EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000186666 (Gene tree)
Gene ID: 144233
Gene Symbol: BCDIN3D
Alias: N
Full Name: BCDIN3 domain containing RNA methyltransferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 7,091 bases
Position: chr12:49,836,039-49,843,129
Accession: 27050
RBP type: canonical RBP
Summary: This gene encodes an RNA methyltransferase which belongs to the rossmann fold methyltransferase family, and serves as a 5'-methylphosphate capping enzyme that is specific for cytoplasmic histidyl tRNA. The encoded protein contains an S-adenosylmethionine binding domain and uses the methyl group donor, S-adenosylmethionine. This gene is overexpressed in breast cancer cells, and is related to the tumorigenic phenotype and poor prognosis of breast cancer. The encoded protein is thought to promote the cellular invasion of breast cancer cells, by downregulating the expression of tumor suppressor miRNAs through the dimethylation of the 5-monophosphate of the corresponding precursor miRNAs. [provided by RefSeq, Apr 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000335201	Bin3	PF06859.12	4.4e-18	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000550861	BCDIN3D-202	1129	-	-	- (aa)	-	-
ENST00000333924	BCDIN3D-201	3253	-	ENSP00000335201	292 (aa)	-	Q7Z5W3

Gene Model

Click here to download ENSG00000186666's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000186666	Body Mass Index	5E-18	26604143
ENSG00000186666	Body Mass Index	2E-17	25673413
ENSG00000186666	Menarche	2E-12	25231870
ENSG00000186666	Menarche	1E-8	27182965
ENSG00000186666	Body Mass Index	6E-11	25673413
ENSG00000186666	Body Mass Index	2E-9	23563607
ENSG00000186666	Body Weight	2E-7	19079260
ENSG00000186666	Waist Circumference	9E-12	25673412
ENSG00000186666	Body Mass Index	5E-26	25673413
ENSG00000186666	Body Mass Index	2E-17	20935630
ENSG00000186666	Waist Circumference	8E-7	25673412
ENSG00000186666	Body Mass Index	1E-7	19079260
ENSG00000186666	Waist Circumference	2E-15	25673412
ENSG00000186666	Body Mass Index	8E-24	25673413
ENSG00000186666	Hip	8E-13	25673412
ENSG00000186666	Obesity	1E-20	23563607
ENSG00000186666	Obesity	1E-16	23563607
ENSG00000186666	Waist Circumference	8E-7	19557197
ENSG00000186666	Hip	2E-15	25673412

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000186666's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000186666	BCDIN3D	86	40.711	ENSAPOG00000011693	bcdin3d	89	42.795	Acanthochromis_polyacanthus
ENSG00000186666	BCDIN3D	95	89.493	ENSAMEG00000001025	BCDIN3D	100	89.493	Ailuropoda_melanoleuca
ENSG00000186666	BCDIN3D	82	50.833	ENSACIG00000014124	bcdin3d	93	50.833	Amphilophus_citrinellus
ENSG00000186666	BCDIN3D	85	50.607	ENSAOCG00000021202	bcdin3d	88	50.607	Amphiprion_ocellaris
ENSG00000186666	BCDIN3D	86	49.402	ENSAPEG00000011187	bcdin3d	89	49.799	Amphiprion_percula
ENSG00000186666	BCDIN3D	87	47.656	ENSATEG00000025077	bcdin3d	93	47.656	Anabas_testudineus
ENSG00000186666	BCDIN3D	64	64.894	ENSAPLG00000000887	BCDIN3D	100	64.894	Anas_platyrhynchos
