EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000187837 (Gene tree)
Gene ID: 3006
Gene Symbol: HIST1H1C
Alias: H1.2|H1s-1|H1c|H1F2
Full Name: histone cluster 1 H1 family member c
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 732 bases
Position: chr6:26,055,740-26,056,471
Accession: 4716
RBP type: non-canonical RBP
Summary: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000343677	HIST1H1C-201	642	-	ENSP00000339566	213 (aa)	-	P16403

Gene Model

Click here to download ENSG00000187837's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000187837's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000786	nucleosome	-	IEA	Component
GO:0003690	double-stranded DNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	21873635.	IBA	Function
GO:0005515	protein binding	22720776.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	21383955.22720776.	IDA	Component
GO:0005719	nuclear euchromatin	21873635.	IBA	Component
GO:0005719	nuclear euchromatin	15911621.	IDA	Component
GO:0006334	nucleosome assembly	-	IEA	Process
GO:0006355	regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0016584	nucleosome positioning	21873635.	IBA	Process
GO:0030261	chromosome condensation	21873635.	IBA	Process
GO:0031490	chromatin DNA binding	15911621.	IDA	Function
GO:0031492	nucleosomal DNA binding	21873635.	IBA	Function
GO:0031936	negative regulation of chromatin silencing	21873635.	IBA	Process
GO:0035327	transcriptionally active chromatin	21873635.	IBA	Component
GO:0045910	negative regulation of DNA recombination	21873635.	IBA	Process
GO:0080182	histone H3-K4 trimethylation	21873635.	IBA	Process
GO:0098532	histone H3-K27 trimethylation	21873635.	IBA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26209608	Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence.	Mol Cell Proteomics	2016 Mar	Chen Y	doi: 10.1074/mcp.M114.046441

