EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000187772 (Gene tree)
Gene ID: 389421
Gene Symbol: LIN28B
Alias: FLJ16517|CSDD2
Full Name: lin-28 homolog B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 146,717 bases
Position: chr6:104,936,616-105,083,332
Accession: 32207
RBP type: canonical RBP
Summary: The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000489735	CSD	PF00313.22	3.3e-16	1	1
ENSP00000344401	CSD	PF00313.22	4.7e-16	1	1
ENSP00000490468	CSD	PF00313.22	5e-16	1	1
ENSP00000489735	zf-CCHC	PF00098.23	3.5e-08	1	2
ENSP00000489735	zf-CCHC	PF00098.23	3.5e-08	2	2
ENSP00000344401	zf-CCHC	PF00098.23	5.4e-08	1	2
ENSP00000344401	zf-CCHC	PF00098.23	5.4e-08	2	2
ENSP00000490468	zf-CCHC	PF00098.23	5.9e-08	1	2
ENSP00000490468	zf-CCHC	PF00098.23	5.9e-08	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28132840	A Rapid Induction Mechanism for Lin28a in Trophic Responses.	Mol Cell	2017 Feb 2	Amen AM	doi: 10.1016/j.molcel.2016.12.025
29787985	RNA binding protein Lin28B confers gastric cancer cells stemness via directly binding to NRP-1.	Biomed Pharmacother	2018 Aug	Wang X	doi: 10.1016/j.biopha.2018.05.064
19713958	Lin28 recruits the TUTase Zcchc11 to inhibit let-7 maturation in mouse embryonic stem cells.	Nat Struct Mol Biol	2009 Oct	Hagan JP	doi: 10.1038/nsmb.1676
19557079	Tumors line up for a letdown.	Nat Genet	2009 Jul	Mendell JT	doi: 10.1038/ng0709-768.
23052130	A LIN28B polymorphism predicts for colon cancer survival.	Cancer Biol Ther	2012 Dec	Ye Y	doi: 10.4161/cbt.22336
19477633	Pluripotent factor lin-28 and its homologue lin-28b in epithelial ovarian cancer and their associations with disease outcomes and expression of let-7a and IGF-II.	Eur J Cancer	2009 Aug	Lu L	doi: 10.1016/j.ejca.2009.05.003
19483683	Lin28 promotes transformation and is associated with advanced human malignancies.	Nat Genet	2009 Jul	Viswanathan SR	doi: 10.1038/ng.392
19211792	Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation.	Proc Natl Acad Sci U S A	2009 Mar 3	Chang TC	doi: 10.1073/pnas.0808300106
18951094	Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA.	Mol Cell	2008 Oct 24	Heo I	doi: 10.1016/j.molcel.2008.09.014.
22713243	Lin28 regulates HER2 and promotes malignancy through multiple mechanisms.	Cell Cycle	2012 Jul 1	Feng C	doi: 10.4161/cc.20893
23337528	Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism.	Endocrinology	2013 Mar	Gaytan F	doi: 10.1210/en.2012-1745
23291449	Changes in hypothalamic expression of the Lin28/let-7 system and related microRNAs during postnatal maturation and after experimental manipulations of puberty.	Endocrinology	2013 Feb	Sangiao-Alvarellos S	doi: 10.1210/en.2012-2006
21625210	LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms.	Oncogene	2011 Oct 6	King CE	doi: 10.1038/onc.2011.131
20512147	Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies.	Nat Genet	2010 Jul	Zhu H	doi: 10.1038/ng.593
20525879	Lin-28B expression promotes transformation and invasion in human hepatocellular carcinoma.	Carcinogenesis	2010 Sep	Wang YC	doi: 10.1093/carcin/bgq107
25368430	MUC1-C Induces the LIN28B-LET-7-HMGA2 Axis to Regulate Self-Renewal in NSCLC.	Mol Cancer Res	2015 Mar	Alam M	doi: 10.1158/1541-7786.MCR-14-0363
25117712	Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models.	Cancer Cell	2014 Aug 11	Nguyen LH	doi: 10.1016/j.ccr.2014.06.018.
24885919	Lin28B expression correlates with aggressive clinicopathological characteristics in breast invasive ductal carcinoma.	Cancer Biother Radiopharm	2014 Jun	Xie R	doi: 10.1089/cbr.2014.1610
24498170	The Lin28/Let-7 system in early human embryonic tissue and ectopic pregnancy.	PLoS One	2014 Jan 31	Lozoya T	doi: 10.1371/journal.pone.0087698
24142874	LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7.	Genes Dev	2013 Oct 15	Madison BB	doi: 10.1101/gad.224659.113.
27793996	Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF--and-beta; Signaling.	J Immunol	2016 Dec 1	Bronevetsky Y	-
23770886	Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation.	RNA Biol	2013 Jul	Graf R	doi: 10.4161/rna.25194
27384999	Lin28B promotes Muller glial cell de-differentiation and proliferation in the regenerative rat retinas.	Oncotarget	2016 Aug 2	Tao Z	doi: 10.18632/oncotarget.10343.
23481595	Identification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition.	RNA	2013 May	Hafner M	doi: 10.1261/rna.036491.112
27320042	LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency.	Cell Stem Cell	2016 Jul 7	Zhang J	doi: 10.1016/j.stem.2016.05.009
26851235	Hepatic Premalignant Alterations Triggered by Human Nephrotoxin Aristolochic Acid I in Canines.	Cancer Prev Res (Phila)	2016 Apr	Jin K	doi: 10.1158/1940-6207.CAPR-15-0339
26399619	Biogenesis and regulation of the let-7 miRNAs and their functional implications.	Protein Cell	2016 Feb	Lee H	doi: 10.1007/s13238-015-0212-y
25922525	Lin28 promotes the proliferative capacity of neural progenitor cells in brain development.	Development	2015 May 1	Yang M	doi: 10.1242/dev.120543.
27529677	Elevation of Il6 is associated with disturbed let-7 biogenesis in a genetic model of depression.	Transl Psychiatry	2016 Aug 16	Wei YB	doi: 10.1038/tp.2016.136.
27533015	Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level.	Immunity	2016 Aug 16	Kristiansen TA	doi: 10.1016/j.immuni.2016.07.014.
26674877	Lin28B and Let-7 in the Control of Sympathetic Neurogenesis and Neuroblastoma Development.	J Neurosci	2015 Dec 16	Hennchen M	doi: 10.1523/JNEUROSCI.2560-15.2015.
26494358	Testicular expression of the Lin28/let-7 system: Hormonal regulation and changes during postnatal maturation and after manipulations of puberty.	Sci Rep	2015 Oct 23	Sangiao-Alvarellos S	doi: 10.1038/srep15683.
26478718	The pluripotency factor LIN28B is involved in oral carcinogenesis and associates with tumor aggressiveness and unfavorable prognosis.	Cancer Cell Int	2015 Oct 15	Wang D	doi: 10.1186/s12935-015-0252-7
26244988	Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2.	PLoS Genet	2015 Aug 5	Madison BB	doi: 10.1371/journal.pgen.1005408
26158423	Overexpression of the RNA-binding proteins Lin28B and IGF2BP3 (IMP3) is associated with chemoresistance and poor disease outcome in ovarian cancer.	Br J Cancer	2015 Jul 28	Hsu KF	doi: 10.1038/bjc.2015.254
26139524	The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea.	Proc Natl Acad Sci U S A	2015 Jul 21	Golden EJ	doi: 10.1073/pnas.1501077112
25956904	LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans.	Genes Dev	2015 May 15	Tu HC	doi: 10.1101/gad.256693.114
28400788	The LIN28/let-7 Pathway in Cancer.	Front Genet	2017 Mar 28	Balzeau J	doi: 10.3389/fgene.2017.00031
27771326	Identification of a TSPY co-expression network associated with DNA hypomethylation and tumor gene expression in somatic cancers.	J Genet Genomics	2016 Oct 20	Kido T	doi: 10.1016/j.jgg.2016.09.003
28683410	Different expression patterns of Lin28 and Lin28b in mouse molar development.	Arch Oral Biol	2017 Oct	Dong N	doi: 10.1016/j.archoralbio.2017.06.023
29099484	Lin28B and miR-142-3p regulate neuronal differentiation by modulating Staufen1 expression.	Cell Death Differ	2018 Feb	Oh Y	doi: 10.1038/cdd.2017.182
29301498	PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells.	BMC Cancer	2018 Jan 4	Qu TT	doi: 10.1186/s12885-017-3959-0.
29330293	Differential Regulation of LET-7 by LIN28B Isoform-Specific Functions.	Mol Cancer Res	2018 Mar	Mizuno R	doi: 10.1158/1541-7786.MCR-17-0514
29414528	Control of B-1a cell development by instructive BCR signaling.	Curr Opin Immunol	2018 Apr	Kreslavsky T	doi: 10.1016/j.coi.2018.01.001
29503447	LIN28B enhanced tumorigenesis in an autochthonous KRASG12V-driven lung carcinoma mouse model.	Oncogene	2018 May	Meder L	doi: 10.1038/s41388-018-0158-7
29669301	LIN28B promotes the progression of colon cancer by increasing B-cell lymphoma 2 expression.	Biomed Pharmacother	2018 Jul	Yuan L	doi: 10.1016/j.biopha.2018.04.002
29725425	Oncogene Lin28B increases chemosensitivity of colon cancer cells in a let-7-independent manner.	Oncol Lett	2018 May	Ma L	doi: 10.3892/ol.2018.8250
29950144	LncRNA H19-elevated LIN28B promotes lung cancer progression through sequestering miR-196b.	Cell Cycle	2018	Ren J	doi: 10.1080/15384101.2018.1482137
30137214	HMGA2 is regulated by LIN28 and BRCA1 in human placental cells.	Biol Reprod	2019 Jan 1	West RC	doi: 10.1093/biolre/ioy183.
30174831	RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells.	Signal Transduct Target Ther	2018 Aug 31	Lin X	doi: 10.1038/s41392-018-0026-5
30622145	Lin28b regulates age-dependent differences in murine platelet function.	Blood Adv	2019 Jan 8	Stolla MC	doi: 10.1182/bloodadvances.2018020859.
31064784	Lin28-mediated temporal promotion of protein synthesis is crucial for neural progenitor cell maintenance and brain development in mice.	Development	2019 May 28	Herrlinger S	doi: 10.1242/dev.173765.
