense_Mutation	NA	D506Y	0.28
UCEC	chr17	81844054	Missense_Mutation	novel	M495I	0.1
UCEC	chr17	81847315	Missense_Mutation	novel	E219D	0.1
UCEC	chr17	81845888	Frame_Shift_Del	rs773547908	*N387Tfs118**	0.36
UCEC	chr17	81843946	3'UTR	novel		0.41
UCEC	chr17	81846586	Missense_Mutation	NA	R300H	0.15
UCEC	chr17	81855540	Silent	rs370423809	T133T	0.27
UCEC	chr17	81845888	Frame_Shift_Del	rs773547908	*N387Tfs118**	0.45
UCEC	chr17	81845208	Missense_Mutation	rs769747717	R461H	0.28
UCEC	chr17	81845888	Frame_Shift_Del	rs773547908	*N387Tfs118**	0.37
UCEC	chr17	81846538	Missense_Mutation	rs776010531	R316H	0.37
UCEC	chr17	81846459	Silent	novel	F342F	0.36
UCEC	chr17	81855240	Missense_Mutation	novel	A176T	0.1
UCEC	chr17	81845888	Frame_Shift_Del	rs773547908	*N387Tfs118**	0.32
UCEC	chr17	81859204	Missense_Mutation	rs760119422	T110M	0.46
UCEC	chr17	81859247	Missense_Mutation	NA	V96M	0.24
UCEC	chr17	81845659	Missense_Mutation	rs573703484	V421I	0.38
UCEC	chr17	81843977	3'UTR	novel		0.22
UCEC	chr17	81859221	Missense_Mutation	NA	F104L	0.52
UCEC	chr17	81843906	3'UTR	novel		0.15
UCEC	chr17	81847073	Splice_Site	novel	X244_splice	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3922	0.00012456
CESC	DEL	0.1051	0.00067839
KIRP	AMP	0.6701	0.14801
LGG	AMP	0.0663	1.52e-05
SARC	AMP	0.1984	0.032181
SKCM	AMP	0.2834	7.0388e-08
THCA	DEL	0.002	0.221
UVM	AMP	0.1625	0.054583

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00043	Kaplan-Meier Survival Analysis
ACC	0.00072	Kaplan-Meier Survival Analysis
PRAD	0.024	Kaplan-Meier Survival Analysis
KIRP	0.0001	Kaplan-Meier Survival Analysis
COAD	0.017	Kaplan-Meier Survival Analysis
BLCA	0.00036	Kaplan-Meier Survival Analysis
CESC	0.0094	Kaplan-Meier Survival Analysis
KICH	0.0036	Kaplan-Meier Survival Analysis
UCEC	0.0063	Kaplan-Meier Survival Analysis
GBM	0.0021	Kaplan-Meier Survival Analysis
THCA	0.049	Kaplan-Meier Survival Analysis
UVM	0.00039	Kaplan-Meier Survival Analysis
OV	0.016	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742