EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000186416 (Gene tree)
Gene ID: 55922
Gene Symbol: NKRF
Alias: ITBA4|NRF
Full Name: NFKB repressing factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 18,107 bases
Position: chrX:119,588,337-119,606,443
Accession: 19374
RBP type: canonical RBP
Summary: This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000304803	R3H	PF01424.22	2.9e-12	1	1
ENSP00000360582	R3H	PF01424.22	2.9e-12	1	1
ENSP00000442308	R3H	PF01424.22	3.1e-12	1	1
ENSP00000304803	G-patch	PF01585.23	2.6e-13	1	1
ENSP00000360582	G-patch	PF01585.23	2.6e-13	1	1
ENSP00000442308	G-patch	PF01585.23	2.7e-13	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17592041	NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element.	RNA	2007 Aug	Reboll MR	-
21300069	JKTBP1 is involved in stabilization and IRES-dependent translation of NRF mRNAs by binding to 5' and 3' untranslated regions.	J Mol Biol	2011 Apr 8	Omnus DJ	doi: 10.1016/j.jmb.2011.01.050
15226370	Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF.	J Cell Sci	2004 Jul 15	Niedick I	-
30659143	Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-kB repressing factor.	Proc Natl Acad Sci U S A	2019 Feb 5	Chen XJ	doi: 10.1073/pnas.1818539116
16107696	NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity-inducing factor.	Mol Cell Biol	2005 Sep	Dreikhausen U	-
25135111	NF-kB repressing factor downregulates basal expression and mycobacterium tuberculosis induced IP-10 and IL-8 synthesis via interference with NF-kB in monocytes.	J Biomed Sci	2014 Aug 19	Huang KH	doi: 10.1186/s12929-014-0071-5.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000487600	NKRF-203	390	-	-	- (aa)	-	-
ENST00000542113	NKRF-204	3351	-	ENSP00000442308	705 (aa)	-	O15226
ENST00000649446	NKRF-205	3741	-	-	- (aa)	-	-
ENST00000371527	NKRF-202	3737	-	ENSP00000360582	690 (aa)	-	O15226
ENST00000304449	NKRF-201	3817	XM_011531365	ENSP00000304803	690 (aa)	XP_011529667	O15226

Gene Model

Click here to download ENSG00000186416's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000186416	Amyotrophic Lateral Sclerosis	6.485E-5	17362836

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000186416's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000186416	NKRF	92	51.115	ENSAPOG00000012969	nkrf	99	45.120	Acanthochromis_polyacanthus
ENSG00000186416	NKRF	100	95.072	ENSAMEG00000000152	NKRF	100	95.072	Ailuropoda_melanoleuca
ENSG00000186416	NKRF	91	52.724	ENSACIG00000013701	nkrf	98	46.095	Amphilophus_citrinellus
ENSG00000186416	NKRF	93	52.982	ENSAOCG00000011327	nkrf	98	45.671	Amphiprion_ocellaris
ENSG00000186416	NKRF	92	51.463	ENSAPEG00000005444	nkrf	99	45.489	Amphiprion_percula
ENSG00000186416	NKRF	85	55.114	ENSATEG00000018834	nkrf	99	45.844	Anabas_testudineus
ENSG00000186416	NKRF	100	68.848	ENSAPLG00000012272	NKRF	100	68.547	Anas_platyrhynchos
ENSG00000186416	NKRF	99	62.942	ENSACAG00000012140	NKRF	99	62.973	Anolis_carolinensis
ENSG00000186416	NKRF	100	98.014	ENSANAG00000025604	NKRF	100	98.014	Aotus_nancymaae
ENSG00000186416	NKRF	82	49.585	ENSACLG00000001752	nkrf	72	49.751	Astatotilapia_calliptera
