EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000196419 (Gene tree)
Gene ID: 2547
Gene Symbol: XRCC6
Alias: D22S731|D22S671|KU70|ML8|G22P1
Full Name: X-ray repair cross complementing 6
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 42,930 bases
Position: chr22:41,621,119-41,664,048
Accession: 4055
RBP type: canonical RBP
Summary: The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000384082	SAP	PF02037.27	7.9e-09	1	1
ENSP00000403679	SAP	PF02037.27	7.9e-09	1	1
ENSP00000384941	SAP	PF02037.27	9.5e-09	1	1
ENSP00000352257	SAP	PF02037.27	1.1e-08	1	1
ENSP00000353192	SAP	PF02037.27	1.1e-08	1	1
ENSP00000384257	SAP	PF02037.27	1.1e-08	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21846828	Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins.	MBio	2011 Aug 16	Bortz E	doi: 10.1128/mBio.00151-11
25712094	Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages.	Nucleic Acids Res	2015 Mar 11	Liang XH	doi: 10.1093/nar/gkv143

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000405878	XRCC6-205	2200	-	ENSP00000384257	609 (aa)	-	P12956
ENST00000405506	XRCC6-204	1958	-	ENSP00000384082	559 (aa)	-	B1AHC9
ENST00000428575	XRCC6-206	2148	-	ENSP00000403679	559 (aa)	-	B1AHC9
ENST00000464116	XRCC6-207	359	-	-	- (aa)	-	-
ENST00000478914	XRCC6-208	550	-	-	- (aa)	-	-
ENST00000360079	XRCC6-202	2296	-	ENSP00000353192	609 (aa)	-	P12956
ENST00000402580	XRCC6-203	2006	-	ENSP00000384941	568 (aa)	-	P12956
ENST00000359308	XRCC6-201	2709	-	ENSP00000352257	609 (aa)	-	P12956

Gene Model

Click here to download ENSG00000196419's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03450	Non-homologous end-joining	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000196419	rs28741121	22	41629819	G	Highest math class taken	30038396	[0.011-0.023] unit decrease	0.0172	EFO_0004875
ENSG00000196419	rs28741121	22	41629819	A	Educational attainment (MTAG)	30038396	[0.0092-0.0158] unit increase	0.0125	EFO_0004784
ENSG00000196419	rs28741121	22	41629819	A	Highest math class taken (MTAG)	30038396	[0.014-0.023] unit increase	0.0182	EFO_0004875
ENSG00000196419	rs73161324	22	41642782	T	Pulse pressure	28135244	[0.36-0.63] unit increase	0.496	EFO_0005763
ENSG00000196419	rs28741121	22	41629819	A	Intelligence	29942086	z-score increase	6.609	EFO_0004337
ENSG00000196419	rs73161324	22	41642782	T	Breast cancer	29059683	[1.02-1.09] (Oncoarray)	1.06	EFO_0000305

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196419's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000196419	XRCC6	99	56.414	ENSAPOG00000012704	xrcc6	99	56.414	Acanthochromis_polyacanthus
ENSG00000196419	XRCC6	99	56.086	ENSACIG00000021277	xrcc6	99	56.086	Amphilophus_citrinellus
ENSG00000196419	XRCC6	99	55.337	ENSAOCG00000021344	xrcc6	99	55.410	Amphiprion_ocellaris
ENSG00000196419	XRCC6	99	55.665	ENSAPEG00000020712	xrcc6	99	55.738	Amphiprion_percula
ENSG00000196419	XRCC6	99	56.250	ENSATEG00000007119	xrcc6	99	56.086	Anabas_testudineus
ENSG00000196419	XRCC6	97	71.402	ENSAPLG00000004469	XRCC6	99	70.962	Anas_platyrhynchos
ENSG00000196419	XRCC6	100	85.714	ENSANAG00000035230	-	100	85.714	Aotus_nancymaae
