EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000189060 (Gene tree)
Gene ID: 3005
Gene Symbol: H1F0
Alias: H10|H1FV
Full Name: H1 histone family member 0
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 2,344 bases
Position: chr22:37,805,093-37,807,436
Accession: 4714
RBP type: non-canonical RBP
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
31015254	The Pluripotency Regulator PRDM14 Requires Hematopoietic Regulator CBFA2T3 to Initiate Leukemia in Mice.	Mol Cancer Res	2019 Jul	Tracey LJ	doi: 10.1158/1541-7786.MCR-18-1327
30136864	Gordon H. Dixon's trace in my personal career and the quantic jump experienced in regulatory information.	Syst Biol Reprod Med	2018 Dec	Mezquita-Pla J	doi: 10.1080/19396368.2018.1503752
6540147	The transcriptional regulation of Xenopus 5s RNA genes in chromatin: the roles of active stable transcription complexes and histone H1.	Cell	1984 Jul	Schlissel MS	-
2995030	Events in glucocorticoid hormone action. A correlation of histone H1 variant pattern changes, hormone binding to cell nuclei, and induction of mouse mammary tumor virus RNA.	Eur J Biochem	1985 Oct 1	Wurtz T	-
9585517	Histone H1 binding does not inhibit transcription of nucleosomal Xenopus laevis somatic 5S rRNA templates.	Biochemistry	1998 May 19	Howe L	-
9492295	Phosphatidylinositol 4,5-bisphosphate reverses the inhibition of RNA transcription caused by histone H1.	Eur J Biochem	1998 Jan 15	Yu H	-
8636143	A single high affinity binding site for histone H1 in a nucleosome containing the Xenopus borealis 5 S ribosomal RNA gene.	J Biol Chem	1996 Mar 22	Nightingale KP	-
7708492	Influence of histone H1 on the in vitro replication of DNA and chromatin.	Nucleic Acids Res	1995 Mar 11	Halmer L	-
10998317	Nucleolin as the earliest target molecule of autoantibodies produced in MRL/lpr lupus-prone mice.	Clin Immunol	2000 Oct	Hirata D	-
18258916	Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes.	Science	2008 Feb 8	Krishnakumar R	doi: 10.1126/science.1149250.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000340857	H1F0-201	2344	-	ENSP00000344504	194 (aa)	-	P07305