31066045	Lin28B regulates the fate of grafted mesenchymal stem cells and enhances their protective effects against Alzheimer's disease by upregulating IGF-2.	J Cell Physiol	2019 May 8	Wu K	doi: 10.1002/jcp.28750
31079917	DLL3 is regulated by LIN28B and miR-518d-5p and regulates cell proliferation, migration and chemotherapy response in advanced small cell lung cancer.	Biochem Biophys Res Commun	2019 Jun 30	Huang J	doi: 10.1016/j.bbrc.2019.04.130
31215730	LIN28B regulates androgen receptor in human trophoblast cells through Let-7c.	Mol Reprod Dev	2019 Jun 19	McWhorter ES	doi: 10.1002/mrd.23226
31221665	Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3.	Genes Dev	2019 Jun 20	Wang S	doi: 10.1101/gad.325100.119
31240246	C/EBP-and-beta;-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice.	Commun Biol	2019 Jun 14	Ackermann T	doi: 10.1038/s42003-019-0461-z

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000635857	LIN28B-202	912	XM_006715477	ENSP00000489735	209 (aa)	XP_006715540	A0A1B0GTK2
ENST00000637759	LIN28B-203	2635	XM_011535818	ENSP00000490468	258 (aa)	XP_011534120	A0A1B0GVD3
ENST00000345080	LIN28B-201	5505	-	ENSP00000344401	250 (aa)	-	Q6ZN17

Gene Model

Click here to download ENSG00000187772's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000187772	Neuroblastoma	6.85e-005	23222812
ENSG00000187772	Personality	6.434e-005	-
ENSG00000187772	Body Height	9.9780000E-006	-
ENSG00000187772	Body Height	3.6880000E-005	-
ENSG00000187772	Body Height	8.8940000E-006	-
ENSG00000187772	Body Height	2.3110000E-005	-
ENSG00000187772	Waist Circumference	2.3950000E-008	-
ENSG00000187772	Waist Circumference	4.2420000E-008	-
ENSG00000187772	Waist Circumference	4.2030000E-008	-
ENSG00000187772	Waist Circumference	6.1860000E-006	-
ENSG00000187772	Waist Circumference	8.4360000E-005	-
ENSG00000187772	Platelet Function Tests	8.1000000E-006	-
ENSG00000187772	Body Mass Index	1E-15	25673412
ENSG00000187772	Waist Circumference	1E-15	25673412
ENSG00000187772	Body Mass Index	2E-6	25673412
ENSG00000187772	Waist Circumference	2E-6	25673412
ENSG00000187772	Neuroblastoma	1E-8	22941191
ENSG00000187772	Puberty	2E-8	24770850
ENSG00000187772	Schizophrenia	10E-7	26198764
ENSG00000187772	Body Height	8E-7	18391951
ENSG00000187772	Menarche	3E-13	19448621
ENSG00000187772	Menarche	2E-14	19448622
ENSG00000187772	Menarche	5E-7	23667675
ENSG00000187772	Androgens	2E-6	20303062
ENSG00000187772	Body Mass Index	2E-12	25673412
ENSG00000187772	Waist Circumference	2E-12	25673412
ENSG00000187772	Body Height	1E-8	18391950
ENSG00000187772	Menarche	4E-16	19448623

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000187772	rs314263	6	104944870	C	Intraocular pressure	29617998	[0.052-0.11] unit increase	0.081	EFO_0004695
ENSG00000187772	rs314277	6	104959787	A	Digit length ratio (left hand)	29659830	[0.31-0.49] unit increase	0.404	EFO_0004841
ENSG00000187772	rs314277	6	104959787	A	Digit length ratio (left hand)	29659830	[0.33-0.53] unit increase	0.428	EFO_0004841
ENSG00000187772	rs1475120	6	104942078	G	Major depressive disorder	27479909	[0.017-0.041] unit decrease	0.0292	EFO_0003761
ENSG00000187772	rs11285463	6	104944130	AT	Menarche (age at onset)	29773799	[0.06-0.1] year increase	0.08	EFO_0004703
ENSG00000187772	rs395962	6	104949543	T	Menopause (age at onset)	29773799	[0.059-0.099] year increase	0.079	EFO_0004704
ENSG00000187772	rs7766336	6	104940530	?	Menarche (age at onset)	27182965	[0.065-0.083] unit increase	0.074	EFO_0004703
ENSG00000187772	rs364663	6	104995314	A	Menarche (age at onset)	23667675	[0.054-0.124] year decrease	0.089	EFO_0004703
ENSG00000187772	rs314277	6	104959787	A	Height	18391950	[0.26-0.59] cm increase	0.41	EFO_0004339
ENSG00000187772	rs314268	6	104970103	C	Height	18391951	[2.84-6.36] % s.d. increase	4.6	EFO_0004339
ENSG00000187772	rs314272	6	105014129	G	Schizophrenia	26198764	[NR]	1.0526316	EFO_0000692
ENSG00000187772	rs17065417	6	104958399	A	Neuroblastoma	22941191	[1.23-1.54]	1.38	EFO_0000621
ENSG00000187772	rs314277	6	104959787	A	Digit length ratio	20303062	[0.41-0.85] mean 2D:4D increase	0.63	EFO_0004841
ENSG00000187772	rs314276	6	104960124	C	Puberty onset	24770850	[0.053-0.107] unit increase	0.08	EFO_0005677
ENSG00000187772	rs314276	6	104960124	C	Menarche (age at onset)	19448623	[0.11-0.17] year decrease	0.14	EFO_0004703
ENSG00000187772	rs314280	6	104952962	T	Menarche (age at onset)	19448622	[0.9-1.5] months increase	1.2	EFO_0004703
ENSG00000187772	rs314277	6	104959787	A	Menarche and menopause (age at onset)	19448621	[0.12-0.20] years increase	0.16	EFO_0004703
ENSG00000187772	rs160593	6	105018457	G	Schizophrenia	28991256	[1.04-1.07]	1.0559661	EFO_0000692
ENSG00000187772	rs314283	6	104991461	C	Depressive symptoms (MTAG)	29292387	[0.008-0.0162] unit increase	0.0121	EFO_0007006
ENSG00000187772	rs314277	6	104959787	?	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction)	28560309			HP_0100543\|EFO_0000249\|EFO_0007710
ENSG00000187772	rs395962	6	104949543	T	Waist circumference adjusted for BMI in smokers	28443625	[0.021-0.052] unit increase	0.0367	EFO_0004318\|EFO_0007789
ENSG00000187772	rs395962	6	104949543	T	Waist circumference adjusted for BMI in active individuals	28448500	[0.031-0.057] cm increase	0.0438	EFO_0007789\|EFO_0008002
ENSG00000187772	rs395962	6	104949543	T	Waist circumference adjusted for body mass index	25673412	[0.013-0.032] unit increase	0.0223	EFO_0007789
ENSG00000187772	rs395962	6	104949543	T	Waist circumference adjusted for body mass index	25673412	[0.022-0.036] unit increase	0.0288	EFO_0007789
ENSG00000187772	rs395962	6	104949543	T	Waist circumference adjusted for body mass index	25673412	[0.026-0.046] unit increase	0.0358	EFO_0007789
ENSG00000187772	rs395962	6	104949543	T	Waist circumference adjusted for BMI in non-smokers	28443625	[0.018-0.034] unit increase	0.0257	EFO_0007789
ENSG00000187772	rs395962	6	104949543	T	Waist circumference adjusted for BMI in non-smokers	28443625	[0.022-0.047] unit increase	0.0344	EFO_0007789
ENSG00000187772	rs395962	6	104949543	T	Waist circumference adjusted for BMI in smokers	28443625	[0.033-0.077] unit increase	0.0548	EFO_0004318\|EFO_0007789
ENSG00000187772	rs314263	6	104944870	T	Height	25282103	[0.037-0.049] unit decrease	0.043	EFO_0004339
ENSG00000187772	rs395962	6	104949543	T	Waist circumference adjusted for BMI (adjusted for smoking behaviour)	28443625	[0.029-0.05] unit increase	0.0398	EFO_0004318\|EFO_0007789
ENSG00000187772	rs395962	6	104949543	T	Waist circumference adjusted for BMI (adjusted for smoking behaviour)	28443625	[0.021-0.035] unit increase	0.0281	EFO_0004318\|EFO_0007789
ENSG00000187772	rs395962	6	104949543	T	Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0007789
ENSG00000187772	rs395962	6	104949543	T	Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0007789
ENSG00000187772	rs17065417	6	104958399	C	Sporadic neuroblastoma	28545128	[1.25-1.67]	1.4285715	EFO_0000621
ENSG00000187772	rs314277	6	104959787	A	Digit length ratio (right hand)	29659830	[0.39-0.61] unit increase	0.498	EFO_0004841
ENSG00000187772	rs314277	6	104959787	A	Digit length ratio	29659830	[0.38-0.57] unit increase	0.476	EFO_0004841
ENSG00000187772	rs12528131	6	104941229	A	Feeling guilty	29500382	z score decrease	6.42	EFO_0009595
ENSG00000187772	rs314261	6	105005542	?	Heel bone mineral density	30048462	[0.0093-0.0174] unit decrease	0.0133438	EFO_0009270
ENSG00000187772	rs1475120	6	104942078	G	Heel bone mineral density	30598549	[0.0098-0.017] unit decrease	0.0133593	EFO_0009270
ENSG00000187772	rs370771	6	104950211	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000187772	rs314280	6	104952962	G	Insomnia symptoms (never/rarely vs. usually)	30804566	[1.00-1.03]	1.01	EFO_0007876