ENSG00000196419	XRCC6	100	98.686	ENSANAG00000018684	XRCC6	100	98.686	Aotus_nancymaae
ENSG00000196419	XRCC6	100	83.713	ENSANAG00000023445	-	100	83.713	Aotus_nancymaae
ENSG00000196419	XRCC6	100	87.192	ENSANAG00000020017	-	91	96.535	Aotus_nancymaae
ENSG00000196419	XRCC6	99	56.414	ENSACLG00000018608	xrcc6	99	56.250	Astatotilapia_calliptera
ENSG00000196419	XRCC6	99	57.516	ENSAMXG00000007545	xrcc6	99	57.353	Astyanax_mexicanus
ENSG00000196419	XRCC6	100	98.522	ENSCJAG00000045512	XRCC6	100	98.522	Callithrix_jacchus
ENSG00000196419	XRCC6	99	87.007	ENSTSYG00000011348	XRCC6	99	87.007	Carlito_syrichta
ENSG00000196419	XRCC6	100	92.447	ENSCCAG00000030041	-	95	92.447	Cebus_capucinus
ENSG00000196419	XRCC6	100	79.310	ENSCCAG00000035711	-	100	79.310	Cebus_capucinus
ENSG00000196419	XRCC6	90	98.438	ENSCCAG00000030468	-	100	98.438	Cebus_capucinus
ENSG00000196419	XRCC6	100	79.310	ENSCCAG00000037663	-	97	78.654	Cebus_capucinus
ENSG00000196419	XRCC6	100	99.179	ENSCATG00000042366	XRCC6	100	99.179	Cercocebus_atys
ENSG00000196419	XRCC6	99	85.667	ENSCLAG00000016669	XRCC6	99	85.667	Chinchilla_lanigera
ENSG00000196419	XRCC6	100	99.179	ENSCSAG00000005784	XRCC6	100	99.179	Chlorocebus_sabaeus
ENSG00000196419	XRCC6	99	74.056	ENSCPBG00000020535	XRCC6	99	74.220	Chrysemys_picta_bellii
ENSG00000196419	XRCC6	97	35.949	ENSCING00000000633	-	95	35.678	Ciona_intestinalis
ENSG00000196419	XRCC6	100	99.179	ENSCANG00000031032	XRCC6	100	99.179	Colobus_angolensis_palliatus
ENSG00000196419	XRCC6	99	77.138	ENSCGRG00001019029	Xrcc6	99	77.138	Cricetulus_griseus_chok1gshd
ENSG00000196419	XRCC6	99	84.868	ENSCGRG00000001528	Xrcc6	99	84.868	Cricetulus_griseus_crigri
ENSG00000196419	XRCC6	99	56.373	ENSCSEG00000020434	xrcc6	99	56.209	Cynoglossus_semilaevis
ENSG00000196419	XRCC6	99	56.158	ENSCVAG00000002189	xrcc6	99	56.158	Cyprinodon_variegatus
ENSG00000196419	XRCC6	99	58.033	ENSDARG00000071551	xrcc6	99	58.361	Danio_rerio
ENSG00000196419	XRCC6	84	76.923	ENSETEG00000015333	-	78	76.923	Echinops_telfairi
ENSG00000196419	XRCC6	99	85.691	ENSEASG00005001514	XRCC6	99	86.020	Equus_asinus_asinus
ENSG00000196419	XRCC6	99	85.197	ENSECAG00000017563	XRCC6	99	86.275	Equus_caballus
ENSG00000196419	XRCC6	100	54.560	ENSELUG00000020301	xrcc6	100	54.560	Esox_lucius
ENSG00000196419	XRCC6	99	70.328	ENSFALG00000011908	XRCC6	97	69.771	Ficedula_albicollis
ENSG00000196419	XRCC6	99	57.190	ENSFHEG00000016833	xrcc6	99	57.026	Fundulus_heteroclitus
ENSG00000196419	XRCC6	99	48.768	ENSGMOG00000013524	xrcc6	99	48.768	Gadus_morhua
ENSG00000196419	XRCC6	99	69.722	ENSGALG00000011932	XRCC6	99	69.558	Gallus_gallus
ENSG00000196419	XRCC6	99	55.065	ENSGAFG00000008130	xrcc6	99	55.065	Gambusia_affinis
ENSG00000196419	XRCC6	99	54.098	ENSGACG00000004868	xrcc6	99	54.098	Gasterosteus_aculeatus
ENSG00000196419	XRCC6	99	73.892	ENSGAGG00000017518	XRCC6	99	74.056	Gopherus_agassizii
ENSG00000196419	XRCC6	100	99.672	ENSGGOG00000015885	XRCC6	100	99.672	Gorilla_gorilla
ENSG00000196419	XRCC6	96	57.196	ENSHBUG00000023281	xrcc6	99	56.506	Haplochromis_burtoni
ENSG00000196419	XRCC6	99	84.020	ENSHGLG00000018078	XRCC6	99	84.020	Heterocephalus_glaber_female
