EuRBPDB

Description

Ensembl ID: ENSG00000185722 (Gene tree)
Gene ID: 51479
Gene Symbol: ANKFY1
Alias: ANKHZN|KIAA1255|ZFYVE14|BTBD23|RANK-5
Full Name: ankyrin repeat and FYVE domain containing 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 100,638 bases
Position: chr17:4,163,371-4,264,008
Accession: 20763
RBP type: non-canonical RBP
Summary: This gene encodes a cytoplasmic protein that contains a coiled-coil structure and a BTB/POZ domain at its N-terminus, ankyrin repeats in the middle portion, and a FYVE-finger motif at its C-terminus. This protein belongs to a subgroup of double zinc finger proteins which may be involved in vesicle or protein transport. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Apr 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000574736	ANKFY1-210	570	-	ENSP00000459247	60 (aa)	-	I3L1Z9
ENST00000341657	ANKFY1-201	7418	-	ENSP00000343362	1169 (aa)	-	Q9P2R3
ENST00000573722	ANKFY1-208	430	-	-	- (aa)	-	-
ENST00000573250	ANKFY1-207	588	-	-	- (aa)	-	-
ENST00000572564	ANKFY1-206	2555	-	-	- (aa)	-	-
ENST00000575298	ANKFY1-211	665	-	ENSP00000467522	80 (aa)	-	K7EPT2
ENST00000648043	ANKFY1-214	6162	-	ENSP00000497187	1169 (aa)	-	UPI0000038C5D
ENST00000575955	ANKFY1-213	948	-	-	- (aa)	-	-
ENST00000570934	ANKFY1-203	1881	-	-	- (aa)	-	-
ENST00000575509	ANKFY1-212	2410	-	-	- (aa)	-	-
ENST00000570535	ANKFY1-202	6458	XM_011523926	ENSP00000459943	1211 (aa)	XP_011522228	Q9P2R3
ENST00000572412	ANKFY1-205	3352	-	ENSP00000460619	69 (aa)	-	I3L3P8
ENST00000574367	ANKFY1-209	5033	XM_011523928	ENSP00000459775	1170 (aa)	XP_011522230	Q9P2R3
ENST00000571547	ANKFY1-204	465	-	-	- (aa)	-	-

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000185722	rs77246175	17	4169467	G	Blood protein levels	30072576	[0.25-0.43] unit decrease	0.342	EFO_0007937
ENSG00000185722	rs2278524	17	4178680	?	Type 2 diabetes	30595370			EFO_0001360
ENSG00000185722	rs12943517	17	4180628	A	Diastolic blood pressure	30578418	[0.13-0.24] mmHg increase	0.1865	EFO_0006336

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	15328530.20562859.22284051.27189942.	IPI	Function
GO:0005765	lysosomal membrane	17897319.	HDA	Component
GO:0005768	endosome	-	IDA	Component
GO:0005769	early endosome	15328530.	IDA	Component
GO:0005829	cytosol	-	IEA	Component
GO:0006897	endocytosis	-	IEA	Process
GO:0010008	endosome membrane	-	ISS	Component
GO:0016020	membrane	10940552.	IDA	Component
GO:0016197	endosomal transport	24102721.	IMP	Process
GO:0017137	Rab GTPase binding	15328530.	IDA	Function
GO:0030904	retromer complex	22284051.	IDA	Component
GO:0034058	endosomal vesicle fusion	15328530.	IDA	Process
GO:0042147	retrograde transport, endosome to Golgi	22284051.	IMP	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0044354	macropinosome	15328530.	IDA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0048549	positive regulation of pinocytosis	15328530.	IDA	Process
GO:0070062	extracellular exosome	18570454.19056867.	HDA	Component
GO:0090160	Golgi to lysosome transport	22284051.	IMP	Process
GO:1901981	phosphatidylinositol phosphate binding	15328530.	IDA	Function