EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000186566 (Gene tree)
Gene ID: 23131
Gene Symbol: GPATCH8
Alias: KIAA0553|GPATC8
Full Name: G-patch domain containing 8
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 108,326 bases
Position: chr17:44,395,277-44,503,602
Accession: 29066
RBP type: canonical RBP
Summary: The protein encoded by this gene contains an RNA-processing domain, a zinc finger domain, a lysine-rich region and a serine-rich region. A mutation in the serine-rich region of the protein is thought to be associated with hyperuricemia (PMID: 21594610). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000465781	zf-C2H2_jaz	PF12171.8	5e-07	1	1
ENSP00000467556	zf-C2H2_jaz	PF12171.8	1e-05	1	1
ENSP00000465781	G-patch	PF01585.23	1.6e-13	1	1
ENSP00000467556	G-patch	PF01585.23	3.1e-12	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30597088	Convergent Evidence That ZNF804A Is a Regulator of Pre-messenger RNA Processing and Gene Expression.	Schizophr Bull	2018 Dec 29	Chapman RM	doi: 10.1093/schbul/sby183

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000590041	GPATCH8-207	829	-	ENSP00000467233	46 (aa)	-	K7EQK8
ENST00000587228	GPATCH8-205	4713	-	ENSP00000468719	43 (aa)	-	Q9UKJ3
ENST00000588554	GPATCH8-206	565	-	-	- (aa)	-	-
ENST00000585614	GPATCH8-202	686	-	ENSP00000465781	221 (aa)	-	K7EKU0
ENST00000635257	GPATCH8-211	5602	-	-	- (aa)	-	-
ENST00000586037	GPATCH8-203	345	-	ENSP00000468821	46 (aa)	-	K7EQK8
ENST00000592746	GPATCH8-210	457	-	ENSP00000464815	46 (aa)	-	K7EQK8
ENST00000335500	GPATCH8-201	8109	-	-	- (aa)	-	-
ENST00000586265	GPATCH8-204	484	-	-	- (aa)	-	-
ENST00000591680	GPATCH8-208	4692	XM_011524557	ENSP00000467556	1502 (aa)	XP_011522859	Q9UKJ3
ENST00000592154	GPATCH8-209	650	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000186566's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000186566	Platelet Function Tests	7.6401637E-006	-
ENSG00000186566	Platelet Function Tests	1.1258700E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000186566	rs117964596	17	44463788	T	Pulse pressure	30578418	[0.34-0.59] mmHg decrease	0.4634	EFO_0005763

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000186566's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000186566	GPATCH8	100	93.418	ENSAMEG00000018376	GPATCH8	99	93.609	Ailuropoda_melanoleuca
ENSG00000186566	GPATCH8	83	97.268	ENSAPLG00000003095	GPATCH8	54	64.466	Anas_platyrhynchos
ENSG00000186566	GPATCH8	93	100.000	ENSACAG00000012522	GPATCH8	54	59.005	Anolis_carolinensis
ENSG00000186566	GPATCH8	100	97.870	ENSANAG00000032773	GPATCH8	100	97.870	Aotus_nancymaae
ENSG00000186566	GPATCH8	93	100.000	ENSBTAG00000038316	GPATCH8	100	92.185	Bos_taurus
ENSG00000186566	GPATCH8	100	97.004	ENSCJAG00000009807	GPATCH8	100	97.004	Callithrix_jacchus
ENSG00000186566	GPATCH8	100	94.149	ENSCAFG00000014136	GPATCH8	100	94.215	Canis_familiaris
ENSG00000186566	GPATCH8	99	94.098	ENSCAFG00020009830	GPATCH8	99	94.165	Canis_lupus_dingo
ENSG00000186566	GPATCH8	99	92.241	ENSCHIG00000008962	GPATCH8	99	91.512	Capra_hircus
ENSG00000186566	GPATCH8	93	100.000	ENSTSYG00000033153	GPATCH8	100	86.521	Carlito_syrichta
ENSG00000186566	GPATCH8	100	97.736	ENSCCAG00000030686	GPATCH8	100	97.736	Cebus_capucinus
ENSG00000186566	GPATCH8	100	98.535	ENSCATG00000028156	GPATCH8	100	98.535	Cercocebus_atys
ENSG00000186566	GPATCH8	100	98.469	ENSCSAG00000003586	GPATCH8	100	98.469	Chlorocebus_sabaeus
