EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000186298 (Gene tree)
Gene ID: 5501
Gene Symbol: PPP1CC
Alias: PP1C|PP1gamma
Full Name: protein phosphatase 1 catalytic subunit gamma
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 34,009 bases
Position: chr12:110,708,970-110,742,978
Accession: 9283
RBP type: non-canonical RBP
Summary: The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12358598	Functional interaction between nuclear inhibitor of protein phosphatase type 1 (NIPP1) and protein phosphatase type 1 (PP1) in Drosophila: consequences of over-expression of NIPP1 in flies and suppression by co-expression of PP1.	Biochem J	2002 Dec 15	Parker L	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000550991	PPP1CC-206	1882	-	ENSP00000448981	304 (aa)	-	F8VYE8
ENST00000551690	PPP1CC-209	603	-	-	- (aa)	-	-
ENST00000335007	PPP1CC-201	2559	XM_011538504	ENSP00000335084	323 (aa)	XP_011536806	P36873
ENST00000551582	PPP1CC-207	563	-	ENSP00000447090	83 (aa)	-	F8W1A0
ENST00000553024	PPP1CC-210	2797	-	-	- (aa)	-	-
ENST00000546904	PPP1CC-203	1133	-	-	- (aa)	-	-
ENST00000340766	PPP1CC-202	1472	-	ENSP00000341779	337 (aa)	-	P36873
ENST00000550261	PPP1CC-205	747	-	ENSP00000447528	54 (aa)	-	F8W0V8
ENST00000620030	PPP1CC-211	582	-	ENSP00000482210	140 (aa)	-	A0A087WYY5
ENST00000551676	PPP1CC-208	1581	-	ENSP00000448437	270 (aa)	-	F8VR82
ENST00000546933	PPP1CC-204	2154	-	ENSP00000447122	332 (aa)	-	F8W0W8

Gene Model

Click here to download ENSG00000186298's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG
hsa04022	cGMP-PKG signaling pathway	KEGG
hsa04024	cAMP signaling pathway	KEGG
hsa04114	Oocyte meiosis	KEGG
hsa04218	Cellular senescence	KEGG
hsa04261	Adrenergic signaling in cardiomyocytes	KEGG
hsa04270	Vascular smooth muscle contraction	KEGG
hsa04390	Hippo signaling pathway	KEGG
hsa04510	Focal adhesion	KEGG
hsa04611	Platelet activation	KEGG
hsa04720	Long-term potentiation	KEGG
hsa04728	Dopaminergic synapse	KEGG
hsa04750	Inflammatory mediator regulation of TRP channels	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa04910	Insulin signaling pathway	KEGG
hsa04921	Oxytocin signaling pathway	KEGG
hsa04931	Insulin resistance	KEGG
hsa05031	Amphetamine addiction	KEGG
hsa05034	Alcoholism	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG
hsa05205	Proteoglycans in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000186298	Alpha-Globulins	5.1410000E-005	-
ENSG00000186298	Heart Rate	6E-7	23583979

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000186298's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000186298	PPP1CC	97	94.118	FBgn0004103	Pp1-87B	99	93.311	Drosophila_melanogaster
ENSG00000186298	PPP1CC	100	94.286	ENSG00000172531	PPP1CA	100	90.663	Homo_sapiens
ENSG00000186298	PPP1CC	100	93.571	ENSMUSG00000040385	Ppp1ca	100	90.361	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000164	protein phosphatase type 1 complex	-	IEA	Component
GO:0000777	condensed chromosome kinetochore	-	IEA	Component
GO:0000784	nuclear chromosome, telomeric region	24270157.	IDA	Component
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004721	phosphoprotein phosphatase activity	-	TAS	Function
GO:0004722	protein serine/threonine phosphatase activity	21873635.	IBA	Function
GO:0004722	protein serine/threonine phosphatase activity	10880350.17936702.	IMP	Function
GO:0005515	protein binding	10807923.11739654.12761178.15231748.17511879.17936702.17965019.18448430.20516061.20926688.21397856.21988832.21998301.23414517.23555304.24366813.25416956.25785436.26496610.27173435.27505673.27913189.28330616.	IPI	Function
GO:0005521	lamin binding	-	IEA	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	11739654.	IDA	Component
GO:0005730	nucleolus	11739654.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	11739654.	IDA	Component
GO:0005739	mitochondrion	17936702.	IDA	Component
GO:0005741	mitochondrial outer membrane	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005977	glycogen metabolic process	-	IEA	Process
GO:0006470	protein dephosphorylation	22801782.	IMP	Process
GO:0006470	protein dephosphorylation	-	ISS	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0008022	protein C-terminus binding	-	IEA	Function
GO:0008157	protein phosphatase 1 binding	21873635.	IBA	Function
GO:0016607	nuclear speck	-	IEA	Component
GO:0016791	phosphatase activity	-	ISS	Function
GO:0019901	protein kinase binding	10880350.	IPI	Function
GO:0019904	protein domain specific binding	-	IEA	Function
GO:0030182	neuron differentiation	-	IEA	Process
GO:0030496	midbody	-	IEA	Component
GO:0032154	cleavage furrow	-	IEA	Component
GO:0032922	circadian regulation of gene expression	-	ISS	Process
GO:0032991	protein-containing complex	10880350.	IMP	Component
GO:0042752	regulation of circadian rhythm	21873635.	IBA	Process
GO:0042752	regulation of circadian rhythm	21712997.	IMP	Process
GO:0043153	entrainment of circadian clock by photoperiod	21873635.	IBA	Process
GO:0043153	entrainment of circadian clock by photoperiod	-	ISS	Process
GO:0043197	dendritic spine	-	IEA	Component
GO:0044877	protein-containing complex binding	-	IEA	Function
GO:0046822	regulation of nucleocytoplasmic transport	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0047485	protein N-terminus binding	23789093.	IDA	Function
GO:0051301	cell division	-	IEA	Process
GO:0060252	positive regulation of glial cell proliferation	-	IEA	Process
GO:0072357	PTW/PP1 phosphatase complex	20516061.	IDA	Component
GO:0098793	presynapse	-	IEA	Component
GO:0098978	glutamatergic synapse	-	IEA	Component