ENSG00000187772	rs314263	6	104944870	C	Body fat distribution (leg fat ratio)	30664634	NR unit decrease (replication)	0.03054	EFO_0004341
ENSG00000187772	rs314263	6	104944870	C	Body fat distribution (leg fat ratio)	30664634	NR unit decrease (replication)	0.03303	EFO_0004341
ENSG00000187772	rs314272	6	105014129	G	Schizophrenia	30285260	[1.04-1.08]	1.0570824	EFO_0000692
ENSG00000187772	rs314262	6	104946746	A	Neuroticism	30643256	[0.0052-0.011] unit increase	0.008068154	EFO_0007660
ENSG00000187772	rs314262	6	104946746	A	Depressive symptoms	30643256	[0.0033-0.007] unit increase	0.005163756	EFO_0007006
ENSG00000187772	rs314262	6	104946746	A	Well-being spectrum (multivariate analysis)	30643256	[0.0032-0.0069] unit increase	0.005054806	EFO_0007869
ENSG00000187772	rs160593	6	105018457	G	Schizophrenia	30285260	[1.04-1.08]	1.059322	EFO_0000692
ENSG00000187772	rs314263	6	104944870	C	Body fat distribution (arm fat ratio)	30664634	NR unit decrease (replication)	0.01491	EFO_0004341
ENSG00000187772	rs314263	6	104944870	C	Body fat distribution (arm fat ratio)	30664634	NR unit decrease (replication)	0.01352	EFO_0004341
ENSG00000187772	rs314263	6	104944870	C	Body fat distribution (trunk fat ratio)	30664634	NR unit increase (replication)	0.03898	EFO_0004341
ENSG00000187772	rs314263	6	104944870	C	Body fat distribution (trunk fat ratio)	30664634	NR unit increase (replication)	0.03328	EFO_0004341
ENSG00000187772	rs314263	6	104944870	C	Body fat distribution (trunk fat ratio)	30664634	NR unit increase (replication)	0.03644	EFO_0004341
ENSG00000187772	rs314263	6	104944870	C	Body fat distribution (leg fat ratio)	30664634	NR unit decrease (replication)	0.03499	EFO_0004341

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000187772's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000187772	LIN28B	76	77.358	ENSG00000131914	LIN28A	85	72.626

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000187772	LIN28B	96	62.963	ENSAPOG00000014016	lin28b	94	63.492	Acanthochromis_polyacanthus
ENSG00000187772	LIN28B	74	70.968	ENSAPOG00000014331	lin28a	81	70.968	Acanthochromis_polyacanthus
ENSG00000187772	LIN28B	74	79.870	ENSAPOG00000024256	si:ch1073-284b18.2	79	79.870	Acanthochromis_polyacanthus
ENSG00000187772	LIN28B	84	73.864	ENSAMEG00000010582	-	84	73.864	Ailuropoda_melanoleuca
ENSG00000187772	LIN28B	84	63.068	ENSAMEG00000019027	-	83	63.068	Ailuropoda_melanoleuca
ENSG00000187772	LIN28B	100	93.200	ENSAMEG00000011453	LIN28B	99	94.332	Ailuropoda_melanoleuca
ENSG00000187772	LIN28B	96	63.374	ENSACIG00000009818	lin28b	93	63.745	Amphilophus_citrinellus
ENSG00000187772	LIN28B	81	72.727	ENSACIG00000017279	si:ch1073-284b18.2	89	73.837	Amphilophus_citrinellus
ENSG00000187772	LIN28B	73	71.895	ENSAOCG00000014049	lin28a	83	65.909	Amphiprion_ocellaris
ENSG00000187772	LIN28B	89	70.899	ENSAOCG00000015180	lin28b	83	79.245	Amphiprion_ocellaris
ENSG00000187772	LIN28B	74	79.355	ENSAOCG00000021583	si:ch1073-284b18.2	79	79.355	Amphiprion_ocellaris
ENSG00000187772	LIN28B	74	79.355	ENSAPEG00000006197	si:ch1073-284b18.2	79	79.355	Amphiprion_percula
ENSG00000187772	LIN28B	79	67.879	ENSAPEG00000007421	lin28a	81	67.879	Amphiprion_percula
ENSG00000187772	LIN28B	89	70.899	ENSAPEG00000021919	lin28b	83	79.245	Amphiprion_percula
ENSG00000187772	LIN28B	87	74.457	ENSAPEG00000021809	LIN28B	90	74.457	Amphiprion_percula
ENSG00000187772	LIN28B	74	80.000	ENSATEG00000010132	si:ch1073-284b18.2	79	80.000	Anabas_testudineus
ENSG00000187772	LIN28B	82	77.011	ENSATEG00000014088	lin28b	83	80.233	Anabas_testudineus
ENSG00000187772	LIN28B	70	73.288	ENSATEG00000008862	lin28a	90	64.205	Anabas_testudineus
ENSG00000187772	LIN28B	98	78.682	ENSACAG00000003957	LIN28B	97	79.310	Anolis_carolinensis
ENSG00000187772	LIN28B	55	83.333	ENSACAG00000017764	LIN28A	84	83.333	Anolis_carolinensis
ENSG00000187772	LIN28B	99	95.951	ENSANAG00000032418	-	98	95.902	Aotus_nancymaae
ENSG00000187772	LIN28B	76	77.358	ENSANAG00000021009	-	85	72.626	Aotus_nancymaae
ENSG00000187772	LIN28B	100	97.200	ENSANAG00000036677	-	100	97.200	Aotus_nancymaae
ENSG00000187772	LIN28B	67	62.590	ENSANAG00000038124	-	77	55.114	Aotus_nancymaae
ENSG00000187772	LIN28B	66	69.343	ENSANAG00000029599	-	83	64.968	Aotus_nancymaae
ENSG00000187772	LIN28B	83	76.136	ENSACLG00000021564	lin28b	100	64.567	Astatotilapia_calliptera
ENSG00000187772	LIN28B	78	74.118	ENSACLG00000027769	si:ch1073-284b18.2	84	74.118	Astatotilapia_calliptera
ENSG00000187772	LIN28B	85	71.958	ENSAMXG00000001433	LIN28B	99	59.524	Astyanax_mexicanus
ENSG00000187772	LIN28B	91	59.389	ENSAMXG00000001888	lin28b	99	58.566	Astyanax_mexicanus
ENSG00000187772	LIN28B	78	70.760	ENSAMXG00000042088	si:ch1073-284b18.2	86	73.295	Astyanax_mexicanus
ENSG00000187772	LIN28B	73	74.342	ENSAMXG00000038508	lin28a	90	70.286	Astyanax_mexicanus
ENSG00000187772	LIN28B	94	91.026	ENSBTAG00000043973	LIN28B	99	91.093	Bos_taurus
ENSG00000187772	LIN28B	84	73.864	ENSBTAG00000040497	LIN28A	93	69.588	Bos_taurus
ENSG00000187772	LIN28B	75	75.159	ENSBTAG00000048376	-	79	75.159	Bos_taurus
ENSG00000187772	LIN28B	79	72.619	ENSBTAG00000048256	-	83	72.619	Bos_taurus
ENSG00000187772	LIN28B	75	71.975	ENSCJAG00000021979	-	85	67.039	Callithrix_jacchus
ENSG00000187772	LIN28B	76	77.358	ENSCJAG00000009796	LIN28A	85	72.626	Callithrix_jacchus
ENSG00000187772	LIN28B	100	96.800	ENSCJAG00000001671	LIN28B	100	96.800	Callithrix_jacchus
ENSG00000187772	LIN28B	74	74.026	ENSCJAG00000022770	-	85	68.156	Callithrix_jacchus
ENSG00000187772	LIN28B	76	68.553	ENSCJAG00000046922	-	79	64.804	Callithrix_jacchus
ENSG00000187772	LIN28B	100	88.095	ENSCAFG00000003598	LIN28B	100	88.095	Canis_familiaris
ENSG00000187772	LIN28B	84	73.864	ENSCAFG00000012488	LIN28A	84	73.864	Canis_familiaris
ENSG00000187772	LIN28B	100	88.095	ENSCAFG00020017606	LIN28B	100	88.095	Canis_lupus_dingo
ENSG00000187772	LIN28B	84	73.864	ENSCAFG00020021405	LIN28A	84	73.864	Canis_lupus_dingo
ENSG00000187772	LIN28B	76	78.616	ENSCHIG00000020597	-	93	69.543	Capra_hircus
ENSG00000187772	LIN28B	82	61.494	ENSCHIG00000026545	-	94	55.882	Capra_hircus
ENSG00000187772	LIN28B	100	91.085	ENSCHIG00000011133	LIN28B	100	91.085	Capra_hircus
ENSG00000187772	LIN28B	99	79.435	ENSTSYG00000032245	-	84	79.134	Carlito_syrichta
ENSG00000187772	LIN28B	100	94.574	ENSTSYG00000006480	-	100	94.574	Carlito_syrichta
ENSG00000187772	LIN28B	76	77.358	ENSTSYG00000027067	LIN28A	85	72.626	Carlito_syrichta
ENSG00000187772	LIN28B	97	88.017	ENSCAPG00000009019	LIN28B	100	88.017	Cavia_aperea
ENSG00000187772	LIN28B	94	87.660	ENSCPOG00000006178	LIN28B	100	87.600	Cavia_porcellus
ENSG00000187772	LIN28B	74	78.571	ENSCPOG00000024027	-	85	71.508	Cavia_porcellus
ENSG00000187772	LIN28B	76	77.358	ENSCCAG00000012963	-	85	72.626	Cebus_capucinus
ENSG00000187772	LIN28B	76	66.667	ENSCCAG00000037041	-	84	63.128	Cebus_capucinus
ENSG00000187772	LIN28B	100	97.200	ENSCCAG00000020904	LIN28B	100	97.200	Cebus_capucinus
ENSG00000187772	LIN28B	76	67.901	ENSCCAG00000010683	-	84	64.286	Cebus_capucinus
ENSG00000187772	LIN28B	76	77.358	ENSCATG00000020825	LIN28A	85	72.626	Cercocebus_atys
ENSG00000187772	LIN28B	100	98.062	ENSCATG00000037900	LIN28B	100	98.062	Cercocebus_atys
ENSG00000187772	LIN28B	74	79.221	ENSCLAG00000013508	LIN28A	85	72.067	Chinchilla_lanigera
ENSG00000187772	LIN28B	100	91.600	ENSCLAG00000010534	LIN28B	100	91.600	Chinchilla_lanigera
ENSG00000187772	LIN28B	84	97.619	ENSCSAG00000014708	LIN28B	100	97.619	Chlorocebus_sabaeus
ENSG00000187772	LIN28B	76	76.875	ENSCSAG00000000975	LIN28A	85	72.222	Chlorocebus_sabaeus
ENSG00000187772	LIN28B	70	96.825	ENSCHOG00000001682	LIN28B	99	96.825	Choloepus_hoffmanni
