EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact

  • Description
  • RBDs
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000188120 (Gene tree)
Gene ID
1617
Gene Symbol
DAZ1
Alias
SPGY|DAZ
Full Name
deleted in azoospermia 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
69,769 bases
Position
chrY:23,129,355-23,199,123
Accession
2682
RBP type
canonical RBP
Summary
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts containing three copies of the RRM domain have been described; thus the RefSeq for this gene contains only two RRM domains. [provided by RefSeq, Jul 2008]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000371950RRM_5PF13893.63e-1013
ENSP00000371950RRM_5PF13893.63e-1023
ENSP00000371950RRM_5PF13893.63e-1033
ENSP00000384573RRM_5PF13893.67.4e-1013
ENSP00000384573RRM_5PF13893.67.4e-1023
ENSP00000384573RRM_5PF13893.67.4e-1033
ENSP00000371950RRM_1PF00076.221.3e-3613
ENSP00000371950RRM_1PF00076.221.3e-3623
ENSP00000371950RRM_1PF00076.221.3e-3633
ENSP00000384573RRM_1PF00076.222.7e-3613
ENSP00000384573RRM_1PF00076.222.7e-3623
ENSP00000384573RRM_1PF00076.222.7e-3633
ENSP00000400716RRM_1PF00076.228.8e-1111
ENSP00000444407RRM_1PF00076.229.7e-1111
ENSP00000484907RRM_1PF00076.221.3e-1011

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
9143498Gene sequence, localization, and evolutionary conservation of DAZLA, a candidate male sterility gene.Genomics1997 Apr 15Seboun E-
22021443Kinked β-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.Proc Natl Acad Sci U S A2011 Nov 8Jenkins HTdoi: 10.1073/pnas.1105211108
8661148Mouse autosomal homolog of DAZ, a candidate male sterility gene in humans, is expressed in male germ cells before and after puberty.Genomics1996 Jul 15Reijo R-
19838299DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish.PLoS One2009 Oct 19Takeda Ydoi: 10.1371/journal.pone.0007513.
25605553Oncogenic Role of BOLL in Colorectal Cancer.Dig Dis Sci2015 JunKang KJdoi: 10.1007/s10620-015-3533-z
26327816DAZ Family Proteins, Key Players for Germ Cell Development.Int J Biol Sci2015 Aug 15Fu XFdoi: 10.7150/ijbs.11536
12296827Zebrafish DAZ-like protein controls translation via the sequence 'GUUC'.Genes Cells2002 SepMaegawa S-
9882490Biphasic subcellular localization of the DAZL-related protein boule in Drosophila spermatogenesis.Dev Biol1998 Dec 15Cheng MH-
9806824A long-range restriction map of deletion interval 6 of the human Y chromosome: a region frequently deleted in azoospermic males.Genomics1998 Nov 15Yen PH-
9588208The Dazh gene is expressed in male and female embryonic gonads before germ cell sex differentiation.Biochem Biophys Res Commun1998 Apr 28Seligman J-
9486791A Xenopus DAZ-like gene encodes an RNA component of germ plasm and is a functional homologue of Drosophila boule.Development1998 JanHouston DW-
9375979Y-chromosome microdeletions and male infertility.Ann Med1997 AugBhasin S-
9288969The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis.Nature1997 Sep 4Ruggiu M-
9108067Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm.Proc Natl Acad Sci U S A1997 Apr 15Elliott DJ-
8923005Recurrent duplication and deletion polymorphisms on the long arm of the Y chromosome in normal males.Hum Mol Genet1996 NovJobling MA-
8845845A murine homologue of the human DAZ gene is autosomal and expressed only in male and female gonads.Hum Mol Genet1996 AprCooke HJ-
10393944A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype.Proc Natl Acad Sci U S A1999 Jul 6Slee R-