ENSG00000186566	GPATCH8	93	100.000	ENSCPBG00000008955	GPATCH8	54	65.274	Chrysemys_picta_bellii
ENSG00000186566	GPATCH8	100	98.535	ENSCANG00000039731	GPATCH8	100	98.535	Colobus_angolensis_palliatus
ENSG00000186566	GPATCH8	93	100.000	ENSCGRG00001020210	Gpatch8	100	88.675	Cricetulus_griseus_chok1gshd
ENSG00000186566	GPATCH8	93	100.000	ENSCGRG00000017090	Gpatch8	100	88.675	Cricetulus_griseus_crigri
ENSG00000186566	GPATCH8	100	90.855	ENSDNOG00000005102	GPATCH8	100	90.192	Dasypus_novemcinctus
ENSG00000186566	GPATCH8	93	100.000	ENSDORG00000027664	Gpatch8	100	91.126	Dipodomys_ordii
ENSG00000186566	GPATCH8	93	100.000	ENSETEG00000001325	GPATCH8	100	86.161	Echinops_telfairi
ENSG00000186566	GPATCH8	93	87.500	ENSEBUG00000005749	gpatch8	70	48.445	Eptatretus_burgeri
ENSG00000186566	GPATCH8	100	94.212	ENSEASG00005010264	GPATCH8	92	94.212	Equus_asinus_asinus
ENSG00000186566	GPATCH8	100	94.145	ENSECAG00000040232	GPATCH8	99	94.145	Equus_caballus
ENSG00000186566	GPATCH8	94	100.000	ENSEEUG00000008586	GPATCH8	94	100.000	Erinaceus_europaeus
ENSG00000186566	GPATCH8	93	100.000	ENSFCAG00000043334	GPATCH8	56	92.900	Felis_catus
ENSG00000186566	GPATCH8	91	94.030	ENSFALG00000009554	GPATCH8	51	64.879	Ficedula_albicollis
ENSG00000186566	GPATCH8	93	87.805	ENSGMOG00000005249	-	100	86.580	Gadus_morhua
ENSG00000186566	GPATCH8	93	100.000	ENSGALG00000041556	GPATCH8	54	61.510	Gallus_gallus
ENSG00000186566	GPATCH8	93	100.000	ENSGAGG00000008358	GPATCH8	54	65.306	Gopherus_agassizii
ENSG00000186566	GPATCH8	100	97.270	ENSGGOG00000013860	GPATCH8	100	97.270	Gorilla_gorilla
ENSG00000186566	GPATCH8	93	100.000	ENSHGLG00000017687	GPATCH8	55	70.228	Heterocephalus_glaber_female
ENSG00000186566	GPATCH8	93	96.098	ENSHGLG00100010738	GPATCH8	98	77.446	Heterocephalus_glaber_male
ENSG00000186566	GPATCH8	100	93.227	ENSSTOG00000025022	GPATCH8	100	92.430	Ictidomys_tridecemlineatus
ENSG00000186566	GPATCH8	93	100.000	ENSJJAG00000017797	Gpatch8	100	89.788	Jaculus_jaculus
ENSG00000186566	GPATCH8	93	95.000	ENSLACG00000017530	GPATCH8	55	56.568	Latimeria_chalumnae
ENSG00000186566	GPATCH8	93	95.000	ENSLOCG00000012265	gpatch8	55	75.000	Lepisosteus_oculatus
ENSG00000186566	GPATCH8	93	97.573	ENSLAFG00000032250	GPATCH8	100	90.809	Loxodonta_africana
ENSG00000186566	GPATCH8	100	98.735	ENSMFAG00000039126	GPATCH8	100	98.735	Macaca_fascicularis
ENSG00000186566	GPATCH8	100	98.735	ENSMMUG00000012658	GPATCH8	100	98.735	Macaca_mulatta
ENSG00000186566	GPATCH8	100	98.602	ENSMNEG00000031426	GPATCH8	100	98.602	Macaca_nemestrina
ENSG00000186566	GPATCH8	100	98.735	ENSMLEG00000038860	GPATCH8	100	98.735	Mandrillus_leucophaeus
ENSG00000186566	GPATCH8	72	96.226	ENSMGAG00000009586	-	100	75.224	Meleagris_gallopavo
ENSG00000186566	GPATCH8	93	100.000	ENSMAUG00000021770	Gpatch8	100	88.867	Mesocricetus_auratus
ENSG00000186566	GPATCH8	100	95.606	ENSMICG00000028586	GPATCH8	100	95.606	Microcebus_murinus
ENSG00000186566	GPATCH8	93	100.000	ENSMOCG00000001658	Gpatch8	100	88.434	Microtus_ochrogaster
ENSG00000186566	GPATCH8	93	100.000	ENSMODG00000011442	GPATCH8	100	80.093	Monodelphis_domestica
ENSG00000186566	GPATCH8	93	100.000	MGP_CAROLIEiJ_G0017255	Gpatch8	100	89.418	Mus_caroli
ENSG00000186566	GPATCH8	93	100.000	ENSMUSG00000034621	Gpatch8	100	88.882	Mus_musculus
ENSG00000186566	GPATCH8	93	100.000	MGP_PahariEiJ_G0018385	Gpatch8	100	89.380	Mus_pahari
ENSG00000186566	GPATCH8	93	100.000	MGP_SPRETEiJ_G0018098	Gpatch8	100	89.050	Mus_spretus