ENSG00000187772	LIN28B	75	45.513	ENSCHOG00000002073	-	84	43.750	Choloepus_hoffmanni
ENSG00000187772	LIN28B	100	84.800	ENSCPBG00000004104	LIN28B	100	84.800	Chrysemys_picta_bellii
ENSG00000187772	LIN28B	84	76.705	ENSCPBG00000025010	LIN28A	93	72.539	Chrysemys_picta_bellii
ENSG00000187772	LIN28B	76	76.730	ENSCANG00000029848	LIN28A	85	72.067	Colobus_angolensis_palliatus
ENSG00000187772	LIN28B	100	97.287	ENSCANG00000011024	LIN28B	100	97.287	Colobus_angolensis_palliatus
ENSG00000187772	LIN28B	70	57.534	ENSCANG00000039698	-	77	54.321	Colobus_angolensis_palliatus
ENSG00000187772	LIN28B	84	72.067	ENSCGRG00001017186	Lin28a	85	72.067	Cricetulus_griseus_chok1gshd
ENSG00000187772	LIN28B	100	77.737	ENSCGRG00001024078	Lin28b	100	79.562	Cricetulus_griseus_chok1gshd
ENSG00000187772	LIN28B	100	77.737	ENSCGRG00000014674	Lin28b	100	79.562	Cricetulus_griseus_crigri
ENSG00000187772	LIN28B	74	78.571	ENSCGRG00000011390	Lin28a	93	68.041	Cricetulus_griseus_crigri
ENSG00000187772	LIN28B	74	78.710	ENSCSEG00000019091	si:ch1073-284b18.2	88	73.256	Cynoglossus_semilaevis
ENSG00000187772	LIN28B	100	64.961	ENSCSEG00000000312	lin28b	100	64.961	Cynoglossus_semilaevis
ENSG00000187772	LIN28B	86	74.033	ENSCVAG00000001868	lin28b	100	63.386	Cyprinodon_variegatus
ENSG00000187772	LIN28B	74	78.065	ENSCVAG00000017320	si:ch1073-284b18.2	77	78.065	Cyprinodon_variegatus
ENSG00000187772	LIN28B	82	72.254	ENSDARG00000052511	lin28b	99	56.855	Danio_rerio
ENSG00000187772	LIN28B	77	70.807	ENSDARG00000016999	lin28a	85	73.548	Danio_rerio
ENSG00000187772	LIN28B	75	75.000	ENSDARG00000004328	LIN28A	93	69.189	Danio_rerio
ENSG00000187772	LIN28B	99	95.142	ENSDNOG00000015300	LIN28B	99	95.142	Dasypus_novemcinctus
ENSG00000187772	LIN28B	75	78.981	ENSDNOG00000010710	LIN28A	86	72.778	Dasypus_novemcinctus
ENSG00000187772	LIN28B	84	56.250	ENSDNOG00000031694	-	84	56.250	Dasypus_novemcinctus
ENSG00000187772	LIN28B	99	89.113	ENSDORG00000023330	-	100	89.113	Dipodomys_ordii
ENSG00000187772	LIN28B	100	91.200	ENSDORG00000009587	-	100	91.200	Dipodomys_ordii
ENSG00000187772	LIN28B	74	79.221	ENSDORG00000027432	Lin28a	85	72.626	Dipodomys_ordii
ENSG00000187772	LIN28B	74	55.000	ENSDORG00000005491	-	81	55.000	Dipodomys_ordii
ENSG00000187772	LIN28B	100	91.600	ENSETEG00000015340	LIN28B	100	91.600	Echinops_telfairi
ENSG00000187772	LIN28B	67	50.355	ENSEBUG00000008325	lin28a	79	48.148	Eptatretus_burgeri
ENSG00000187772	LIN28B	100	93.600	ENSEASG00005006422	LIN28B	100	93.600	Equus_asinus_asinus
ENSG00000187772	LIN28B	84	74.432	ENSEASG00005003947	LIN28A	93	70.103	Equus_asinus_asinus
ENSG00000187772	LIN28B	84	74.432	ENSECAG00000020267	LIN28A	93	70.103	Equus_caballus
ENSG00000187772	LIN28B	100	93.411	ENSECAG00000020994	LIN28B	100	93.411	Equus_caballus
ENSG00000187772	LIN28B	70	79.452	ENSEEUG00000012085	LIN28A	72	79.452	Erinaceus_europaeus
ENSG00000187772	LIN28B	100	86.508	ENSEEUG00000003632	LIN28B	100	86.508	Erinaceus_europaeus
ENSG00000187772	LIN28B	89	71.728	ENSELUG00000001315	lin28b	90	72.081	Esox_lucius
ENSG00000187772	LIN28B	74	76.774	ENSELUG00000018033	si:ch1073-284b18.2	80	76.774	Esox_lucius
ENSG00000187772	LIN28B	85	68.927	ENSELUG00000010131	lin28a	72	77.551	Esox_lucius
ENSG00000187772	LIN28B	84	73.864	ENSFCAG00000012810	LIN28A	84	73.864	Felis_catus
ENSG00000187772	LIN28B	100	92.636	ENSFCAG00000044308	LIN28B	100	92.636	Felis_catus
ENSG00000187772	LIN28B	79	92.216	ENSFALG00000011574	LIN28B	100	86.559	Ficedula_albicollis
ENSG00000187772	LIN28B	81	76.923	ENSFALG00000000374	LIN28A	88	72.043	Ficedula_albicollis
ENSG00000187772	LIN28B	83	73.563	ENSFDAG00000015707	LIN28A	93	68.528	Fukomys_damarensis
ENSG00000187772	LIN28B	100	92.400	ENSFDAG00000006141	LIN28B	100	92.400	Fukomys_damarensis
ENSG00000187772	LIN28B	74	78.710	ENSFHEG00000001038	si:ch1073-284b18.2	77	78.710	Fundulus_heteroclitus
ENSG00000187772	LIN28B	86	75.000	ENSFHEG00000022590	lin28b	94	66.667	Fundulus_heteroclitus
ENSG00000187772	LIN28B	74	78.065	ENSGMOG00000015660	si:ch1073-284b18.2	81	78.065	Gadus_morhua
ENSG00000187772	LIN28B	65	77.206	ENSGMOG00000015523	lin28a	96	77.206	Gadus_morhua
ENSG00000187772	LIN28B	82	76.437	ENSGMOG00000010704	lin28b	74	76.437	Gadus_morhua
ENSG00000187772	LIN28B	100	82.470	ENSGALG00000026761	LIN28B	100	82.470	Gallus_gallus
ENSG00000187772	LIN28B	81	78.107	ENSGALG00000036022	LIN28A	91	73.118	Gallus_gallus
ENSG00000187772	LIN28B	72	67.105	ENSGAFG00000013047	lin28b	85	58.824	Gambusia_affinis
ENSG00000187772	LIN28B	74	78.065	ENSGAFG00000008380	si:ch1073-284b18.2	87	73.143	Gambusia_affinis
ENSG00000187772	LIN28B	74	78.710	ENSGACG00000013893	si:ch1073-284b18.2	76	78.710	Gasterosteus_aculeatus
ENSG00000187772	LIN28B	74	70.323	ENSGACG00000007826	lin28a	91	70.323	Gasterosteus_aculeatus
ENSG00000187772	LIN28B	85	75.000	ENSGACG00000009428	lin28b	99	63.095	Gasterosteus_aculeatus
ENSG00000187772	LIN28B	84	76.705	ENSGAGG00000000401	LIN28A	93	72.539	Gopherus_agassizii
ENSG00000187772	LIN28B	100	84.400	ENSGAGG00000004857	LIN28B	100	84.400	Gopherus_agassizii
ENSG00000187772	LIN28B	100	98.837	ENSGGOG00000015437	LIN28B	100	98.837	Gorilla_gorilla
ENSG00000187772	LIN28B	76	67.925	ENSGGOG00000023305	-	84	64.246	Gorilla_gorilla
ENSG00000187772	LIN28B	76	77.358	ENSGGOG00000040223	LIN28A	85	72.626	Gorilla_gorilla
ENSG00000187772	LIN28B	84	76.536	ENSHBUG00000014195	lin28b	100	64.567	Haplochromis_burtoni
ENSG00000187772	LIN28B	78	74.118	ENSHBUG00000009265	si:ch1073-284b18.2	84	74.118	Haplochromis_burtoni
ENSG00000187772	LIN28B	99	77.733	ENSHGLG00000007160	-	98	77.559	Heterocephalus_glaber_female
ENSG00000187772	LIN28B	75	71.338	ENSHGLG00000008794	-	78	71.338	Heterocephalus_glaber_female
ENSG00000187772	LIN28B	100	83.942	ENSHGLG00000002468	-	100	83.942	Heterocephalus_glaber_female
ENSG00000187772	LIN28B	74	68.182	ENSHGLG00000001037	-	80	67.296	Heterocephalus_glaber_female
ENSG00000187772	LIN28B	75	78.344	ENSHGLG00000014608	-	93	68.020	Heterocephalus_glaber_female
ENSG00000187772	LIN28B	84	65.341	ENSHGLG00000019546	-	84	65.341	Heterocephalus_glaber_female
ENSG00000187772	LIN28B	84	64.804	ENSHGLG00000013109	-	84	64.804	Heterocephalus_glaber_female
ENSG00000187772	LIN28B	84	54.190	ENSHGLG00100005396	-	82	54.190	Heterocephalus_glaber_male
ENSG00000187772	LIN28B	74	80.288	ENSHGLG00100014464	-	100	80.288	Heterocephalus_glaber_male
ENSG00000187772	LIN28B	75	78.344	ENSHGLG00100017589	-	85	72.067	Heterocephalus_glaber_male
ENSG00000187772	LIN28B	99	77.733	ENSHGLG00100001729	-	98	77.559	Heterocephalus_glaber_male
ENSG00000187772	LIN28B	84	65.341	ENSHGLG00100006225	-	84	65.341	Heterocephalus_glaber_male
ENSG00000187772	LIN28B	73	82.353	ENSHCOG00000010844	lin28b	95	61.382	Hippocampus_comes
ENSG00000187772	LIN28B	86	72.778	ENSHCOG00000006614	si:ch1073-284b18.2	94	67.317	Hippocampus_comes
ENSG00000187772	LIN28B	77	75.155	ENSIPUG00000014952	si:ch1073-284b18.2	77	75.155	Ictalurus_punctatus
ENSG00000187772	LIN28B	77	72.727	ENSIPUG00000013520	lin28b	88	72.131	Ictalurus_punctatus
ENSG00000187772	LIN28B	76	76.875	ENSIPUG00000014304	LIN28B	88	59.912	Ictalurus_punctatus
ENSG00000187772	LIN28B	83	71.264	ENSIPUG00000011583	lin28a	88	72.000	Ictalurus_punctatus
ENSG00000187772	LIN28B	70	70.946	ENSSTOG00000022629	-	77	70.946	Ictidomys_tridecemlineatus
ENSG00000187772	LIN28B	84	72.067	ENSSTOG00000004329	-	94	67.500	Ictidomys_tridecemlineatus
ENSG00000187772	LIN28B	100	86.861	ENSSTOG00000002692	LIN28B	100	86.861	Ictidomys_tridecemlineatus
ENSG00000187772	LIN28B	100	79.600	ENSJJAG00000011024	Lin28b	100	79.600	Jaculus_jaculus
ENSG00000187772	LIN28B	90	61.257	ENSJJAG00000000679	-	91	61.257	Jaculus_jaculus
ENSG00000187772	LIN28B	74	75.974	ENSJJAG00000018806	Lin28a	89	69.274	Jaculus_jaculus
