EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000185651 (Gene tree)
Gene ID: 7332
Gene Symbol: UBE2L3
Alias: UBCH7
Full Name: ubiquitin conjugating enzyme E2 L3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 74,588 bases
Position: chr22:21,549,447-21,624,034
Accession: 12488
RBP type: non-canonical RBP
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000342192	UBE2L3-201	3028	-	ENSP00000344259	154 (aa)	-	P68036
ENST00000545681	UBE2L3-204	2932	-	ENSP00000445931	122 (aa)	-	P68036
ENST00000458578	UBE2L3-202	3007	-	ENSP00000400906	212 (aa)	-	P68036
ENST00000496722	UBE2L3-203	3451	NR_046082	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000185651's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04120	Ubiquitin mediated proteolysis	KEGG
hsa05012	Parkinson disease	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000185651	Erythrocyte Count	8.3820000E-005	-
ENSG00000185651	Cholesterol, HDL	1E-8	20686565
ENSG00000185651	Erythrocyte Count	2E-7	28017375
ENSG00000185651	Inflammatory Bowel Diseases	4E-15	28067908
ENSG00000185651	Lupus Erythematosus, Systemic	5E-6	23273568
ENSG00000185651	Erythrocyte Count	2E-10	28017375
ENSG00000185651	Arthritis, Rheumatoid	2E-11	27193031
ENSG00000185651	Lupus Erythematosus, Systemic	2E-11	27193031
ENSG00000185651	Lupus Erythematosus, Systemic	2E-6	27399966
ENSG00000185651	Crohn Disease	1E-15	28067908
ENSG00000185651	Hepatitis B, Chronic	2E-12	24162738
ENSG00000185651	Inflammatory Bowel Diseases	3E-13	26192919
ENSG00000185651	Erythrocyte Count	9E-10	23222517
ENSG00000185651	Lupus Erythematosus, Systemic	2E-6	21408207
ENSG00000185651	Inflammatory Bowel Diseases	1E-16	23128233
ENSG00000185651	Colitis, Ulcerative	9E-6	28067908
ENSG00000185651	Lupus Erythematosus, Systemic	2E-22	26502338
ENSG00000185651	Crohn Disease	6E-12	26192919
ENSG00000185651	Lupus Erythematosus, Systemic	1E-13	27399966
ENSG00000185651	Psoriasis	2E-7	26626624
ENSG00000185651	Lupus Erythematosus, Systemic	1E-16	19838193
ENSG00000185651	Cholesterol, HDL	4E-18	24097068
ENSG00000185651	Cholesterol, HDL	2E-10	25961943
ENSG00000185651	Erythrocyte Count	1E-8	20139978
ENSG00000185651	Arthritis, Rheumatoid	2E-7	24390342
ENSG00000185651	Arthritis, Rheumatoid	2E-9	24390342
ENSG00000185651	Crohn Disease	5E-16	21102463

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000185651	rs5754102	22	21561983	C	Intraocular pressure	29617998	[0.064-0.136] unit increase	0.0998	EFO_0004695
ENSG00000185651	rs181362	22	21577779	C	Intraocular pressure	29617998	[0.062-0.132] unit increase	0.0968	EFO_0004695
ENSG00000185651	rs131656	22	21563161	A	High light scatter reticulocyte count	27863252	[0.026-0.044] unit decrease	0.034824	EFO_0007986
ENSG00000185651	rs131656	22	21563161	A	High light scatter reticulocyte percentage of red cells	27863252	[0.028-0.046] unit decrease	0.03695907	EFO_0007986
ENSG00000185651	rs530685161	22	21597965	A	Reticulocyte count	27863252	[0.024-0.042] unit decrease	0.03286029	EFO_0007986
ENSG00000185651	rs34977459	22	21578365	G	Mean corpuscular hemoglobin	27863252	[0.028-0.046] unit decrease	0.03717346	EFO_0004527
ENSG00000185651	rs138665726	22	21563570	C	Mean corpuscular volume	27863252	[0.049-0.067] unit decrease	0.05817883	EFO_0004526
ENSG00000185651	rs7444	22	21622645	G	Systemic lupus erythematosus	28714469	[1.15-1.24]	1.2	EFO_0002690
ENSG00000185651	rs181359	22	21574352	T	Crohn's disease	21102463	[1.06-1.15]	1.1	EFO_0000384
ENSG00000185651	rs4821112	22	21610472	A	Mean corpuscular volume	20139978	[0.043-0.091] unit decrease	0.067	EFO_0004526
ENSG00000185651	rs4820091	22	21585900	T	Mean corpuscular volume	28017375	[0.0019-0.0043] unit increase	0.0031	EFO_0004526
ENSG00000185651	rs5754217	22	21585386	?	Mean corpuscular volume	28017375			EFO_0004526
