EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000187109 (Gene tree)
Gene ID: 4673
Gene Symbol: NAP1L1
Alias: NRP|NAP1|NAP1L|MGC8688|MGC23410
Full Name: nucleosome assembly protein 1 like 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 48,447 bases
Position: chr12:76,036,587-76,085,033
Accession: 7637
RBP type: non-canonical RBP
Summary: This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000547773	NAP1L1-210	1967	XM_017019339	ENSP00000448167	328 (aa)	XP_016874828	F8W543
ENST00000550934	NAP1L1-218	851	-	ENSP00000448133	237 (aa)	-	F8VUX1
ENST00000393263	NAP1L1-202	1896	-	ENSP00000376947	391 (aa)	-	P55209
ENST00000547969	NAP1L1-211	543	-	-	- (aa)	-	-
ENST00000551600	NAP1L1-221	786	-	ENSP00000448836	215 (aa)	-	F8VXI6
ENST00000548273	NAP1L1-214	818	-	ENSP00000446787	209 (aa)	-	F8W118
ENST00000551524	NAP1L1-220	460	-	ENSP00000448661	114 (aa)	-	F8VRJ2
ENST00000548044	NAP1L1-213	1339	-	ENSP00000449649	327 (aa)	-	F8VV59
ENST00000542344	NAP1L1-205	1675	-	ENSP00000444759	349 (aa)	-	B7Z9C2
ENST00000547479	NAP1L1-207	623	-	ENSP00000449333	161 (aa)	-	F8VVB5
ENST00000551500	NAP1L1-219	552	-	-	- (aa)	-	-
ENST00000547529	NAP1L1-208	892	-	ENSP00000446520	177 (aa)	-	H0YH88
ENST00000544816	NAP1L1-206	1597	-	ENSP00000437507	208 (aa)	-	B7Z4K9
ENST00000547704	NAP1L1-209	760	-	ENSP00000446756	207 (aa)	-	F8W020
ENST00000261182	NAP1L1-201	4441	XM_011538393	ENSP00000261182	391 (aa)	XP_011536695	P55209
ENST00000552056	NAP1L1-224	1981	-	ENSP00000450236	385 (aa)	-	H0YIV4
ENST00000552013	NAP1L1-223	679	-	-	- (aa)	-	-
ENST00000618691	NAP1L1-227	13505	-	ENSP00000477538	391 (aa)	-	P55209
ENST00000535020	NAP1L1-204	1686	-	ENSP00000445008	383 (aa)	-	F5H4R6
ENST00000549479	NAP1L1-215	573	-	-	- (aa)	-	-
ENST00000549596	NAP1L1-216	1838	-	ENSP00000447793	368 (aa)	-	P55209
ENST00000547993	NAP1L1-212	2481	-	-	- (aa)	-	-
ENST00000549988	NAP1L1-217	544	-	-	- (aa)	-	-
ENST00000552342	NAP1L1-226	1526	-	ENSP00000447196	379 (aa)	-	F8W0J6
ENST00000431879	NAP1L1-203	2031	-	ENSP00000409795	323 (aa)	-	P55209
ENST00000551992	NAP1L1-222	1074	-	ENSP00000448764	264 (aa)	-	F8VY35
ENST00000552147	NAP1L1-225	1009	-	ENSP00000446804	198 (aa)	-	H0YHC3

Gene Model

Click here to download ENSG00000187109's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000187109	Platelet Function Tests	2.0741000E-005	-
ENSG00000187109	Heart Rate	1E-6	23251661
ENSG00000187109	Glucose	7E-6	25524916

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000187109	rs1368578	12	76083176	A	Obesity-related traits	23251661	[NR] bpm increase	0.04	EFO_0004326
ENSG00000187109	rs7294592	12	76071465	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000187109's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000187109	NAP1L1	100	73.239	ENSG00000205531	NAP1L4	89	76.923	Homo_sapiens
ENSG00000187109	NAP1L1	100	99.038	ENSMUSG00000058799	Nap1l1	100	98.210	Mus_musculus
ENSG00000187109	NAP1L1	100	73.460	ENSMUSG00000059119	Nap1l4	99	66.234	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	11940655.16169070.18226242.18331838.20195357.21044950.25852190.29128334.	IPI	Function
GO:0005634	nucleus	-	ISS	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0006260	DNA replication	8297347.	TAS	Process
GO:0006334	nucleosome assembly	-	IEA	Process
GO:0008284	positive regulation of cell proliferation	8297347.	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0042470	melanosome	-	IEA	Component
GO:0050769	positive regulation of neurogenesis	-	ISS	Process
GO:2000179	positive regulation of neural precursor cell proliferation	-	ISS	Process