EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000185669 (Gene tree)
Gene ID: 333929
Gene Symbol: SNAI3
Alias: SMUC|Zfp293|ZNF293
Full Name: snail family transcriptional repressor 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 8,812 bases
Position: chr16:88,677,682-88,686,493
Accession: 18411
RBP type: canonical RBP
Summary: SNAI3 is a member of the SNAIL gene family, named for the Drosophila snail gene, which plays roles in mesodermal formation during embryogenesis (Katoh and Katoh, 2003 [PubMed 12579345]).[supplied by OMIM, Apr 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000327968	zf-C2H2	PF00096.26	2.3e-23	1	4
ENSP00000327968	zf-C2H2	PF00096.26	2.3e-23	2	4
ENSP00000327968	zf-C2H2	PF00096.26	2.3e-23	3	4
ENSP00000327968	zf-C2H2	PF00096.26	2.3e-23	4	4
ENSP00000327968	zf-met	PF12874.7	3.6e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000332281	SNAI3-201	1732	-	ENSP00000327968	292 (aa)	-	Q3KNW1

Gene Model

Click here to download ENSG00000185669's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000185669's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000185669	SNAI3	99	49.175	ENSAMEG00000009606	SNAI2	99	49.488	Ailuropoda_melanoleuca
ENSG00000185669	SNAI3	100	90.411	ENSANAG00000032748	SNAI3	100	90.411	Aotus_nancymaae
ENSG00000185669	SNAI3	99	50.000	ENSANAG00000021163	SNAI2	99	49.829	Aotus_nancymaae
ENSG00000185669	SNAI3	99	72.260	ENSBTAG00000017528	SNAI3	99	72.260	Bos_taurus
ENSG00000185669	SNAI3	99	50.345	ENSBTAG00000013227	SNAI2	99	50.685	Bos_taurus
ENSG00000185669	SNAI3	99	50.342	ENSCJAG00000013499	SNAI2	99	50.171	Callithrix_jacchus
ENSG00000185669	SNAI3	99	49.164	ENSCAFG00000006638	SNAI2	99	49.488	Canis_familiaris
ENSG00000185669	SNAI3	100	77.740	ENSCAFG00000029458	SNAI3	100	77.740	Canis_familiaris
ENSG00000185669	SNAI3	100	78.082	ENSCAFG00020004719	SNAI3	100	78.082	Canis_lupus_dingo
ENSG00000185669	SNAI3	99	49.164	ENSCAFG00020015384	SNAI2	99	49.488	Canis_lupus_dingo
ENSG00000185669	SNAI3	99	50.690	ENSCHIG00000024410	SNAI2	99	51.027	Capra_hircus
ENSG00000185669	SNAI3	99	72.945	ENSCHIG00000018087	SNAI3	99	72.945	Capra_hircus
ENSG00000185669	SNAI3	91	78.947	ENSTSYG00000025594	SNAI3	91	79.245	Carlito_syrichta
ENSG00000185669	SNAI3	99	50.342	ENSCCAG00000024100	SNAI2	99	50.171	Cebus_capucinus
ENSG00000185669	SNAI3	100	92.466	ENSCATG00000031714	SNAI3	100	92.466	Cercocebus_atys
ENSG00000185669	SNAI3	99	50.342	ENSCATG00000028656	SNAI2	99	50.171	Cercocebus_atys
ENSG00000185669	SNAI3	100	86.644	ENSCSAG00000003047	SNAI3	100	86.644	Chlorocebus_sabaeus
ENSG00000185669	SNAI3	99	50.342	ENSCSAG00000014787	SNAI2	99	50.171	Chlorocebus_sabaeus
