EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000189369 (Gene tree)
Gene ID: 23708
Gene Symbol: GSPT2
Alias: eRF3b|FLJ10441
Full Name: G1 to S phase transition 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 2,848 bases
Position: chrX:51,743,385-51,746,232
Accession: 4622
RBP type: canonical RBP
Summary: This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000341247	PAM2	PF07145.15	1.1e-05	1	1
ENSP00000341247	GTP_EFTU	PF00009.27	2.9e-45	1	1
ENSP00000341247	GTP_EFTU_D2	PF03144.25	7.3e-07	1	1
ENSP00000341247	GTP_EFTU_D3	PF03143.17	2.9e-30	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000340438	GSPT2-201	2802	-	ENSP00000341247	628 (aa)	-	Q8IYD1

Gene Model

Click here to download ENSG00000189369's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000189369's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000189369	GSPT2	68	37.613	ENSG00000156508	EEF1A1	98	51.408
ENSG00000189369	GSPT2	68	36.878	ENSG00000101210	EEF1A2	97	52.381
ENSG00000189369	GSPT2	99	87.279	ENSG00000103342	GSPT1	100	93.788
ENSG00000189369	GSPT2	75	40.292	ENSG00000112339	HBS1L	94	42.945

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000189369	GSPT2	100	93.949	ENSAMEG00000019869	GSPT2	98	94.013	Ailuropoda_melanoleuca
ENSG00000189369	GSPT2	100	96.656	ENSANAG00000031086	GSPT2	100	96.656	Aotus_nancymaae
ENSG00000189369	GSPT2	98	92.283	ENSBTAG00000013311	GSPT2	98	92.765	Bos_taurus
ENSG00000189369	GSPT2	100	97.134	ENSCJAG00000000368	GSPT2	100	97.134	Callithrix_jacchus
ENSG00000189369	GSPT2	100	94.108	ENSCAFG00020020040	GSPT2	98	94.175	Canis_lupus_dingo
ENSG00000189369	GSPT2	100	93.312	ENSCPOG00000007083	GSPT2	98	93.366	Cavia_porcellus
ENSG00000189369	GSPT2	100	97.293	ENSCCAG00000032215	GSPT2	100	97.293	Cebus_capucinus
ENSG00000189369	GSPT2	100	99.363	ENSCSAG00000000126	GSPT2	100	99.363	Chlorocebus_sabaeus
ENSG00000189369	GSPT2	100	90.252	ENSCGRG00001002796	Gspt2	99	89.776	Cricetulus_griseus_chok1gshd
ENSG00000189369	GSPT2	100	90.252	ENSCGRG00000018704	Gspt2	99	89.776	Cricetulus_griseus_crigri
ENSG00000189369	GSPT2	100	88.854	ENSDNOG00000011822	GSPT2	98	88.835	Dasypus_novemcinctus
ENSG00000189369	GSPT2	100	92.834	ENSDORG00000012719	Gspt2	97	92.880	Dipodomys_ordii
ENSG00000189369	GSPT2	76	73.478	ENSEBUG00000004339	GSPT2	90	73.478	Eptatretus_burgeri
ENSG00000189369	GSPT2	98	90.081	ENSEEUG00000005355	GSPT2	99	89.644	Erinaceus_europaeus
ENSG00000189369	GSPT2	100	93.949	ENSFCAG00000001558	GSPT2	98	94.013	Felis_catus
ENSG00000189369	GSPT2	100	94.586	ENSFDAG00000009123	GSPT2	98	94.660	Fukomys_damarensis
