EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000187609 (Gene tree)
Gene ID: 54932
Gene Symbol: EXD3
Alias: LOC54932|FLJ20433|mut-7
Full Name: exonuclease 3'-5' domain containing 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 116,375 bases
Position: chr9:137,306,894-137,423,268
Accession: 26023
RBP type: canonical RBP
Summary: EXD3 (Exonuclease 3'-5' Domain Containing 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and 3'-5' exonuclease activity. An important paralog of this gene is EXD2.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000340474	DNA_pol_A_exo1	PF01612.20	2.5e-20	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000340951	EXD3-201	2872	XM_011518810	ENSP00000340474	876 (aa)	XP_011517112	Q8N9H8
ENST00000479452	EXD3-208	962	-	ENSP00000431859	246 (aa)	-	Q8N9H8
ENST00000487745	EXD3-210	1992	-	-	- (aa)	-	-
ENST00000465160	EXD3-203	1585	-	ENSP00000432895	56 (aa)	-	Q8N9H8
ENST00000475006	EXD3-205	1132	-	-	- (aa)	-	-
ENST00000472958	EXD3-204	542	-	-	- (aa)	-	-
ENST00000478344	EXD3-206	2932	-	ENSP00000433010	36 (aa)	-	H0YD51
ENST00000490886	EXD3-211	1123	-	-	- (aa)	-	-
ENST00000491734	EXD3-212	2176	-	ENSP00000435830	140 (aa)	-	E9PSB6
ENST00000478350	EXD3-207	556	-	-	- (aa)	-	-
ENST00000484392	EXD3-209	754	-	-	- (aa)	-	-
ENST00000460390	EXD3-202	1432	-	ENSP00000436717	40 (aa)	-	E9PI94

Gene Model

Click here to download ENSG00000187609's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000187609	Platelet Function Tests	2.8188700E-005	-
ENSG00000187609	Citalopram	3.1460000E-006	-
ENSG00000187609	Circadian Rhythm	7E-9	27494321
ENSG00000187609	Circadian Rhythm	2E-12	27494321
ENSG00000187609	Loneliness	8E-6	27629369

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000187609	rs140109554	9	137316808	?	Loneliness	27629369	[0.071-0.183] unit increase	0.127	EFO_0007865
ENSG00000187609	rs77641763	9	137371330	C	Chronotype	27494321	[0.027-0.051] unit increase	0.039	EFO_0004354
ENSG00000187609	rs77641763	9	137371330	C	Morning vs. evening chronotype	27494321	[1.04-1.1]	1.07	EFO_0004354
ENSG00000187609	rs73581580	9	137357006	A	Educational attainment (MTAG)	30038396	[0.015-0.023] unit decrease	0.0191	EFO_0004784
ENSG00000187609	rs113727800	9	137364350	G	Self-reported math ability	30038396	[0.013-0.025] unit increase	0.0189	EFO_0004875
ENSG00000187609	rs113727800	9	137364350	G	Highest math class taken	30038396	[0.015-0.028] unit increase	0.0216	EFO_0004875
ENSG00000187609	rs73581580	9	137357006	A	Self-reported math ability (MTAG)	30038396	[0.016-0.027] unit decrease	0.0214	EFO_0004875
ENSG00000187609	rs73581580	9	137357006	A	Highest math class taken (MTAG)	30038396	[0.019-0.029] unit decrease	0.024	EFO_0004875
ENSG00000187609	rs28458909	9	137362737	T	Ease of getting up in the morning	28604731	[0.024-0.048] unit decrease	0.036	EFO_0008328
ENSG00000187609	rs73581580	9	137357006	A	Cognitive performance (MTAG)	30038396	[0.02-0.034] unit decrease	0.0267	EFO_0008354
