EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000186141 (Gene tree)
Gene ID: 10623
Gene Symbol: POLR3C
Alias: RPC62|RPC3
Full Name: RNA polymerase III subunit C
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 20,334 bases
Position: chr1:145,824,069-145,844,402
Accession: 30076
RBP type: canonical RBP
Summary: POLR3C (RNA Polymerase III Subunit C) is a Protein Coding gene. Diseases associated with POLR3C include Thrombocytopenia-Absent Radius Syndrome and Chickenpox. Among its related pathways are RNA Polymerase III Transcription Initiation and Transcription of tRNA. Gene Ontology (GO) annotations related to this gene include DNA-directed 5'-3' RNA polymerase activity and RNA polymerase III activity.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000358300	RNA_pol_Rpc82	PF05645.13	4.1e-43	1	1
ENSP00000334564	RNA_pol_Rpc82	PF05645.13	5.4e-43	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9171375	Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation.	Genes Dev	1997 May 15	Wang Z	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000466003	POLR3C-203	847	-	-	- (aa)	-	-
ENST00000334163	POLR3C-201	1851	XM_005272927	ENSP00000334564	534 (aa)	XP_005272984	Q9BUI4
ENST00000471254	POLR3C-204	1186	-	-	- (aa)	-	-
ENST00000369294	POLR3C-202	1590	-	ENSP00000358300	411 (aa)	-	E9PHH9
ENST00000479819	POLR3C-205	372	-	-	- (aa)	-	-
ENST00000489436	POLR3C-206	820	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000186141's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03020	RNA polymerase	KEGG
hsa04623	Cytosolic DNA-sensing pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000186141's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000186141	POLR3C	99	63.787	ENSAPOG00000008722	polr3c	99	63.787	Acanthochromis_polyacanthus
ENSG00000186141	POLR3C	100	96.629	ENSAMEG00000017531	POLR3C	100	96.629	Ailuropoda_melanoleuca
ENSG00000186141	POLR3C	99	64.260	ENSACIG00000008064	polr3c	99	63.884	Amphilophus_citrinellus
ENSG00000186141	POLR3C	99	65.478	ENSAOCG00000011695	polr3c	99	65.478	Amphiprion_ocellaris
ENSG00000186141	POLR3C	99	65.478	ENSAPEG00000004426	polr3c	99	65.478	Amphiprion_percula
ENSG00000186141	POLR3C	99	65.000	ENSATEG00000023618	polr3c	92	65.000	Anabas_testudineus
ENSG00000186141	POLR3C	100	98.783	ENSANAG00000036434	POLR3C	100	98.783	Aotus_nancymaae
ENSG00000186141	POLR3C	99	64.182	ENSACLG00000019970	polr3c	99	63.985	Astatotilapia_calliptera
ENSG00000186141	POLR3C	99	63.168	ENSAMXG00000008273	polr3c	99	62.963	Astyanax_mexicanus
ENSG00000186141	POLR3C	99	95.872	ENSBTAG00000021637	POLR3C	100	95.872	Bos_taurus
ENSG00000186141	POLR3C	100	98.783	ENSCJAG00000002314	POLR3C	100	98.783	Callithrix_jacchus
ENSG00000186141	POLR3C	100	96.255	ENSCAFG00000011257	POLR3C	100	96.255	Canis_familiaris
ENSG00000186141	POLR3C	99	95.823	ENSCAFG00020020066	POLR3C	99	96.260	Canis_lupus_dingo
ENSG00000186141	POLR3C	100	96.067	ENSCHIG00000022431	POLR3C	100	96.067	Capra_hircus
ENSG00000186141	POLR3C	100	96.816	ENSTSYG00000002292	POLR3C	100	96.816	Carlito_syrichta