ENSG00000186416	NKRF	87	50.000	ENSAMXG00000000131	nkrf	70	50.092	Astyanax_mexicanus
ENSG00000186416	NKRF	100	96.377	ENSBTAG00000045744	NKRF	100	96.011	Bos_taurus
ENSG00000186416	NKRF	100	98.261	ENSCJAG00000005088	NKRF	89	98.276	Callithrix_jacchus
ENSG00000186416	NKRF	100	97.826	ENSCAFG00000018411	NKRF	89	97.845	Canis_familiaris
ENSG00000186416	NKRF	100	97.826	ENSCAFG00020004162	NKRF	100	97.826	Canis_lupus_dingo
ENSG00000186416	NKRF	100	96.667	ENSCHIG00000008436	NKRF	100	96.667	Capra_hircus
ENSG00000186416	NKRF	100	97.536	ENSTSYG00000000890	NKRF	100	97.536	Carlito_syrichta
ENSG00000186416	NKRF	94	92.485	ENSCAPG00000011069	NKRF	99	92.485	Cavia_aperea
ENSG00000186416	NKRF	100	95.797	ENSCPOG00000011912	NKRF	100	95.797	Cavia_porcellus
ENSG00000186416	NKRF	100	98.406	ENSCCAG00000021029	NKRF	100	98.406	Cebus_capucinus
ENSG00000186416	NKRF	100	99.574	ENSCATG00000031763	NKRF	100	99.574	Cercocebus_atys
ENSG00000186416	NKRF	100	95.942	ENSCLAG00000002890	NKRF	100	95.942	Chinchilla_lanigera
ENSG00000186416	NKRF	100	99.420	ENSCSAG00000018353	NKRF	89	99.425	Chlorocebus_sabaeus
ENSG00000186416	NKRF	100	70.270	ENSCPBG00000020704	NKRF	89	70.099	Chrysemys_picta_bellii
ENSG00000186416	NKRF	100	99.574	ENSCANG00000028878	NKRF	100	99.574	Colobus_angolensis_palliatus
ENSG00000186416	NKRF	100	94.203	ENSCGRG00001001105	Nkrf	89	94.253	Cricetulus_griseus_chok1gshd
ENSG00000186416	NKRF	100	94.203	ENSCGRG00000011374	Nkrf	100	94.203	Cricetulus_griseus_crigri
ENSG00000186416	NKRF	80	54.457	ENSCSEG00000002024	nkrf	99	43.822	Cynoglossus_semilaevis
ENSG00000186416	NKRF	98	43.943	ENSCVAG00000004926	nkrf	99	43.943	Cyprinodon_variegatus
ENSG00000186416	NKRF	87	57.143	ENSDARG00000100536	nkrf	75	49.821	Danio_rerio
ENSG00000186416	NKRF	100	96.957	ENSDNOG00000031378	NKRF	89	96.839	Dasypus_novemcinctus
ENSG00000186416	NKRF	100	95.362	ENSDORG00000024123	Nkrf	100	95.362	Dipodomys_ordii
ENSG00000186416	NKRF	71	97.059	ENSETEG00000001275	-	55	97.059	Echinops_telfairi
ENSG00000186416	NKRF	90	35.448	ENSEBUG00000012286	NKRF	98	35.448	Eptatretus_burgeri
ENSG00000186416	NKRF	100	97.536	ENSEASG00005012904	NKRF	89	97.557	Equus_asinus_asinus
ENSG00000186416	NKRF	100	97.536	ENSECAG00000022495	NKRF	89	97.557	Equus_caballus
ENSG00000186416	NKRF	100	92.899	ENSEEUG00000007576	NKRF	100	92.899	Erinaceus_europaeus
ENSG00000186416	NKRF	89	53.432	ENSELUG00000020577	nkrf	80	52.878	Esox_lucius
ENSG00000186416	NKRF	100	97.971	ENSFCAG00000008742	NKRF	99	97.727	Felis_catus
ENSG00000186416	NKRF	100	67.376	ENSFALG00000001584	NKRF	93	67.229	Ficedula_albicollis
ENSG00000186416	NKRF	100	95.652	ENSFDAG00000014857	NKRF	91	95.690	Fukomys_damarensis
ENSG00000186416	NKRF	88	52.797	ENSFHEG00000017996	nkrf	99	45.269	Fundulus_heteroclitus
ENSG00000186416	NKRF	89	53.545	ENSGMOG00000001688	nkrf	99	45.895	Gadus_morhua
ENSG00000186416	NKRF	100	69.318	ENSGALG00000008645	NKRF	92	69.014	Gallus_gallus
ENSG00000186416	NKRF	88	52.028	ENSGAFG00000000966	nkrf	99	44.515	Gambusia_affinis
ENSG00000186416	NKRF	99	45.503	ENSGACG00000017457	nkrf	99	45.833	Gasterosteus_aculeatus
ENSG00000186416	NKRF	100	70.555	ENSGAGG00000001146	NKRF	100	70.697	Gopherus_agassizii