ENSG00000185669	SNAI3	99	46.823	ENSCPBG00000020255	SNAI2	99	49.320	Chrysemys_picta_bellii
ENSG00000185669	SNAI3	99	64.548	ENSCPBG00000023474	SNAI3	99	63.245	Chrysemys_picta_bellii
ENSG00000185669	SNAI3	59	54.335	ENSCSAVG00000009819	-	75	61.111	Ciona_savignyi
ENSG00000185669	SNAI3	99	50.342	ENSCANG00000029656	SNAI2	99	50.171	Colobus_angolensis_palliatus
ENSG00000185669	SNAI3	93	91.513	ENSCANG00000031124	SNAI3	83	91.513	Colobus_angolensis_palliatus
ENSG00000185669	SNAI3	100	71.575	ENSCGRG00001011389	Snai3	100	70.548	Cricetulus_griseus_chok1gshd
ENSG00000185669	SNAI3	100	71.575	ENSCGRG00000014932	Snai3	100	70.548	Cricetulus_griseus_crigri
ENSG00000185669	SNAI3	80	50.215	ENSDNOG00000035204	-	100	51.709	Dasypus_novemcinctus
ENSG00000185669	SNAI3	99	47.826	ENSDORG00000029620	Snai2	99	48.161	Dipodomys_ordii
ENSG00000185669	SNAI3	91	75.188	ENSEASG00005000614	SNAI3	87	75.188	Equus_asinus_asinus
ENSG00000185669	SNAI3	99	76.289	ENSECAG00000012131	SNAI3	99	76.289	Equus_caballus
ENSG00000185669	SNAI3	100	65.411	ENSEEUG00000000841	SNAI3	100	65.411	Erinaceus_europaeus
ENSG00000185669	SNAI3	99	51.007	ENSELUG00000018742	-	99	48.993	Esox_lucius
ENSG00000185669	SNAI3	99	48.639	ENSELUG00000021795	SNAI2	78	48.966	Esox_lucius
ENSG00000185669	SNAI3	100	70.548	ENSFCAG00000043885	SNAI3	100	70.548	Felis_catus
ENSG00000185669	SNAI3	99	64.527	ENSGAGG00000023571	SNAI3	99	64.527	Gopherus_agassizii
ENSG00000185669	SNAI3	99	46.823	ENSGAGG00000000426	SNAI2	99	49.320	Gopherus_agassizii
ENSG00000185669	SNAI3	99	50.342	ENSGGOG00000000959	SNAI2	99	50.171	Gorilla_gorilla
ENSG00000185669	SNAI3	100	98.630	ENSGGOG00000012559	SNAI3	100	98.630	Gorilla_gorilla
ENSG00000185669	SNAI3	99	48.621	ENSIPUG00000000131	snai2	99	49.310	Ictalurus_punctatus
ENSG00000185669	SNAI3	100	75.685	ENSJJAG00000019934	Snai3	100	75.685	Jaculus_jaculus
ENSG00000185669	SNAI3	99	48.148	ENSLOCG00000005992	SNAI2	99	49.315	Lepisosteus_oculatus
ENSG00000185669	SNAI3	100	72.260	ENSLAFG00000005117	SNAI3	100	72.260	Loxodonta_africana
ENSG00000185669	SNAI3	99	48.845	ENSLAFG00000009299	SNAI2	99	48.980	Loxodonta_africana
ENSG00000185669	SNAI3	99	50.342	ENSMFAG00000046061	SNAI2	99	50.171	Macaca_fascicularis
ENSG00000185669	SNAI3	100	93.151	ENSMFAG00000032064	SNAI3	100	93.151	Macaca_fascicularis
ENSG00000185669	SNAI3	99	50.342	ENSMMUG00000016195	SNAI2	99	50.171	Macaca_mulatta
ENSG00000185669	SNAI3	100	93.151	ENSMMUG00000008716	SNAI3	100	93.151	Macaca_mulatta
ENSG00000185669	SNAI3	100	93.493	ENSMNEG00000045515	SNAI3	100	93.493	Macaca_nemestrina