ENSG00000186566	GPATCH8	100	93.285	ENSMPUG00000009274	GPATCH8	100	93.351	Mustela_putorius_furo
ENSG00000186566	GPATCH8	93	96.117	ENSMLUG00000013840	GPATCH8	99	95.918	Myotis_lucifugus
ENSG00000186566	GPATCH8	93	100.000	ENSNGAG00000021860	Gpatch8	100	90.470	Nannospalax_galili
ENSG00000186566	GPATCH8	100	86.992	ENSMEUG00000011799	GPATCH8	100	78.194	Notamacropus_eugenii
ENSG00000186566	GPATCH8	93	100.000	ENSOPRG00000008816	GPATCH8	100	84.032	Ochotona_princeps
ENSG00000186566	GPATCH8	63	96.296	ENSOANG00000029558	-	79	92.982	Ornithorhynchus_anatinus
ENSG00000186566	GPATCH8	72	97.484	ENSOANG00000032243	-	99	80.258	Ornithorhynchus_anatinus
ENSG00000186566	GPATCH8	93	100.000	ENSOCUG00000003291	GPATCH8	100	91.151	Oryctolagus_cuniculus
ENSG00000186566	GPATCH8	97	95.212	ENSOGAG00000033643	GPATCH8	100	95.212	Otolemur_garnettii
ENSG00000186566	GPATCH8	93	100.000	ENSOARG00000008370	GPATCH8	100	87.931	Ovis_aries
ENSG00000186566	GPATCH8	100	99.534	ENSPPAG00000040523	GPATCH8	100	99.534	Pan_paniscus
ENSG00000186566	GPATCH8	100	94.082	ENSPPRG00000023310	GPATCH8	100	94.149	Panthera_pardus
ENSG00000186566	GPATCH8	93	100.000	ENSPTIG00000020001	GPATCH8	100	92.287	Panthera_tigris_altaica
ENSG00000186566	GPATCH8	100	99.601	ENSPTRG00000009278	GPATCH8	100	99.601	Pan_troglodytes
ENSG00000186566	GPATCH8	100	98.602	ENSPANG00000021304	GPATCH8	100	98.602	Papio_anubis
ENSG00000186566	GPATCH8	83	98.361	ENSPSIG00000006255	GPATCH8	56	62.110	Pelodiscus_sinensis
ENSG00000186566	GPATCH8	93	100.000	ENSPEMG00000008337	Gpatch8	100	88.999	Peromyscus_maniculatus_bairdii
ENSG00000186566	GPATCH8	58	69.531	ENSPMAG00000009583	-	100	48.254	Petromyzon_marinus
ENSG00000186566	GPATCH8	95	81.729	ENSPCIG00000019927	GPATCH8	100	79.219	Phascolarctos_cinereus
ENSG00000186566	GPATCH8	100	98.469	ENSPPYG00000008329	GPATCH8	100	98.469	Pongo_abelii
ENSG00000186566	GPATCH8	93	100.000	ENSPCAG00000004441	GPATCH8	77	100.000	Procavia_capensis
ENSG00000186566	GPATCH8	99	99.087	ENSPCOG00000019209	GPATCH8	100	93.542	Propithecus_coquereli
ENSG00000186566	GPATCH8	93	100.000	ENSPVAG00000003155	GPATCH8	100	92.093	Pteropus_vampyrus
ENSG00000186566	GPATCH8	93	100.000	ENSRNOG00000021044	Gpatch8	55	85.457	Rattus_norvegicus
ENSG00000186566	GPATCH8	100	98.535	ENSRBIG00000033713	GPATCH8	100	98.535	Rhinopithecus_bieti
ENSG00000186566	GPATCH8	100	98.535	ENSRROG00000029623	GPATCH8	100	98.535	Rhinopithecus_roxellana
ENSG00000186566	GPATCH8	100	97.936	ENSSBOG00000023544	GPATCH8	100	97.936	Saimiri_boliviensis_boliviensis
ENSG00000186566	GPATCH8	93	100.000	ENSSHAG00000016140	GPATCH8	100	79.855	Sarcophilus_harrisii
ENSG00000186566	GPATCH8	100	89.037	ENSSARG00000007516	GPATCH8	100	89.037	Sorex_araneus
ENSG00000186566	GPATCH8	100	93.179	ENSSSCG00000017357	ITGA2B	100	92.039	Sus_scrofa
ENSG00000186566	GPATCH8	65	88.811	ENSTNIG00000011682	-	80	55.172	Tetraodon_nigroviridis
ENSG00000186566	GPATCH8	93	100.000	ENSTBEG00000009486	GPATCH8	91	96.894	Tupaia_belangeri
ENSG00000186566	GPATCH8	99	88.621	ENSTTRG00000010527	GPATCH8	100	88.019	Tursiops_truncatus
ENSG00000186566	GPATCH8	95	90.884	ENSUMAG00000013891	GPATCH8	100	90.884	Ursus_maritimus
ENSG00000186566	GPATCH8	99	86.008	ENSVPAG00000006937	GPATCH8	99	91.355	Vicugna_pacos
ENSG00000186566	GPATCH8	100	94.082	ENSVVUG00000017996	GPATCH8	100	94.149	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	16713569.	IPI	Function
GO:0005575	cellular_component	-	ND	Component
GO:0008150	biological_process	-	ND	Process
GO:0046872	metal ion binding	-	IEA	Function