ENSG00000189369	GSPT2	100	93.312	ENSHGLG00000001568	GSPT2	98	93.528	Heterocephalus_glaber_female
ENSG00000189369	GSPT2	100	92.516	ENSHGLG00100005633	GSPT2	98	92.718	Heterocephalus_glaber_male
ENSG00000189369	GSPT2	100	95.223	ENSSTOG00000008532	GSPT2	98	95.307	Ictidomys_tridecemlineatus
ENSG00000189369	GSPT2	100	88.235	ENSJJAG00000000985	Gspt2	96	88.673	Jaculus_jaculus
ENSG00000189369	GSPT2	99	90.851	ENSLAFG00000002545	GSPT2	99	91.100	Loxodonta_africana
ENSG00000189369	GSPT2	100	98.885	ENSMFAG00000036045	GSPT2	100	98.885	Macaca_fascicularis
ENSG00000189369	GSPT2	100	98.885	ENSMMUG00000029293	GSPT2	100	98.885	Macaca_mulatta
ENSG00000189369	GSPT2	99	87.520	ENSMOCG00000001273	Gspt2	98	87.220	Microtus_ochrogaster
ENSG00000189369	GSPT2	100	88.854	MGP_CAROLIEiJ_G0033239	Gspt2	99	88.517	Mus_caroli
ENSG00000189369	GSPT2	100	88.854	ENSMUSG00000071723	Gspt2	99	88.517	Mus_musculus
ENSG00000189369	GSPT2	100	88.540	MGP_PahariEiJ_G0031780	Gspt2	99	88.198	Mus_pahari
ENSG00000189369	GSPT2	100	88.697	MGP_SPRETEiJ_G0034406	Gspt2	99	88.517	Mus_spretus
ENSG00000189369	GSPT2	100	93.471	ENSMPUG00000018783	GSPT2	98	93.528	Mustela_putorius_furo
ENSG00000189369	GSPT2	100	92.528	ENSMLUG00000014559	GSPT2	98	92.569	Myotis_lucifugus
ENSG00000189369	GSPT2	98	89.968	ENSNGAG00000013281	Gspt2	98	88.997	Nannospalax_galili
ENSG00000189369	GSPT2	100	94.904	ENSOGAG00000005266	GSPT2	98	94.984	Otolemur_garnettii
ENSG00000189369	GSPT2	94	93.909	ENSOARG00000005636	GSPT2	99	93.456	Ovis_aries
ENSG00000189369	GSPT2	100	93.471	ENSPPRG00000011599	GSPT2	98	93.689	Panthera_pardus
ENSG00000189369	GSPT2	100	92.994	ENSPTIG00000008104	GSPT2	98	93.042	Panthera_tigris_altaica
ENSG00000189369	GSPT2	100	98.089	ENSPPYG00000020360	GSPT2	100	98.089	Pongo_abelii
ENSG00000189369	GSPT2	84	92.762	ENSPCAG00000013962	GSPT2	100	92.762	Procavia_capensis
ENSG00000189369	GSPT2	100	89.185	ENSRNOG00000048817	Gspt2	99	89.490	Rattus_norvegicus
ENSG00000189369	GSPT2	100	96.815	ENSRBIG00000034444	GSPT2	100	96.815	Rhinopithecus_bieti
ENSG00000189369	GSPT2	100	96.975	ENSSBOG00000036422	GSPT2	100	96.975	Saimiri_boliviensis_boliviensis
ENSG00000189369	GSPT2	89	86.964	ENSSARG00000011841	GSPT2	100	87.143	Sorex_araneus
ENSG00000189369	GSPT2	97	92.869	ENSSSCG00000012317	GSPT2	94	92.751	Sus_scrofa
ENSG00000189369	GSPT2	100	92.259	ENSTTRG00000010721	GSPT2	98	92.926	Tursiops_truncatus
ENSG00000189369	GSPT2	100	93.323	ENSUAMG00000011563	GSPT2	98	93.851	Ursus_americanus
ENSG00000189369	GSPT2	79	96.994	ENSUMAG00000013348	GSPT2	100	96.994	Ursus_maritimus
ENSG00000189369	GSPT2	98	93.659	ENSVPAG00000003204	GSPT2	98	93.689	Vicugna_pacos