ENSG00000186416	NKRF	100	99.858	ENSGGOG00000006862	NKRF	100	99.858	Gorilla_gorilla
ENSG00000186416	NKRF	93	59.375	ENSHBUG00000017543	nkrf	99	44.583	Haplochromis_burtoni
ENSG00000186416	NKRF	100	95.072	ENSHGLG00000013935	NKRF	100	95.072	Heterocephalus_glaber_female
ENSG00000186416	NKRF	100	95.072	ENSHGLG00100004379	NKRF	100	95.072	Heterocephalus_glaber_male
ENSG00000186416	NKRF	95	50.000	ENSHCOG00000017066	nkrf	93	47.619	Hippocampus_comes
ENSG00000186416	NKRF	99	44.744	ENSIPUG00000022475	nkrf	93	44.968	Ictalurus_punctatus
ENSG00000186416	NKRF	100	96.243	ENSSTOG00000020483	NKRF	100	96.243	Ictidomys_tridecemlineatus
ENSG00000186416	NKRF	100	95.087	ENSJJAG00000020550	Nkrf	100	95.520	Jaculus_jaculus
ENSG00000186416	NKRF	91	52.847	ENSKMAG00000020188	nkrf	84	52.847	Kryptolebias_marmoratus
ENSG00000186416	NKRF	93	50.256	ENSLBEG00000028681	nkrf	81	50.596	Labrus_bergylta
ENSG00000186416	NKRF	99	51.210	ENSLACG00000009612	NKRF	91	51.200	Latimeria_chalumnae
ENSG00000186416	NKRF	100	46.561	ENSLOCG00000015232	nkrf	91	46.719	Lepisosteus_oculatus
ENSG00000186416	NKRF	100	96.812	ENSLAFG00000027138	NKRF	100	96.812	Loxodonta_africana
ENSG00000186416	NKRF	100	99.433	ENSMFAG00000031196	NKRF	100	99.433	Macaca_fascicularis
ENSG00000186416	NKRF	100	99.275	ENSMMUG00000022670	NKRF	89	99.282	Macaca_mulatta
ENSG00000186416	NKRF	100	99.433	ENSMNEG00000027985	NKRF	100	99.433	Macaca_nemestrina
ENSG00000186416	NKRF	100	99.574	ENSMLEG00000041865	NKRF	100	99.574	Mandrillus_leucophaeus
ENSG00000186416	NKRF	90	59.690	ENSMAMG00000019975	nkrf	99	46.768	Mastacembelus_armatus
ENSG00000186416	NKRF	94	49.585	ENSMZEG00005007953	nkrf	99	44.875	Maylandia_zebra
ENSG00000186416	NKRF	100	68.892	ENSMGAG00000007788	NKRF	100	68.592	Meleagris_gallopavo
ENSG00000186416	NKRF	100	94.058	ENSMAUG00000021303	Nkrf	100	94.058	Mesocricetus_auratus
ENSG00000186416	NKRF	100	97.246	ENSMICG00000004220	NKRF	99	96.875	Microcebus_murinus
ENSG00000186416	NKRF	100	93.333	ENSMOCG00000000942	Nkrf	100	93.333	Microtus_ochrogaster
ENSG00000186416	NKRF	91	52.542	ENSMMOG00000004175	nkrf	86	50.259	Mola_mola
ENSG00000186416	NKRF	99	66.667	ENSMODG00000024032	-	99	66.667	Monodelphis_domestica
ENSG00000186416	NKRF	92	52.677	ENSMALG00000007869	NF-kb	99	45.269	Monopterus_albus
ENSG00000186416	NKRF	100	94.928	MGP_CAROLIEiJ_G0032995	Nkrf	100	94.928	Mus_caroli
ENSG00000186416	NKRF	100	94.783	ENSMUSG00000044149	Nkrf	100	94.783	Mus_musculus
ENSG00000186416	NKRF	100	94.493	MGP_PahariEiJ_G0031539	Nkrf	100	94.493	Mus_pahari
ENSG00000186416	NKRF	100	94.493	MGP_SPRETEiJ_G0034148	Nkrf	100	94.493	Mus_spretus
ENSG00000186416	NKRF	100	96.232	ENSMPUG00000001548	NKRF	89	96.264	Mustela_putorius_furo
ENSG00000186416	NKRF	100	94.645	ENSMLUG00000005621	NKRF	100	94.645	Myotis_lucifugus
ENSG00000186416	NKRF	100	93.623	ENSNGAG00000023851	Nkrf	100	93.623	Nannospalax_galili
ENSG00000186416	NKRF	95	53.076	ENSNBRG00000011707	nkrf	99	46.718	Neolamprologus_brichardi
ENSG00000186416	NKRF	100	99.858	ENSNLEG00000034548	NKRF	100	99.858	Nomascus_leucogenys
ENSG00000186416	NKRF	100	73.555	ENSMEUG00000003028	NKRF	100	73.555	Notamacropus_eugenii