ENSG00000186666	BCDIN3D	91	62.082	ENSACAG00000008417	BCDIN3D	98	62.082	Anolis_carolinensis
ENSG00000186666	BCDIN3D	97	95.053	ENSANAG00000038086	BCDIN3D	97	95.053	Aotus_nancymaae
ENSG00000186666	BCDIN3D	86	49.407	ENSACLG00000021365	bcdin3d	97	49.407	Astatotilapia_calliptera
ENSG00000186666	BCDIN3D	87	50.196	ENSAMXG00000004546	bcdin3d	94	50.196	Astyanax_mexicanus
ENSG00000186666	BCDIN3D	100	86.644	ENSBTAG00000017781	BCDIN3D	84	86.644	Bos_taurus
ENSG00000186666	BCDIN3D	100	93.515	ENSCJAG00000021042	BCDIN3D	100	93.515	Callithrix_jacchus
ENSG00000186666	BCDIN3D	100	86.689	ENSCAFG00000008389	BCDIN3D	82	86.689	Canis_familiaris
ENSG00000186666	BCDIN3D	100	86.689	ENSCAFG00020014478	BCDIN3D	100	86.689	Canis_lupus_dingo
ENSG00000186666	BCDIN3D	100	86.301	ENSCHIG00000014358	BCDIN3D	100	86.301	Capra_hircus
ENSG00000186666	BCDIN3D	100	86.007	ENSTSYG00000001190	BCDIN3D	100	86.007	Carlito_syrichta
ENSG00000186666	BCDIN3D	89	88.168	ENSCPOG00000039774	BCDIN3D	100	88.168	Cavia_porcellus
ENSG00000186666	BCDIN3D	100	93.857	ENSCCAG00000029244	BCDIN3D	100	93.857	Cebus_capucinus
ENSG00000186666	BCDIN3D	98	96.167	ENSCATG00000044648	BCDIN3D	99	96.167	Cercocebus_atys
ENSG00000186666	BCDIN3D	96	87.544	ENSCLAG00000000912	BCDIN3D	99	87.544	Chinchilla_lanigera
ENSG00000186666	BCDIN3D	98	96.864	ENSCSAG00000006048	BCDIN3D	99	96.864	Chlorocebus_sabaeus
ENSG00000186666	BCDIN3D	100	96.575	ENSCANG00000029922	BCDIN3D	99	96.575	Colobus_angolensis_palliatus
ENSG00000186666	BCDIN3D	92	82.156	ENSCGRG00001007320	Bcdin3d	99	82.156	Cricetulus_griseus_chok1gshd
ENSG00000186666	BCDIN3D	92	82.156	ENSCGRG00000001387	Bcdin3d	99	82.156	Cricetulus_griseus_crigri
ENSG00000186666	BCDIN3D	90	46.212	ENSCSEG00000019757	bcdin3d	96	46.212	Cynoglossus_semilaevis
ENSG00000186666	BCDIN3D	79	47.186	ENSCVAG00000018391	bcdin3d	94	47.521	Cyprinodon_variegatus
ENSG00000186666	BCDIN3D	82	50.397	ENSDARG00000074111	bcdin3d	94	50.397	Danio_rerio
ENSG00000186666	BCDIN3D	91	87.313	ENSDORG00000025460	Bcdin3d	97	87.313	Dipodomys_ordii
ENSG00000186666	BCDIN3D	82	35.391	FBgn0035537	CG11342	97	33.600	Drosophila_melanogaster
ENSG00000186666	BCDIN3D	97	81.754	ENSETEG00000008854	BCDIN3D	97	81.754	Echinops_telfairi
ENSG00000186666	BCDIN3D	100	86.301	ENSEASG00005004210	BCDIN3D	87	86.301	Equus_asinus_asinus
ENSG00000186666	BCDIN3D	100	86.644	ENSECAG00000020861	BCDIN3D	100	86.644	Equus_caballus
ENSG00000186666	BCDIN3D	99	82.818	ENSEEUG00000001515	BCDIN3D	100	82.818	Erinaceus_europaeus
ENSG00000186666	BCDIN3D	89	46.183	ENSELUG00000015623	bcdin3d	99	46.183	Esox_lucius
ENSG00000186666	BCDIN3D	100	87.329	ENSFCAG00000009453	BCDIN3D	100	87.329	Felis_catus
ENSG00000186666	BCDIN3D	98	84.615	ENSFDAG00000008477	BCDIN3D	97	84.615	Fukomys_damarensis
ENSG00000186666	BCDIN3D	84	46.341	ENSFHEG00000012627	bcdin3d	96	46.341	Fundulus_heteroclitus
ENSG00000186666	BCDIN3D	82	48.739	ENSGMOG00000013101	bcdin3d	98	48.739	Gadus_morhua
ENSG00000186666	BCDIN3D	86	66.142	ENSGALG00000043400	BCDIN3D	94	66.142	Gallus_gallus