ENSG00000189369	GSPT2	97	93.954	ENSVVUG00000005605	GSPT2	98	94.020	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	-	TAS	Process
GO:0002184	cytoplasmic translational termination	21873635.	IBA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003747	translation release factor activity	21873635.	IBA	Function
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0005515	protein binding	9712840.14685257.18447585.23340509.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005829	cytosol	-	TAS	Component
GO:0006412	translation	21873635.	IBA	Process
GO:0007049	cell cycle	-	IEA	Process
GO:0018444	translation release factor complex	21873635.	IBA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24466059	eRF3b, a biomarker for hepatocellular carcinoma, influences cell cycle and phosphoralation status of 4E-BP1.	PLoS One	2014 Jan 23	Li M	doi: 10.1371/journal.pone.0086371

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chrX	51743953	Silent	novel	P109P	0.18
BLCA	chrX	51743714	Missense_Mutation	novel	D30Y	0.53
BLCA	chrX	51745193	Missense_Mutation	novel	D523H	0.13	PAM2
BLCA	chrX	51743770	Silent	novel	F48F	0.33
BLCA	chrX	51745351	Silent	NA	F575F	0.97
BLCA	chrX	51743807	Missense_Mutation	novel	P61S	0.26
BLCA	chrX	51745389	Missense_Mutation	novel	T588K	0.36	PAM2
BLCA	chrX	51745502	Missense_Mutation	novel	E626Q	0.8
BRCA	chrX	51744801	Missense_Mutation	novel	G392E	0.09
BRCA	chrX	51745257	Missense_Mutation	NA	H544P	0.44	PAM2
BRCA	chrX	51744906	Missense_Mutation	rs782287535	I427T	0.41
BRCA	chrX	51744596	Missense_Mutation	novel	E324K	0.04
BRCA	chrX	51745665	3'UTR	novel		0.32
BRCA	chrX	51744680	Missense_Mutation	NA	D352N	0.13
BRCA	chrX	51745402	Silent	NA	I592I	0.25
BRCA	chrX	51743468	5'UTR	novel		0.2
BRCA	chrX	51745761	3'UTR	novel		0.29
BRCA	chrX	51743621	5'UTR	novel		0.67
BRCA	chrX	51745418	Missense_Mutation	NA	K598E	0.33	PAM2
BRCA	chrX	51745331	Missense_Mutation	novel	S569G	0.06	PAM2
BRCA	chrX	51743924	Nonsense_Mutation	NA	Q100*	0.21
BRCA	chrX	51745601	3'UTR	novel		0.25
CESC	chrX	51743587	5'UTR	novel		0.21
CESC	chrX	51743763	Missense_Mutation	NA	S46L	0.24
CESC	chrX	51745354	Silent	novel	V576V	0.29
CESC	chrX	51744908	Missense_Mutation	NA	D428N	0.05
CESC	chrX	51743457	5'UTR	novel		0.29
CESC	chrX	51745295	Missense_Mutation	novel	L557V	0.07	PAM2
CESC	chrX	51743532	5'UTR	novel		0.4
CESC	chrX	51744449	Missense_Mutation	novel	Y275H	0.15
CESC	chrX	51743413	5'Flank	novel		0.13
CESC	chrX	51743710	Silent	rs782357792	S28S	0.33
CESC	chrX	51745895	3'UTR	novel		0.09
CESC	chrX	51745352	Missense_Mutation	NA	V576M	0.21	PAM2