ENSG00000186141	POLR3C	99	74.817	ENSCAPG00000011559	POLR3C	100	73.425	Cavia_aperea
ENSG00000186141	POLR3C	100	93.258	ENSCPOG00000004654	POLR3C	100	93.258	Cavia_porcellus
ENSG00000186141	POLR3C	100	99.027	ENSCCAG00000027077	POLR3C	100	99.027	Cebus_capucinus
ENSG00000186141	POLR3C	100	99.251	ENSCATG00000040166	POLR3C	100	99.251	Cercocebus_atys
ENSG00000186141	POLR3C	89	93.976	ENSCLAG00000001652	POLR3C	100	93.976	Chinchilla_lanigera
ENSG00000186141	POLR3C	100	99.251	ENSCSAG00000001762	POLR3C	100	99.251	Chlorocebus_sabaeus
ENSG00000186141	POLR3C	99	94.595	ENSCHOG00000006911	POLR3C	99	93.996	Choloepus_hoffmanni
ENSG00000186141	POLR3C	99	87.054	ENSCPBG00000007883	POLR3C	99	87.054	Chrysemys_picta_bellii
ENSG00000186141	POLR3C	99	47.458	ENSCING00000007024	-	99	47.458	Ciona_intestinalis
ENSG00000186141	POLR3C	99	47.280	ENSCSAVG00000008586	-	99	47.280	Ciona_savignyi
ENSG00000186141	POLR3C	100	99.270	ENSCANG00000032538	POLR3C	100	99.270	Colobus_angolensis_palliatus
ENSG00000186141	POLR3C	100	94.944	ENSCGRG00001005471	Polr3c	100	94.944	Cricetulus_griseus_chok1gshd
ENSG00000186141	POLR3C	100	94.944	ENSCGRG00000016787	Polr3c	100	94.944	Cricetulus_griseus_crigri
ENSG00000186141	POLR3C	99	64.088	ENSCSEG00000002425	polr3c	99	64.630	Cynoglossus_semilaevis
ENSG00000186141	POLR3C	99	62.274	ENSCVAG00000009443	polr3c	99	62.477	Cyprinodon_variegatus
ENSG00000186141	POLR3C	99	62.274	ENSCVAG00000022458	polr3c	99	62.477	Cyprinodon_variegatus
ENSG00000186141	POLR3C	99	65.985	ENSDARG00000057562	polr3c	99	65.242	Danio_rerio
ENSG00000186141	POLR3C	72	97.650	ENSDNOG00000012149	POLR3C	100	97.650	Dasypus_novemcinctus
ENSG00000186141	POLR3C	99	94.559	ENSDORG00000013430	Polr3c	99	94.559	Dipodomys_ordii
ENSG00000186141	POLR3C	97	33.270	FBgn0038057	CG12267	96	33.270	Drosophila_melanogaster
ENSG00000186141	POLR3C	99	92.138	ENSETEG00000017696	POLR3C	100	83.521	Echinops_telfairi
ENSG00000186141	POLR3C	100	96.629	ENSEASG00005007417	POLR3C	100	96.629	Equus_asinus_asinus
ENSG00000186141	POLR3C	100	94.007	ENSECAG00000023713	POLR3C	100	94.007	Equus_caballus
ENSG00000186141	POLR3C	99	90.056	ENSEEUG00000011124	POLR3C	99	90.056	Erinaceus_europaeus
ENSG00000186141	POLR3C	99	66.667	ENSELUG00000013209	polr3c	99	66.667	Esox_lucius
ENSG00000186141	POLR3C	100	96.629	ENSFCAG00000013360	POLR3C	100	96.629	Felis_catus
ENSG00000186141	POLR3C	100	94.195	ENSFDAG00000021078	POLR3C	100	94.195	Fukomys_damarensis
ENSG00000186141	POLR3C	99	63.985	ENSFHEG00000000872	polr3c	99	63.985	Fundulus_heteroclitus
ENSG00000186141	POLR3C	99	62.409	ENSGMOG00000018937	polr3c	99	62.752	Gadus_morhua
ENSG00000186141	POLR3C	99	77.451	ENSGALG00000052515	-	100	77.778	Gallus_gallus
ENSG00000186141	POLR3C	99	62.883	ENSGAFG00000014721	polr3c	99	63.686	Gambusia_affinis
ENSG00000186141	POLR3C	99	64.916	ENSGACG00000011829	polr3c	99	64.916	Gasterosteus_aculeatus
ENSG00000186141	POLR3C	99	86.492	ENSGAGG00000010176	POLR3C	99	86.492	Gopherus_agassizii
ENSG00000186141	POLR3C	100	99.757	ENSGGOG00000007279	POLR3C	100	99.757	Gorilla_gorilla