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr6	26056159	Silent	NA	K90K	0.25
BLCA	chr6	26055880	Missense_Mutation	NA	K183N	0.36
BLCA	chr6	26056055	Missense_Mutation	novel	G125E	0.17
BLCA	chr6	26056102	Missense_Mutation	NA	K109N	0.44
BLCA	chr6	26056240	Frame_Shift_Del	novel	S51*	0.13
BLCA	chr6	26055889	Silent	rs773564861	A180A	0.26
BLCA	chr6	26056432	5'Flank	rs779418596		0.19
BLCA	chr6	26055784	3'Flank	novel		0.31
BLCA	chr6	26056165	Silent	NA	V88V	0.2
BLCA	chr6	26055889	Silent	NA	A180A	0.53
BLCA	chr6	26056089	Missense_Mutation	novel	G114R	0.24
BLCA	chr6	26056279	Silent	rs150897775	A50A	0.37
BLCA	chr6	26056215	Missense_Mutation	NA	D72H	0.17
BLCA	chr6	26056152	Silent	rs751365843	L93L	0.1
BLCA	chr6	26055964	Silent	NA	P155P	0.7
BLCA	chr6	26055784	3'Flank	novel		0.08
BLCA	chr6	26055988	Silent	NA	P147P	0.33
BLCA	chr6	26055913	Missense_Mutation	novel	K172N	0.17
BLCA	chr6	26055990	Missense_Mutation	rs527943061	P147S	0.17
BRCA	chr6	26055889	Silent	NA	A180A	0.15
BRCA	chr6	26055834	Missense_Mutation	NA	K199E	0.27
BRCA	chr6	26055878	Missense_Mutation	novel	K184R	0.08
BRCA	chr6	26055940	In_Frame_Del	novel	K159_A163del	0.4
BRCA	chr6	26055811	Missense_Mutation	NA	K206N	0.3
CESC	chr6	26056445	5'Flank	rs201648183		0.12
CESC	chr6	26056471	5'Flank	novel		0.08
CESC	chr6	26056042	Missense_Mutation	rs766767455	K129N	0.41
CESC	chr6	26056285	Frame_Shift_Ins	novel	*A49Gfs4**	0.64
COAD	chr6	26055808	In_Frame_Del	NA	K207del	0.43
COAD	chr6	26056102	Silent	NA	K109K	0.12
COAD	chr6	26056115	Missense_Mutation	novel	F105C	0.2
COAD	chr6	26055975	Missense_Mutation	novel	K152E	0.32
COAD	chr6	26056029	Frame_Shift_Del	novel	*A134Qfs33**	0.24
COAD	chr6	26055861	Missense_Mutation	novel	A190T	0.16
COAD	chr6	26056192	Silent	NA	R79R	0.27
COAD	chr6	26056153	Silent	novel	T92T	0.06
COAD	chr6	26056256	Missense_Mutation	rs550065694	S58Y	0.33
COAD	chr6	26055990	Missense_Mutation	rs527943061	P147S	0.41
DLBC	chr6	26056272	Missense_Mutation	novel	E53K	0.57
DLBC	chr6	26056102	Missense_Mutation	NA	K109N	0.2
DLBC	chr6	26056251	Missense_Mutation	novel	A60P	0.36
DLBC	chr6	26055758	3'Flank	novel		0.22
DLBC	chr6	26056243	Silent	rs770676686	L62L	0.31
DLBC	chr6	26055925	Frame_Shift_Del	novel	*A162Efs4**	0.09
DLBC	chr6	26056163	Missense_Mutation	novel	S89N	0.15
DLBC	chr6	26056235	Missense_Mutation	rs79562358	A65V	0.39
DLBC	chr6	26056005	Missense_Mutation	rs774761285	A142T	0.06
DLBC	chr6	26056157	Missense_Mutation	rs781062933	G91D	0.46
DLBC	chr6	26056260	Missense_Mutation	NA	V57I	0.42
ESCA	chr6	26056448	5'Flank	rs778395124		0.16
ESCA	chr6	26055796	Silent	rs750505144	K211K	0.45
ESCA	chr6	26056079	Missense_Mutation	novel	K117R	0.63
ESCA	chr6	26056366	Missense_Mutation	novel	K21N	0.14
GBM	chr6	26056156	Frame_Shift_Ins	novel	*T92Hfs15**	0.43
GBM	chr6	26055919	Frame_Shift_Ins	novel	*A171Gfs2**	0.41
GBM	chr6	26056009	In_Frame_Del	rs749190253	P138_K140del	0.38
HNSC	chr6	26056035	Missense_Mutation	NA	V132F	0.17
HNSC	chr6	26056324	Silent	rs139532972	A35A	0.08
HNSC	chr6	26055750	3'Flank	rs373098851		0.17
HNSC	chr6	26055925	Missense_Mutation	rs534420299	K168N	0.67
HNSC	chr6	26056320	Frame_Shift_Ins	novel	*G37Wfs16**	0.78
HNSC	chr6	26056166	Missense_Mutation	novel	V88G	0.12
HNSC	chr6	26056141	Silent	novel	T96T	0.17
HNSC	chr6	26056073	Missense_Mutation	rs374398098	K119R	0.32
HNSC	chr6	26056275	Missense_Mutation	rs141424312	K52E	0.27
HNSC	chr6	26055889	Silent	rs773564861	A180A	0.32
HNSC	chr6	26055784	3'Flank	novel		0.24
KIRP	chr6	26055868	Silent	NA	K187K	0.09
LGG	chr6	26056118	Missense_Mutation	NA	S104F	0.22
LGG	chr6	26056402	Silent	NA	P9P	0.36
LIHC	chr6	26055969	Missense_Mutation	rs548795634	T154A	0.28
LIHC	chr6	26056174	Missense_Mutation	NA	K85N	0.13
LIHC	chr6	26056151	Missense_Mutation	NA	L93P	0.46
LIHC	chr6	26055913	Missense_Mutation	novel	K172N	0.2
LIHC	chr6	26056386	In_Frame_Del	novel	E3_P14del	0.08