ENSG00000187772	LIN28B	74	76.774	ENSKMAG00000013435	si:ch1073-284b18.2	77	76.774	Kryptolebias_marmoratus
ENSG00000187772	LIN28B	84	75.000	ENSKMAG00000016334	lin28b	99	62.348	Kryptolebias_marmoratus
ENSG00000187772	LIN28B	74	78.710	ENSLBEG00000027533	si:ch1073-284b18.2	98	67.857	Labrus_bergylta
ENSG00000187772	LIN28B	78	66.667	ENSLBEG00000000893	lin28a	95	62.500	Labrus_bergylta
ENSG00000187772	LIN28B	78	66.667	ENSLBEG00000018630	-	95	62.500	Labrus_bergylta
ENSG00000187772	LIN28B	83	75.568	ENSLBEG00000019319	lin28b	98	62.214	Labrus_bergylta
ENSG00000187772	LIN28B	73	79.739	ENSLACG00000002747	LIN28A	84	75.429	Latimeria_chalumnae
ENSG00000187772	LIN28B	100	82.283	ENSLACG00000004053	LIN28B	91	82.283	Latimeria_chalumnae
ENSG00000187772	LIN28B	76	78.616	ENSLOCG00000003353	lin28a	78	78.616	Lepisosteus_oculatus
ENSG00000187772	LIN28B	100	76.096	ENSLOCG00000016539	lin28b	100	76.096	Lepisosteus_oculatus
ENSG00000187772	LIN28B	99	95.547	ENSLAFG00000017788	LIN28B	99	95.547	Loxodonta_africana
ENSG00000187772	LIN28B	75	78.344	ENSLAFG00000017525	LIN28A	93	69.072	Loxodonta_africana
ENSG00000187772	LIN28B	76	77.358	ENSMFAG00000037808	LIN28A	85	72.626	Macaca_fascicularis
ENSG00000187772	LIN28B	100	98.062	ENSMFAG00000013463	LIN28B	100	98.062	Macaca_fascicularis
ENSG00000187772	LIN28B	100	98.000	ENSMMUG00000014470	LIN28B	100	98.000	Macaca_mulatta
ENSG00000187772	LIN28B	76	77.358	ENSMMUG00000044953	LIN28A	85	72.626	Macaca_mulatta
ENSG00000187772	LIN28B	76	77.358	ENSMNEG00000035868	LIN28A	85	72.626	Macaca_nemestrina
ENSG00000187772	LIN28B	100	98.062	ENSMNEG00000038148	LIN28B	100	98.062	Macaca_nemestrina
ENSG00000187772	LIN28B	100	98.062	ENSMLEG00000028886	LIN28B	100	98.062	Mandrillus_leucophaeus
ENSG00000187772	LIN28B	76	77.358	ENSMLEG00000011746	LIN28A	85	72.626	Mandrillus_leucophaeus
ENSG00000187772	LIN28B	79	70.482	ENSMAMG00000002030	lin28a	84	70.482	Mastacembelus_armatus
ENSG00000187772	LIN28B	76	79.874	ENSMAMG00000007271	si:ch1073-284b18.2	81	79.874	Mastacembelus_armatus
ENSG00000187772	LIN28B	84	75.141	ENSMAMG00000006635	lin28b	79	75.269	Mastacembelus_armatus
ENSG00000187772	LIN28B	83	76.136	ENSMZEG00005018178	lin28b	100	64.567	Maylandia_zebra
ENSG00000187772	LIN28B	78	74.118	ENSMZEG00005006914	si:ch1073-284b18.2	87	74.118	Maylandia_zebra
ENSG00000187772	LIN28B	74	72.432	ENSMGAG00000013531	LIN28B	100	72.432	Meleagris_gallopavo
ENSG00000187772	LIN28B	81	78.107	ENSMGAG00000009456	LIN28A	82	78.107	Meleagris_gallopavo
ENSG00000187772	LIN28B	100	59.524	ENSMAUG00000006523	Lin28b	100	59.524	Mesocricetus_auratus
ENSG00000187772	LIN28B	74	78.571	ENSMAUG00000018852	Lin28a	85	71.508	Mesocricetus_auratus
ENSG00000187772	LIN28B	75	73.248	ENSMICG00000035289	-	84	68.715	Microcebus_murinus
ENSG00000187772	LIN28B	76	77.358	ENSMICG00000035023	-	92	72.626	Microcebus_murinus
ENSG00000187772	LIN28B	75	69.427	ENSMICG00000034716	-	83	65.341	Microcebus_murinus
ENSG00000187772	LIN28B	74	69.481	ENSMICG00000013694	-	84	63.687	Microcebus_murinus
ENSG00000187772	LIN28B	100	96.124	ENSMICG00000047923	LIN28B	100	96.124	Microcebus_murinus
ENSG00000187772	LIN28B	100	87.200	ENSMOCG00000015558	Lin28b	100	87.200	Microtus_ochrogaster
ENSG00000187772	LIN28B	74	78.571	ENSMOCG00000007819	Lin28a	85	71.508	Microtus_ochrogaster
ENSG00000187772	LIN28B	75	68.153	ENSMMOG00000014314	lin28a	95	64.773	Mola_mola
ENSG00000187772	LIN28B	74	78.065	ENSMMOG00000002137	si:ch1073-284b18.2	76	78.065	Mola_mola
ENSG00000187772	LIN28B	76	75.460	ENSMMOG00000014877	lin28b	73	63.362	Mola_mola
ENSG00000187772	LIN28B	84	75.000	ENSMODG00000014236	LIN28A	85	75.000	Monodelphis_domestica
ENSG00000187772	LIN28B	100	76.531	ENSMODG00000018035	LIN28B	99	76.531	Monodelphis_domestica
ENSG00000187772	LIN28B	74	80.000	ENSMALG00000012505	si:ch1073-284b18.2	77	80.000	Monopterus_albus
ENSG00000187772	LIN28B	79	66.061	ENSMALG00000004941	lin28a	88	62.360	Monopterus_albus
ENSG00000187772	LIN28B	99	62.550	ENSMALG00000000365	lin28b	99	62.550	Monopterus_albus
ENSG00000187772	LIN28B	74	79.221	MGP_CAROLIEiJ_G0026603	Lin28a	100	86.747	Mus_caroli
ENSG00000187772	LIN28B	100	78.467	MGP_CAROLIEiJ_G0015299	Lin28b	100	78.467	Mus_caroli
ENSG00000187772	LIN28B	100	78.102	ENSMUSG00000063804	Lin28b	100	78.102	Mus_musculus
ENSG00000187772	LIN28B	75	78.846	ENSMUSG00000050966	Lin28a	100	87.654	Mus_musculus
ENSG00000187772	LIN28B	74	78.571	MGP_PahariEiJ_G0028936	Lin28a	100	86.420	Mus_pahari
ENSG00000187772	LIN28B	100	78.102	MGP_PahariEiJ_G0030716	Lin28b	100	78.102	Mus_pahari
ENSG00000187772	LIN28B	75	78.846	MGP_SPRETEiJ_G0027583	Lin28a	100	87.654	Mus_spretus
ENSG00000187772	LIN28B	100	77.737	MGP_SPRETEiJ_G0016108	Lin28b	100	77.737	Mus_spretus
ENSG00000187772	LIN28B	100	94.000	ENSMPUG00000009489	LIN28B	100	94.000	Mustela_putorius_furo
ENSG00000187772	LIN28B	76	78.616	ENSMPUG00000015724	LIN28A	76	78.616	Mustela_putorius_furo
ENSG00000187772	LIN28B	74	92.432	ENSMLUG00000006883	LIN28B	100	92.432	Myotis_lucifugus
ENSG00000187772	LIN28B	74	78.571	ENSMLUG00000010158	-	77	77.987	Myotis_lucifugus
ENSG00000187772	LIN28B	100	89.200	ENSNGAG00000022808	Lin28b	100	89.200	Nannospalax_galili
ENSG00000187772	LIN28B	84	71.508	ENSNGAG00000018842	Lin28a	85	71.508	Nannospalax_galili
ENSG00000187772	LIN28B	78	74.118	ENSNBRG00000009446	si:ch1073-284b18.2	84	74.118	Neolamprologus_brichardi
ENSG00000187772	LIN28B	83	76.136	ENSNBRG00000020118	lin28b	96	63.636	Neolamprologus_brichardi
ENSG00000187772	LIN28B	74	68.831	ENSNLEG00000027494	-	84	64.773	Nomascus_leucogenys
ENSG00000187772	LIN28B	76	75.472	ENSNLEG00000030680	-	80	75.472	Nomascus_leucogenys
ENSG00000187772	LIN28B	100	99.225	ENSNLEG00000014146	LIN28B	100	99.225	Nomascus_leucogenys
ENSG00000187772	LIN28B	75	77.707	ENSNLEG00000028132	LIN28A	85	72.626	Nomascus_leucogenys
ENSG00000187772	LIN28B	84	75.000	ENSMEUG00000008743	LIN28A	85	75.000	Notamacropus_eugenii
ENSG00000187772	LIN28B	98	75.203	ENSMEUG00000003066	LIN28B	100	75.203	Notamacropus_eugenii
ENSG00000187772	LIN28B	84	73.184	ENSOPRG00000001591	LIN28A	85	73.184	Ochotona_princeps
ENSG00000187772	LIN28B	98	88.618	ENSOPRG00000006333	LIN28B	100	88.618	Ochotona_princeps
ENSG00000187772	LIN28B	74	75.325	ENSODEG00000019263	-	85	68.715	Octodon_degus
ENSG00000187772	LIN28B	100	90.800	ENSODEG00000013568	LIN28B	100	90.800	Octodon_degus
ENSG00000187772	LIN28B	74	76.623	ENSODEG00000004283	-	86	69.832	Octodon_degus
ENSG00000187772	LIN28B	57	70.248	ENSODEG00000016070	-	63	70.248	Octodon_degus
ENSG00000187772	LIN28B	78	73.529	ENSONIG00000016204	si:ch1073-284b18.2	84	73.529	Oreochromis_niloticus
ENSG00000187772	LIN28B	69	80.690	ENSONIG00000014706	lin28b	100	64.623	Oreochromis_niloticus
ENSG00000187772	LIN28B	90	82.323	ENSOANG00000010299	LIN28B	96	76.522	Ornithorhynchus_anatinus
ENSG00000187772	LIN28B	84	72.067	ENSOCUG00000027473	-	85	72.067	Oryctolagus_cuniculus
ENSG00000187772	LIN28B	84	72.067	ENSOCUG00000000299	-	85	72.067	Oryctolagus_cuniculus
ENSG00000187772	LIN28B	84	91.905	ENSOCUG00000017850	LIN28B	100	91.905	Oryctolagus_cuniculus
ENSG00000187772	LIN28B	62	57.364	ENSOCUG00000022420	-	64	57.364	Oryctolagus_cuniculus
ENSG00000187772	LIN28B	84	69.886	ENSOCUG00000027786	-	84	69.886	Oryctolagus_cuniculus
ENSG00000187772	LIN28B	84	64.804	ENSOCUG00000011640	-	98	64.804	Oryctolagus_cuniculus
ENSG00000187772	LIN28B	76	76.730	ENSORLG00000028106	si:ch1073-284b18.2	78	76.730	Oryzias_latipes
ENSG00000187772	LIN28B	100	63.780	ENSORLG00000012891	lin28b	100	63.780	Oryzias_latipes
ENSG00000187772	LIN28B	100	63.780	ENSORLG00020013527	lin28b	100	63.780	Oryzias_latipes_hni
ENSG00000187772	LIN28B	76	76.730	ENSORLG00020019710	si:ch1073-284b18.2	78	76.730	Oryzias_latipes_hni