ENSG00000185651	rs7444	22	21622645	?	Systemic lupus erythematosus	27399966	[NR]	1.28	EFO_0002690
ENSG00000185651	rs7444	22	21622645	?	Systemic lupus erythematosus	27399966	[NR]	1.23	EFO_0002690
ENSG00000185651	rs181359	22	21574352	A	Psoriasis vulgaris	26626624	NR	1.158	EFO_1001494
ENSG00000185651	rs181362	22	21577779	T	HDL cholesterol	24097068	[NR] unit decrease	0.038	EFO_0004612
ENSG00000185651	rs5754344	22	21609497	A	HDL cholesterol	25961943	[0.031-0.059] s.d. increase	0.045	EFO_0004612
ENSG00000185651	rs2283790	22	21602364	?	Systemic lupus erythematosus or rheumatoid arthritis	27193031	[NR]	1.22	EFO_0000685\|EFO_0002690
ENSG00000185651	rs2256609	22	21570728	G	Crohn's disease	26192919	[1.08-1.14]	1.1082332	EFO_0000384
ENSG00000185651	rs2266961	22	21574308	?	Inflammatory bowel disease	26192919			EFO_0003767
ENSG00000185651	rs5754217	22	21585386	T	Systemic lupus erythematosus	23273568		1.1236	EFO_0002690
ENSG00000185651	rs5754217	22	21585386	G	Red blood cell traits	23222517	[0.13-0.25] unit increase	0.194	EFO_0004526
ENSG00000185651	rs131654	22	21562901	A	Systemic lupus erythematosus	19838193	[1.20-1.35]	1.28	EFO_0002690
ENSG00000185651	rs4821116	22	21619030	G	Hepatitis B	24162738	[1.15-1.3]	1.2195	EFO_0004197
ENSG00000185651	rs2283790	22	21602364	G	Ankylosing spondylitis	23749187		1.12	EFO_0003898
ENSG00000185651	rs2266959	22	21568615	A	Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular)	23603761	[1.15-1.33]	1.24	EFO_1001999\|EFO_1002020\|EFO_1002019
ENSG00000185651	rs2283790	22	21602364	G	Ankylosing spondylitis	23749187		1.12	EFO_0003898
ENSG00000185651	rs7445	22	21622758	?	High density lipoprotein cholesterol levels	29403010	[0.03-0.051] unit decrease novel	0.04087	EFO_0004612
ENSG00000185651	rs8137950	22	21615351	?	Mean corpuscular volume	29403010	[0.036-0.053] unit decrease novel	0.04441	EFO_0004526
ENSG00000185651	rs140496	22	21572167	?	Non-albumin protein levels	29403010	[0.018-0.036] unit increase novel	0.02663	EFO_0004568
ENSG00000185651	rs5754100	22	21561877	C	Lymphocyte counts	27863252	[0.037-0.055] unit decrease	0.04611012	EFO_0004587
ENSG00000185651	rs5998509	22	21563190	T	Lymphocyte percentage of white cells	27863252	[0.026-0.043] unit decrease	0.0345522	EFO_0007993
ENSG00000185651	rs530685161	22	21597965	A	Reticulocyte fraction of red cells	27863252	[0.028-0.045] unit decrease	0.03652537	EFO_0007986
ENSG00000185651	rs5998509	22	21563190	T	Neutrophil percentage of white cells	27863252	[0.019-0.037] unit increase	0.02838968	EFO_0007990
ENSG00000185651	rs138665726	22	21563570	C	Red cell distribution width	27863252	[0.021-0.038] unit increase	0.02944599	EFO_0005192
ENSG00000185651	rs5754217	22	21585386	T	Systemic lupus erythematosus	19838195	[1.13-1.27]	1.2	EFO_0002690
ENSG00000185651	rs2266959	22	21568615	?	Crohn's disease	28067908			EFO_0000384
ENSG00000185651	rs2266959	22	21568615	?	Inflammatory bowel disease	28067908			EFO_0003767
ENSG00000185651	rs2266959	22	21568615	?	Ulcerative colitis	28067908			EFO_0000729
ENSG00000185651	rs374588807	22	21584179	A	Mean corpuscular hemoglobin concentration	27863252	[0.02-0.037] unit increase	0.02885185	EFO_0004528
ENSG00000185651	rs181362	22	21577779	T	HDL cholesterol	20686565	[0.28-0.64] mg/dL decrease	0.46	EFO_0004612
ENSG00000185651	rs5754217	22	21585386	T	Systemic lupus erythematosus	21408207	[1.21-1.57]	1.38	EFO_0002690
ENSG00000185651	rs2266959	22	21568615	T	Inflammatory bowel disease	23128233	[1.066-1.145]	1.105	EFO_0003767
ENSG00000185651	rs4821116	22	21619030	T	HDL cholesterol levels	28334899	[0.026-0.062] unit decrease	0.044	EFO_0004612
ENSG00000185651	rs4821116	22	21619030	T	HDL cholesterol levels	28334899	[0.028-0.06] unit decrease	0.044	EFO_0004612
ENSG00000185651	rs181360	22	21574627	T	HDL cholesterol levels	28334899	[0.029-0.046] unit increase (EA Beta values)	0.0376	EFO_0004612