Gene Model

Click here to download ENSG00000189060's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000189060's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000189060	H1F0	100	94.845	ENSMUSG00000096210	H1f0	73	96.454	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	19158276.	IGI	Process
GO:0000786	nucleosome	-	IEA	Component
GO:0000790	nuclear chromatin	21873635.	IBA	Component
GO:0000790	nuclear chromatin	19882353.	IDA	Component
GO:0003680	AT DNA binding	-	IEA	Function
GO:0003690	double-stranded DNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	21873635.	IBA	Function
GO:0005515	protein binding	9499053.26503038.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	21383955.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005719	nuclear euchromatin	21873635.	IBA	Component
GO:0005719	nuclear euchromatin	15911621.	IDA	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0006309	apoptotic DNA fragmentation	-	TAS	Process
GO:0006334	nucleosome assembly	-	IEA	Process
GO:0006342	chromatin silencing	19158276.	IGI	Process
GO:0006355	regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0015629	actin cytoskeleton	-	IDA	Component
GO:0016584	nucleosome positioning	21873635.	IBA	Process
GO:0016604	nuclear body	21873635.	IBA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0017053	transcriptional repressor complex	19158276.	IDA	Component
GO:0030261	chromosome condensation	21873635.	IBA	Process
GO:0031490	chromatin DNA binding	15911621.	IDA	Function
GO:0031492	nucleosomal DNA binding	21873635.	IBA	Function
GO:0031936	negative regulation of chromatin silencing	21873635.	IBA	Process
GO:0045910	negative regulation of DNA recombination	21873635.	IBA	Process
GO:2000679	positive regulation of transcription regulatory region DNA binding	19158276.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27708074	The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity.	Science	2016 Sep 30	Torres CM	doi: 10.1126/science.aaf1644.
12149419	H1(0) histone and differentiation of dendritic cells. A molecular target for tumor-derived factors.	J Leukoc Biol	2002 Aug	Gabrilovich DI	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr22	37805741	Missense_Mutation	NA	S66L	0.43
BLCA	chr22	37805558	Missense_Mutation	novel	S5F	0.45
BLCA	chr22	37805989	Missense_Mutation	NA	K149Q	0.57
BRCA	chr22	37806560	3'UTR	novel		0.3
CESC	chr22	37805764	Missense_Mutation	NA	R74C	0.44
CESC	chr22	37807331	3'UTR	novel		0.08
CESC	chr22	37807331	3'UTR	novel		0.47
CHOL	chr22	37807264	3'UTR	novel		0.43
COAD	chr22	37806802	3'UTR	novel		0.42
COAD	chr22	37807332	3'UTR	novel		0.41
COAD	chr22	37806192	3'UTR	novel		0.24
COAD	chr22	37807107	3'UTR	novel		0.48
COAD	chr22	37805685	Silent	NA	R47R	0.1
COAD	chr22	37807332	3'UTR	novel		0.24
COAD	chr22	37807332	3'UTR	novel		0.35
COAD	chr22	37806407	3'UTR	novel		0.09
COAD	chr22	37806257	3'UTR	novel		0.21
COAD	chr22	37806344	3'UTR	novel		0.31
COAD	chr22	37807332	3'UTR	novel		0.45
COAD	chr22	37807109	3'UTR	novel		0.36
ESCA	chr22	37805151	5'UTR	novel		0.33
GBM	chr22	37805614	Missense_Mutation	novel	D24Y	0.27
HNSC	chr22	37806081	Silent	novel	V179V	0.31
KIRC	chr22	37805967	Silent	NA	T141T	0.19
KIRC	chr22	37805640	Silent	rs151035348	I32I	0.17
KIRP	chr22	37805465	5'UTR	novel		0.53
LIHC	chr22	37806319	3'UTR	rs188218991		0.52
LIHC	chr22	37805676	Frame_Shift_Ins	novel	*S45Ffs18**	0.09
LIHC	chr22	37806427	3'UTR	novel		0.05
LIHC	chr22	37806742	3'UTR	novel		0.7
LUAD	chr22	37805490	5'UTR	novel		0.3
LUAD	chr22	37805551	Missense_Mutation	NA	E3Q	0.17
LUAD	chr22	37805984	Missense_Mutation	novel	K147R	0.14
LUSC	chr22	37806149	3'UTR	rs369827028		0.26
LUSC	chr22	37806181	3'UTR	novel		0.15
LUSC	chr22	37805945	Missense_Mutation	novel	P134L	0.12
OV	chr22	37805886	Frame_Shift_Del	novel	*K115Rfs3**	0.21
OV	chr22	37805639	Missense_Mutation	novel	I32S	0.11
OV	chr22	37805913	Silent	novel	A123A	0.5
OV	chr22	37805914	Missense_Mutation	novel	S124A	0.5
PCPG	chr22	37805884	Missense_Mutation	novel	I114V	0.26
PRAD	chr22	37806043	Missense_Mutation	NA	P167S	0.08
READ	chr22	37807332	3'UTR	novel		0.32
SKCM	chr22	37805581	Missense_Mutation	NA	P13S	0.22
SKCM	chr22	37805938	Missense_Mutation	NA	K132E	0.71
STAD	chr22	37806063	Silent	novel	P173P	0.39
STAD	chr22	37805670	Silent	rs758978049	R42R	0.27
STAD	chr22	37805801	Missense_Mutation	NA	G86E	0.4
STAD	chr22	37806016	Frame_Shift_Del	NA	*K159Nfs21**	0.2
UCEC	chr22	37806365	3'UTR	novel		0.42
UCEC	chr22	37806144	3'UTR	NA		0.18
UCEC	chr22	37805751	Silent	NA	K69K	0.27
UCEC	chr22	37805764	Missense_Mutation	NA	R74C	0.32
UCEC	chr22	37807332	3'UTR	novel		0.4
UCEC	chr22	37805850	Missense_Mutation	novel	K102N	0.58
UCEC	chr22	37805707	Missense_Mutation	novel	K55Q	0.51
UCEC	chr22	37806524	3'UTR	novel		0.4
UCEC	chr22	37807025	3'UTR	novel		0.39
UCEC	chr22	37805918	Missense_Mutation	novel	K125T	0.33
UCEC	chr22	37807389	3'UTR	novel		0.39
UCEC	chr22	37806802	3'UTR	novel		0.45
UCEC	chr22	37805925	Missense_Mutation	novel	K127N	0.22
UCEC	chr22	37806714	3'UTR	novel		0.56
UCEC	chr22	37807332	3'UTR	novel		0.48
UCEC	chr22	37807008	3'UTR	novel		0.25
UCEC	chr22	37806802	3'UTR	novel		0.43
UCEC	chr22	37807332	3'UTR	novel		0.56
UCEC	chr22	37805632	Missense_Mutation	novel	D30Y	0.47
UCEC	chr22	37807192	3'UTR	novel		0.42
UCEC	chr22	37805774	Missense_Mutation	NA	T77I	0.53
UCEC	chr22	37806056	Missense_Mutation	novel	S171F	0.44
UCEC	chr22	37807332	3'UTR	novel		0.94
UCEC	chr22	37805682	In_Frame_Del	NA	R47del	0.33
UCEC	chr22	37807332	3'UTR	novel		0.22
UCEC	chr22	37806798	3'UTR	novel		0.34
UCEC	chr22	37807290	3'UTR	novel		0.3
UCEC	chr22	37806450	3'UTR	novel		0.38
UCEC	chr22	37807332	3'UTR	novel		0.5
UCEC	chr22	37807332	3'UTR	novel		0.34
UCEC	chr22	37807332	3'UTR	novel		0.6
UCEC	chr22	37806320	3'UTR	novel		0.32

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
PCPG	DEL	0.321	0.044123
THCA	DEL	0.1563	0.046486
THYM	DEL	0.0732	0.063154

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.025	Kaplan-Meier Survival Analysis
MESO	0.0093	Kaplan-Meier Survival Analysis
ACC	0.00015	Kaplan-Meier Survival Analysis
UCS	0.024	Kaplan-Meier Survival Analysis
SKCM	0.012	Kaplan-Meier Survival Analysis
PRAD	0.023	Kaplan-Meier Survival Analysis
BRCA	0.033	Kaplan-Meier Survival Analysis
ESCA	0.0094	Kaplan-Meier Survival Analysis
KIRP	0.00086	Kaplan-Meier Survival Analysis
PAAD	0.0095	Kaplan-Meier Survival Analysis
GBM	0.0049	Kaplan-Meier Survival Analysis
LGG	0.0043	Kaplan-Meier Survival Analysis
THCA	0.039	Kaplan-Meier Survival Analysis
LUAD	0.031	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742