CESC	chrX	51745107	Missense_Mutation	NA	R494T	0.43
CESC	chrX	51745058	Missense_Mutation	novel	D478N	0.48
COAD	chrX	51744242	Missense_Mutation	rs782167047	V206I	0.26
COAD	chrX	51743722	Silent	novel	V32V	0.73
COAD	chrX	51745671	3'UTR	novel		0.14
COAD	chrX	51745313	Frame_Shift_Del	NA	*K564Nfs13**	0.21	PAM2
COAD	chrX	51744357	Frame_Shift_Del	NA	*N246Tfs11**	0.8
COAD	chrX	51743943	Frame_Shift_Del	NA	*A108Hfs11**	0.66
COAD	chrX	51744171	Frame_Shift_Del	novel	*E184Rfs3**	0.29
COAD	chrX	51744837	Missense_Mutation	novel	F404S	0.34
COAD	chrX	51745237	Silent	NA	P537P	0.17
COAD	chrX	51745705	3'UTR	novel		0.28
COAD	chrX	51744178	Missense_Mutation	NA	E184D	0.45
COAD	chrX	51744419	Missense_Mutation	NA	K265E	0.12
COAD	chrX	51745719	3'UTR	novel		0.05
COAD	chrX	51745727	3'UTR	novel		0.27
COAD	chrX	51744088	Silent	NA	K154K	0.69
COAD	chrX	51743775	Missense_Mutation	novel	R50H	0.21
COAD	chrX	51744171	Missense_Mutation	rs141788007	E182G	0.5
ESCA	chrX	51745537	3'UTR	novel		0.16
GBM	chrX	51744593	Missense_Mutation	novel	F323I	0.09
GBM	chrX	51744442	Silent	novel	G272G	0.26
GBM	chrX	51745347	Missense_Mutation	NA	R574H	0.27	PAM2
GBM	chrX	51745480	Silent	novel	G618G	0.21
GBM	chrX	51745509	Missense_Mutation	novel	D628V	0.06
GBM	chrX	51745277	Nonsense_Mutation	novel	E551*	0.23	PAM2
GBM	chrX	51744284	Missense_Mutation	NA	G220R	0.33
GBM	chrX	51743941	Silent	novel	G105G	0.22
HNSC	chrX	51745280	Missense_Mutation	novel	V552F	0.25	PAM2
HNSC	chrX	51744461	Missense_Mutation	novel	E279K	0.13
HNSC	chrX	51745258	Missense_Mutation	novel	H544Q	0.51	PAM2
HNSC	chrX	51743774	Missense_Mutation	novel	R50C	0.22
HNSC	chrX	51744062	Missense_Mutation	novel	L146V	0.77
HNSC	chrX	51744956	Missense_Mutation	novel	T444P	0.52
KIRC	chrX	51745042	Silent	NA	V472V	0.39
KIRP	chrX	51743863	Silent	NA	P79P	0.26
KIRP	chrX	51743864	Missense_Mutation	rs782786209	P80S	0.25
LAML	chrX	51745255	Silent	novel	L543L	0.05
LGG	chrX	51745159	Missense_Mutation	rs782490092	D511E	0.49
LGG	chrX	51745352	Missense_Mutation	NA	V576M	0.55	PAM2
LGG	chrX	51743735	Missense_Mutation	novel	A37T	0.5
LGG	chrX	51745341	Missense_Mutation	novel	R572Q	0.32	PAM2
LIHC	chrX	51744127	Silent	novel	G167G	0.24
LUAD	chrX	51743687	Nonsense_Mutation	NA	E21*	0.31
LUAD	chrX	51744974	Missense_Mutation	novel	L450V	0.09
LUAD	chrX	51745187	Missense_Mutation	novel	T521A	0.24	PAM2
LUAD	chrX	51744087	Missense_Mutation	novel	K154T	0.27
LUAD	chrX	51744829	Missense_Mutation	novel	Q401H	0.18
LUAD	chrX	51745374	Missense_Mutation	NA	I583N	0.43	PAM2
LUAD	chrX	51744758	Missense_Mutation	novel	G378R	0.68