ENSG00000185669	SNAI3	99	50.342	ENSMNEG00000034216	SNAI2	99	50.171	Macaca_nemestrina
ENSG00000185669	SNAI3	99	50.342	ENSMLEG00000034407	SNAI2	99	50.171	Mandrillus_leucophaeus
ENSG00000185669	SNAI3	93	91.144	ENSMLEG00000033191	SNAI3	93	91.144	Mandrillus_leucophaeus
ENSG00000185669	SNAI3	100	72.603	ENSMAUG00000001685	Snai3	100	70.548	Mesocricetus_auratus
ENSG00000185669	SNAI3	52	72.258	ENSMAUG00000008119	Snai2	99	49.488	Mesocricetus_auratus
ENSG00000185669	SNAI3	100	73.973	ENSMOCG00000003536	Snai3	100	72.260	Microtus_ochrogaster
ENSG00000185669	SNAI3	99	47.619	ENSMOCG00000006622	Snai2	99	47.619	Microtus_ochrogaster
ENSG00000185669	SNAI3	99	48.515	ENSMODG00000010173	SNAI2	99	49.660	Monodelphis_domestica
ENSG00000185669	SNAI3	100	71.575	MGP_CAROLIEiJ_G0031662	Snai3	100	69.521	Mus_caroli
ENSG00000185669	SNAI3	99	49.655	MGP_CAROLIEiJ_G0020483	Snai2	99	48.630	Mus_caroli
ENSG00000185669	SNAI3	99	49.655	ENSMUSG00000022676	Snai2	99	48.630	Mus_musculus
ENSG00000185669	SNAI3	100	73.288	ENSMUSG00000006587	Snai3	100	71.233	Mus_musculus
ENSG00000185669	SNAI3	99	49.655	MGP_PahariEiJ_G0016188	Snai2	99	48.630	Mus_pahari
ENSG00000185669	SNAI3	100	72.696	MGP_PahariEiJ_G0023260	Snai3	100	70.648	Mus_pahari
ENSG00000185669	SNAI3	99	49.655	MGP_SPRETEiJ_G0021379	Snai2	99	48.630	Mus_spretus
ENSG00000185669	SNAI3	100	73.288	MGP_SPRETEiJ_G0032780	Snai3	100	71.233	Mus_spretus
ENSG00000185669	SNAI3	100	70.205	ENSMPUG00000008104	SNAI3	100	70.205	Mustela_putorius_furo
ENSG00000185669	SNAI3	99	49.175	ENSMPUG00000010793	SNAI2	99	49.488	Mustela_putorius_furo
ENSG00000185669	SNAI3	99	49.658	ENSMLUG00000001086	SNAI2	99	48.311	Myotis_lucifugus
ENSG00000185669	SNAI3	100	73.973	ENSNGAG00000023039	Snai3	100	73.973	Nannospalax_galili
ENSG00000185669	SNAI3	100	96.233	ENSNLEG00000000595	SNAI3	100	96.233	Nomascus_leucogenys
ENSG00000185669	SNAI3	99	49.324	ENSNLEG00000013421	SNAI2	99	49.488	Nomascus_leucogenys
ENSG00000185669	SNAI3	98	47.492	ENSMEUG00000009510	SNAI2	100	48.621	Notamacropus_eugenii
ENSG00000185669	SNAI3	99	48.621	ENSOANG00000007267	SNAI2	99	48.639	Ornithorhynchus_anatinus
ENSG00000185669	SNAI3	100	77.397	ENSOGAG00000000419	SNAI3	100	78.767	Otolemur_garnettii
ENSG00000185669	SNAI3	90	52.747	ENSOARG00000013069	-	99	52.747	Ovis_aries
ENSG00000185669	SNAI3	99	50.690	ENSOARG00000013030	SNAI2	99	51.027	Ovis_aries
ENSG00000185669	SNAI3	99	50.342	ENSPPAG00000015662	SNAI2	99	50.171	Pan_paniscus
ENSG00000185669	SNAI3	100	98.288	ENSPPAG00000043301	SNAI3	100	98.288	Pan_paniscus
ENSG00000185669	SNAI3	99	70.139	ENSPPRG00000008511	SNAI3	99	70.139	Panthera_pardus