ENSG00000186141	POLR3C	99	64.364	ENSHBUG00000003619	polr3c	99	64.168	Haplochromis_burtoni
ENSG00000186141	POLR3C	100	93.258	ENSHGLG00000014978	POLR3C	100	93.258	Heterocephalus_glaber_female
ENSG00000186141	POLR3C	100	93.258	ENSHGLG00100015620	POLR3C	100	93.258	Heterocephalus_glaber_male
ENSG00000186141	POLR3C	99	64.312	ENSHCOG00000000823	polr3c	99	64.299	Hippocampus_comes
ENSG00000186141	POLR3C	99	65.018	ENSIPUG00000008657	polr3c	99	65.804	Ictalurus_punctatus
ENSG00000186141	POLR3C	100	97.004	ENSSTOG00000014601	POLR3C	100	97.004	Ictidomys_tridecemlineatus
ENSG00000186141	POLR3C	100	92.884	ENSJJAG00000011447	Polr3c	100	92.884	Jaculus_jaculus
ENSG00000186141	POLR3C	99	63.063	ENSKMAG00000001574	polr3c	99	64.154	Kryptolebias_marmoratus
ENSG00000186141	POLR3C	99	63.187	ENSLBEG00000026567	polr3c	99	63.187	Labrus_bergylta
ENSG00000186141	POLR3C	99	72.932	ENSLACG00000017216	POLR3C	99	74.060	Latimeria_chalumnae
ENSG00000186141	POLR3C	99	59.559	ENSLOCG00000006400	polr3c	99	59.630	Lepisosteus_oculatus
ENSG00000186141	POLR3C	99	96.811	ENSLAFG00000029485	POLR3C	100	96.811	Loxodonta_africana
ENSG00000186141	POLR3C	100	99.438	ENSMFAG00000040338	POLR3C	100	99.438	Macaca_fascicularis
ENSG00000186141	POLR3C	100	99.438	ENSMMUG00000016735	POLR3C	100	99.438	Macaca_mulatta
ENSG00000186141	POLR3C	100	99.438	ENSMNEG00000040944	POLR3C	100	99.438	Macaca_nemestrina
ENSG00000186141	POLR3C	100	99.438	ENSMLEG00000031091	POLR3C	100	99.438	Mandrillus_leucophaeus
ENSG00000186141	POLR3C	99	64.286	ENSMAMG00000014770	polr3c	99	63.553	Mastacembelus_armatus
ENSG00000186141	POLR3C	99	64.182	ENSMZEG00005015882	polr3c	99	63.985	Maylandia_zebra
ENSG00000186141	POLR3C	100	94.944	ENSMAUG00000001454	-	100	94.944	Mesocricetus_auratus
ENSG00000186141	POLR3C	100	77.381	ENSMAUG00000021521	-	100	77.381	Mesocricetus_auratus
ENSG00000186141	POLR3C	100	97.191	ENSMICG00000034253	POLR3C	100	97.191	Microcebus_murinus
ENSG00000186141	POLR3C	99	86.007	ENSMOCG00000000997	Polr3c	99	86.007	Microtus_ochrogaster
ENSG00000186141	POLR3C	99	65.683	ENSMMOG00000003989	polr3c	99	64.945	Mola_mola
ENSG00000186141	POLR3C	99	91.011	ENSMODG00000018745	-	74	91.011	Monodelphis_domestica
ENSG00000186141	POLR3C	99	64.469	ENSMALG00000000156	polr3c	99	63.603	Monopterus_albus
ENSG00000186141	POLR3C	100	93.633	MGP_CAROLIEiJ_G0025390	Polr3c	100	93.633	Mus_caroli
ENSG00000186141	POLR3C	100	93.820	ENSMUSG00000028099	Polr3c	100	93.820	Mus_musculus
ENSG00000186141	POLR3C	100	93.446	MGP_PahariEiJ_G0026835	Polr3c	100	93.446	Mus_pahari
ENSG00000186141	POLR3C	100	93.258	MGP_SPRETEiJ_G0026337	Polr3c	100	93.258	Mus_spretus
ENSG00000186141	POLR3C	100	96.067	ENSMPUG00000000656	POLR3C	100	96.067	Mustela_putorius_furo
ENSG00000186141	POLR3C	100	93.097	ENSMLUG00000004060	POLR3C	100	93.097	Myotis_lucifugus
ENSG00000186141	POLR3C	100	94.382	ENSNGAG00000013090	Polr3c	100	94.382	Nannospalax_galili
ENSG00000186141	POLR3C	99	64.182	ENSNBRG00000003707	polr3c	99	64.351	Neolamprologus_brichardi