ENSG00000187772	LIN28B	76	76.730	ENSORLG00015004663	si:ch1073-284b18.2	78	76.730	Oryzias_latipes_hsok
ENSG00000187772	LIN28B	100	63.780	ENSORLG00015008232	lin28b	100	63.780	Oryzias_latipes_hsok
ENSG00000187772	LIN28B	72	80.921	ENSOMEG00000006425	lin28b	76	75.862	Oryzias_melastigma
ENSG00000187772	LIN28B	75	76.282	ENSOMEG00000018521	si:ch1073-284b18.2	81	76.101	Oryzias_melastigma
ENSG00000187772	LIN28B	75	76.433	ENSOGAG00000003971	LIN28A	85	71.751	Otolemur_garnettii
ENSG00000187772	LIN28B	99	95.565	ENSOGAG00000011042	LIN28B	99	95.565	Otolemur_garnettii
ENSG00000187772	LIN28B	94	91.026	ENSOARG00000011404	LIN28B	90	91.200	Ovis_aries
ENSG00000187772	LIN28B	75	78.981	ENSOARG00000004614	LIN28A	86	73.446	Ovis_aries
ENSG00000187772	LIN28B	84	68.750	ENSOARG00000003913	-	85	68.750	Ovis_aries
ENSG00000187772	LIN28B	74	69.481	ENSPPAG00000012576	-	85	64.804	Pan_paniscus
ENSG00000187772	LIN28B	100	99.612	ENSPPAG00000038725	LIN28B	100	99.612	Pan_paniscus
ENSG00000187772	LIN28B	76	77.358	ENSPPAG00000037906	LIN28A	92	69.231	Pan_paniscus
ENSG00000187772	LIN28B	100	92.636	ENSPPRG00000016158	LIN28B	100	92.636	Panthera_pardus
ENSG00000187772	LIN28B	84	73.864	ENSPPRG00000009198	LIN28A	84	73.864	Panthera_pardus
ENSG00000187772	LIN28B	100	91.085	ENSPTIG00000009405	LIN28B	100	91.085	Panthera_tigris_altaica
ENSG00000187772	LIN28B	75	78.981	ENSPTIG00000015007	LIN28A	75	78.616	Panthera_tigris_altaica
ENSG00000187772	LIN28B	100	99.612	ENSPTRG00000018453	LIN28B	100	99.612	Pan_troglodytes
ENSG00000187772	LIN28B	74	69.481	ENSPTRG00000049314	-	93	61.735	Pan_troglodytes
ENSG00000187772	LIN28B	76	77.358	ENSPTRG00000000384	LIN28A	95	68.182	Pan_troglodytes
ENSG00000187772	LIN28B	100	98.062	ENSPANG00000032324	-	100	98.062	Papio_anubis
ENSG00000187772	LIN28B	76	77.358	ENSPANG00000009841	LIN28A	85	72.626	Papio_anubis
ENSG00000187772	LIN28B	100	98.062	ENSPANG00000005196	-	100	98.062	Papio_anubis
ENSG00000187772	LIN28B	73	77.632	ENSPKIG00000004532	lin28a	87	73.143	Paramormyrops_kingsleyae
ENSG00000187772	LIN28B	83	81.034	ENSPKIG00000013309	lin28b	100	66.538	Paramormyrops_kingsleyae
ENSG00000187772	LIN28B	54	83.186	ENSPSIG00000018001	LIN28A	85	76.154	Pelodiscus_sinensis
ENSG00000187772	LIN28B	100	85.200	ENSPSIG00000002635	LIN28B	100	85.200	Pelodiscus_sinensis
ENSG00000187772	LIN28B	80	66.864	ENSPMGG00000003595	-	88	66.867	Periophthalmus_magnuspinnatus
ENSG00000187772	LIN28B	84	73.034	ENSPMGG00000022825	lin28b	83	61.633	Periophthalmus_magnuspinnatus
ENSG00000187772	LIN28B	79	75.758	ENSPMGG00000004200	si:ch1073-284b18.2	99	68.205	Periophthalmus_magnuspinnatus
ENSG00000187772	LIN28B	100	86.400	ENSPEMG00000015724	Lin28b	100	86.400	Peromyscus_maniculatus_bairdii
ENSG00000187772	LIN28B	74	79.221	ENSPEMG00000012419	Lin28a	85	72.626	Peromyscus_maniculatus_bairdii
ENSG00000187772	LIN28B	84	75.000	ENSPCIG00000012691	LIN28A	85	75.000	Phascolarctos_cinereus
ENSG00000187772	LIN28B	74	86.486	ENSPCIG00000019464	LIN28B	92	73.333	Phascolarctos_cinereus
ENSG00000187772	LIN28B	74	78.065	ENSPFOG00000014054	si:ch1073-284b18.2	77	78.065	Poecilia_formosa
ENSG00000187772	LIN28B	83	76.571	ENSPFOG00000019352	lin28b	100	63.424	Poecilia_formosa
ENSG00000187772	LIN28B	74	78.065	ENSPLAG00000020857	si:ch1073-284b18.2	79	78.065	Poecilia_latipinna
ENSG00000187772	LIN28B	83	76.571	ENSPLAG00000009101	lin28b	94	66.529	Poecilia_latipinna
ENSG00000187772	LIN28B	83	76.571	ENSPMEG00000015694	lin28b	100	63.424	Poecilia_mexicana
ENSG00000187772	LIN28B	74	78.065	ENSPMEG00000013212	si:ch1073-284b18.2	77	78.065	Poecilia_mexicana
ENSG00000187772	LIN28B	74	78.065	ENSPREG00000005259	si:ch1073-284b18.2	77	78.065	Poecilia_reticulata
ENSG00000187772	LIN28B	72	67.105	ENSPREG00000006170	lin28b	96	54.505	Poecilia_reticulata
ENSG00000187772	LIN28B	76	77.358	ENSPPYG00000001684	LIN28A	85	72.626	Pongo_abelii
ENSG00000187772	LIN28B	98	99.187	ENSPPYG00000016875	LIN28B	100	99.187	Pongo_abelii
ENSG00000187772	LIN28B	85	71.751	ENSPCAG00000013674	LIN28A	85	71.751	Procavia_capensis
ENSG00000187772	LIN28B	78	73.171	ENSPCOG00000019441	-	82	73.171	Propithecus_coquereli
ENSG00000187772	LIN28B	79	64.242	ENSPCOG00000016166	-	80	64.242	Propithecus_coquereli
ENSG00000187772	LIN28B	100	96.899	ENSPCOG00000016875	LIN28B	100	96.899	Propithecus_coquereli
ENSG00000187772	LIN28B	76	77.358	ENSPCOG00000026551	-	85	72.626	Propithecus_coquereli
ENSG00000187772	LIN28B	83	73.295	ENSPVAG00000017267	LIN28A	88	73.295	Pteropus_vampyrus
ENSG00000187772	LIN28B	100	93.600	ENSPVAG00000008797	LIN28B	91	93.600	Pteropus_vampyrus
ENSG00000187772	LIN28B	83	76.136	ENSPNYG00000022590	lin28b	96	63.636	Pundamilia_nyererei
ENSG00000187772	LIN28B	78	74.118	ENSPNYG00000014005	si:ch1073-284b18.2	87	74.118	Pundamilia_nyererei
ENSG00000187772	LIN28B	71	76.351	ENSPNAG00000019008	lin28a	78	74.194	Pygocentrus_nattereri
ENSG00000187772	LIN28B	73	75.776	ENSPNAG00000016114	LIN28B	99	55.351	Pygocentrus_nattereri
ENSG00000187772	LIN28B	95	59.414	ENSPNAG00000002632	lin28b	99	59.684	Pygocentrus_nattereri
ENSG00000187772	LIN28B	79	75.152	ENSPNAG00000015739	si:ch1073-284b18.2	89	73.184	Pygocentrus_nattereri
ENSG00000187772	LIN28B	74	79.221	ENSRNOG00000060320	Lin28a	93	68.020	Rattus_norvegicus
ENSG00000187772	LIN28B	100	85.200	ENSRNOG00000025938	Lin28b	100	85.200	Rattus_norvegicus
ENSG00000187772	LIN28B	100	97.287	ENSRBIG00000036241	LIN28B	100	97.287	Rhinopithecus_bieti
ENSG00000187772	LIN28B	76	76.730	ENSRBIG00000032004	LIN28A	85	72.067	Rhinopithecus_bieti
ENSG00000187772	LIN28B	69	64.583	ENSRBIG00000011346	-	82	61.585	Rhinopithecus_bieti
ENSG00000187772	LIN28B	68	64.789	ENSRROG00000032651	-	81	61.728	Rhinopithecus_roxellana
ENSG00000187772	LIN28B	76	76.730	ENSRROG00000013874	LIN28A	85	72.067	Rhinopithecus_roxellana
ENSG00000187772	LIN28B	100	96.899	ENSRROG00000033602	LIN28B	100	96.899	Rhinopithecus_roxellana
ENSG00000187772	LIN28B	84	63.687	ENSSBOG00000031930	-	83	63.687	Saimiri_boliviensis_boliviensis
ENSG00000187772	LIN28B	100	96.800	ENSSBOG00000025323	LIN28B	100	96.800	Saimiri_boliviensis_boliviensis
ENSG00000187772	LIN28B	74	75.974	ENSSBOG00000033280	-	84	69.886	Saimiri_boliviensis_boliviensis
ENSG00000187772	LIN28B	66	80.292	ENSSBOG00000005545	-	93	74.522	Saimiri_boliviensis_boliviensis
ENSG00000187772	LIN28B	74	86.022	ENSSHAG00000012716	-	100	86.022	Sarcophilus_harrisii
ENSG00000187772	LIN28B	75	79.487	ENSSFOG00015006164	lin28a	77	79.747	Scleropages_formosus
ENSG00000187772	LIN28B	96	68.880	ENSSFOG00015010561	lin28b	88	69.444	Scleropages_formosus
ENSG00000187772	LIN28B	68	72.535	ENSSMAG00000020241	lin28a	87	65.868	Scophthalmus_maximus
ENSG00000187772	LIN28B	79	76.364	ENSSMAG00000005221	si:ch1073-284b18.2	88	70.370	Scophthalmus_maximus
ENSG00000187772	LIN28B	70	76.027	ENSSDUG00000011644	lin28a	81	76.027	Seriola_dumerili
ENSG00000187772	LIN28B	76	79.375	ENSSDUG00000000613	lin28b	99	62.400	Seriola_dumerili
ENSG00000187772	LIN28B	76	79.245	ENSSDUG00000009722	si:ch1073-284b18.2	84	79.245	Seriola_dumerili
ENSG00000187772	LIN28B	73	73.203	ENSSLDG00000020568	lin28a	93	65.574	Seriola_lalandi_dorsalis
ENSG00000187772	LIN28B	74	80.000	ENSSLDG00000003150	si:ch1073-284b18.2	79	80.000	Seriola_lalandi_dorsalis
ENSG00000187772	LIN28B	80	76.190	ENSSLDG00000001858	lin28b	100	64.032	Seriola_lalandi_dorsalis
ENSG00000187772	LIN28B	54	57.500	ENSSARG00000013135	-	90	57.500	Sorex_araneus
ENSG00000187772	LIN28B	100	89.600	ENSSARG00000008374	LIN28B	100	89.600	Sorex_araneus
ENSG00000187772	LIN28B	100	84.524	ENSSPUG00000013225	LIN28B	100	84.921	Sphenodon_punctatus
ENSG00000187772	LIN28B	84	75.000	ENSSPUG00000010213	LIN28A	85	75.000	Sphenodon_punctatus