LUSC	chrX	51744810	Missense_Mutation	novel	G395E	0.73
LUSC	chrX	51743819	Missense_Mutation	novel	A65S	0.42
LUSC	chrX	51743830	Missense_Mutation	novel	F68L	0.1
LUSC	chrX	51744140	Missense_Mutation	novel	P172S	0.1
LUSC	chrX	51745351	Silent	NA	F575F	0.1
LUSC	chrX	51745495	Silent	NA	L623L	0.84
LUSC	chrX	51744736	Silent	NA	L370L	0.33
LUSC	chrX	51745129	Missense_Mutation	novel	E501D	0.82
LUSC	chrX	51744567	Missense_Mutation	NA	A314D	0.16
LUSC	chrX	51745589	3'UTR	novel		0.22
OV	chrX	51745047	Missense_Mutation	novel	G474V	0.25
OV	chrX	51745525	3'UTR	novel		0.05
OV	chrX	51743674	Silent	NA	D16D	0.51
OV	chrX	51745672	3'UTR	novel		0.14
OV	chrX	51744350	Missense_Mutation	novel	A242S	0.05
READ	chrX	51744134	Missense_Mutation	novel	G170W	0.28
SARC	chrX	51743813	Missense_Mutation	rs782057159	V63I	0.4
SKCM	chrX	51744491	Missense_Mutation	NA	P289S	0.74
SKCM	chrX	51744831	Missense_Mutation	novel	S402L	0.41
SKCM	chrX	51745427	Missense_Mutation	NA	P601S	0.35	PAM2
SKCM	chrX	51745351	Silent	NA	F575F	0.18
SKCM	chrX	51743964	Missense_Mutation	NA	S113F	0.58
SKCM	chrX	51743691	Missense_Mutation	NA	S22F	0.68
SKCM	chrX	51743843	Silent	NA	L73L	0.13
SKCM	chrX	51744017	Missense_Mutation	NA	E131K	0.15
SKCM	chrX	51745351	Silent	NA	F575F	0.68
SKCM	chrX	51745228	Silent	NA	I534I	0.24
SKCM	chrX	51744748	Silent	NA	L374L	0.4
SKCM	chrX	51744356	Missense_Mutation	NA	E244K	0.21
SKCM	chrX	51745139	Missense_Mutation	NA	P505S	0.18
SKCM	chrX	51744983	Missense_Mutation	novel	G453W	0.29
SKCM	chrX	51744855	Missense_Mutation	NA	G410E	0.47
STAD	chrX	51744724	Silent	novel	C366C	0.29
STAD	chrX	51744089	Nonsense_Mutation	novel	E155*	0.55
STAD	chrX	51745056	Missense_Mutation	novel	S477F	0.55
STAD	chrX	51744769	Frame_Shift_Del	novel	*K383Rfs11**	0.26
STAD	chrX	51744768	Frame_Shift_Ins	novel	*D384Gfs16**	0.23
STAD	chrX	51743942	Missense_Mutation	novel	R106W	0.35
STAD	chrX	51744357	Frame_Shift_Del	NA	*N246Tfs11**	0.35
STAD	chrX	51745198	Silent	NA	V524V	0.41
STAD	chrX	51744505	Missense_Mutation	NA	S293R	0.17
STAD	chrX	51745409	Missense_Mutation	novel	E595K	0.4	PAM2
STAD	chrX	51744258	Missense_Mutation	NA	H211P	0.36
STAD	chrX	51744622	Silent	NA	H332H	0.23
STAD	chrX	51744173	Missense_Mutation	NA	K183E	0.09
STAD	chrX	51744982	Silent	NA	S452S	0.47
UCEC	chrX	51743971	Missense_Mutation	NA	E115D	0.37
UCEC	chrX	51744584	Missense_Mutation	NA	E320K	0.35
UCEC	chrX	51745507	Silent	rs782654487	K627K	0.37
UCEC	chrX	51743748	Missense_Mutation	novel	R41H	0.14
UCEC	chrX	51743593	5'UTR	novel		0.45
UCEC	chrX	51744354	Missense_Mutation	NA	K243T	0.32
UCEC	chrX	51744585	Missense_Mutation	novel	E320G	0.05