ENSG00000185651	rs181359	22	21574352	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000185651	rs5754387	22	21620414	G	Heel bone mineral density	30598549	[0.012-0.021] unit increase	0.0162822	EFO_0009270
ENSG00000185651	rs181362	22	21577779	C	High density lipoprotein cholesterol levels	29507422	unit increase	0.028	EFO_0004612
ENSG00000185651	rs181362	22	21577779	C	High density lipoprotein cholesterol levels	29507422	unit increase	0.029	EFO_0004612
ENSG00000185651	rs5754100	22	21561877	?	Autoimmune traits	30595370			EFO_0005140
ENSG00000185651	rs131656	22	21563161	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000185651	rs5754387	22	21620414	?	Heel bone mineral density	30595370			EFO_0009270
ENSG00000185651	rs131658	22	21563337	G	Systemic lupus erythematosus	28714469	[1.19-1.32]	1.25	EFO_0002690
ENSG00000185651	rs5749502	22	21590807	A	HDL cholesterol x physical activity interaction (2df test)	30670697			EFO_0007805\|EFO_0003940

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000185651's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000185651	UBE2L3	100	100.000	ENSMUSG00000038965	Ube2l3	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000151	ubiquitin ligase complex	21873635.	IBA	Component
GO:0000151	ubiquitin ligase complex	8563171.	TAS	Component
GO:0000209	protein polyubiquitination	10888878.14765125.	IDA	Process
GO:0003713	transcription coactivator activity	15367689.	IDA	Function
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004842	ubiquitin-protein transferase activity	14765125.20061386.21532592.	IDA	Function
GO:0004842	ubiquitin-protein transferase activity	10888878.	IMP	Function
GO:0004842	ubiquitin-protein transferase activity	8563171.8576257.	TAS	Function
GO:0005515	protein binding	9990509.10888878.15367689.16118314.16169070.16709802.17003263.19340006.19549727.23707686.24076655.24446487.27565346.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	11278816.17003263.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	9990509.11278816.17003263.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006355	regulation of transcription, DNA-templated	17003263.	IDA	Process
GO:0006355	regulation of transcription, DNA-templated	15367689.	IMP	Process
GO:0006464	cellular protein modification process	8576257.	TAS	Process
GO:0006511	ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0006511	ubiquitin-dependent protein catabolic process	8563171.8672131.	TAS	Process
GO:0008283	cell proliferation	18946090.	IMP	Process
GO:0016567	protein ubiquitination	9990509.21532592.	IDA	Process
GO:0016567	protein ubiquitination	-	TAS	Process
GO:0019899	enzyme binding	8563171.	TAS	Function
GO:0031398	positive regulation of protein ubiquitination	12628165.	IGI	Process
GO:0031625	ubiquitin protein ligase binding	21873635.	IBA	Function
GO:0031625	ubiquitin protein ligase binding	11278816.12628165.21532592.	IPI	Function
GO:0044770	cell cycle phase transition	18946090.	IMP	Process
GO:0051443	positive regulation of ubiquitin-protein transferase activity	12628165.	IGI	Process
GO:0061631	ubiquitin conjugating enzyme activity	21873635.	IBA	Function
GO:0061631	ubiquitin conjugating enzyme activity	20061386.	IDA	Function
GO:0070979	protein K11-linked ubiquitination	21873635.	IBA	Process
GO:0070979	protein K11-linked ubiquitination	20061386.	IDA	Process
GO:0071383	cellular response to steroid hormone stimulus	15367689.	IMP	Process
GO:0071385	cellular response to glucocorticoid stimulus	17003263.	IDA	Process
GO:0097027	ubiquitin-protein transferase activator activity	12628165.	IGI	Function
GO:1903508	positive regulation of nucleic acid-templated transcription	-	IEA	Process
GO:1903955	positive regulation of protein targeting to mitochondrion	24270810.	HMP	Process