ENSG00000186141	POLR3C	100	99.757	ENSNLEG00000005645	POLR3C	100	99.757	Nomascus_leucogenys
ENSG00000186141	POLR3C	87	93.651	ENSMEUG00000012664	POLR3C	87	93.651	Notamacropus_eugenii
ENSG00000186141	POLR3C	99	92.629	ENSOPRG00000004244	POLR3C	99	92.120	Ochotona_princeps
ENSG00000186141	POLR3C	100	92.509	ENSODEG00000000304	POLR3C	100	92.509	Octodon_degus
ENSG00000186141	POLR3C	99	64.899	ENSONIG00000006370	polr3c	99	64.717	Oreochromis_niloticus
ENSG00000186141	POLR3C	87	62.500	ENSOANG00000000559	-	100	62.500	Ornithorhynchus_anatinus
ENSG00000186141	POLR3C	99	96.060	ENSOCUG00000003050	POLR3C	99	96.060	Oryctolagus_cuniculus
ENSG00000186141	POLR3C	99	64.351	ENSORLG00000010133	polr3c	99	64.154	Oryzias_latipes
ENSG00000186141	POLR3C	99	63.736	ENSORLG00020009245	polr3c	99	63.736	Oryzias_latipes_hni
ENSG00000186141	POLR3C	99	63.803	ENSORLG00015015223	polr3c	99	63.603	Oryzias_latipes_hsok
ENSG00000186141	POLR3C	99	63.469	ENSOMEG00000008558	polr3c	99	63.284	Oryzias_melastigma
ENSG00000186141	POLR3C	99	96.998	ENSOGAG00000000209	POLR3C	99	96.998	Otolemur_garnettii
ENSG00000186141	POLR3C	100	96.067	ENSOARG00000020588	POLR3C	100	96.067	Ovis_aries
ENSG00000186141	POLR3C	100	99.813	ENSPPAG00000025184	POLR3C	100	99.813	Pan_paniscus
ENSG00000186141	POLR3C	100	96.442	ENSPPRG00000008809	POLR3C	100	96.442	Panthera_pardus
ENSG00000186141	POLR3C	100	96.442	ENSPTIG00000009916	POLR3C	100	96.442	Panthera_tigris_altaica
ENSG00000186141	POLR3C	100	100.000	ENSPTRG00000001208	POLR3C	100	100.000	Pan_troglodytes
ENSG00000186141	POLR3C	100	99.064	ENSPANG00000019404	POLR3C	100	99.064	Papio_anubis
ENSG00000186141	POLR3C	99	65.863	ENSPKIG00000014883	polr3c	99	65.863	Paramormyrops_kingsleyae
ENSG00000186141	POLR3C	99	87.242	ENSPSIG00000004694	POLR3C	99	87.242	Pelodiscus_sinensis
ENSG00000186141	POLR3C	99	63.873	ENSPMGG00000007761	polr3c	99	63.636	Periophthalmus_magnuspinnatus
ENSG00000186141	POLR3C	99	95.310	ENSPEMG00000016322	Polr3c	99	95.310	Peromyscus_maniculatus_bairdii
ENSG00000186141	POLR3C	99	63.197	ENSPMAG00000006993	polr3c	99	63.197	Petromyzon_marinus
ENSG00000186141	POLR3C	99	90.449	ENSPCIG00000011954	POLR3C	99	90.449	Phascolarctos_cinereus
ENSG00000186141	POLR3C	99	63.063	ENSPFOG00000014106	polr3c	99	64.234	Poecilia_formosa
ENSG00000186141	POLR3C	99	65.854	ENSPLAG00000018932	polr3c	99	66.041	Poecilia_latipinna
ENSG00000186141	POLR3C	99	62.883	ENSPMEG00000023273	polr3c	99	64.051	Poecilia_mexicana
ENSG00000186141	POLR3C	99	64.154	ENSPREG00000017050	polr3c	99	64.510	Poecilia_reticulata
ENSG00000186141	POLR3C	100	99.064	ENSPPYG00000000936	POLR3C	100	99.064	Pongo_abelii
ENSG00000186141	POLR3C	91	95.041	ENSPCAG00000010501	POLR3C	99	95.041	Procavia_capensis
ENSG00000186141	POLR3C	96	94.706	ENSPCOG00000024937	POLR3C	100	94.706	Propithecus_coquereli
ENSG00000186141	POLR3C	99	95.497	ENSPVAG00000014483	POLR3C	100	95.497	Pteropus_vampyrus
ENSG00000186141	POLR3C	99	64.364	ENSPNYG00000004504	polr3c	99	64.168	Pundamilia_nyererei
ENSG00000186141	POLR3C	98	62.873	ENSPNAG00000018675	polr3c	99	62.915	Pygocentrus_nattereri
