EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000185728 (Gene tree)
Gene ID: 253943
Gene Symbol: YTHDF3
Alias: FLJ31657
Full Name: YTH N6-methyladenosine RNA binding protein 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 44,236 bases
Position: chr8:63,168,553-63,212,788
Accession: 26465
RBP type: canonical RBP
Summary: This gene encodes a member of the YTH (YT521-B homology) domain protein family. The YTH domain is common in eukaryotes, is often found in the middle of the protein sequence, and may function in binding to RNA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000478825	YTH	PF04146.15	8.7e-40	1	1
ENSP00000481497	YTH	PF04146.15	8.7e-40	1	1
ENSP00000485046	YTH	PF04146.15	8.7e-40	1	1
ENSP00000483580	YTH	PF04146.15	1.1e-39	1	1
ENSP00000473496	YTH	PF04146.15	1.1e-39	1	1
ENSP00000478490	YTH	PF04146.15	1.1e-39	1	1
ENSP00000481476	YTH	PF04146.15	1.1e-39	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30306128	Cross-talk among writers, readers, and erasers of m6A regulates cancer growth and progression.	Sci Adv	2018 Oct 3	Panneerdoss S	doi: 10.1126/sciadv.aar8263
30591559	RNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translation.	Proc Natl Acad Sci U S A	2019 Jan 15	Zhang Y	doi: 10.1073/pnas.1812536116

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000517371	YTHDF3-201	3122	-	ENSP00000473986	52 (aa)	-	S4R373
ENST00000621413	YTHDF3-212	2370	XM_011517509	ENSP00000478490	588 (aa)	XP_011515811	A0A087WY31
ENST00000518373	YTHDF3-202	524	-	-	- (aa)	-	-
ENST00000522282	YTHDF3-204	445	-	-	- (aa)	-	-
ENST00000619337	YTHDF3-211	545	-	ENSP00000478398	102 (aa)	-	A0A087WU63
ENST00000617200	YTHDF3-209	5076	XM_011517510	ENSP00000481497	534 (aa)	XP_011515812	A0A024R7W5
ENST00000613853	YTHDF3-207	563	-	ENSP00000483659	119 (aa)	-	A0A087X0U5
ENST00000621820	YTHDF3-213	2363	-	ENSP00000481476	588 (aa)	-	A0A087WY31
ENST00000623280	YTHDF3-216	5193	-	ENSP00000485046	534 (aa)	-	A0A024R7W5
ENST00000612880	YTHDF3-206	593	-	ENSP00000480086	111 (aa)	-	A0A087WWB0
ENST00000621890	YTHDF3-214	2296	-	ENSP00000478825	534 (aa)	-	A0A024R7W5
ENST00000621957	YTHDF3-215	2387	-	ENSP00000483580	583 (aa)	-	A0A087X0Q1
ENST00000615676	YTHDF3-208	5092	-	ENSP00000483267	41 (aa)	-	A0A087X0C3
ENST00000519428	YTHDF3-203	676	-	-	- (aa)	-	-
ENST00000539294	YTHDF3-205	5163	-	ENSP00000473496	585 (aa)	-	Q7Z739
ENST00000617952	YTHDF3-210	420	-	ENSP00000478356	86 (aa)	-	A0A087WU40

Gene Model

Click here to download ENSG00000185728's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000185728	Stroke	4.8150136E-004	-
ENSG00000185728	Erythrocyte Count	2.3640000E-005	-
ENSG00000185728	Erythrocyte Count	5.5850000E-005	-