ENSG00000187772	LIN28B	74	79.355	ENSSPAG00000012590	si:ch1073-284b18.2	77	79.355	Stegastes_partitus
ENSG00000187772	LIN28B	76	79.375	ENSSPAG00000009877	lin28b	89	65.639	Stegastes_partitus
ENSG00000187772	LIN28B	70	73.288	ENSSPAG00000018737	lin28a	81	70.779	Stegastes_partitus
ENSG00000187772	LIN28B	58	62.810	ENSSSCG00000039310	-	57	62.810	Sus_scrofa
ENSG00000187772	LIN28B	84	73.864	ENSSSCG00000003557	LIN28A	93	69.588	Sus_scrofa
ENSG00000187772	LIN28B	99	93.522	ENSSSCG00000037612	LIN28B	96	92.460	Sus_scrofa
ENSG00000187772	LIN28B	84	42.614	ENSSSCG00000039497	-	81	42.614	Sus_scrofa
ENSG00000187772	LIN28B	100	84.064	ENSTGUG00000012225	LIN28B	100	84.064	Taeniopygia_guttata
ENSG00000187772	LIN28B	55	83.333	ENSTGUG00000001037	LIN28A	97	75.573	Taeniopygia_guttata
ENSG00000187772	LIN28B	55	55.372	ENSTRUG00000009454	lin28a	65	55.372	Takifugu_rubripes
ENSG00000187772	LIN28B	72	80.892	ENSTRUG00000019692	lin28b	99	62.948	Takifugu_rubripes
ENSG00000187772	LIN28B	77	77.500	ENSTRUG00000006069	si:ch1073-284b18.2	78	78.710	Takifugu_rubripes
ENSG00000187772	LIN28B	67	71.942	ENSTNIG00000009802	lin28a	90	69.128	Tetraodon_nigroviridis
ENSG00000187772	LIN28B	69	84.247	ENSTNIG00000012302	lin28b	99	60.643	Tetraodon_nigroviridis
ENSG00000187772	LIN28B	74	91.304	ENSTBEG00000005872	LIN28B	73	91.304	Tupaia_belangeri
ENSG00000187772	LIN28B	100	91.600	ENSTTRG00000014919	LIN28B	91	91.600	Tursiops_truncatus
ENSG00000187772	LIN28B	82	74.138	ENSTTRG00000005678	LIN28A	90	73.446	Tursiops_truncatus
ENSG00000187772	LIN28B	100	94.400	ENSUAMG00000022834	LIN28B	100	94.400	Ursus_americanus
ENSG00000187772	LIN28B	84	73.864	ENSUAMG00000006984	LIN28A	84	73.864	Ursus_americanus
ENSG00000187772	LIN28B	84	73.864	ENSUMAG00000012579	LIN28A	84	73.864	Ursus_maritimus
ENSG00000187772	LIN28B	100	94.400	ENSUMAG00000020916	LIN28B	100	94.400	Ursus_maritimus
ENSG00000187772	LIN28B	98	84.553	ENSVPAG00000011202	LIN28B	100	84.553	Vicugna_pacos
ENSG00000187772	LIN28B	84	73.295	ENSVVUG00000011926	-	84	73.295	Vulpes_vulpes
ENSG00000187772	LIN28B	76	77.215	ENSVVUG00000010329	-	80	77.215	Vulpes_vulpes
ENSG00000187772	LIN28B	95	93.970	ENSVVUG00000003739	LIN28B	100	88.462	Vulpes_vulpes
ENSG00000187772	LIN28B	81	61.538	ENSVVUG00000013087	-	62	61.538	Vulpes_vulpes
ENSG00000187772	LIN28B	78	68.966	ENSXETG00000012324	lin28a	89	68.966	Xenopus_tropicalis
ENSG00000187772	LIN28B	99	66.135	ENSXETG00000013293	lin28b	100	66.535	Xenopus_tropicalis
ENSG00000187772	LIN28B	80	76.786	ENSXCOG00000004261	lin28b	86	64.629	Xiphophorus_couchianus
ENSG00000187772	LIN28B	79	73.256	ENSXCOG00000000815	si:ch1073-284b18.2	85	73.256	Xiphophorus_couchianus
ENSG00000187772	LIN28B	83	76.000	ENSXMAG00000003450	lin28b	94	66.116	Xiphophorus_maculatus
ENSG00000187772	LIN28B	79	73.256	ENSXMAG00000014593	si:ch1073-284b18.2	85	73.256	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003723	RNA binding	19703396.	IDA	Function
GO:0005515	protein binding	19703396.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0008270	zinc ion binding	-	IEA	Function
GO:0010587	miRNA catabolic process	19703396.	IMP	Process
GO:0031054	pre-miRNA processing	19703396.	IMP	Process
GO:0031123	RNA 3'-end processing	19703396.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21512136	LIN28B promotes colon cancer progression and metastasis.	Cancer Res	2011 Jun 15	King CE	doi: 10.1158/0008-5472.CAN-10-4637
20827722	MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2.	Hepatology	2010 Nov	Liang L	doi: 10.1002/hep.23904.
24732380	Lin28 sustains early renal progenitors and induces Wilms tumor.	Genes Dev	2014 May 1	Urbach A	doi: 10.1101/gad.237149.113
25726847	Elevated Lin28B expression is correlated with lymph node metastasis in oral squamous cell carcinomas.	J Oral Pathol Med	2015 Nov	Lin WT	doi: 10.1111/jop.12314
28301057	The correlation between LIN28B gene potentially functional variants and Wilms tumor susceptibility in Chinese children.	J Clin Lab Anal	2018 Jan	Fu W	doi: 10.1002/jcla.22200
29503447	LIN28B enhanced tumorigenesis in an autochthonous KRASG12V-driven lung carcinoma mouse model.	Oncogene	2018 May	Meder L	doi: 10.1038/s41388-018-0158-7
19483683	Lin28 promotes transformation and is associated with advanced human malignancies.	Nat Genet	2009 Jul	Viswanathan SR	doi: 10.1038/ng.392
26898455	Let-7a mimic attenuates CCL18 induced breast cancer cell metastasis through Lin 28 pathway.	Biomed Pharmacother	2016 Mar	Wang L	doi: 10.1016/j.biopha.2016.01.028
25858147	Lin28B/Let-7 Regulates Expression of Oct4 and Sox2 and Reprograms Oral Squamous Cell Carcinoma Cells to a Stem-like State.	Cancer Res	2015 Jun 15	Chien CS	doi: 10.1158/0008-5472.CAN-14-2215
25201220	A potential regulatory loop between Lin28B:miR212 in androgen-independent prostate cancer.	Int J Oncol	2014 Dec	Borrego-Diaz E	doi: 10.3892/ijo.2014.2647
23494474	The oncoprotein HBXIP upregulates Lin28B via activating TF II D to promote proliferation of breast cancer cells.	Int J Cancer	2013 Sep 15	Liu Q	doi: 10.1002/ijc.28154
24780874	Genetic variants of the LIN28B gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.	Eur J Cancer	2014 Jul	Wen J	doi: 10.1016/j.ejca.2014.03.008
25503985	Genetic variants in let-7/Lin28 modulate the risk of oral cavity cancer in a Chinese Han population.	Sci Rep	2014 Dec 11	Zhang Y	doi: 10.1038/srep07434.
21625210	LIN28B fosters colon cancer migration, invasion and transformation through let-7-dependent and -independent mechanisms.	Oncogene	2011 Oct 6	King CE	doi: 10.1038/onc.2011.131
19745602	LIN28B confers radio-resistance through the posttranscriptional control of KRAS.	Exp Mol Med	2009 Dec 31	Jeong SH	doi: 10.3858/emm.2009.41.12.097.
26080928	A role of uridylation pathway for blockade of let-7 microRNA biogenesis by Lin28B.	Cancer Sci	2015 Sep	Suzuki HI	doi: 10.1111/cas.12721
24244607	Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma.	PLoS One	2013 Nov 14	Cheng SW	doi: 10.1371/journal.pone.0080053
25200669	Expression of LIN28 and its regulatory microRNAs in adult adrenocortical cancer.	Clin Endocrinol (Oxf)	2015 Apr	Faria AM	doi: 10.1111/cen.12607
23052130	A LIN28B polymorphism predicts for colon cancer survival.	Cancer Biol Ther	2012 Dec	Ye Y	doi: 10.4161/cbt.22336
21533284	Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.	PLoS One	2011 Apr 13	Helland	doi: 10.1371/journal.pone.0018064.
24885919	Lin28B expression correlates with aggressive clinicopathological characteristics in breast invasive ductal carcinoma.	Cancer Biother Radiopharm	2014 Jun	Xie R	doi: 10.1089/cbr.2014.1610
22822098	Functional study of risk loci of stem cell-associated gene lin-28B and associations with disease survival outcomes in epithelial ovarian cancer.	Carcinogenesis	2012 Nov	Lu L	doi: 10.1093/carcin/bgs243
27383785	Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma.	Nature	2016 Jul 14	Powers JT	doi: 10.1038/nature18632
28102845	H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance.	Cell Death Dis	2017 Jan 19	Peng F	doi: 10.1038/cddis.2016.438.
27793004	Comparison of the expression and function of Lin28A and Lin28B in colon cancer.	Oncotarget	2016 Nov 29	Wang T	doi: 10.18632/oncotarget.12869.
26158423	Overexpression of the RNA-binding proteins Lin28B and IGF2BP3 (IMP3) is associated with chemoresistance and poor disease outcome in ovarian cancer.	Br J Cancer	2015 Jul 28	Hsu KF	doi: 10.1038/bjc.2015.254
29336272	Let-7 miRNA Precursors Co-express with LIN28B in Cervical Cells.	Microrna	2018	Zamora-Contreras AM	doi: 10.2174/2211536607666180115143014.
29301498	PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells.	BMC Cancer	2018 Jan 4	Qu TT	doi: 10.1186/s12885-017-3959-0.