UCEC	chrX	51745522	3'UTR	NA		0.31
UCEC	chrX	51743846	Missense_Mutation	novel	R74W	0.16
UCEC	chrX	51744294	Missense_Mutation	novel	I223T	0.33
UCEC	chrX	51745307	Missense_Mutation	novel	V561L	0.07	PAM2
UCEC	chrX	51743707	Silent	NA	P27P	0.38
UCEC	chrX	51744929	Missense_Mutation	NA	I435L	0.36
UCEC	chrX	51744019	Missense_Mutation	novel	E131D	0.55
UCEC	chrX	51745347	Missense_Mutation	NA	R574H	0.31	PAM2
UCEC	chrX	51745185	Missense_Mutation	novel	R520H	0.07	PAM2
UCEC	chrX	51745351	Silent	NA	F575F	0.17
UCEC	chrX	51744140	Missense_Mutation	NA	P172T	0.41
UCEC	chrX	51744707	Missense_Mutation	rs782713927	E361K	0.4
UCEC	chrX	51743903	Missense_Mutation	rs782282888	C93G	0.23
UCEC	chrX	51743815	Silent	NA	V63V	0.45
UCEC	chrX	51744008	Missense_Mutation	NA	V128I	0.58
UCEC	chrX	51745855	3'UTR	novel		0.37
UCEC	chrX	51744433	Silent	novel	V269V	0.22
UCEC	chrX	51744211	Silent	novel	P195P	0.1
UCEC	chrX	51744270	Missense_Mutation	NA	G215D	0.21
UCEC	chrX	51744735	Missense_Mutation	NA	L370R	0.24
UCEC	chrX	51745560	3'UTR	NA		0.29
UCEC	chrX	51743635	Silent	novel	S3S	0.44
UCEC	chrX	51744809	Missense_Mutation	novel	G395R	0.08
UCEC	chrX	51745711	3'UTR	novel		0.17
UCEC	chrX	51744808	Silent	NA	T394T	0.42
UCEC	chrX	51745009	Silent	NA	L461L	0.47
UCEC	chrX	51743514	5'UTR	novel		0.44
UCEC	chrX	51744248	Missense_Mutation	novel	F208V	0.5
UCEC	chrX	51743942	Frame_Shift_Ins	novel	*A108Gfs15**	0.24
UCEC	chrX	51745473	Missense_Mutation	novel	A616V	0.31	PAM2
UCEC	chrX	51744434	Missense_Mutation	NA	E270K	0.48
UCEC	chrX	51745096	Silent	novel	N490N	0.36
UCEC	chrX	51745522	3'UTR	NA		0.29
UCEC	chrX	51743452	5'UTR	novel		0.23
UCEC	chrX	51743976	Missense_Mutation	novel	P117Q	0.18
UCEC	chrX	51744967	Silent	novel	L447L	0.2
UCEC	chrX	51745734	3'UTR	novel		0.33
UCEC	chrX	51745184	Missense_Mutation	NA	R520C	0.19	PAM2
UCEC	chrX	51743566	5'UTR	novel		0.36
UCEC	chrX	51743803	Silent	novel	F59F	0.43
UCEC	chrX	51744368	Nonsense_Mutation	novel	E248*	0.31
UCEC	chrX	51745525	3'UTR	NA		0.15
UCEC	chrX	51744433	Silent	novel	V269V	0.13
UCEC	chrX	51745551	3'UTR	novel		0.25
UCEC	chrX	51744228	Missense_Mutation	novel	K201T	0.57
UCEC	chrX	51745189	Silent	novel	T521T	0.48
UCEC	chrX	51743967	Missense_Mutation	novel	R114Q	0.42
UCEC	chrX	51744355	Silent	rs200173199	K243K	0.53
UCEC	chrX	51744808	Silent	rs376744022	T394T	0.11
UCEC	chrX	51744030	Missense_Mutation	NA	P135H	0.38
UCEC	chrX	51744434	Missense_Mutation	NA	E270K	0.39
UCEC	chrX	51744356	Frame_Shift_Ins	novel	*N246Kfs22**	0.53
UCEC	chrX	51745132	Missense_Mutation	novel	E502D	0.32
UCEC	chrX	51745361	Missense_Mutation	novel	D579Y	0.35	PAM2