ENSG00000185728	Erythrocyte Indices	3.3120000E-005	-
ENSG00000185728	Blood Pressure	6.0437539E-005	-
ENSG00000185728	Myocardial Infarction	7E-9	26708285

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000185728	rs4739066	8	63191534	A	Myocardial infarction	26708285	[NR]	1.369863	EFO_0000612

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000185728's network

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000185728	YTHDF3	100	74.074	ENSG00000149658	YTHDF1	100	74.074
ENSG00000185728	YTHDF3	100	75.490	ENSG00000198492	YTHDF2	98	69.898

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000185728	YTHDF3	100	100.000	ENSAMEG00000018113	YTHDF3	100	98.803	Ailuropoda_melanoleuca
ENSG00000185728	YTHDF3	100	93.137	ENSATEG00000011478	ythdf3	94	93.514	Anabas_testudineus
ENSG00000185728	YTHDF3	100	99.099	ENSAPLG00000011329	YTHDF3	97	93.226	Anas_platyrhynchos
ENSG00000185728	YTHDF3	100	99.099	ENSACAG00000016837	YTHDF3	100	92.308	Anolis_carolinensis
ENSG00000185728	YTHDF3	100	100.000	ENSANAG00000037920	YTHDF3	100	99.830	Aotus_nancymaae
ENSG00000185728	YTHDF3	100	97.059	ENSAMXG00000030366	ythdf3	97	76.871	Astyanax_mexicanus
ENSG00000185728	YTHDF3	100	100.000	ENSBTAG00000018557	YTHDF3	100	98.632	Bos_taurus
ENSG00000185728	YTHDF3	100	100.000	ENSCJAG00000009217	YTHDF3	100	99.830	Callithrix_jacchus
ENSG00000185728	YTHDF3	100	100.000	ENSCAFG00000007215	YTHDF3	100	99.320	Canis_familiaris
ENSG00000185728	YTHDF3	100	100.000	ENSCAFG00020015995	YTHDF3	100	99.487	Canis_lupus_dingo
ENSG00000185728	YTHDF3	100	100.000	ENSCHIG00000026460	YTHDF3	100	98.974	Capra_hircus
ENSG00000185728	YTHDF3	100	100.000	ENSTSYG00000009117	YTHDF3	100	98.980	Carlito_syrichta
ENSG00000185728	YTHDF3	100	100.000	ENSCAPG00000014006	YTHDF3	100	98.614	Cavia_aperea
ENSG00000185728	YTHDF3	100	100.000	ENSCPOG00000002961	YTHDF3	100	99.316	Cavia_porcellus
ENSG00000185728	YTHDF3	100	100.000	ENSCCAG00000022316	YTHDF3	100	99.660	Cebus_capucinus
ENSG00000185728	YTHDF3	100	100.000	ENSCATG00000038669	YTHDF3	100	100.000	Cercocebus_atys
ENSG00000185728	YTHDF3	100	100.000	ENSCLAG00000002515	YTHDF3	100	99.133	Chinchilla_lanigera
ENSG00000185728	YTHDF3	100	100.000	ENSCSAG00000014280	YTHDF3	100	99.829	Chlorocebus_sabaeus
ENSG00000185728	YTHDF3	100	100.000	ENSCHOG00000010194	YTHDF3	100	97.069	Choloepus_hoffmanni
ENSG00000185728	YTHDF3	100	97.297	ENSCPBG00000021405	YTHDF3	100	96.246	Chrysemys_picta_bellii
ENSG00000185728	YTHDF3	100	100.000	ENSCANG00000032631	YTHDF3	100	100.000	Colobus_angolensis_palliatus
ENSG00000185728	YTHDF3	100	99.099	ENSCGRG00001021204	Ythdf3	100	98.632	Cricetulus_griseus_chok1gshd