ENSG00000196419	XRCC6	99	84.020	ENSHGLG00100011264	XRCC6	99	84.020	Heterocephalus_glaber_male
ENSG00000196419	XRCC6	99	53.618	ENSHCOG00000009821	xrcc6	99	53.947	Hippocampus_comes
ENSG00000196419	XRCC6	97	57.038	ENSIPUG00000000767	xrcc6	96	57.167	Ictalurus_punctatus
ENSG00000196419	XRCC6	99	88.158	ENSSTOG00000009490	XRCC6	99	87.993	Ictidomys_tridecemlineatus
ENSG00000196419	XRCC6	99	78.618	ENSJJAG00000017136	Xrcc6	99	79.605	Jaculus_jaculus
ENSG00000196419	XRCC6	99	56.158	ENSKMAG00000002141	xrcc6	99	55.993	Kryptolebias_marmoratus
ENSG00000196419	XRCC6	99	55.556	ENSLBEG00000002691	xrcc6	99	55.556	Labrus_bergylta
ENSG00000196419	XRCC6	90	58.824	ENSLOCG00000011533	xrcc6	99	58.824	Lepisosteus_oculatus
ENSG00000196419	XRCC6	100	99.179	ENSMFAG00000003352	XRCC6	100	99.179	Macaca_fascicularis
ENSG00000196419	XRCC6	100	99.179	ENSMMUG00000001856	XRCC6	100	99.179	Macaca_mulatta
ENSG00000196419	XRCC6	100	99.179	ENSMNEG00000035076	XRCC6	100	99.179	Macaca_nemestrina
ENSG00000196419	XRCC6	100	99.179	ENSMLEG00000019869	XRCC6	100	99.179	Mandrillus_leucophaeus
ENSG00000196419	XRCC6	96	55.331	ENSMAMG00000003405	xrcc6	96	55.403	Mastacembelus_armatus
ENSG00000196419	XRCC6	99	54.918	ENSMAMG00000003368	xrcc6	99	55.082	Mastacembelus_armatus
ENSG00000196419	XRCC6	99	56.414	ENSMZEG00005028080	xrcc6	99	56.250	Maylandia_zebra
ENSG00000196419	XRCC6	99	69.494	ENSMGAG00000012146	XRCC6	99	69.331	Meleagris_gallopavo
ENSG00000196419	XRCC6	99	84.539	ENSMAUG00000017340	Xrcc6	99	84.539	Mesocricetus_auratus
ENSG00000196419	XRCC6	99	84.375	ENSMOCG00000015717	Xrcc6	99	84.539	Microtus_ochrogaster
ENSG00000196419	XRCC6	99	54.680	ENSMMOG00000003536	xrcc6	99	54.680	Mola_mola
ENSG00000196419	XRCC6	99	57.401	ENSMALG00000013912	xrcc6	94	57.237	Monopterus_albus
ENSG00000196419	XRCC6	99	77.467	MGP_CAROLIEiJ_G0020067	Xrcc6	99	77.467	Mus_caroli
ENSG00000196419	XRCC6	99	83.224	ENSMUSG00000022471	Xrcc6	99	83.224	Mus_musculus
ENSG00000196419	XRCC6	99	82.401	MGP_PahariEiJ_G0020069	Xrcc6	99	82.401	Mus_pahari
ENSG00000196419	XRCC6	97	83.272	MGP_SPRETEiJ_G0020967	Xrcc6	99	83.821	Mus_spretus
ENSG00000196419	XRCC6	99	83.553	ENSNGAG00000013750	Xrcc6	99	83.553	Nannospalax_galili
ENSG00000196419	XRCC6	99	56.908	ENSNBRG00000004125	xrcc6	99	56.743	Neolamprologus_brichardi
ENSG00000196419	XRCC6	97	82.505	ENSOPRG00000002386	XRCC6	99	82.931	Ochotona_princeps
ENSG00000196419	XRCC6	99	82.208	ENSODEG00000015847	XRCC6	99	82.372	Octodon_degus
ENSG00000196419	XRCC6	99	56.743	ENSONIG00000019715	xrcc6	99	56.908	Oreochromis_niloticus
ENSG00000196419	XRCC6	74	79.612	ENSOANG00000011328	XRCC6	99	79.612	Ornithorhynchus_anatinus
ENSG00000196419	XRCC6	100	86.207	ENSOCUG00000006948	XRCC6	100	86.535	Oryctolagus_cuniculus
ENSG00000196419	XRCC6	99	55.574	ENSORLG00020007820	xrcc6	99	55.574	Oryzias_latipes_hni
ENSG00000196419	XRCC6	99	54.976	ENSORLG00015006406	xrcc6	99	55.246	Oryzias_latipes_hsok
ENSG00000196419	XRCC6	99	54.812	ENSOMEG00000008998	xrcc6	99	54.812	Oryzias_melastigma
ENSG00000196419	XRCC6	99	87.171	ENSOGAG00000008821	XRCC6	99	87.007	Otolemur_garnettii
ENSG00000196419	XRCC6	94	100.000	ENSPPAG00000037167	XRCC6	100	100.000	Pan_paniscus