UCEC	chrX	51744769	Frame_Shift_Del	novel	*K383Rfs11**	0.3
UCEC	chrX	51743519	5'UTR	novel		0.42
UCEC	chrX	51743634	Missense_Mutation	novel	S3L	0.18
UCEC	chrX	51743830	Silent	novel	F68F	0.08
UCEC	chrX	51744250	Silent	novel	F208F	0.28
UCEC	chrX	51745234	Silent	novel	C536C	0.12
UCEC	chrX	51743468	5'UTR	novel		0.53
UCEC	chrX	51744809	Missense_Mutation	novel	G395R	0.45
UCEC	chrX	51743822	Missense_Mutation	novel	A66T	0.4
UCEC	chrX	51745673	3'UTR	novel		0.3
UCEC	chrX	51744414	Missense_Mutation	novel	R263Q	0.43
UCEC	chrX	51745316	Missense_Mutation	novel	K564Q	0.38	PAM2
UCEC	chrX	51745409	Missense_Mutation	novel	E595K	0.36	PAM2
UCEC	chrX	51743985	Missense_Mutation	novel	S120L	0.35
UCEC	chrX	51743911	Silent	novel	G95G	0.54
UCEC	chrX	51744434	Missense_Mutation	NA	E270K	0.52
UCEC	chrX	51745547	3'UTR	novel		0.36
UCEC	chrX	51745228	Silent	NA	I534I	0.23
UCEC	chrX	51744159	Missense_Mutation	novel	E178V	0.28
UCEC	chrX	51744214	Silent	novel	S196S	0.45
UCEC	chrX	51745340	Nonsense_Mutation	novel	R572*	0.35	PAM2
UCEC	chrX	51743667	Missense_Mutation	novel	C14Y	0.28
UCEC	chrX	51745626	3'UTR	NA		0.49
UCEC	chrX	51744363	Missense_Mutation	novel	N246S	0.55
UCEC	chrX	51744356	Frame_Shift_Ins	novel	*N246Kfs22**	0.5
UCEC	chrX	51744345	Missense_Mutation	NA	R240I	0.34
UCEC	chrX	51743976	Missense_Mutation	novel	P117L	0.09
UCEC	chrX	51745325	Missense_Mutation	novel	E567K	0.07	PAM2
UCEC	chrX	51743878	Silent	rs372010626	A84A	0.26
UCEC	chrX	51745823	3'UTR	novel		0.33
UCEC	chrX	51745313	Frame_Shift_Del	NA	*K564Nfs13**	0.4	PAM2
UCEC	chrX	51744206	Missense_Mutation	rs367676302	V194I	0.16
UCEC	chrX	51744759	Missense_Mutation	NA	G378D	0.31
UCEC	chrX	51745398	Missense_Mutation	NA	T591I	0.22	PAM2
UCEC	chrX	51745542	3'UTR	NA		0.31
UCEC	chrX	51745200	Missense_Mutation	NA	Q525P	0.38	PAM2
UCEC	chrX	51744871	Silent	rs202017797	P415P	0.39
UCEC	chrX	51744624	Missense_Mutation	novel	A333V	0.39
UCS	chrX	51743970	Missense_Mutation	novel	E115G	0.2

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
SARC	AMP	0.3035	0.19108
THCA	DEL	0.002	0.21991

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00078	Kaplan-Meier Survival Analysis
STAD	0.018	Kaplan-Meier Survival Analysis
MESO	0.004	Kaplan-Meier Survival Analysis
ACC	0.0026	Kaplan-Meier Survival Analysis
BRCA	0.011	Kaplan-Meier Survival Analysis
ESCA	0.023	Kaplan-Meier Survival Analysis
TGCT	0.038	Kaplan-Meier Survival Analysis
READ	0.028	Kaplan-Meier Survival Analysis
LAML	0.0021	Kaplan-Meier Survival Analysis
UCEC	0.039	Kaplan-Meier Survival Analysis
LGG	0.0027	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742