29669301	LIN28B promotes the progression of colon cancer by increasing B-cell lymphoma 2 expression.	Biomed Pharmacother	2018 Jul	Yuan L	doi: 10.1016/j.biopha.2018.04.002
29787985	RNA binding protein Lin28B confers gastric cancer cells stemness via directly binding to NRP-1.	Biomed Pharmacother	2018 Aug	Wang X	doi: 10.1016/j.biopha.2018.05.064

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr6	105078549	Silent	novel	P173P	0.49
BLCA	chr6	104957112	5'UTR	novel		0.17
BLCA	chr6	105078856	3'UTR	novel		0.08
BLCA	chr6	104957202	5'UTR	novel		0.22
BRCA	chr6	105082213	3'UTR	novel		0.31
BRCA	chr6	104958223	Missense_Mutation	NA	F45L	0.16
BRCA	chr6	105078588	Silent	NA	P186P	0.6
BRCA	chr6	105078467	Missense_Mutation	NA	P146L	0.41
BRCA	chr6	105082061	3'UTR	novel		0.5
BRCA	chr6	105078477	Missense_Mutation	NA	K149N	0.33
BRCA	chr6	104957063	5'UTR	novel		0.33
CESC	chr6	105078566	Missense_Mutation	novel	R179T	0.39
CESC	chr6	105082591	3'UTR	novel		0.3
CESC	chr6	105026313	Missense_Mutation	NA	E72Q	0.44
CESC	chr6	105080947	3'UTR	rs573512821		0.4
CESC	chr6	105080661	3'UTR	novel		0.1
CHOL	chr6	105080204	3'UTR	novel		0.18
COAD	chr6	105078680	Missense_Mutation	rs76912525	R217Q	0.2
COAD	chr6	105078792	3'UTR	novel		0.14
COAD	chr6	104957130	5'UTR	novel		0.29
COAD	chr6	104957152	5'UTR	novel		0.5
COAD	chr6	105078803	3'UTR	novel		0.32
DLBC	chr6	105078551	Missense_Mutation	rs201716597	A174V	0.88	CSD
ESCA	chr6	105082646	3'UTR	novel		0.17
ESCA	chr6	105078654	Missense_Mutation	novel	Q208H	0.27
ESCA	chr6	105080204	3'UTR	novel		0.28
ESCA	chr6	105080947	3'UTR	rs573512821		0.47
GBM	chr6	105078437	Missense_Mutation	novel	D136V	0.08
HNSC	chr6	105026470	Frame_Shift_Ins	novel	*D127Rfs2**	0.24
HNSC	chr6	104958269	Missense_Mutation	NA	D61N	0.25
HNSC	chr6	105026398	Missense_Mutation	novel	T100R	0.21
HNSC	chr6	104958281	Missense_Mutation	novel	H65D	0.41
HNSC	chr6	104958206	Missense_Mutation	novel	R40S	0.44
HNSC	chr6	105026305	Missense_Mutation	novel	L69Q	0.1
HNSC	chr6	104958240	Missense_Mutation	novel	R51Q	0.4
KICH	chr6	105078739	Nonsense_Mutation	novel	Q237*	0.07
KIRC	chr6	105078793	3'UTR	novel		0.31
KIRC	chr6	105078786	3'UTR	novel		0.42
LIHC	chr6	105078785	3'UTR	novel		0.3
LUAD	chr6	105078826	3'UTR	novel		0.12
LUAD	chr6	104958193	Missense_Mutation	novel	K35N	0.27
LUAD	chr6	105078580	Missense_Mutation	novel	S184T	0.21
LUAD	chr6	105078815	3'UTR	novel		0.22
LUAD	chr6	104958185	Missense_Mutation	NA	H33N	0.19
LUAD	chr6	104957260	Missense_Mutation	NA	G4S	0.12
LUAD	chr6	105078607	Missense_Mutation	novel	R193G	0.56
LUAD	chr6	104958269	Missense_Mutation	NA	D61N	0.08
LUSC	chr6	104957257	Missense_Mutation	novel	E3K	0.28
LUSC	chr6	105078711	Silent	NA	S227S	0.16
LUSC	chr6	104958253	Silent	novel	P55P	0.22
LUSC	chr6	104958130	Silent	novel	P14P	0.06
LUSC	chr6	105078809	3'UTR	novel		0.23
LUSC	chr6	105078713	Missense_Mutation	novel	T228K	0.12
LUSC	chr6	105078439	Missense_Mutation	NA	H137N	0.23
LUSC	chr6	104958173	Missense_Mutation	NA	R29C	0.08
LUSC	chr6	104958120	Missense_Mutation	novel	G11A	0.29
LUSC	chr6	104958238	Missense_Mutation	novel	N50K	0.42
LUSC	chr6	104958239	Silent	novel	R51R	0.43
LUSC	chr6	104957241	5'UTR	novel		0.43
OV	chr6	105078828	3'UTR	novel		0.08
OV	chr6	105078467	Missense_Mutation	NA	P146L	0.32
PAAD	chr6	105026300	Missense_Mutation	rs759920340	S67R	0.18
PRAD	chr6	104958219	Missense_Mutation	NA	G44V	0.12
READ	chr6	105026408	Frame_Shift_Ins	novel	*S105Efs7**	0.33
READ	chr6	105078754	Missense_Mutation	novel	P242S	0.35
READ	chr6	105078806	3'UTR	novel		0.2
SKCM	chr6	105026445	Missense_Mutation	novel	G116R	0.21
SKCM	chr6	104958114	Missense_Mutation	novel	G9D	0.35
SKCM	chr6	105026349	Missense_Mutation	NA	E84K	0.33
SKCM	chr6	104958101	Missense_Mutation	NA	G5R	0.1
SKCM	chr6	104958211	Missense_Mutation	NA	M41I	0.37
SKCM	chr6	105026461	Missense_Mutation	NA	K121I	0.34
SKCM	chr6	105078616	Missense_Mutation	NA	G196R	0.39
SKCM	chr6	105078807	3'UTR	novel		0.15
SKCM	chr6	105078714	Silent	NA	T228T	0.3
SKCM	chr6	105026393	Silent	NA	R98R	0.54
SKCM	chr6	104958213	Missense_Mutation	NA	G42E	0.08
SKCM	chr6	105078563	Missense_Mutation	NA	G178E	0.23
SKCM	chr6	105026459	Silent	novel	Q120Q	0.22
SKCM	chr6	105026349	Missense_Mutation	NA	E84K	0.16
SKCM	chr6	104958213	Missense_Mutation	NA	G42E	0.3
SKCM	chr6	105026446	Missense_Mutation	NA	G116E	0.4
SKCM	chr6	105026407	Missense_Mutation	NA	G103A	0.52
SKCM	chr6	105078751	Missense_Mutation	NA	G241R	0.35
SKCM	chr6	105078714	Silent	NA	T228T	0.42
SKCM	chr6	105078477	Silent	novel	K149K	0.54
STAD	chr6	105026407	Missense_Mutation	novel	G103V	0.06
STAD	chr6	105026361	Frame_Shift_Del	novel	*K89Nfs11**	0.43
STAD	chr6	104957135	5'UTR	novel		0.37
STAD	chr6	105026468	Silent	novel	K123K	0.36
STAD	chr6	105078600	Silent	NA	T190T	0.14
STAD	chr6	105078621	Silent	rs141067774	G197G	0.27
UCEC	chr6	105079398	3'UTR	rs527412913		0.34
UCEC	chr6	104957136	5'UTR	rs543233322		0.3
UCEC	chr6	105079241	3'UTR	novel		0.14
UCEC	chr6	105082724	3'UTR	novel		0.44
UCEC	chr6	105080816	3'UTR	novel		0.35
UCEC	chr6	105082920	3'UTR	novel		0.07
UCEC	chr6	105083181	3'UTR	novel		0.44
UCEC	chr6	104957181	5'UTR	novel		0.25
UCEC	chr6	105078815	3'UTR	rs144813272		0.39
UCEC	chr6	105079386	3'UTR	novel		0.13
UCEC	chr6	105081123	3'UTR	novel		0.23
UCEC	chr6	105080318	3'UTR	novel		0.49
UCEC	chr6	105078790	3'UTR	novel		0.21
UCEC	chr6	105079218	3'UTR	novel		0.47
UCEC	chr6	105080427	3'UTR	novel		0.5
UCEC	chr6	105078758	Nonsense_Mutation	NA	S243*	0.39
UCEC	chr6	105080947	3'UTR	rs573512821		0.41
UCEC	chr6	105081283	3'UTR	novel		0.57
UCEC	chr6	104957209	5'UTR	novel		0.07
UCEC	chr6	105082203	3'UTR	novel		0.2
UCEC	chr6	105079398	3'UTR	rs527412913		0.38
UCEC	chr6	105082009	3'UTR	novel		0.38
UCEC	chr6	105082447	3'UTR	novel		0.18
UCEC	chr6	105082752	3'UTR	novel		0.45
UCEC	chr6	105082472	3'UTR	novel		0.18
UCEC	chr6	105083063	3'UTR	NA		0.28
UCEC	chr6	105026460	Missense_Mutation	novel	K121E	0.47
UCEC	chr6	105082104	3'UTR	novel		0.36
UCEC	chr6	105082377	3'UTR	novel		0.4
UCEC	chr6	105083133	3'UTR	novel		0.48
UCEC	chr6	105078708	Silent	novel	S226S	0.36
UCEC	chr6	105081463	3'UTR	novel		0.4
UCEC	chr6	105079398	3'UTR	rs527412913		0.19
UCEC	chr6	105078808	3'UTR	novel		0.46
UCEC	chr6	105079398	3'UTR	rs527412913		0.38
UCEC	chr6	105081551	3'UTR	novel		0.67
UCEC	chr6	105083161	3'UTR	rs569264456		0.48
UCEC	chr6	105079384	3'UTR	novel		0.38
UCEC	chr6	105082333	3'UTR	novel		0.13
UCEC	chr6	105080204	3'UTR	novel		0.51
UCEC	chr6	105026306	Silent	novel	L69L	0.14
UCEC	chr6	105079398	3'UTR	rs527412913		0.22
UCEC	chr6	105080277	3'UTR	novel		0.35
UCEC	chr6	105081438	3'UTR	novel		0.52
UCEC	chr6	105080947	3'UTR	rs573512821		0.67
UCEC	chr6	105078965	3'UTR	novel		0.4
UCEC	chr6	105080767	3'UTR	novel		0.15
UCEC	chr6	105081097	3'UTR	novel		0.11
UCEC	chr6	105081283	3'UTR	novel		0.29
UCEC	chr6	105081046	3'UTR	novel		0.39
UCEC	chr6	104958219	Missense_Mutation	novel	G44E	0.36
UCEC	chr6	105081429	3'UTR	novel		0.3
UCEC	chr6	105081844	3'UTR	novel		0.32
UCEC	chr6	105078644	Missense_Mutation	rs150452636	P205L	0.41
UCEC	chr6	105081843	3'UTR	novel		0.48
UCEC	chr6	105082305	3'UTR	novel		0.49
UCEC	chr6	105079404	3'UTR	novel		0.28
UCEC	chr6	105079713	3'UTR	novel		0.33
UCEC	chr6	105081074	3'UTR	novel		0.22
UCEC	chr6	105080561	3'UTR	novel		0.35
UCEC	chr6	105081123	3'UTR	novel		0.62
UCEC	chr6	105081843	3'UTR	novel		0.5
UCEC	chr6	105082199	3'UTR	novel		0.54
UCEC	chr6	105083043	3'UTR	novel		0.34
UCEC	chr6	105083097	3'UTR	novel		0.08
UCEC	chr6	105026325	Missense_Mutation	novel	S76R	0.33
UCEC	chr6	105081335	3'UTR	novel		0.22
UCEC	chr6	105080242	3'UTR	novel		0.37
UCEC	chr6	105081333	3'UTR	novel		0.38
UCEC	chr6	105082348	3'UTR	novel		0.13
UCEC	chr6	105080213	3'UTR	novel		0.33
UCEC	chr6	104958100	Splice_Region	NA	G4G	0.07
UCEC	chr6	104957214	5'UTR	novel		0.06
UCEC	chr6	105082332	3'UTR	rs185554685		0.33
UCEC	chr6	105026368	Missense_Mutation	novel	S90Y	0.08
UCEC	chr6	105078911	3'UTR	novel		0.36
UCEC	chr6	105078818	3'UTR	novel		0.06
UCEC	chr6	105082699	3'UTR	novel		0.42
UCEC	chr6	105026368	Missense_Mutation	novel	S90Y	0.56
UCEC	chr6	105080145	3'UTR	novel		0.36
UCEC	chr6	105080947	3'UTR	rs573512821		0.57
UCEC	chr6	105082743	3'UTR	novel		0.67
UCEC	chr6	105080947	3'UTR	rs573512821		0.36
UCEC	chr6	105082154	3'UTR	novel		0.12
UCEC	chr6	105082744	3'UTR	novel		0.38
UCEC	chr6	105078432	Silent	novel	G134G	0.09
UCEC	chr6	105078601	Missense_Mutation	novel	L191F	0.11
UCEC	chr6	105082836	3'UTR	novel		0.52

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3578	3.4915e-05
DLBC	DEL	0.3542	0.00052595
ESCA	DEL	0.2337	0.036953
LUAD	DEL	0.4089	0.0021365
MESO	DEL	0.4368	0.05642
PAAD	DEL	0.3587	0.11274
SKCM	DEL	0.5286	1.5442e-06
STAD	DEL	0.1519	0.0044196
THYM	DEL	0.1301	0.10691

Survival Analysis

Cancer	P-value	Q-value
STAD	0.026	Kaplan-Meier Survival Analysis
TGCT	0.049	Kaplan-Meier Survival Analysis
UCEC	0.00026	Kaplan-Meier Survival Analysis
LGG	0.028	Kaplan-Meier Survival Analysis