ENSG00000186666	BCDIN3D	84	49.187	ENSGAFG00000001353	bcdin3d	85	49.187	Gambusia_affinis
ENSG00000186666	BCDIN3D	82	50.628	ENSGACG00000005676	bcdin3d	98	50.628	Gasterosteus_aculeatus
ENSG00000186666	BCDIN3D	69	61.765	ENSGAGG00000007915	BCDIN3D	81	61.765	Gopherus_agassizii
ENSG00000186666	BCDIN3D	86	49.407	ENSHBUG00000003414	bcdin3d	97	49.407	Haplochromis_burtoni
ENSG00000186666	BCDIN3D	100	83.959	ENSHGLG00000006401	BCDIN3D	100	83.959	Heterocephalus_glaber_female
ENSG00000186666	BCDIN3D	100	80.546	ENSHGLG00100017051	BCDIN3D	100	80.546	Heterocephalus_glaber_male
ENSG00000186666	BCDIN3D	90	45.247	ENSHCOG00000001123	bcdin3d	99	45.247	Hippocampus_comes
ENSG00000186666	BCDIN3D	89	50.965	ENSIPUG00000009539	bcdin3d	97	50.965	Ictalurus_punctatus
ENSG00000186666	BCDIN3D	91	89.474	ENSSTOG00000021275	BCDIN3D	99	89.811	Ictidomys_tridecemlineatus
ENSG00000186666	BCDIN3D	96	85.409	ENSJJAG00000013981	Bcdin3d	99	85.409	Jaculus_jaculus
ENSG00000186666	BCDIN3D	86	48.207	ENSKMAG00000014656	bcdin3d	98	48.207	Kryptolebias_marmoratus
ENSG00000186666	BCDIN3D	86	48.425	ENSLBEG00000003408	bcdin3d	98	48.425	Labrus_bergylta
ENSG00000186666	BCDIN3D	81	58.159	ENSLACG00000018048	BCDIN3D	96	56.296	Latimeria_chalumnae
ENSG00000186666	BCDIN3D	93	49.632	ENSLOCG00000005406	bcdin3d	99	49.632	Lepisosteus_oculatus
ENSG00000186666	BCDIN3D	90	90.909	ENSLAFG00000018388	BCDIN3D	100	87.368	Loxodonta_africana
ENSG00000186666	BCDIN3D	98	96.167	ENSMFAG00000038249	BCDIN3D	99	96.167	Macaca_fascicularis
ENSG00000186666	BCDIN3D	98	96.167	ENSMMUG00000022911	BCDIN3D	100	95.472	Macaca_mulatta
ENSG00000186666	BCDIN3D	98	96.167	ENSMNEG00000029191	BCDIN3D	99	96.167	Macaca_nemestrina
ENSG00000186666	BCDIN3D	98	96.516	ENSMLEG00000008159	BCDIN3D	99	96.516	Mandrillus_leucophaeus
ENSG00000186666	BCDIN3D	82	50.000	ENSMAMG00000006088	bcdin3d	93	50.000	Mastacembelus_armatus
ENSG00000186666	BCDIN3D	84	47.984	ENSMZEG00005004155	bcdin3d	91	47.984	Maylandia_zebra
ENSG00000186666	BCDIN3D	96	78.014	ENSMAUG00000011271	Bcdin3d	88	78.014	Mesocricetus_auratus
ENSG00000186666	BCDIN3D	100	89.761	ENSMICG00000031908	BCDIN3D	100	89.761	Microcebus_murinus
ENSG00000186666	BCDIN3D	87	85.433	ENSMOCG00000019038	Bcdin3d	97	83.206	Microtus_ochrogaster
ENSG00000186666	BCDIN3D	87	48.235	ENSMMOG00000004063	bcdin3d	98	48.235	Mola_mola
ENSG00000186666	BCDIN3D	90	68.441	ENSMODG00000004282	BCDIN3D	95	68.441	Monodelphis_domestica
ENSG00000186666	BCDIN3D	82	49.160	ENSMALG00000011642	bcdin3d	93	49.580	Monopterus_albus
ENSG00000186666	BCDIN3D	97	80.212	MGP_CAROLIEiJ_G0020267	Bcdin3d	99	80.212	Mus_caroli
ENSG00000186666	BCDIN3D	97	79.859	ENSMUSG00000037525	Bcdin3d	99	79.859	Mus_musculus
ENSG00000186666	BCDIN3D	97	80.919	MGP_PahariEiJ_G0020270	Bcdin3d	99	80.919	Mus_pahari
ENSG00000186666	BCDIN3D	97	80.212	MGP_SPRETEiJ_G0021162	Bcdin3d	99	80.212	Mus_spretus
ENSG00000186666	BCDIN3D	92	87.407	ENSMPUG00000014557	BCDIN3D	99	87.407	Mustela_putorius_furo
ENSG00000186666	BCDIN3D	98	87.805	ENSMLUG00000009857	BCDIN3D	99	87.805	Myotis_lucifugus
ENSG00000186666	BCDIN3D	99	82.414	ENSNGAG00000014829	Bcdin3d	100	82.414	Nannospalax_galili