ENSG00000187609	rs79140116	9	137349516	?	General cognitive ability	29844566	z-score decrease	5.084	EFO_0004337
ENSG00000187609	rs73581580	9	137357006	A	Educational attainment (years of education)	30038396	[0.014-0.022] unit decrease	0.0181	EFO_0004784
ENSG00000187609	rs28458909	9	137362737	?	Morning person	30595370			EFO_0008328
ENSG00000187609	rs28458909	9	137362737	C	Chronotype	30696823		1.0727227	EFO_0008328
ENSG00000187609	rs28458909	9	137362737	C	Morning person	30696823		1.0713521	EFO_0008328

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000187609's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000187609	EXD3	98	34.590	ENSAPOG00000015520	exd3	94	39.604	Acanthochromis_polyacanthus
ENSG00000187609	EXD3	96	38.488	ENSACIG00000005561	exd3	92	38.631	Amphilophus_citrinellus
ENSG00000187609	EXD3	98	39.207	ENSAOCG00000007721	exd3	96	39.618	Amphiprion_ocellaris
ENSG00000187609	EXD3	98	39.427	ENSAPEG00000007019	exd3	97	39.843	Amphiprion_percula
ENSG00000187609	EXD3	97	38.742	ENSATEG00000019941	exd3	99	38.920	Anabas_testudineus
ENSG00000187609	EXD3	81	50.249	ENSAPLG00000015358	EXD3	99	50.070	Anas_platyrhynchos
ENSG00000187609	EXD3	100	82.500	ENSANAG00000019674	EXD3	99	81.134	Aotus_nancymaae
ENSG00000187609	EXD3	97	39.397	ENSACLG00000021922	exd3	98	39.462	Astatotilapia_calliptera
ENSG00000187609	EXD3	96	40.791	ENSAMXG00000019494	exd3	97	40.791	Astyanax_mexicanus
ENSG00000187609	EXD3	95	66.229	ENSBTAG00000023788	EXD3	99	66.106	Bos_taurus
ENSG00000187609	EXD3	100	81.621	ENSCJAG00000013170	EXD3	99	81.597	Callithrix_jacchus
ENSG00000187609	EXD3	98	69.150	ENSCAFG00000019444	EXD3	98	69.596	Canis_familiaris
ENSG00000187609	EXD3	95	68.111	ENSCAFG00020003171	EXD3	92	68.447	Canis_lupus_dingo
ENSG00000187609	EXD3	97	84.161	ENSCCAG00000027996	EXD3	99	83.912	Cebus_capucinus
ENSG00000187609	EXD3	99	90.394	ENSCSAG00000016661	EXD3	99	90.394	Chlorocebus_sabaeus
ENSG00000187609	EXD3	83	52.451	ENSCPBG00000011686	EXD3	89	50.959	Chrysemys_picta_bellii
ENSG00000187609	EXD3	53	41.406	ENSCSAVG00000005704	-	93	42.188	Ciona_savignyi
ENSG00000187609	EXD3	99	90.586	ENSCANG00000040692	EXD3	99	90.625	Colobus_angolensis_palliatus
ENSG00000187609	EXD3	96	39.232	ENSCSEG00000000750	exd3	97	39.535	Cynoglossus_semilaevis
ENSG00000187609	EXD3	96	39.614	ENSCVAG00000011560	exd3	97	39.955	Cyprinodon_variegatus
ENSG00000187609	EXD3	96	40.867	ENSDARG00000063140	exd3	97	41.071	Danio_rerio
ENSG00000187609	EXD3	72	61.453	ENSETEG00000001025	-	62	70.455	Echinops_telfairi
ENSG00000187609	EXD3	93	72.405	ENSEASG00005016023	EXD3	96	72.209	Equus_asinus_asinus
ENSG00000187609	EXD3	98	71.626	ENSECAG00000017546	EXD3	99	71.445	Equus_caballus
ENSG00000187609	EXD3	76	66.667	ENSEEUG00000000405	-	90	66.667	Erinaceus_europaeus
ENSG00000187609	EXD3	96	41.422	ENSELUG00000007181	exd3	98	41.961	Esox_lucius
ENSG00000187609	EXD3	99	69.001	ENSFCAG00000003579	EXD3	99	69.860	Felis_catus