ENSG00000186416	NKRF	94	96.467	ENSOPRG00000016532	-	100	96.467	Ochotona_princeps
ENSG00000186416	NKRF	100	96.377	ENSODEG00000003502	NKRF	100	96.377	Octodon_degus
ENSG00000186416	NKRF	92	53.251	ENSONIG00000002526	nkrf	100	47.172	Oreochromis_niloticus
ENSG00000186416	NKRF	100	76.149	ENSOANG00000002598	-	100	76.149	Ornithorhynchus_anatinus
ENSG00000186416	NKRF	52	80.712	ENSOANG00000001806	-	100	80.712	Ornithorhynchus_anatinus
ENSG00000186416	NKRF	92	68.740	ENSOANG00000013932	-	100	68.740	Ornithorhynchus_anatinus
ENSG00000186416	NKRF	100	96.957	ENSOCUG00000016741	NKRF	100	96.957	Oryctolagus_cuniculus
ENSG00000186416	NKRF	99	44.788	ENSORLG00000022867	nkrf	99	44.659	Oryzias_latipes
ENSG00000186416	NKRF	91	51.664	ENSORLG00020003902	nkrf	99	45.174	Oryzias_latipes_hni
ENSG00000186416	NKRF	91	51.313	ENSORLG00015013035	nkrf	99	44.659	Oryzias_latipes_hsok
ENSG00000186416	NKRF	99	45.161	ENSOMEG00000014617	nkrf	99	45.935	Oryzias_melastigma
ENSG00000186416	NKRF	100	96.957	ENSOGAG00000009703	NKRF	93	96.983	Otolemur_garnettii
ENSG00000186416	NKRF	100	96.522	ENSOARG00000016167	NKRF	100	96.522	Ovis_aries
ENSG00000186416	NKRF	100	100.000	ENSPPAG00000002315	NKRF	100	100.000	Pan_paniscus
ENSG00000186416	NKRF	100	97.826	ENSPPRG00000023645	NKRF	100	97.826	Panthera_pardus
ENSG00000186416	NKRF	100	97.826	ENSPTIG00000015381	NKRF	100	97.826	Panthera_tigris_altaica
ENSG00000186416	NKRF	100	100.000	ENSPTRG00000022226	NKRF	100	100.000	Pan_troglodytes
ENSG00000186416	NKRF	100	99.574	ENSPANG00000010949	NKRF	100	99.574	Papio_anubis
ENSG00000186416	NKRF	99	38.776	ENSPKIG00000013989	NKRF	98	39.048	Paramormyrops_kingsleyae
ENSG00000186416	NKRF	93	52.509	ENSPKIG00000019002	nkrf	87	52.509	Paramormyrops_kingsleyae
ENSG00000186416	NKRF	100	68.354	ENSPSIG00000006177	NKRF	96	68.534	Pelodiscus_sinensis
ENSG00000186416	NKRF	96	44.945	ENSPMGG00000012086	nkrf	97	45.082	Periophthalmus_magnuspinnatus
ENSG00000186416	NKRF	90	51.950	ENSPLAG00000019829	nkrf	82	52.128	Poecilia_latipinna
ENSG00000186416	NKRF	90	52.205	ENSPMEG00000023417	nkrf	82	52.205	Poecilia_mexicana
ENSG00000186416	NKRF	90	52.220	ENSPREG00000012340	nkrf	82	52.398	Poecilia_reticulata
ENSG00000186416	NKRF	100	99.855	ENSPPYG00000020672	NKRF	89	99.856	Pongo_abelii
ENSG00000186416	NKRF	100	97.681	ENSPCOG00000026266	NKRF	100	97.681	Propithecus_coquereli
ENSG00000186416	NKRF	97	96.577	ENSPVAG00000003266	NKRF	100	96.577	Pteropus_vampyrus
ENSG00000186416	NKRF	93	59.375	ENSPNYG00000009655	nkrf	99	44.638	Pundamilia_nyererei
ENSG00000186416	NKRF	88	52.065	ENSPNAG00000018967	nkrf	73	52.783	Pygocentrus_nattereri
ENSG00000186416	NKRF	100	99.420	ENSRBIG00000033103	NKRF	100	99.291	Rhinopithecus_bieti
ENSG00000186416	NKRF	100	99.420	ENSRROG00000034488	NKRF	100	99.420	Rhinopithecus_roxellana
ENSG00000186416	NKRF	100	98.261	ENSSBOG00000021175	NKRF	100	98.261	Saimiri_boliviensis_boliviensis
ENSG00000186416	NKRF	100	73.699	ENSSHAG00000006903	-	100	73.699	Sarcophilus_harrisii
ENSG00000186416	NKRF	99	65.945	ENSSHAG00000006028	-	99	65.945	Sarcophilus_harrisii
ENSG00000186416	NKRF	73	68.317	ENSSHAG00000005164	-	100	68.317	Sarcophilus_harrisii