ENSG00000185728	YTHDF3	100	99.099	ENSCGRG00000005613	-	100	98.094	Cricetulus_griseus_crigri
ENSG00000185728	YTHDF3	74	67.595	ENSCGRG00000008289	-	64	73.932	Cricetulus_griseus_crigri
ENSG00000185728	YTHDF3	100	97.297	ENSDARG00000057939	ythdf3	100	76.683	Danio_rerio
ENSG00000185728	YTHDF3	100	100.000	ENSDNOG00000037156	YTHDF3	100	98.302	Dasypus_novemcinctus
ENSG00000185728	YTHDF3	100	100.000	ENSDORG00000014699	Ythdf3	100	99.316	Dipodomys_ordii
ENSG00000185728	YTHDF3	100	100.000	ENSETEG00000007144	YTHDF3	100	98.772	Echinops_telfairi
ENSG00000185728	YTHDF3	100	100.000	ENSEASG00005016224	YTHDF3	100	99.829	Equus_asinus_asinus
ENSG00000185728	YTHDF3	100	100.000	ENSECAG00000011093	YTHDF3	100	99.829	Equus_caballus
ENSG00000185728	YTHDF3	100	100.000	ENSFCAG00000025314	YTHDF3	100	99.487	Felis_catus
ENSG00000185728	YTHDF3	100	99.099	ENSFALG00000005503	YTHDF3	100	93.071	Ficedula_albicollis
ENSG00000185728	YTHDF3	100	100.000	ENSFDAG00000002735	YTHDF3	100	99.307	Fukomys_damarensis
ENSG00000185728	YTHDF3	100	93.137	ENSFHEG00000016395	ythdf3	89	75.522	Fundulus_heteroclitus
ENSG00000185728	YTHDF3	100	99.099	ENSGALG00000039774	YTHDF3	100	96.068	Gallus_gallus
ENSG00000185728	YTHDF3	100	98.198	ENSGAGG00000003851	YTHDF3	100	96.075	Gopherus_agassizii
ENSG00000185728	YTHDF3	100	100.000	ENSGGOG00000027681	YTHDF3	100	100.000	Gorilla_gorilla
ENSG00000185728	YTHDF3	100	100.000	ENSHGLG00000009954	YTHDF3	100	99.316	Heterocephalus_glaber_female
ENSG00000185728	YTHDF3	100	100.000	ENSHGLG00100012403	YTHDF3	100	99.307	Heterocephalus_glaber_male
ENSG00000185728	YTHDF3	100	97.059	ENSIPUG00000014157	YTHDF1	97	79.153	Ictalurus_punctatus
ENSG00000185728	YTHDF3	100	100.000	ENSSTOG00000027792	YTHDF3	100	98.974	Ictidomys_tridecemlineatus
ENSG00000185728	YTHDF3	100	100.000	ENSJJAG00000017742	Ythdf3	100	99.480	Jaculus_jaculus
ENSG00000185728	YTHDF3	100	95.098	ENSLACG00000002281	YTHDF3	100	84.255	Latimeria_chalumnae
ENSG00000185728	YTHDF3	100	97.297	ENSLOCG00000004932	ythdf3	100	81.154	Lepisosteus_oculatus
ENSG00000185728	YTHDF3	100	100.000	ENSLAFG00000016052	YTHDF3	100	97.148	Loxodonta_africana
ENSG00000185728	YTHDF3	100	100.000	ENSMFAG00000043451	YTHDF3	100	100.000	Macaca_fascicularis
ENSG00000185728	YTHDF3	100	100.000	ENSMMUG00000006729	YTHDF3	100	100.000	Macaca_mulatta
ENSG00000185728	YTHDF3	100	100.000	ENSMNEG00000031200	YTHDF3	100	100.000	Macaca_nemestrina
ENSG00000185728	YTHDF3	100	100.000	ENSMLEG00000036763	YTHDF3	100	100.000	Mandrillus_leucophaeus
ENSG00000185728	YTHDF3	100	99.099	ENSMGAG00000011168	YTHDF3	100	92.650	Meleagris_gallopavo
ENSG00000185728	YTHDF3	73	94.602	ENSMAUG00000012560	Ythdf3	97	93.651	Mesocricetus_auratus