ENSG00000187609	EXD3	91	48.592	ENSFALG00000005132	EXD3	98	48.592	Ficedula_albicollis
ENSG00000187609	EXD3	96	35.877	ENSFHEG00000011352	exd3	97	35.991	Fundulus_heteroclitus
ENSG00000187609	EXD3	74	41.905	ENSGMOG00000013542	-	88	33.333	Gadus_morhua
ENSG00000187609	EXD3	96	48.552	ENSGALG00000052646	EXD3	97	48.552	Gallus_gallus
ENSG00000187609	EXD3	96	37.970	ENSGAFG00000007328	exd3	97	37.970	Gambusia_affinis
ENSG00000187609	EXD3	81	41.160	ENSGACG00000017442	exd3	100	41.160	Gasterosteus_aculeatus
ENSG00000187609	EXD3	79	51.795	ENSGAGG00000011888	EXD3	91	48.085	Gopherus_agassizii
ENSG00000187609	EXD3	100	92.500	ENSGGOG00000024724	EXD3	98	98.047	Gorilla_gorilla
ENSG00000187609	EXD3	98	39.174	ENSHBUG00000001405	exd3	98	39.462	Haplochromis_burtoni
ENSG00000187609	EXD3	96	38.009	ENSHCOG00000020087	exd3	98	37.911	Hippocampus_comes
ENSG00000187609	EXD3	96	39.703	ENSIPUG00000020343	exd3	96	40.210	Ictalurus_punctatus
ENSG00000187609	EXD3	98	39.845	ENSKMAG00000011881	exd3	98	40.045	Kryptolebias_marmoratus
ENSG00000187609	EXD3	89	38.776	ENSLBEG00000004079	exd3	92	38.776	Labrus_bergylta
ENSG00000187609	EXD3	95	44.068	ENSLOCG00000002330	exd3	99	44.559	Lepisosteus_oculatus
ENSG00000187609	EXD3	75	77.143	ENSLAFG00000001122	EXD3	100	66.486	Loxodonta_africana
ENSG00000187609	EXD3	99	90.856	ENSMFAG00000037569	EXD3	99	90.856	Macaca_fascicularis
ENSG00000187609	EXD3	99	90.509	ENSMNEG00000033487	EXD3	99	90.509	Macaca_nemestrina
ENSG00000187609	EXD3	99	87.269	ENSMLEG00000040548	EXD3	99	87.269	Mandrillus_leucophaeus
ENSG00000187609	EXD3	86	37.883	ENSMAMG00000008407	exd3	95	37.803	Mastacembelus_armatus
ENSG00000187609	EXD3	97	39.397	ENSMZEG00005017270	exd3	98	39.462	Maylandia_zebra
ENSG00000187609	EXD3	81	54.000	ENSMGAG00000001267	EXD3	100	50.559	Meleagris_gallopavo
ENSG00000187609	EXD3	93	39.568	ENSMMOG00000021267	exd3	98	40.359	Mola_mola
ENSG00000187609	EXD3	57	48.084	ENSMODG00000028091	-	97	48.084	Monodelphis_domestica
ENSG00000187609	EXD3	96	37.625	ENSMALG00000018523	exd3	94	39.318	Monopterus_albus
ENSG00000187609	EXD3	95	68.585	ENSMPUG00000015130	EXD3	98	67.944	Mustela_putorius_furo
ENSG00000187609	EXD3	98	37.614	ENSNBRG00000019734	exd3	97	38.293	Neolamprologus_brichardi
ENSG00000187609	EXD3	88	89.637	ENSNLEG00000009095	-	100	89.637	Nomascus_leucogenys
ENSG00000187609	EXD3	64	58.696	ENSMEUG00000002121	-	78	58.696	Notamacropus_eugenii
ENSG00000187609	EXD3	84	39.842	ENSONIG00000003880	exd3	100	39.842	Oreochromis_niloticus
ENSG00000187609	EXD3	86	49.289	ENSOANG00000012485	-	99	47.561	Ornithorhynchus_anatinus
ENSG00000187609	EXD3	98	38.710	ENSORLG00000010377	exd3	98	39.526	Oryzias_latipes
ENSG00000187609	EXD3	98	38.598	ENSORLG00020012287	exd3	97	39.071	Oryzias_latipes_hni
ENSG00000187609	EXD3	98	38.522	ENSORLG00015001156	exd3	98	39.109	Oryzias_latipes_hsok
ENSG00000187609	EXD3	96	39.886	ENSOMEG00000023060	exd3	97	40.000	Oryzias_melastigma
ENSG00000187609	EXD3	100	97.267	ENSPPAG00000042435	EXD3	100	97.267	Pan_paniscus