ENSG00000186416	NKRF	99	44.414	ENSSFOG00015010898	NKRF	91	44.368	Scleropages_formosus
ENSG00000186416	NKRF	88	54.613	ENSSFOG00015005460	nkrf	70	54.244	Scleropages_formosus
ENSG00000186416	NKRF	84	53.005	ENSSMAG00000012780	nkrf	99	44.975	Scophthalmus_maximus
ENSG00000186416	NKRF	85	53.005	ENSSDUG00000005559	nkrf	82	52.144	Seriola_dumerili
ENSG00000186416	NKRF	85	53.102	ENSSLDG00000003347	nkrf	82	52.234	Seriola_lalandi_dorsalis
ENSG00000186416	NKRF	99	64.356	ENSSPUG00000013178	NKRF	91	64.095	Sphenodon_punctatus
ENSG00000186416	NKRF	99	44.110	ENSSPAG00000010145	nkrf	99	45.113	Stegastes_partitus
ENSG00000186416	NKRF	100	97.536	ENSSSCG00000012620	NKRF	89	97.557	Sus_scrofa
ENSG00000186416	NKRF	78	78.545	ENSTGUG00000003354	-	100	78.545	Taeniopygia_guttata
ENSG00000186416	NKRF	100	68.534	ENSTGUG00000003356	-	100	68.822	Taeniopygia_guttata
ENSG00000186416	NKRF	81	51.489	ENSTRUG00000023782	nkrf	73	51.489	Takifugu_rubripes
ENSG00000186416	NKRF	99	46.866	ENSTNIG00000015760	nkrf	99	46.866	Tetraodon_nigroviridis
ENSG00000186416	NKRF	100	87.826	ENSTBEG00000017226	NKRF	99	87.826	Tupaia_belangeri
ENSG00000186416	NKRF	99	96.930	ENSTTRG00000013108	NKRF	100	96.930	Tursiops_truncatus
ENSG00000186416	NKRF	100	97.101	ENSUAMG00000028368	NKRF	100	97.101	Ursus_americanus
ENSG00000186416	NKRF	100	97.101	ENSUMAG00000002134	NKRF	100	97.101	Ursus_maritimus
ENSG00000186416	NKRF	82	99.020	ENSVPAG00000000648	NKRF	83	99.020	Vicugna_pacos
ENSG00000186416	NKRF	100	97.681	ENSVVUG00000011528	NKRF	100	97.681	Vulpes_vulpes
ENSG00000186416	NKRF	94	51.156	ENSXETG00000007438	nkrf	86	51.156	Xenopus_tropicalis
ENSG00000186416	NKRF	100	44.473	ENSXCOG00000016716	nkrf	98	44.572	Xiphophorus_couchianus
ENSG00000186416	NKRF	99	44.819	ENSXMAG00000013716	nkrf	99	44.819	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	21873635.	IBA	Function
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	10562553.	IDA	Function
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	10562553.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	21900206.21903422.29021621.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	10562553.	IDA	Component
GO:0005654	nucleoplasm	21873635.	IBA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0045892	negative regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0045892	negative regulation of transcription, DNA-templated	10562553.	IDA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	10562553.	IDA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
17186550	Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells.	Mol Carcinog	2007 May	Fukuyama R	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chrX	119592533	Intron	novel		0.8
BLCA	chrX	119589356	Missense_Mutation	NA	N690S	0.68
BLCA	chrX	119589348	3'UTR	novel		0.08
BLCA	chrX	119591259	Missense_Mutation	novel	R56C	0.29
BLCA	chrX	119589672	Missense_Mutation	novel	Q585K	0.36	R3H
BLCA	chrX	119592410	Nonsense_Mutation	novel	Q30*	0.11
BLCA	chrX	119590573	Silent	novel	R284R	0.12
BLCA	chrX	119590771	Silent	novel	Y218Y	0.19
BRCA	chrX	119589137	3'UTR	novel		0.25
BRCA	chrX	119590271	Missense_Mutation	novel	H385R	0.15