ENSG00000185669	SNAI3	99	49.164	ENSPPRG00000012562	-	99	49.488	Panthera_pardus
ENSG00000185669	SNAI3	100	97.945	ENSPTRG00000008460	SNAI3	100	97.945	Pan_troglodytes
ENSG00000185669	SNAI3	99	50.342	ENSPTRG00000020235	SNAI2	99	50.171	Pan_troglodytes
ENSG00000185669	SNAI3	99	50.342	ENSPANG00000017540	SNAI2	99	50.171	Papio_anubis
ENSG00000185669	SNAI3	100	93.151	ENSPANG00000000509	SNAI3	100	93.151	Papio_anubis
ENSG00000185669	SNAI3	99	48.701	ENSPKIG00000007872	SNAI3	99	50.167	Paramormyrops_kingsleyae
ENSG00000185669	SNAI3	99	49.315	ENSPKIG00000002254	SNAI2	99	48.464	Paramormyrops_kingsleyae
ENSG00000185669	SNAI3	99	46.823	ENSPSIG00000016395	SNAI2	99	49.320	Pelodiscus_sinensis
ENSG00000185669	SNAI3	77	64.069	ENSPSIG00000004262	SNAI3	91	64.069	Pelodiscus_sinensis
ENSG00000185669	SNAI3	59	64.368	ENSPMGG00000013179	SNAI2	99	48.464	Periophthalmus_magnuspinnatus
ENSG00000185669	SNAI3	99	46.945	ENSPEMG00000011739	Snai2	99	49.147	Peromyscus_maniculatus_bairdii
ENSG00000185669	SNAI3	99	48.515	ENSPCIG00000025156	SNAI2	99	49.660	Phascolarctos_cinereus
ENSG00000185669	SNAI3	58	64.045	ENSPREG00000008528	SNAI2	51	76.087	Poecilia_reticulata
ENSG00000185669	SNAI3	100	96.233	ENSPPYG00000007643	SNAI3	100	96.233	Pongo_abelii
ENSG00000185669	SNAI3	99	50.342	ENSPPYG00000018578	SNAI2	99	50.171	Pongo_abelii
ENSG00000185669	SNAI3	99	49.007	ENSPCOG00000015656	SNAI2	99	49.488	Propithecus_coquereli
ENSG00000185669	SNAI3	99	49.164	ENSPVAG00000009457	SNAI2	99	48.322	Pteropus_vampyrus
ENSG00000185669	SNAI3	100	71.575	ENSRNOG00000013586	Snai3	100	69.521	Rattus_norvegicus
ENSG00000185669	SNAI3	99	50.342	ENSRBIG00000041133	SNAI2	99	50.171	Rhinopithecus_bieti
ENSG00000185669	SNAI3	100	92.466	ENSRBIG00000025770	SNAI3	100	92.466	Rhinopithecus_bieti
ENSG00000185669	SNAI3	99	50.342	ENSRROG00000032273	SNAI2	99	50.171	Rhinopithecus_roxellana
ENSG00000185669	SNAI3	100	91.438	ENSRROG00000032757	SNAI3	100	91.438	Rhinopithecus_roxellana
ENSG00000185669	SNAI3	99	50.342	ENSSBOG00000035774	SNAI2	99	50.171	Saimiri_boliviensis_boliviensis
ENSG00000185669	SNAI3	99	48.515	ENSSHAG00000004205	SNAI2	99	49.660	Sarcophilus_harrisii
ENSG00000185669	SNAI3	99	46.078	ENSSFOG00015016115	snai3	93	46.405	Scleropages_formosus
ENSG00000185669	SNAI3	99	50.690	ENSSFOG00015018025	SNAI2	99	49.655	Scleropages_formosus
ENSG00000185669	SNAI3	99	47.883	ENSSPUG00000005427	-	99	47.973	Sphenodon_punctatus
ENSG00000185669	SNAI3	99	49.338	ENSSSCG00000039568	SNAI2	99	50.512	Sus_scrofa
ENSG00000185669	SNAI3	99	72.509	ENSTTRG00000006262	SNAI3	99	72.509	Tursiops_truncatus
ENSG00000185669	SNAI3	100	77.055	ENSUAMG00000020030	SNAI3	100	77.055	Ursus_americanus