ENSG00000186666	BCDIN3D	85	51.406	ENSNBRG00000007102	bcdin3d	98	51.406	Neolamprologus_brichardi
ENSG00000186666	BCDIN3D	100	98.973	ENSNLEG00000017818	BCDIN3D	99	98.973	Nomascus_leucogenys
ENSG00000186666	BCDIN3D	98	75.524	ENSOPRG00000005446	BCDIN3D	99	75.524	Ochotona_princeps
ENSG00000186666	BCDIN3D	98	85.764	ENSODEG00000009705	BCDIN3D	98	85.172	Octodon_degus
ENSG00000186666	BCDIN3D	86	50.199	ENSONIG00000006870	bcdin3d	93	50.199	Oreochromis_niloticus
ENSG00000186666	BCDIN3D	82	62.500	ENSOANG00000007743	BCDIN3D	88	58.824	Ornithorhynchus_anatinus
ENSG00000186666	BCDIN3D	91	86.466	ENSOCUG00000001545	BCDIN3D	99	86.466	Oryctolagus_cuniculus
ENSG00000186666	BCDIN3D	82	51.250	ENSORLG00000022941	bcdin3d	80	51.250	Oryzias_latipes
ENSG00000186666	BCDIN3D	86	49.603	ENSORLG00020013764	bcdin3d	96	49.603	Oryzias_latipes_hni
ENSG00000186666	BCDIN3D	86	50.000	ENSORLG00015009027	bcdin3d	82	50.000	Oryzias_latipes_hsok
ENSG00000186666	BCDIN3D	86	49.603	ENSOMEG00000013355	bcdin3d	88	49.603	Oryzias_melastigma
ENSG00000186666	BCDIN3D	99	88.966	ENSOGAG00000013908	BCDIN3D	100	88.966	Otolemur_garnettii
ENSG00000186666	BCDIN3D	85	87.903	ENSOGAG00000028083	-	97	87.097	Otolemur_garnettii
ENSG00000186666	BCDIN3D	99	86.254	ENSOARG00000018239	-	99	86.254	Ovis_aries
ENSG00000186666	BCDIN3D	99	78.351	ENSOARG00000015498	-	99	78.694	Ovis_aries
ENSG00000186666	BCDIN3D	100	99.315	ENSPPAG00000019278	BCDIN3D	99	99.315	Pan_paniscus
ENSG00000186666	BCDIN3D	100	87.329	ENSPPRG00000001284	BCDIN3D	100	87.329	Panthera_pardus
ENSG00000186666	BCDIN3D	100	87.329	ENSPTIG00000013513	BCDIN3D	100	87.329	Panthera_tigris_altaica
ENSG00000186666	BCDIN3D	100	99.315	ENSPTRG00000004916	BCDIN3D	99	99.315	Pan_troglodytes
ENSG00000186666	BCDIN3D	89	50.192	ENSPKIG00000024617	bcdin3d	87	50.192	Paramormyrops_kingsleyae
ENSG00000186666	BCDIN3D	85	48.193	ENSPMGG00000001614	bcdin3d	92	48.193	Periophthalmus_magnuspinnatus
ENSG00000186666	BCDIN3D	90	84.151	ENSPEMG00000011046	Bcdin3d	95	82.657	Peromyscus_maniculatus_bairdii
ENSG00000186666	BCDIN3D	88	71.212	ENSPCIG00000026825	BCDIN3D	96	71.212	Phascolarctos_cinereus
ENSG00000186666	BCDIN3D	82	50.000	ENSPFOG00000012788	bcdin3d	82	50.000	Poecilia_formosa
ENSG00000186666	BCDIN3D	84	49.593	ENSPLAG00000017261	bcdin3d	93	50.417	Poecilia_latipinna
ENSG00000186666	BCDIN3D	82	50.417	ENSPMEG00000003765	bcdin3d	82	50.417	Poecilia_mexicana
ENSG00000186666	BCDIN3D	84	49.180	ENSPREG00000010840	bcdin3d	93	49.180	Poecilia_reticulata
ENSG00000186666	BCDIN3D	100	97.945	ENSPPYG00000004498	BCDIN3D	100	97.945	Pongo_abelii
ENSG00000186666	BCDIN3D	100	90.102	ENSPCOG00000025127	BCDIN3D	100	90.102	Propithecus_coquereli
ENSG00000186666	BCDIN3D	99	85.911	ENSPVAG00000015495	BCDIN3D	100	85.911	Pteropus_vampyrus
ENSG00000186666	BCDIN3D	86	49.012	ENSPNYG00000006788	bcdin3d	97	49.012	Pundamilia_nyererei
ENSG00000186666	BCDIN3D	86	53.200	ENSPNAG00000023242	bcdin3d	97	53.200	Pygocentrus_nattereri
ENSG00000186666	BCDIN3D	95	81.227	ENSRNOG00000058430	Bcdin3d	97	81.227	Rattus_norvegicus