BRCA	chrX	119590850	Missense_Mutation	novel	S192F	0.05
BRCA	chrX	119590356	Missense_Mutation	NA	A357T	0.15
BRCA	chrX	119590357	Silent	NA	S356S	0.15
BRCA	chrX	119590890	Missense_Mutation	novel	A179T	0.18
BRCA	chrX	119589328	3'UTR	novel		0.21
BRCA	chrX	119589863	Missense_Mutation	NA	N521I	0.2
BRCA	chrX	119590304	Missense_Mutation	rs774986165	R374H	0.23
BRCA	chrX	119589140	3'UTR	novel		0.26
BRCA	chrX	119592745	Intron	novel		0.33
CESC	chrX	119592418	Missense_Mutation	novel	S27C	0.26
CESC	chrX	119589462	Missense_Mutation	NA	D655N	0.29
CESC	chrX	119588932	3'UTR	novel		0.24
CESC	chrX	119588907	3'UTR	novel		0.14
CESC	chrX	119590260	Missense_Mutation	novel	E389K	0.09
CESC	chrX	119589580	Silent	novel	R615R	0.36
CESC	chrX	119590435	Silent	novel	F330F	0.06
CESC	chrX	119590889	Missense_Mutation	NA	A179V	0.3
CESC	chrX	119591264	Missense_Mutation	NA	R54I	0.24
CESC	chrX	119590620	Missense_Mutation	novel	L269I	0.23
CESC	chrX	119605742	5'UTR	novel		0.15
CESC	chrX	119588856	3'UTR	novel		0.26
CESC	chrX	119590071	Missense_Mutation	NA	V452M	0.28
COAD	chrX	119589282	3'UTR	rs530938687		0.11
COAD	chrX	119591266	Silent	NA	A53A	0.12
COAD	chrX	119590064	Missense_Mutation	rs767690358	T454M	0.46
COAD	chrX	119590037	Missense_Mutation	novel	R463Q	0.71
COAD	chrX	119590941	Missense_Mutation	NA	F162I	0.3
COAD	chrX	119589224	3'UTR	novel		0.38
COAD	chrX	119590576	Silent	NA	V283V	0.28
COAD	chrX	119590725	Missense_Mutation	NA	K234Q	0.09
COAD	chrX	119592485	Missense_Mutation	NA	L5I	0.76
COAD	chrX	119589435	Frame_Shift_Del	NA	*R664Dfs7**	0.22
ESCA	chrX	119590483	Silent	novel	P314P	0.17
ESCA	chrX	119589506	Missense_Mutation	novel	A640V	0.87
GBM	chrX	119590060	Silent	novel	L455L	0.33
HNSC	chrX	119590019	Missense_Mutation	novel	V469D	0.35
HNSC	chrX	119589922	Silent	novel	Y501Y	0.11
HNSC	chrX	119589578	Missense_Mutation	novel	S616F	0.38
HNSC	chrX	119590299	Missense_Mutation	novel	W376G	0.3
KIRC	chrX	119590277	Missense_Mutation	NA	Q383P	0.56
KIRC	chrX	119591160	Nonsense_Mutation	novel	*H88_F89insDE**	0.04
LAML	chrX	119589979	Silent	NA	V482V	0.04
LAML	chrX	119590612	Silent	NA	V271V	0.1
LAML	chrX	119589996	Missense_Mutation	NA	R477C	0.11
LGG	chrX	119589352	Nonstop_Mutation	novel	691Cext48	0.17
LGG	chrX	119590071	Missense_Mutation	NA	V452M	0.45
LGG	chrX	119590053	Missense_Mutation	NA	T458A	0.28
LUAD	chrX	119589645	Missense_Mutation	novel	D594H	0.25	R3H
LUAD	chrX	119590207	Frame_Shift_Ins	novel	*L406Ffs41**	0.46
LUAD	chrX	119590614	Missense_Mutation	NA	V271L	0.43
LUAD	chrX	119589796	Missense_Mutation	novel	E543D	0.04
LUAD	chrX	119589581	Missense_Mutation	rs754192956	R615L	0.13
LUAD	chrX	119590933	Missense_Mutation	novel	E164D	0.12
LUAD	chrX	119590606	Silent	novel	L273L	0.09
LUAD	chrX	119589923	Missense_Mutation	novel	Y501C	0.2
LUSC	chrX	119589546	Missense_Mutation	novel	E627K	0.1
LUSC	chrX	119590234	Silent	NA	S397S	0.89
LUSC	chrX	119589499	Missense_Mutation	novel	K642N	0.65
LUSC	chrX	119589286	3'UTR	novel		0.17
LUSC	chrX	119589342	3'UTR	rs747237328		0.09
LUSC	chrX	119589587	Missense_Mutation	novel	Y613S	0.1
LUSC	chrX	119589889	Silent	novel	K512K	0.72
LUSC	chrX	119592437	Silent	rs749369156	L21L	0.14