ENSG00000196419	XRCC6	100	100.000	ENSPTRG00000022548	XRCC6	100	100.000	Pan_troglodytes
ENSG00000196419	XRCC6	100	100.000	ENSPTRG00000045824	XRCC6	100	100.000	Pan_troglodytes
ENSG00000196419	XRCC6	100	99.015	ENSPANG00000001252	XRCC6	100	99.015	Papio_anubis
ENSG00000196419	XRCC6	99	60.526	ENSPKIG00000003974	xrcc6	99	60.526	Paramormyrops_kingsleyae
ENSG00000196419	XRCC6	99	55.537	ENSPMGG00000014220	xrcc6	100	55.702	Periophthalmus_magnuspinnatus
ENSG00000196419	XRCC6	99	83.553	ENSPEMG00000023446	Xrcc6	99	83.553	Peromyscus_maniculatus_bairdii
ENSG00000196419	XRCC6	100	79.016	ENSPCIG00000026409	XRCC6	99	78.852	Phascolarctos_cinereus
ENSG00000196419	XRCC6	99	55.556	ENSPFOG00000017173	xrcc6	99	55.392	Poecilia_formosa
ENSG00000196419	XRCC6	99	55.229	ENSPLAG00000000562	xrcc6	99	55.065	Poecilia_latipinna
ENSG00000196419	XRCC6	99	55.719	ENSPMEG00000018478	xrcc6	99	55.556	Poecilia_mexicana
ENSG00000196419	XRCC6	99	55.537	ENSPREG00000020957	xrcc6	93	55.375	Poecilia_reticulata
ENSG00000196419	XRCC6	100	88.670	ENSPPYG00000011876	XRCC6	100	88.670	Pongo_abelii
ENSG00000196419	XRCC6	99	85.033	ENSPVAG00000001168	XRCC6	99	84.704	Pteropus_vampyrus
ENSG00000196419	XRCC6	99	56.414	ENSPNYG00000003815	xrcc6	99	53.521	Pundamilia_nyererei
ENSG00000196419	XRCC6	99	83.388	ENSRNOG00000006392	Xrcc6	99	83.388	Rattus_norvegicus
ENSG00000196419	XRCC6	100	99.120	ENSRBIG00000039794	XRCC6	100	99.120	Rhinopithecus_bieti
ENSG00000196419	XRCC6	100	99.179	ENSRROG00000030297	XRCC6	100	99.179	Rhinopithecus_roxellana
ENSG00000196419	XRCC6	73	85.504	ENSSBOG00000024724	-	100	85.504	Saimiri_boliviensis_boliviensis
ENSG00000196419	XRCC6	99	78.161	ENSSHAG00000010790	XRCC6	99	77.833	Sarcophilus_harrisii
ENSG00000196419	XRCC6	99	60.820	ENSSFOG00015014409	xrcc6	99	60.656	Scleropages_formosus
ENSG00000196419	XRCC6	99	56.743	ENSSMAG00000006496	xrcc6	99	56.743	Scophthalmus_maximus
ENSG00000196419	XRCC6	99	56.536	ENSSDUG00000007542	xrcc6	99	56.373	Seriola_dumerili
ENSG00000196419	XRCC6	99	55.719	ENSSLDG00000009974	xrcc6	99	55.556	Seriola_lalandi_dorsalis
ENSG00000196419	XRCC6	99	73.727	ENSSPUG00000012086	XRCC6	99	73.399	Sphenodon_punctatus
ENSG00000196419	XRCC6	99	56.373	ENSSPAG00000015199	xrcc6	99	56.209	Stegastes_partitus
ENSG00000196419	XRCC6	97	71.956	ENSTGUG00000009852	-	95	72.165	Taeniopygia_guttata
ENSG00000196419	XRCC6	99	55.263	ENSTRUG00000017070	xrcc6	99	55.099	Takifugu_rubripes
ENSG00000196419	XRCC6	96	57.246	ENSTNIG00000012947	xrcc6	99	56.949	Tetraodon_nigroviridis
ENSG00000196419	XRCC6	97	78.309	ENSTBEG00000011736	XRCC6	99	78.485	Tupaia_belangeri
ENSG00000196419	XRCC6	99	71.217	ENSTTRG00000006749	XRCC6	99	71.546	Tursiops_truncatus
ENSG00000196419	XRCC6	99	55.556	ENSXMAG00000009691	xrcc6	99	55.392	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000723	telomere maintenance	21873635.	IBA	Process
GO:0000723	telomere maintenance	15824061.18710952.24095731.	TAS	Process
GO:0000783	nuclear telomere cap complex	15100233.	TAS	Component
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0000784	nuclear chromosome, telomeric region	21873635.	IBA	Component
GO:0002218	activation of innate immune response	28712728.	IDA	Process