ENSG00000186666	BCDIN3D	100	96.918	ENSRBIG00000044388	BCDIN3D	100	96.918	Rhinopithecus_bieti
ENSG00000186666	BCDIN3D	99	96.886	ENSRROG00000024941	BCDIN3D	100	96.886	Rhinopithecus_roxellana
ENSG00000186666	BCDIN3D	100	93.515	ENSSBOG00000035511	BCDIN3D	100	93.515	Saimiri_boliviensis_boliviensis
ENSG00000186666	BCDIN3D	91	71.053	ENSSHAG00000011007	BCDIN3D	95	71.053	Sarcophilus_harrisii
ENSG00000186666	BCDIN3D	81	52.282	ENSSFOG00015006870	bcdin3d	90	52.282	Scleropages_formosus
ENSG00000186666	BCDIN3D	88	47.471	ENSSMAG00000010097	bcdin3d	97	47.471	Scophthalmus_maximus
ENSG00000186666	BCDIN3D	87	49.412	ENSSDUG00000017056	bcdin3d	98	49.412	Seriola_dumerili
ENSG00000186666	BCDIN3D	65	47.917	ENSSLDG00000020553	bcdin3d	80	47.917	Seriola_lalandi_dorsalis
ENSG00000186666	BCDIN3D	99	79.381	ENSSARG00000005361	BCDIN3D	99	79.381	Sorex_araneus
ENSG00000186666	BCDIN3D	83	64.898	ENSSPUG00000007468	BCDIN3D	92	64.898	Sphenodon_punctatus
ENSG00000186666	BCDIN3D	86	47.809	ENSSPAG00000021374	bcdin3d	98	47.809	Stegastes_partitus
ENSG00000186666	BCDIN3D	100	88.356	ENSSSCG00000040144	BCDIN3D	97	88.356	Sus_scrofa
ENSG00000186666	BCDIN3D	64	63.492	ENSTGUG00000004142	BCDIN3D	100	63.492	Taeniopygia_guttata
ENSG00000186666	BCDIN3D	82	51.452	ENSTRUG00000018395	bcdin3d	94	50.207	Takifugu_rubripes
ENSG00000186666	BCDIN3D	73	88.679	ENSTBEG00000012924	BCDIN3D	99	88.679	Tupaia_belangeri
ENSG00000186666	BCDIN3D	100	88.014	ENSTTRG00000001001	BCDIN3D	100	88.014	Tursiops_truncatus
ENSG00000186666	BCDIN3D	100	86.986	ENSUAMG00000005624	BCDIN3D	100	86.986	Ursus_americanus
ENSG00000186666	BCDIN3D	100	83.219	ENSUMAG00000007798	BCDIN3D	100	83.219	Ursus_maritimus
ENSG00000186666	BCDIN3D	97	85.106	ENSVPAG00000002328	BCDIN3D	97	84.342	Vicugna_pacos
ENSG00000186666	BCDIN3D	100	86.348	ENSVVUG00000023486	BCDIN3D	100	86.348	Vulpes_vulpes
ENSG00000186666	BCDIN3D	86	44.314	ENSXCOG00000016458	bcdin3d	87	43.922	Xiphophorus_couchianus
ENSG00000186666	BCDIN3D	84	49.187	ENSXMAG00000029177	bcdin3d	96	49.187	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001510	RNA methylation	23063121.	IDA	Process
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	23063121.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0008171	O-methyltransferase activity	23063121.	EXP	Function
GO:0008171	O-methyltransferase activity	21873635.	IBA	Function
GO:0008171	O-methyltransferase activity	23063121.	IDA	Function
GO:0008173	RNA methyltransferase activity	21873635.	IBA	Function
GO:0008173	RNA methyltransferase activity	23063121.	IDA	Function
GO:0008175	tRNA methyltransferase activity	28119416.	IDA	Function
GO:0010586	miRNA metabolic process	21873635.	IBA	Process
GO:0010586	miRNA metabolic process	23063121.	IDA	Process
GO:0010586	miRNA metabolic process	-	TAS	Process
GO:0030488	tRNA methylation	28119416.	IDA	Process
GO:0061715	miRNA 2'-O-methylation	28119416.	IDA	Process
GO:2000632	negative regulation of pre-miRNA processing	21873635.	IBA	Process
GO:2000632	negative regulation of pre-miRNA processing	23063121.	IDA	Process