ENSG00000186141	POLR3C	100	93.820	ENSRNOG00000033560	Polr3c	100	93.820	Rattus_norvegicus
ENSG00000186141	POLR3C	100	99.064	ENSRBIG00000035432	POLR3C	100	99.064	Rhinopithecus_bieti
ENSG00000186141	POLR3C	100	99.064	ENSRROG00000039959	POLR3C	100	99.064	Rhinopithecus_roxellana
ENSG00000186141	POLR3C	91	93.182	ENSSBOG00000028429	POLR3C	99	93.182	Saimiri_boliviensis_boliviensis
ENSG00000186141	POLR3C	99	90.075	ENSSHAG00000018565	POLR3C	99	90.075	Sarcophilus_harrisii
ENSG00000186141	POLR3C	99	68.037	ENSSFOG00015021863	polr3c	99	68.037	Scleropages_formosus
ENSG00000186141	POLR3C	99	65.356	ENSSMAG00000016000	polr3c	99	65.356	Scophthalmus_maximus
ENSG00000186141	POLR3C	99	65.672	ENSSDUG00000006590	polr3c	99	65.672	Seriola_dumerili
ENSG00000186141	POLR3C	99	65.543	ENSSLDG00000015614	polr3c	99	65.543	Seriola_lalandi_dorsalis
ENSG00000186141	POLR3C	63	95.238	ENSSARG00000014380	POLR3C	99	95.238	Sorex_araneus
ENSG00000186141	POLR3C	99	85.366	ENSSPUG00000001834	POLR3C	99	85.366	Sphenodon_punctatus
ENSG00000186141	POLR3C	99	64.916	ENSSPAG00000022520	polr3c	99	64.673	Stegastes_partitus
ENSG00000186141	POLR3C	100	95.880	ENSSSCG00000006691	POLR3C	100	95.880	Sus_scrofa
ENSG00000186141	POLR3C	99	71.642	ENSTGUG00000016941	POLR3C	99	71.348	Taeniopygia_guttata
ENSG00000186141	POLR3C	99	63.031	ENSTRUG00000010726	polr3c	99	63.451	Takifugu_rubripes
ENSG00000186141	POLR3C	99	64.325	ENSTNIG00000019501	polr3c	99	64.312	Tetraodon_nigroviridis
ENSG00000186141	POLR3C	75	95.739	ENSTBEG00000015610	POLR3C	100	95.739	Tupaia_belangeri
ENSG00000186141	POLR3C	72	100.000	ENSTTRG00000009216	POLR3C	72	100.000	Tursiops_truncatus
ENSG00000186141	POLR3C	100	96.816	ENSUAMG00000021906	POLR3C	100	96.816	Ursus_americanus
ENSG00000186141	POLR3C	100	96.816	ENSUMAG00000010180	POLR3C	100	96.816	Ursus_maritimus
ENSG00000186141	POLR3C	100	96.067	ENSVVUG00000007421	POLR3C	100	96.067	Vulpes_vulpes
ENSG00000186141	POLR3C	99	61.800	ENSXCOG00000019524	polr3c	99	60.374	Xiphophorus_couchianus
ENSG00000186141	POLR3C	99	62.909	ENSXMAG00000016215	polr3c	99	63.254	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001056	RNA polymerase III activity	21873635.	IBA	Function
GO:0003697	single-stranded DNA binding	21358628.	IDA	Function
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	9171375.	TAS	Function
GO:0005515	protein binding	20154270.21358628.25416956.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005666	RNA polymerase III complex	21873635.	IBA	Component
GO:0005666	RNA polymerase III complex	24107381.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006359	regulation of transcription by RNA polymerase III	9171375.	TAS	Process
GO:0006383	transcription by RNA polymerase III	-	IEA	Process
GO:0032481	positive regulation of type I interferon production	-	TAS	Process
GO:0032728	positive regulation of interferon-beta production	19609254.	IMP	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0045089	positive regulation of innate immune response	19609254.	IMP	Process
GO:0051607	defense response to virus	-	IEA	Process