ENSG00000185728	YTHDF3	74	78.481	ENSMICG00000009379	-	100	75.949	Microcebus_murinus
ENSG00000185728	YTHDF3	100	100.000	ENSMICG00000036869	-	100	99.660	Microcebus_murinus
ENSG00000185728	YTHDF3	100	98.315	ENSMOCG00000011947	Ythdf3	100	98.094	Microtus_ochrogaster
ENSG00000185728	YTHDF3	100	93.137	ENSMMOG00000003402	ythdf3	92	89.894	Mola_mola
ENSG00000185728	YTHDF3	100	99.099	ENSMODG00000008255	YTHDF3	100	97.440	Monodelphis_domestica
ENSG00000185728	YTHDF3	100	93.137	ENSMALG00000000147	ythdf3	92	92.432	Monopterus_albus
ENSG00000185728	YTHDF3	100	99.099	MGP_CAROLIEiJ_G0024863	Ythdf3	100	98.803	Mus_caroli
ENSG00000185728	YTHDF3	100	99.099	ENSMUSG00000047213	Ythdf3	100	98.803	Mus_musculus
ENSG00000185728	YTHDF3	100	99.099	MGP_PahariEiJ_G0026310	Ythdf3	100	98.291	Mus_pahari
ENSG00000185728	YTHDF3	100	99.099	MGP_SPRETEiJ_G0025794	Ythdf3	100	98.632	Mus_spretus
ENSG00000185728	YTHDF3	100	100.000	ENSMPUG00000009857	YTHDF3	100	99.487	Mustela_putorius_furo
ENSG00000185728	YTHDF3	100	100.000	ENSMLUG00000006541	YTHDF3	99	99.139	Myotis_lucifugus
ENSG00000185728	YTHDF3	100	100.000	ENSNGAG00000018434	Ythdf3	96	99.067	Nannospalax_galili
ENSG00000185728	YTHDF3	100	100.000	ENSNLEG00000003872	YTHDF3	100	99.830	Nomascus_leucogenys
ENSG00000185728	YTHDF3	100	99.099	ENSMEUG00000011285	YTHDF3	100	96.902	Notamacropus_eugenii
ENSG00000185728	YTHDF3	100	100.000	ENSODEG00000002033	YTHDF3	100	98.440	Octodon_degus
ENSG00000185728	YTHDF3	100	99.099	ENSOANG00000005053	YTHDF3	100	91.050	Ornithorhynchus_anatinus
ENSG00000185728	YTHDF3	100	100.000	ENSOCUG00000008723	YTHDF3	100	98.319	Oryctolagus_cuniculus
ENSG00000185728	YTHDF3	100	92.793	ENSOMEG00000008212	ythdf3	99	75.904	Oryzias_melastigma
ENSG00000185728	YTHDF3	100	100.000	ENSOGAG00000002302	YTHDF3	99	99.144	Otolemur_garnettii
ENSG00000185728	YTHDF3	100	100.000	ENSOARG00000016882	YTHDF3	98	98.609	Ovis_aries
ENSG00000185728	YTHDF3	100	100.000	ENSPPAG00000043483	YTHDF3	100	99.660	Pan_paniscus
ENSG00000185728	YTHDF3	100	100.000	ENSPPRG00000004665	YTHDF3	100	99.487	Panthera_pardus
ENSG00000185728	YTHDF3	100	100.000	ENSPTIG00000021537	YTHDF3	100	99.438	Panthera_tigris_altaica
ENSG00000185728	YTHDF3	100	100.000	ENSPTRG00000049135	YTHDF3	100	99.830	Pan_troglodytes
ENSG00000185728	YTHDF3	100	100.000	ENSPANG00000008030	YTHDF3	100	100.000	Papio_anubis
ENSG00000185728	YTHDF3	100	96.078	ENSPKIG00000008298	ythdf3	96	81.317	Paramormyrops_kingsleyae
ENSG00000185728	YTHDF3	100	98.198	ENSPSIG00000015861	YTHDF3	100	94.198	Pelodiscus_sinensis
ENSG00000185728	YTHDF3	100	99.099	ENSPEMG00000020975	Ythdf3	100	98.960	Peromyscus_maniculatus_bairdii
ENSG00000185728	YTHDF3	100	99.099	ENSPCIG00000017629	YTHDF3	100	97.611	Phascolarctos_cinereus