OV	chrX	119589186	3'UTR	novel		0.2
OV	chrX	119590165	Missense_Mutation	NA	K420N	0.17
OV	chrX	119590295	Missense_Mutation	novel	R377P	0.39
OV	chrX	119589338	3'UTR	novel		0.48
OV	chrX	119589571	Missense_Mutation	NA	S618R	0.33
OV	chrX	119591088	Nonsense_Mutation	novel	Q113*	0.16
OV	chrX	119589137	3'UTR	novel		0.5
PAAD	chrX	119591295	Nonsense_Mutation	novel	K44*	0.18
PAAD	chrX	119589272	3'UTR	novel		0.26
PAAD	chrX	119590062	Silent	rs192991563	L455L	0.27
PAAD	chrX	119590289	Missense_Mutation	NA	R379Q	0.03
READ	chrX	119589921	Missense_Mutation	novel	E502K	0.88
READ	chrX	119590892	Missense_Mutation	rs144370117	T178M	0.34
SKCM	chrX	119591083	Silent	rs148494768	Y114Y	0.63
SKCM	chrX	119592485	Missense_Mutation	NA	L5I	0.12
STAD	chrX	119592521	Splice_Region	novel		0.71
STAD	chrX	119589368	Missense_Mutation	NA	M686T	0.08
STAD	chrX	119590071	Missense_Mutation	NA	V452M	0.37
STAD	chrX	119590892	Missense_Mutation	rs144370117	T178M	0.13
STAD	chrX	119589995	Missense_Mutation	novel	R477H	0.19
STAD	chrX	119590687	Silent	novel	C246C	0.16
STAD	chrX	119590572	Missense_Mutation	NA	R285W	0.24
STAD	chrX	119590017	Missense_Mutation	novel	Y470N	0.68
STAD	chrX	119589918	Missense_Mutation	NA	A503T	0.23
STAD	chrX	119589379	Silent	rs771236230	Y682Y	0.13
THYM	chrX	119605733	Splice_Region	novel		0.1
UCEC	chrX	119605762	5'UTR	novel		0.3
UCEC	chrX	119589325	3'UTR	novel		0.4
UCEC	chrX	119590018	Silent	NA	V469V	0.33
UCEC	chrX	119591264	Missense_Mutation	NA	R54I	0.32
UCEC	chrX	119592522	Intron	novel		0.27
UCEC	chrX	119589586	Silent	rs777786476	Y613Y	0.28
UCEC	chrX	119592707	Intron	novel		0.63
UCEC	chrX	119590295	Missense_Mutation	rs763380713	R377H	0.38
UCEC	chrX	119589494	Missense_Mutation	novel	G644D	0.21
UCEC	chrX	119589378	Missense_Mutation	NA	E683K	0.37
UCEC	chrX	119590976	Missense_Mutation	NA	S150Y	0.35
UCEC	chrX	119592485	Missense_Mutation	NA	L5I	0.27
UCEC	chrX	119589306	3'UTR	novel		0.18
UCEC	chrX	119590305	Missense_Mutation	novel	R374C	0.4
UCEC	chrX	119590850	Missense_Mutation	novel	S192Y	0.36
UCEC	chrX	119589879	Missense_Mutation	novel	P516S	0.17
UCEC	chrX	119590430	Missense_Mutation	novel	A332V	0.2
UCEC	chrX	119590437	Missense_Mutation	novel	F330V	0.37
UCEC	chrX	119592470	Missense_Mutation	rs759412338	G10C	0.4
UCEC	chrX	119589848	Missense_Mutation	novel	A526V	0.07
UCEC	chrX	119589582	Missense_Mutation	rs140452307	R615C	0.2
UCEC	chrX	119590154	Missense_Mutation	NA	C424Y	0.19
UCEC	chrX	119591142	Missense_Mutation	NA	D95Y	0.21
UCEC	chrX	119589710	Missense_Mutation	NA	S572F	0.39	R3H
UCEC	chrX	119590037	Missense_Mutation	novel	R463Q	0.46
UCEC	chrX	119590142	Missense_Mutation	novel	S428Y	0.41
UCEC	chrX	119591130	Missense_Mutation	novel	D99Y	0.07
UCEC	chrX	119592400	Missense_Mutation	NA	H33R	0.21
UCEC	chrX	119590057	Silent	NA	N456N	0.47
UCEC	chrX	119590403	Missense_Mutation	novel	V341A	0.38
UCEC	chrX	119589282	3'UTR	rs530938687		0.36
UCEC	chrX	119591142	Missense_Mutation	NA	D95Y	0.49
UCEC	chrX	119590289	Missense_Mutation	NA	R379Q	0.4
UCEC	chrX	119592503	5'UTR	rs765165264		0.41
UCEC	chrX	119588401	3'UTR	novel		0.54
UCEC	chrX	119589832	Silent	novel	I531I	0.29