GO:0003677	DNA binding	1537839.	NAS	Function
GO:0003684	damaged DNA binding	-	IEA	Function
GO:0003690	double-stranded DNA binding	21873635.	IBA	Function
GO:0003691	double-stranded telomeric DNA binding	10409678.	IDA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0004003	ATP-dependent DNA helicase activity	-	IEA	Function
GO:0005515	protein binding	8621488.10984620.11328876.12145306.12377759.14734561.15075319.15205477.15383276.15383534.15782130.16169070.17124166.17159921.17220478.17283121.17308091.17334224.19303849.20711232.21044950.21070772.21146485.21575865.21679440.22442688.22451927.22504299.23685356.24095731.24610814.24965446.25574025.25749521.25852083.26175416.26359349.26496610.28330616.28959974.30021884.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005634	nucleus	10508516.	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005667	transcription factor complex	12145306.	IDA	Component
GO:0005730	nucleolus	27829214.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006266	DNA ligation	9826654.	TAS	Process
GO:0006303	double-strand break repair via nonhomologous end joining	21873635.	IBA	Process
GO:0006303	double-strand break repair via nonhomologous end joining	20383123.26359349.	IMP	Process
GO:0006303	double-strand break repair via nonhomologous end joining	15824061.	TAS	Process
GO:0006310	DNA recombination	-	IEA	Process
GO:0007420	brain development	-	IEA	Process
GO:0008022	protein C-terminus binding	10783163.	IPI	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0030332	cyclin binding	15159402.	IPI	Function
GO:0032481	positive regulation of type I interferon production	-	TAS	Process
GO:0032508	DNA duplex unwinding	-	IEA	Process
GO:0032991	protein-containing complex	22504299.	IDA	Component
GO:0032993	protein-DNA complex	22504299.	IDA	Component
GO:0034774	secretory granule lumen	-	TAS	Component
GO:0042162	telomeric DNA binding	21873635.	IBA	Function
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0043564	Ku70:Ku80 complex	21873635.	IBA	Component
GO:0043564	Ku70:Ku80 complex	20383123.24095731.26359349.	IDA	Component
GO:0044212	transcription regulatory region DNA binding	18809223.	IDA	Function
GO:0044877	protein-containing complex binding	12377759.	IPI	Function
GO:0045087	innate immune response	-	IEA	Process
GO:0045860	positive regulation of protein kinase activity	22504299.	IDA	Process
GO:0045892	negative regulation of transcription, DNA-templated	8621488.	IMP	Process
GO:0045893	positive regulation of transcription, DNA-templated	12145306.	IDA	Process
GO:0045893	positive regulation of transcription, DNA-templated	18809223.	IMP	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	18809223.	IMP	Process
GO:0048660	regulation of smooth muscle cell proliferation	25852083.	IMP	Process
GO:0051290	protein heterotetramerization	24095731.	IDA	Process
GO:0051575	5'-deoxyribose-5-phosphate lyase activity	20383123.	IMP	Function
GO:0070419	nonhomologous end joining complex	20383123.25941166.	IDA	Component
GO:0071475	cellular hyperosmotic salinity response	-	IEA	Process
GO:0071480	cellular response to gamma radiation	21873635.	IBA	Process