ENSG00000187609	EXD3	99	68.993	ENSPPRG00000004634	EXD3	98	69.930	Panthera_pardus
ENSG00000187609	EXD3	99	87.269	ENSPANG00000026338	EXD3	99	87.269	Papio_anubis
ENSG00000187609	EXD3	96	42.428	ENSPKIG00000021103	exd3	98	42.428	Paramormyrops_kingsleyae
ENSG00000187609	EXD3	89	50.308	ENSPSIG00000007745	EXD3	93	50.308	Pelodiscus_sinensis
ENSG00000187609	EXD3	96	39.813	ENSPMGG00000023999	exd3	98	40.023	Periophthalmus_magnuspinnatus
ENSG00000187609	EXD3	75	39.048	ENSPMAG00000006135	-	100	40.354	Petromyzon_marinus
ENSG00000187609	EXD3	97	49.091	ENSPCIG00000006180	-	99	49.091	Phascolarctos_cinereus
ENSG00000187609	EXD3	96	38.016	ENSPFOG00000019685	exd3	98	39.532	Poecilia_formosa
ENSG00000187609	EXD3	88	38.634	ENSPLAG00000022290	exd3	98	39.130	Poecilia_latipinna
ENSG00000187609	EXD3	96	39.091	ENSPMEG00000008007	exd3	98	39.532	Poecilia_mexicana
ENSG00000187609	EXD3	96	39.636	ENSPREG00000008142	exd3	97	40.091	Poecilia_reticulata
ENSG00000187609	EXD3	80	64.677	ENSPCAG00000005094	-	66	64.530	Procavia_capensis
ENSG00000187609	EXD3	98	39.174	ENSPNYG00000012849	exd3	98	39.462	Pundamilia_nyererei
ENSG00000187609	EXD3	97	41.800	ENSPNAG00000016753	exd3	98	41.753	Pygocentrus_nattereri
ENSG00000187609	EXD3	99	90.162	ENSRBIG00000031855	EXD3	99	90.162	Rhinopithecus_bieti
ENSG00000187609	EXD3	99	90.394	ENSRROG00000040120	EXD3	99	90.394	Rhinopithecus_roxellana
ENSG00000187609	EXD3	100	82.500	ENSSBOG00000022389	EXD3	94	83.102	Saimiri_boliviensis_boliviensis
ENSG00000187609	EXD3	82	50.621	ENSSHAG00000001276	-	98	50.621	Sarcophilus_harrisii
ENSG00000187609	EXD3	96	43.448	ENSSFOG00015023063	exd3	98	41.281	Scleropages_formosus
ENSG00000187609	EXD3	98	38.058	ENSSMAG00000019809	exd3	97	39.022	Scophthalmus_maximus
ENSG00000187609	EXD3	85	38.308	ENSSDUG00000006265	exd3	98	38.682	Seriola_dumerili
ENSG00000187609	EXD3	90	38.197	ENSSLDG00000004671	exd3	97	38.628	Seriola_lalandi_dorsalis
ENSG00000187609	EXD3	96	39.569	ENSSPAG00000017972	exd3	97	39.569	Stegastes_partitus
ENSG00000187609	EXD3	93	66.462	ENSSSCG00000005855	EXD3	98	66.625	Sus_scrofa
ENSG00000187609	EXD3	81	52.000	ENSTGUG00000002494	EXD3	100	49.931	Taeniopygia_guttata
ENSG00000187609	EXD3	97	37.583	ENSTRUG00000010236	exd3	95	37.320	Takifugu_rubripes
ENSG00000187609	EXD3	88	37.220	ENSTNIG00000013212	exd3	96	40.351	Tetraodon_nigroviridis
ENSG00000187609	EXD3	100	77.500	ENSTTRG00000003815	-	65	73.171	Tursiops_truncatus
ENSG00000187609	EXD3	92	70.807	ENSUAMG00000021470	EXD3	99	71.036	Ursus_americanus
ENSG00000187609	EXD3	93	69.146	ENSVVUG00000029403	EXD3	92	69.146	Vulpes_vulpes
ENSG00000187609	EXD3	87	38.605	ENSXMAG00000001467	exd3	98	38.605	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003676	nucleic acid binding	-	IEA	Function
GO:0005515	protein binding	16189514.19060904.	IPI	Function
GO:0008408	3'-5' exonuclease activity	21873635.	IBA	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0090305	nucleic acid phosphodiester bond hydrolysis	-	IEA	Process