UCEC	chrX	119589626	Missense_Mutation	novel	K600R	0.32	R3H
UCEC	chrX	119588740	3'UTR	novel		0.46
UCEC	chrX	119588845	3'UTR	novel		0.13
UCEC	chrX	119589526	Silent	novel	R633R	0.08
UCEC	chrX	119589811	Silent	novel	G538G	0.24
UCEC	chrX	119588881	3'UTR	novel		0.31
UCEC	chrX	119590921	Silent	rs766020454	A168A	0.39
UCEC	chrX	119588384	3'UTR	novel		0.28
UCEC	chrX	119590873	Missense_Mutation	novel	N184K	0.29
UCEC	chrX	119590659	Missense_Mutation	novel	A256T	0.41
UCEC	chrX	119588659	3'UTR	novel		0.53
UCEC	chrX	119589564	Missense_Mutation	novel	D621Y	0.43
UCEC	chrX	119590566	Missense_Mutation	novel	F287V	0.38
UCEC	chrX	119605774	5'UTR	novel		0.39
UCEC	chrX	119588845	3'UTR	novel		0.44
UCEC	chrX	119589526	Silent	novel	R633R	0.38
UCEC	chrX	119589951	Missense_Mutation	novel	A492S	0.52
UCEC	chrX	119591200	Silent	novel	P75P	0.38
UCEC	chrX	119590287	Missense_Mutation	NA	V380M	0.23
UCEC	chrX	119590290	Nonsense_Mutation	novel	R379*	0.1
UCEC	chrX	119592476	Missense_Mutation	NA	A8T	0.31
UCEC	chrX	119588376	3'UTR	novel		0.35
UCEC	chrX	119588976	3'UTR	novel		0.15
UCEC	chrX	119605833	5'UTR	novel		0.33
UCEC	chrX	119591187	In_Frame_Ins	novel	Q79_T80insLQNLSSDPFI	0.05
UCEC	chrX	119605786	5'UTR	novel		0.08
UCEC	chrX	119589185	3'UTR	novel		0.11
UCEC	chrX	119589568	Silent	rs760355187	H619H	0.27
UCEC	chrX	119589710	Missense_Mutation	NA	S572Y	0.32	R3H
UCEC	chrX	119590892	Missense_Mutation	rs144370117	T178M	0.06
UCEC	chrX	119589887	Missense_Mutation	NA	K513T	0.47
UCEC	chrX	119589586	Silent	rs777786476	Y613Y	0.14
UCEC	chrX	119590082	Missense_Mutation	NA	S448Y	0.09
UCEC	chrX	119590258	Missense_Mutation	NA	E389D	0.28
UCEC	chrX	119590889	Missense_Mutation	NA	A179V	0.33
UCEC	chrX	119592485	Missense_Mutation	NA	L5I	0.38
UCEC	chrX	119589933	Missense_Mutation	novel	T498A	0.25
UCEC	chrX	119590910	Missense_Mutation	novel	Y172C	0.29
UCEC	chrX	119590860	Nonsense_Mutation	NA	E189*	0.34
UCEC	chrX	119588395	3'UTR	novel		0.43
UCEC	chrX	119590596	Missense_Mutation	NA	R277C	0.3
UCEC	chrX	119588932	3'UTR	novel		0.48
UCEC	chrX	119590787	Missense_Mutation	novel	N213S	0.44
UCEC	chrX	119592522	Intron	novel		0.3
UCEC	chrX	119588476	3'UTR	novel		0.35
UCEC	chrX	119589261	3'UTR	novel		0.39
UCEC	chrX	119589350	3'UTR	novel		0.37
UCEC	chrX	119590024	Silent	novel	E467E	0.32
UCEC	chrX	119590572	Missense_Mutation	NA	R285W	0.09
UCEC	chrX	119590872	Missense_Mutation	novel	L185I	0.46
UCS	chrX	119590382	Missense_Mutation	novel	D348G	0.21
UCS	chrX	119590965	Missense_Mutation	novel	P154T	0.28

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRC	AMP	0.0284	0.12739
TGCT	DEL	0.0667	0.08422
THCA	DEL	0	0.21991

Survival Analysis

Cancer	P-value	Q-value
SARC	0.0093	Kaplan-Meier Survival Analysis
MESO	0.024	Kaplan-Meier Survival Analysis
HNSC	0.0065	Kaplan-Meier Survival Analysis
SKCM	0.0014	Kaplan-Meier Survival Analysis
BRCA	0.019	Kaplan-Meier Survival Analysis
ESCA	0.022	Kaplan-Meier Survival Analysis
KIRP	0.0011	Kaplan-Meier Survival Analysis
LIHC	0.00019	Kaplan-Meier Survival Analysis
DLBC	0.028	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
THCA	0.024	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742