10402374Screening for microdeletions of Y chromosome genes in patients undergoing intracytoplasmic sperm injection.Hum Reprod1999 JulKrausz C-
7670487Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene.Nat Genet1995 AugReijo R-
16573709A to G transitions at 260, 386 and 437 in DAZL gene are not associated with spermatogenic failure in Indian population.Int J Androl2006 OctThangaraj K-
12511597Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.Proc Natl Acad Sci U S A2003 Jan 21Moore FL-
11604102Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL.BMC Genomics2001Dai T-
16425031Evolutionary comparison of the reproductive genes, DAZL and BOULE, in primates with and without DAZ.Dev Genes Evol2006 MarTung JY-
11525089[From gene to disease; deletion of the DAZ-gene from the Y-chromosome in oligo- or azoospermia ].Ned Tijdschr Geneeskd2001 Aug 11Tuerlings JH-
11410654The RNA-binding specificity of the mouse Dazl protein.Nucleic Acids Res2001 Jun 15Venables JP-
11390979A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans.Proc Natl Acad Sci U S A2001 Jun 19Xu EY-
11163833Expression of CDY1 may identify complete spermatogenesis.Fertil Steril2001 JanKleiman SE-
10936047Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome.Genomics2000 Aug 1Saxena R-
10857750Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.Genomics2000 May 1Tsui S-
10662646Caenorhabditis elegans homologue of the human azoospermia factor DAZ is required for oogenesis but not for spermatogenesis.Development2000 MarKarashima T-
16278232Dazl binds in vivo to specific transcripts and can regulate the pre-meiotic translation of Mvh in germ cells.Hum Mol Genet2005 Dec 15Reynolds N-
16848763Phosphorylation of the ARE-binding protein DAZAP1 by ERK2 induces its dissociation from DAZ.Biochem J2006 Oct 15Morton S-
15705297Role of the DAZ genes in male fertility.Reprod Biomed Online2005 JanReynolds N-
15572146Caenorhabditis elegans DAZ-1 is expressed in proliferating germ cells and directs proper nuclear organization and cytoplasmic core formation during oogenesis.Dev Biol2005 Jan 1Maruyama R-
15139965Putative biological functions of the DAZ family.Int J Androl2004 JunYen PH-
15081113Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells.Genomics2004 MayMoore FL-
14751364Transcriptional levels of four Y chromosome-linked AZF genes in azoospermic men and their association with successful sperm retrieval.Urology2004 JanKuo PL-
14611631Absence of mDazl produces a final block on germ cell development at meiosis.Reproduction2003 NovSaunders PT-
19540345Structure and RNA binding of the mouse Pumilio-2 Puf domain.J Struct Biol2009 SepJenkins HTdoi: 10.1016/j.jsb.2009.06.007
19564913Boule is present in fish and bisexually expressed in adult and embryonic germ cells of medaka.PLoS One2009 Jun 30Xu Hdoi: 10.1371/journal.pone.0006097.
18987886Cloning and characterization of the gene encoding the bovine BOULE protein.Mol Genet Genomics2009 JanZhang Qdoi: 10.1007/s00438-008-0394-6
16979959Cloning and expression of medaka dazl during embryogenesis and gametogenesis.Gene Expr Patterns2007 JanXu H-
20335278A novel requirement in mammalian spermatid differentiation for the DAZ-family protein Boule.Hum Mol Genet2010 Jun 15VanGompel MJdoi: 10.1093/hmg/ddq109
20300286A386G transition in DAZL gene is not associated with spermatogenic failure in Tamil Nadu, South India.Indian J Hum Genet2008 JanPoongothai Jdoi: 10.4103/0971-6866.42322.
