EuRBPDB

Description

Ensembl ID: ENSG00000188375 (Gene tree)
Gene ID: 440093
Gene Symbol: H3F3C
Alias: H3.5
Full Name: H3 histone family member 3C
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 1,057 bases
Position: chr12:31,791,185-31,792,241
Accession: 33164
RBP type: non-canonical RBP
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family. [provided by RefSeq, Oct 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000340398	H3F3C-201	1057	-	ENSP00000339835	135 (aa)	-	Q6NXT2

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa05034	Alcoholism	KEGG
hsa05202	Transcriptional misregulation in cancer	KEGG
hsa05322	Systemic lupus erythematosus	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000188375	Child Development Disorders, Pervasive	1.3512000E-005	-
ENSG00000188375	Sleep	9E-6	25469926

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000786	nucleosome	21873635.	IBA	Component
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005719	nuclear euchromatin	21274551.	IDA	Component
GO:0030307	positive regulation of cell growth	21274551.	IMP	Process
GO:0031492	nucleosomal DNA binding	21873635.	IBA	Function
GO:0031492	nucleosomal DNA binding	21274551.	IDA	Function
GO:0046982	protein heterodimerization activity	-	IEA	Function