ENSG00000185669	SNAI3	100	77.397	ENSVVUG00000003233	SNAI3	100	77.397	Vulpes_vulpes
ENSG00000185669	SNAI3	99	49.175	ENSVVUG00000017625	SNAI2	99	49.488	Vulpes_vulpes
ENSG00000185669	SNAI3	99	48.161	ENSXETG00000024006	snai2	99	49.310	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	-	IEA	Function
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	-	IEA	Function
GO:0003677	DNA binding	21873635.	IBA	Function
GO:0003700	DNA-binding transcription factor activity	21873635.	IBA	Function
GO:0005507	copper ion binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005667	transcription factor complex	-	IEA	Component
GO:0006355	regulation of transcription, DNA-templated	21873635.	IBA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr16	88681505	Missense_Mutation	novel	R96G	0.16
BLCA	chr16	88678627	Missense_Mutation	rs758761106	E234K	0.31
BLCA	chr16	88681326	Silent	novel	F155F	0.34
BLCA	chr16	88681696	Missense_Mutation	novel	S32F	0.83
BRCA	chr16	88681197	Silent	NA	L198L	0.36
BRCA	chr16	88681178	Missense_Mutation	novel	H205Y	0.08
CESC	chr16	88678449	Silent	NA	*293*	0.18
CESC	chr16	88681339	Frame_Shift_Del	novel	*M145Lfs2**	0.42
CESC	chr16	88681448	Missense_Mutation	novel	P115S	0.29
CESC	chr16	88678477	Missense_Mutation	NA	E284K	0.39
CESC	chr16	88678090	3'UTR	novel		0.2
CESC	chr16	88678252	3'UTR	novel		0.32
COAD	chr16	88681410	Silent	NA	T127T	0.22
COAD	chr16	88681698	Silent	novel	C31C	0.18
COAD	chr16	88681417	Missense_Mutation	NA	S125F	0.23
GBM	chr16	88686341	Silent	novel	E22E	0.52
HNSC	chr16	88681391	Missense_Mutation	rs770113114	G134R	0.43
HNSC	chr16	88681152	Silent	rs552553600	I213I	0.06
KIRC	chr16	88678494	Missense_Mutation	NA	S278F	0.23
LIHC	chr16	88681374	Silent	novel	L139L	0.33
LIHC	chr16	88686416	5'UTR	novel		0.19
LUAD	chr16	88681570	Missense_Mutation	novel	P74L	0.21
LUSC	chr16	88678351	3'UTR	novel		0.5
LUSC	chr16	88681587	Silent	novel	I68I	0.19
LUSC	chr16	88678532	Silent	novel	Y265Y	0.16
LUSC	chr16	88678492	Missense_Mutation	novel	L279I	0.25
OV	chr16	88681198	Missense_Mutation	NA	L198P	0.39	zf-C2H2
PAAD	chr16	88681413	Silent	rs200850230	P126P	0.06
PAAD	chr16	88678598	Frame_Shift_Del	novel	*S243Kfs41**	0.24
PAAD	chr16	88686410	5'UTR	novel		0.2
PRAD	chr16	88681174	Missense_Mutation	rs139790709	T206M	0.09
PRAD	chr16	88681391	Missense_Mutation	rs770113114	G134R	0.46
READ	chr16	88678553	Silent	rs148283723	T258T	0.4
SARC	chr16	88681279	Missense_Mutation	novel	R171Q	0.33
SKCM	chr16	88678568	Silent	novel	R253R	0.57
SKCM	chr16	88678569	Missense_Mutation	rs141257304	R253Q	0.59
SKCM	chr16	88681476	Silent	NA	L105L	0.39