ENSG00000185728	YTHDF3	91	100.000	ENSPPYG00000018626	YTHDF3	90	100.000	Pongo_abelii
ENSG00000185728	YTHDF3	100	100.000	ENSPCAG00000016282	YTHDF3	100	98.448	Procavia_capensis
ENSG00000185728	YTHDF3	100	100.000	ENSPCOG00000004856	YTHDF3	100	99.829	Propithecus_coquereli
ENSG00000185728	YTHDF3	100	98.039	ENSPVAG00000002740	YTHDF3	86	99.468	Pteropus_vampyrus
ENSG00000185728	YTHDF3	100	94.118	ENSPNYG00000002949	ythdf3	96	87.156	Pundamilia_nyererei
ENSG00000185728	YTHDF3	100	99.099	ENSRNOG00000010084	Ythdf3	100	98.632	Rattus_norvegicus
ENSG00000185728	YTHDF3	100	100.000	ENSRBIG00000036465	YTHDF3	100	99.830	Rhinopithecus_bieti
ENSG00000185728	YTHDF3	100	100.000	ENSRROG00000035231	YTHDF3	100	99.658	Rhinopithecus_roxellana
ENSG00000185728	YTHDF3	100	100.000	ENSSBOG00000035287	YTHDF3	100	99.829	Saimiri_boliviensis_boliviensis
ENSG00000185728	YTHDF3	100	99.099	ENSSHAG00000009482	YTHDF3	100	96.763	Sarcophilus_harrisii
ENSG00000185728	YTHDF3	100	91.892	ENSSFOG00015015445	ythdf3	96	75.045	Scleropages_formosus
ENSG00000185728	YTHDF3	100	100.000	ENSSARG00000007626	YTHDF3	99	99.649	Sorex_araneus
ENSG00000185728	YTHDF3	100	98.198	ENSSPUG00000009390	YTHDF3	99	96.034	Sphenodon_punctatus
ENSG00000185728	YTHDF3	100	100.000	ENSSSCG00000033144	YTHDF3	100	99.813	Sus_scrofa
ENSG00000185728	YTHDF3	100	99.099	ENSTGUG00000011243	YTHDF3	98	93.381	Taeniopygia_guttata
ENSG00000185728	YTHDF3	80	99.052	ENSTBEG00000005747	YTHDF3	81	99.052	Tupaia_belangeri
ENSG00000185728	YTHDF3	99	89.828	ENSTTRG00000014564	YTHDF3	98	88.908	Tursiops_truncatus
ENSG00000185728	YTHDF3	100	100.000	ENSUAMG00000012624	YTHDF3	100	99.658	Ursus_americanus
ENSG00000185728	YTHDF3	100	100.000	ENSUMAG00000014104	YTHDF3	100	99.490	Ursus_maritimus
ENSG00000185728	YTHDF3	100	100.000	ENSVPAG00000008104	YTHDF3	98	84.359	Vicugna_pacos
ENSG00000185728	YTHDF3	100	100.000	ENSVVUG00000018384	YTHDF3	100	99.487	Vulpes_vulpes
ENSG00000185728	YTHDF3	100	96.396	ENSXETG00000021659	ythdf3	100	88.889	Xenopus_tropicalis
ENSG00000185728	YTHDF3	100	93.137	ENSXCOG00000009687	ythdf3	99	76.207	Xiphophorus_couchianus
ENSG00000185728	YTHDF3	100	93.137	ENSXMAG00000009698	ythdf3	99	76.552	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	22190034.28106072.	IPI	Function
GO:0005829	cytosol	28106072.	TAS	Component
GO:0043022	ribosome binding	28106076.	IDA	Function
GO:0045727	positive regulation of translation	28106072.	IMP	Process
GO:0045948	positive regulation of translational initiation	28106076.	IDA	Process
GO:0061157	mRNA destabilization	28106072.	IMP	Process
GO:1990247	N6-methyladenosine-containing RNA binding	22575960.24284625.28106072.28106076.	IDA	Function