25726377IGF1 regulation of BOULE and CDC25A transcripts via a testosterone-independent pathway in spermatogenesis of adult mice.Reprod Biol2015 MarGonzalez CRdoi: 10.1016/j.repbio.2014.10.003
24715697The roles of DAZL in RNA biology and development.Wiley Interdiscip Rev RNA2014 Jul-AugSmorag Ldoi: 10.1002/wrna.1228
24086306A developmental stage-specific switch from DAZL to BOLL occurs during fetal oogenesis in humans, but not mice.PLoS One2013 Sep 25He Jdoi: 10.1371/journal.pone.0073996
28115159DND protein functions as a translation repressor during zebrafish embryogenesis.Biochem Biophys Res Commun2017 Mar 4Kobayashi Mdoi: 10.1016/j.bbrc.2017.01.080
19285026DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins.Biochem Biophys Res Commun2009 Mar 13Yang HTdoi: 10.1016/j.bbrc.2009.01.166
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000466332DAZ1-2042242--- (aa)--
ENST00000540248DAZ1-2053268-ENSP00000444407390 (aa)-UPI000000DBFC
ENST00000382510DAZ1-2012382-ENSP00000371950613 (aa)-Q9NQZ3
ENST00000405239DAZ1-2024421XM_011531482ENSP00000384573744 (aa)XP_011529784Q9NQZ3
ENST00000620725DAZ1-2061891-ENSP00000484907486 (aa)-A0A087X2D7
ENST00000426000DAZ1-2031846-ENSP00000400716366 (aa)-A0A0A0MSR9
Gene Model
Click here to download ENSG00000188120's gene model file
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000188120's network
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000188120DAZ18682.584ENSG00000092345DAZL8185.455
ENSG00000188120DAZ1100100.000ENSG00000205916DAZ4100100.000
ENSG00000188120DAZ17030.392ENSG00000151923TIAL15436.000
ENSG00000188120DAZ1100100.000ENSG00000205944DAZ2100100.000
ENSG00000188120DAZ110098.974ENSG00000187191DAZ310098.974
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000188120DAZ18681.633ENSAMEG00000009059-7183.832Ailuropoda_melanoleuca
ENSG00000188120DAZ19064.881ENSAPLG00000007738-7755.085Anas_platyrhynchos
ENSG00000188120DAZ19066.467ENSACAG00000007822-6563.473Anolis_carolinensis
ENSG00000188120DAZ18581.443ENSANAG00000034405DAZL6785.106Aotus_nancymaae
ENSG00000188120DAZ16750.365ENSACLG00000000529dazl5660.440Astatotilapia_calliptera
ENSG00000188120DAZ18682.051ENSBTAG00000000502DAZL7184.431Bos_taurus
ENSG00000188120DAZ18682.584ENSCJAG00000039120DAZL8282.653Callithrix_jacchus
ENSG00000188120DAZ19983.929ENSCAFG00000005867-10083.929Canis_familiaris
ENSG00000188120DAZ18075.581ENSCAFG00020027335-6575.309Canis_lupus_dingo
ENSG00000188120DAZ18682.051ENSCHIG00000017877DAZL7184.431Capra_hircus
ENSG00000188120DAZ18678.212ENSTSYG00000000788DAZL7181.675Carlito_syrichta
ENSG00000188120DAZ17378.169ENSCAPG00000003209DAZL6680.892Cavia_aperea
ENSG00000188120DAZ18977.528ENSCPOG00000007628DAZL7277.528Cavia_porcellus
ENSG00000188120DAZ18682.051ENSCCAG00000035747DAZL7382.143Cebus_capucinus
ENSG00000188120DAZ18683.708ENSCATG00000009078DAZL7383.708Cercocebus_atys
ENSG00000188120DAZ18678.462ENSCLAG00000006407DAZL6782.011Chinchilla_lanigera
ENSG00000188120DAZ18683.708ENSCSAG00000009976DAZL7383.708Chlorocebus_sabaeus
ENSG00000188120DAZ19979.878ENSCSAG00000017742-10079.878Chlorocebus_sabaeus
ENSG00000188120DAZ18667.470ENSCHOG00000005264-6572.222Choloepus_hoffmanni
ENSG00000188120DAZ17274.809ENSCPBG00000022547-6271.756Chrysemys_picta_bellii
ENSG00000188120DAZ18683.708ENSCANG00000006852DAZL7383.708Colobus_angolensis_palliatus
ENSG00000188120DAZ18678.974ENSCGRG00001021961Dazl7080.838Cricetulus_griseus_chok1gshd