LIHC	chr6	26056000	Silent	novel	G143G	0.19
LIHC	chr6	26056001	Missense_Mutation	novel	G143V	0.19
LUAD	chr6	26056236	Frame_Shift_Ins	novel	*A65Sfs8**	0.25
LUAD	chr6	26055913	Missense_Mutation	novel	K172N	0.18
LUAD	chr6	26056174	Silent	NA	K85K	0.16
LUAD	chr6	26056344	Missense_Mutation	novel	G29R	0.1
LUAD	chr6	26056377	Missense_Mutation	novel	A18P	0.05
LUAD	chr6	26055767	3'Flank	novel		0.19
LUAD	chr6	26055889	Silent	rs773564861	A180A	0.1
LUAD	chr6	26056012	Silent	novel	K139K	0.55
LUAD	chr6	26055896	Missense_Mutation	novel	K178M	0.12
LUSC	chr6	26056174	Missense_Mutation	NA	K85N	0.1
LUSC	chr6	26055988	Silent	novel	P147P	0.32
LUSC	chr6	26056209	Missense_Mutation	rs781281855	E74K	0.41
LUSC	chr6	26056021	Missense_Mutation	novel	K136N	0.3
LUSC	chr6	26056319	Missense_Mutation	novel	G37D	0.26
LUSC	chr6	26055988	Silent	NA	P147P	0.32
LUSC	chr6	26056438	5'Flank	novel		0.48
LUSC	chr6	26055889	Silent	rs773564861	A180A	0.04
LUSC	chr6	26055947	Missense_Mutation	rs61742489	P161L	0.13
LUSC	chr6	26056412	Missense_Mutation	novel	P6L	0.23
LUSC	chr6	26056102	Silent	NA	K109K	0.07
LUSC	chr6	26056354	Silent	novel	A25A	0.29
LUSC	chr6	26056314	Missense_Mutation	rs547650580	P39S	0.4
LUSC	chr6	26056315	Silent	rs780590605	P38P	0.4
LUSC	chr6	26056215	Missense_Mutation	NA	D72N	0.18
LUSC	chr6	26056403	Missense_Mutation	novel	P9R	0.1
MESO	chr6	26055916	Frame_Shift_Del	novel	*K172Rfs22**	0.2
OV	chr6	26056102	Missense_Mutation	NA	K109N	0.1
OV	chr6	26056442	5'Flank	rs753834202		0.29
OV	chr6	26056309	Silent	rs766702432	V40V	0.13
OV	chr6	26056386	Missense_Mutation	novel	A15S	0.17
OV	chr6	26056418	Missense_Mutation	NA	T4S	0.27
OV	chr6	26055971	Missense_Mutation	novel	K153R	0.33
OV	chr6	26055787	Nonstop_Mutation	NA	214Yext?	0.13
OV	chr6	26056087	Silent	NA	G114G	0.39
PAAD	chr6	26056183	Silent	novel	L82L	0.2
READ	chr6	26056230	Missense_Mutation	rs561654336	A67T	0.18
SARC	chr6	26056340	Frame_Shift_Del	NA	*G30Vfs33**	0.46
SKCM	chr6	26055784	3'Flank	novel		0.32
SKCM	chr6	26056141	Silent	rs555588749	T96T	0.34
SKCM	chr6	26056163	Missense_Mutation	novel	S89N	0.28
SKCM	chr6	26056389	Missense_Mutation	rs751385999	P14S	0.12
SKCM	chr6	26055884	Missense_Mutation	rs142399492	P182L	0.3
STAD	chr6	26055900	Missense_Mutation	rs761753866	A177T	0.2
STAD	chr6	26055911	Missense_Mutation	rs145521943	S173T	0.48
STAD	chr6	26056445	5'Flank	novel		0.32
STAD	chr6	26056437	5'Flank	novel		0.31
STAD	chr6	26056385	Missense_Mutation	rs759161097	A15V	0.8
STAD	chr6	26056259	Missense_Mutation	NA	V57A	0.17
TGCT	chr6	26056374	Missense_Mutation	rs200705328	P19A	0.34
THCA	chr6	26056012	Silent	novel	K139K	0.13
UCEC	chr6	26056423	Silent	rs764314267	S2S	0.37
UCEC	chr6	26055743	3'Flank	rs773962521		0.52
UCEC	chr6	26055842	Missense_Mutation	novel	K196M	0.34
UCEC	chr6	26055895	Missense_Mutation	NA	K178N	0.1
UCEC	chr6	26056365	Missense_Mutation	NA	K22Q	0.26
UCEC	chr6	26055888	Missense_Mutation	novel	K181E	0.32
UCEC	chr6	26055758	3'Flank	novel		0.38
UCEC	chr6	26055829	Silent	novel	P200P	0.15
UCEC	chr6	26056110	Missense_Mutation	novel	L107F	0.21
UCEC	chr6	26055972	Frame_Shift_Ins	novel	*K153Afs29**	0.05
UCEC	chr6	26056144	Missense_Mutation	novel	Q95H	0.53
UCEC	chr6	26056334	Missense_Mutation	rs377657422	P32L	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1186	0.046699

Survival Analysis

Cancer	P-value	Q-value
THYM	0.023	Kaplan-Meier Survival Analysis
MESO	0.00033	Kaplan-Meier Survival Analysis
ACC	0.00013	Kaplan-Meier Survival Analysis
UCS	0.00012	Kaplan-Meier Survival Analysis
PAAD	0.0063	Kaplan-Meier Survival Analysis
BLCA	0.00029	Kaplan-Meier Survival Analysis
CESC	0.0014	Kaplan-Meier Survival Analysis
LAML	0.0091	Kaplan-Meier Survival Analysis
UCEC	0.015	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
UVM	0.0065	Kaplan-Meier Survival Analysis
OV	0.039	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742