EuRBPDB

Description

Ensembl ID: ENSG00000188612 (Gene tree)
Gene ID: 6613
Gene Symbol: SUMO2
Alias: SMT3B|SMT3H2
Full Name: small ubiquitin like modifier 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 17,418 bases
Position: chr17:75,165,586-75,183,003
Accession: 11125
RBP type: non-canonical RBP
Summary: This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000314523	SUMO2-201	809	-	ENSP00000400886	71 (aa)	-	P61956
ENST00000578238	SUMO2-203	490	-	ENSP00000461997	52 (aa)	-	J3KRH1
ENST00000420826	SUMO2-202	3190	-	ENSP00000405965	95 (aa)	-	P61956

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa05418	Fluid shear stress and atherosclerosis	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000188612	rs35271045	17	75179199	?	Gamma glutamyl transferase levels	29403010	[0.015-0.032] unit increase novel	0.02319	EFO_0004532

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000188612	SUMO2	99	100.000	ENSG00000184900	SUMO3	90	96.809	Homo_sapiens
ENSG00000188612	SUMO2	100	100.000	ENSMUSG00000020738	Sumo2	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001222	transcription corepressor binding	17081986.	IPI	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	15383276.16169070.17081986.17099698.17099700.17491593.20016594.20016603.20802522.21212807.21252943.21326211.21900206.21965678.21988832.22878415.25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	21965678.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0016605	PML body	22406621.	IDA	Component
GO:0016925	protein sumoylation	21873635.	IBA	Process
GO:0016925	protein sumoylation	17081986.17696781.21965678.24105744.	IDA	Process
GO:0019789	SUMO transferase activity	-	IEA	Function
GO:0031386	protein tag	21873635.	IBA	Function
GO:0031625	ubiquitin protein ligase binding	18408734.	IPI	Function
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	18408734.	IDA	Process
GO:0044389	ubiquitin-like protein ligase binding	21873635.	IBA	Function
GO:0045944	positive regulation of transcription by RNA polymerase II	-	IEA	Process