ENSG00000188120DAZ18678.974ENSCGRG00000013515Dazl6980.723Cricetulus_griseus_crigri
ENSG00000188120DAZ15658.824ENSDARG00000036214dazl7865.556Danio_rerio
ENSG00000188120DAZ18585.030ENSDNOG00000019085-6885.030Dasypus_novemcinctus
ENSG00000188120DAZ16480.342ENSDORG00000011497Dazl7571.875Dipodomys_ordii
ENSG00000188120DAZ18581.481ENSEASG00005005756-6983.750Equus_asinus_asinus
ENSG00000188120DAZ18682.051ENSECAG00000010923-7184.431Equus_caballus
ENSG00000188120DAZ18679.487ENSEEUG00000005973-7181.325Erinaceus_europaeus
ENSG00000188120DAZ18682.564ENSFCAG00000023607-6885.789Felis_catus
ENSG00000188120DAZ16567.241ENSFALG00000008893-6064.655Ficedula_albicollis
ENSG00000188120DAZ18879.070ENSFDAG00000017861DAZL7179.070Fukomys_damarensis
ENSG00000188120DAZ17246.032ENSGMOG00000011491dazl9856.250Gadus_morhua
ENSG00000188120DAZ18965.868ENSGALG00000011243DAZL6660.479Gallus_gallus
ENSG00000188120DAZ18682.584ENSGGOG00000023632DAZL7382.653Gorilla_gorilla
ENSG00000188120DAZ16751.095ENSHBUG00000017426dazl5661.538Haplochromis_burtoni
ENSG00000188120DAZ18678.462ENSHGLG00000013488DAZL6782.105Heterocephalus_glaber_female
ENSG00000188120DAZ18678.462ENSHGLG00100019389DAZL6782.105Heterocephalus_glaber_male
ENSG00000188120DAZ16058.252ENSIPUG00000006376dazl7264.444Ictalurus_punctatus
ENSG00000188120DAZ18780.337ENSSTOG00000022122-7083.234Ictidomys_tridecemlineatus
ENSG00000188120DAZ18678.443ENSJJAG00000010767Dazl6879.042Jaculus_jaculus
ENSG00000188120DAZ19059.322ENSLACG00000002895-6657.955Latimeria_chalumnae
ENSG00000188120DAZ18546.535ENSLOCG00000006452dazl8060.870Lepisosteus_oculatus
ENSG00000188120DAZ18680.102ENSLAFG00000009132-7182.036Loxodonta_africana
ENSG00000188120DAZ18684.270ENSMFAG00000002406DAZL7884.946Macaca_fascicularis
ENSG00000188120DAZ18684.270ENSMMUG00000011361DAZL8187.273Macaca_mulatta
ENSG00000188120DAZ110080.473ENSMMUG00000045289-10080.473Macaca_mulatta
ENSG00000188120DAZ19784.971ENSMMUG00000041692-9984.971Macaca_mulatta
ENSG00000188120DAZ18684.270ENSMNEG00000038455DAZL7384.270Macaca_nemestrina
ENSG00000188120DAZ18683.616ENSMLEG00000038997DAZL6686.772Mandrillus_leucophaeus
ENSG00000188120DAZ16750.365ENSMZEG00005009515dazl5660.440Maylandia_zebra
ENSG00000188120DAZ19063.529ENSMGAG00000010878-5867.361Meleagris_gallopavo
ENSG00000188120DAZ18678.462ENSMAUG00000018931Dazl6878.462Mesocricetus_auratus
ENSG00000188120DAZ18681.026ENSMICG00000049389-7183.234Microcebus_murinus
ENSG00000188120DAZ18677.436ENSMOCG00000016627Dazl7079.042Microtus_ochrogaster
ENSG00000188120DAZ19084.940ENSMODG00000014730-7384.940Monodelphis_domestica
ENSG00000188120DAZ18676.923MGP_CAROLIEiJ_G0021735Dazl7079.042Mus_caroli
ENSG00000188120DAZ18677.436ENSMUSG00000010592Dazl7079.042Mus_musculus
ENSG00000188120DAZ18676.410MGP_PahariEiJ_G0020724Dazl7076.531Mus_pahari
ENSG00000188120DAZ18677.436MGP_SPRETEiJ_G0022647Dazl7079.042Mus_spretus
ENSG00000188120DAZ18681.818ENSMPUG00000001426-7184.024Mustela_putorius_furo
ENSG00000188120DAZ18580.838ENSMLUG00000011337-6880.838Myotis_lucifugus
ENSG00000188120DAZ18578.836ENSNGAG00000009472Dazl6779.891Nannospalax_galili
ENSG00000188120DAZ18682.022ENSNLEG00000033788DAZL7382.022Nomascus_leucogenys
ENSG00000188120DAZ18567.857ENSMEUG00000007283-6968.750Notamacropus_eugenii
ENSG00000188120DAZ18672.892ENSOPRG00000001387-6672.892Ochotona_princeps
ENSG00000188120DAZ18674.872ENSODEG00000006167DAZL7077.895Octodon_degus
ENSG00000188120DAZ18568.639ENSOANG00000006742-5774.000Ornithorhynchus_anatinus