SKCM	chr16	88681277	Nonsense_Mutation	NA	Q172*	0.66
SKCM	chr16	88681347	Silent	NA	A148A	0.22
STAD	chr16	88681690	Missense_Mutation	NA	C34Y	0.21
STAD	chr16	88681634	Missense_Mutation	rs45506693	G53S	0.17
STAD	chr16	88686430	5'UTR	novel		0.31
STAD	chr16	88686424	5'UTR	novel		0.33
STAD	chr16	88681207	In_Frame_Ins	novel	S194_L195insR	0.28	zf-C2H2
STAD	chr16	88678554	Missense_Mutation	rs201681397	T258M	0.19
STAD	chr16	88681482	Silent	NA	V103V	0.23
STAD	chr16	88681530	Silent	novel	A87A	0.11
STAD	chr16	88686467	5'UTR	novel		0.21
STAD	chr16	88681428	Silent	NA	P121P	0.44
STAD	chr16	88678485	Missense_Mutation	rs147688628	A281V	0.25
STAD	chr16	88681598	Missense_Mutation	rs776627093	V65I	0.48
STAD	chr16	88681674	Silent	rs762818249	V39V	0.63
STAD	chr16	88678460	Silent	NA	C289C	0.41
STAD	chr16	88681443	Silent	novel	P116P	0.42
UCEC	chr16	88681553	Missense_Mutation	NA	L80M	0.33
UCEC	chr16	88681715	Splice_Site	novel	X26_splice	0.38
UCEC	chr16	88678467	Missense_Mutation	novel	G287D	0.36
UCEC	chr16	88678319	3'UTR	novel		0.44
UCEC	chr16	88681194	Missense_Mutation	NA	K199N	0.2	zf-C2H2
UCEC	chr16	88681345	Missense_Mutation	rs137881385	P149L	0.44
UCEC	chr16	88681715	Splice_Site	novel	X26_splice	0.47
UCEC	chr16	88681105	Missense_Mutation	rs780230398	R229H	0.48
UCEC	chr16	88681147	Missense_Mutation	novel	G215D	0.36
UCEC	chr16	88681683	Frame_Shift_Del	novel	*L37Wfs73**	0.65
UCEC	chr16	88681372	Missense_Mutation	rs779547341	L140P	0.7
UCEC	chr16	88681376	Missense_Mutation	novel	L139M	0.27
UCEC	chr16	88681143	Silent	novel	K216K	0.36
UCEC	chr16	88678102	3'UTR	novel		0.41
UCEC	chr16	88678489	Silent	rs746409341	L280L	0.46
UCEC	chr16	88681593	Silent	novel	A66A	0.11
UCEC	chr16	88681686	Silent	novel	G35G	0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1	0.061428
BRCA	DEL	0.588	7.2395e-08
CHOL	DEL	0.1944	0.23475
GBM	DEL	0.1161	0.023089
KIRP	DEL	0.0417	0.0042101
LAML	DEL	0.0262	0.0010312
LUAD	DEL	0.2636	1.4158e-09
MESO	DEL	0.2529	0.001069
SKCM	DEL	0.3134	0.0077444
TGCT	DEL	0.3867	0.00015997
THCA	DEL	0.01	0.026572
UVM	DEL	0.1875	0.12091

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0032	Kaplan-Meier Survival Analysis
SARC	0.023	Kaplan-Meier Survival Analysis
HNSC	0.0029	Kaplan-Meier Survival Analysis
SKCM	0.00037	Kaplan-Meier Survival Analysis
BRCA	0.017	Kaplan-Meier Survival Analysis
COAD	0.016	Kaplan-Meier Survival Analysis
PAAD	0.002	Kaplan-Meier Survival Analysis
BLCA	0.032	Kaplan-Meier Survival Analysis
CESC	0.00011	Kaplan-Meier Survival Analysis
UCEC	0.0026	Kaplan-Meier Survival Analysis
LUAD	0.00011	Kaplan-Meier Survival Analysis