ENSG00000188120DAZ18681.122ENSOCUG00000012635-7183.234Oryctolagus_cuniculus
ENSG00000188120DAZ18682.143ENSOGAG00000006983-7184.431Otolemur_garnettii
ENSG00000188120DAZ17280.503ENSOARG00000015474-6780.503Ovis_aries
ENSG00000188120DAZ18682.564ENSPPAG00000037518DAZL7382.564Pan_paniscus
ENSG00000188120DAZ18682.564ENSPPRG00000008794-6885.789Panthera_pardus
ENSG00000188120DAZ18682.564ENSPTIG00000020895-6885.789Panthera_tigris_altaica
ENSG00000188120DAZ19693.939ENSPTRG00000047116-9993.939Pan_troglodytes
ENSG00000188120DAZ19690.751ENSPTRG00000028811-10090.751Pan_troglodytes
ENSG00000188120DAZ18682.584ENSPTRG00000014674DAZL7382.653Pan_troglodytes
ENSG00000188120DAZ110089.524ENSPTRG00000023120-10093.413Pan_troglodytes
ENSG00000188120DAZ19693.939ENSPTRG00000050343-9993.939Pan_troglodytes
ENSG00000188120DAZ18683.708ENSPANG00000015077DAZL7383.708Papio_anubis
ENSG00000188120DAZ19072.455ENSPSIG00000009803-6368.862Pelodiscus_sinensis
ENSG00000188120DAZ16677.397ENSPEMG00000019679Dazl8581.429Peromyscus_maniculatus_bairdii
ENSG00000188120DAZ18682.022ENSPCIG00000028322-7184.737Phascolarctos_cinereus
ENSG00000188120DAZ19082.584ENSPPYG00000014080DAZL7382.653Pongo_abelii
ENSG00000188120DAZ18582.447ENSPCAG00000016182-6883.133Procavia_capensis
ENSG00000188120DAZ18584.337ENSPVAG00000007836-7084.337Pteropus_vampyrus
ENSG00000188120DAZ16750.365ENSPNYG00000020484dazl5660.440Pundamilia_nyererei
ENSG00000188120DAZ18876.404ENSRNOG00000023474Dazl7779.042Rattus_norvegicus
ENSG00000188120DAZ18683.616ENSRBIG00000039636DAZL6884.967Rhinopithecus_bieti
ENSG00000188120DAZ18683.708ENSRROG00000036493DAZL7383.708Rhinopithecus_roxellana
ENSG00000188120DAZ18681.538ENSSBOG00000033845DAZL7581.356Saimiri_boliviensis_boliviensis
ENSG00000188120DAZ18681.921ENSSHAG00000005944-7181.921Sarcophilus_harrisii
ENSG00000188120DAZ18679.487ENSSARG00000008473-7182.540Sorex_araneus
ENSG00000188120DAZ18573.077ENSSPUG00000001799-6072.143Sphenodon_punctatus
ENSG00000188120DAZ18682.143ENSSSCG00000030671-7184.431Sus_scrofa
ENSG00000188120DAZ18963.636ENSTGUG00000003145-5867.626Taeniopygia_guttata
ENSG00000188120DAZ15746.429ENSTRUG00000021705-7746.429Takifugu_rubripes
ENSG00000188120DAZ18680.612ENSTBEG00000012225-6783.133Tupaia_belangeri
ENSG00000188120DAZ17680.952ENSUAMG00000020299-6483.453Ursus_americanus
ENSG00000188120DAZ17582.716ENSUMAG00000018079-5884.568Ursus_maritimus
ENSG00000188120DAZ18681.325ENSVPAG00000000468-7181.325Vicugna_pacos
ENSG00000188120DAZ18682.564ENSVVUG00000000673-7185.030Vulpes_vulpes
ENSG00000188120DAZ17858.065ENSXETG00000025199dazl5958.000Xenopus_tropicalis
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003730mRNA 3'-UTR binding21873635.IBAFunction
GO:0005515protein binding10857750.12511597.15081113.16001084.IPIFunction
GO:0005634nucleus15081113.IDAComponent
GO:0005737cytoplasm21873635.IBAComponent
GO:0005737cytoplasm15081113.IDAComponent
GO:0007275multicellular organism development-IEAProcess
GO:0007281germ cell development-IEAProcess
GO:0007283spermatogenesis-IEAProcess
GO:0008494translation activator activity21873635.IBAFunction
GO:0008494translation activator activity16001084.IDAFunction
GO:0032991protein-containing complex10857750.IDAComponent
GO:0045948positive regulation of translational initiation21873635.IBAProcess
GO:0045948positive regulation of translational initiation16001084.IDAProcess
GO:00709353'-UTR-mediated mRNA stabilization21873635.IBAProcess

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us