GO:0071480	cellular response to gamma radiation	26359349.	IDA	Process
GO:0071481	cellular response to X-ray	21873635.	IBA	Process
GO:0075713	establishment of integrated proviral latency	-	TAS	Process
GO:0097680	double-strand break repair via classical nonhomologous end joining	24095731.	IDA	Process
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19177010	Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression.	Cell Cycle	2009 Feb 1	Pucci S	-
25818292	Direct involvement of retinoblastoma family proteins in DNA repair by non-homologous end-joining.	Cell Rep	2015 Mar 31	Cook R	doi: 10.1016/j.celrep.2015.02.059
18546291	Ku70 predicts response and primary tumor recurrence after therapy in locally advanced head and neck cancer.	Int J Cancer	2008 Sep 1	Pav??n MA	doi: 10.1002/ijc.23635.
24615008	Association between polymorphisms at promoters of XRCC5 and XRCC6 genes and risk of breast cancer.	Med Oncol	2014 Apr	Rajaei M	doi: 10.1007/s12032-014-0885-8
27328741	Gene polymorphism in DNA repair genes XRCC1 and XRCC6 and association with colorectal cancer in Swedish patients.	APMIS	2016 Sep	Dimberg J	doi: 10.1111/apm.12563
23745766	Association between the XRCC6 Promoter rs2267437 polymorphism and cancer risk: evidence based on the current literature.	Genet Test Mol Biomarkers	2013 Aug	Xu H	doi: 10.1089/gtmb.2013.0083
19219618	A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure.	J Cancer Res Clin Oncol	2009 Sep	Willems P	doi: 10.1007/s00432-009-0556-x
29397516	Role of polymorphic XRCC6 (Ku70)/XRCC7 (DNA-PKcs) genes towards susceptibility and prognosis of lung cancer patients undergoing platinum based doublet chemotherapy.	Mol Biol Rep	2018 Jun	Singh A	doi: 10.1007/s11033-018-4158-z
21556760	The Ku70 -1310C/G promoter polymorphism is associated with breast cancer susceptibility in Chinese Han population.	Mol Biol Rep	2012 Jan	He W	doi: 10.1007/s11033-011-0773-7
23098447	Association between XRCC5, 6 and 7 gene polymorphisms and the risk of breast cancer: a HuGE review and meta-analysis.	Asian Pac J Cancer Prev	2012	Zhou LP	-
22745744	Interaction of caveolin-1 with Ku70 inhibits Bax-mediated apoptosis.	PLoS One	2012	Zou H	doi: 10.1371/journal.pone.0039379
22399625	Association of DNA double-strand break gene XRCC6 genotypes and lung cancer in Taiwan.	Anticancer Res	2012 Mar	Hsia TC	-
21575261	Genetic polymorphisms of DNA double strand break gene Ku70 and gastric cancer in Taiwan.	BMC Cancer	2011 May 17	Yang MD	doi: 10.1186/1471-2407-11-174.
17982634	Immunohistochemical analysis of Ku70/86 expression of breast cancer tissues.	Oncol Rep	2007 Dec	Someya M	-
23154512	Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN.	Oncotarget	2012 Nov	Beggs AD	-
20127252	BRCA1 is a negative modulator of the PRC2 complex.	EMBO J	2013 May 29	Wang L	doi: 10.1038/emboj.2013.95
23271361	Quantitative assessment of the association between XRCC6 C1310G polymorphism and cancer risk.	Tumour Biol	2013 Apr	Jiang H	doi: 10.1007/s13277-012-0607-9
26754263	Association between single-nucleotide polymorphisms in DNA double-strand break repair genes and prostate cancer aggressiveness in the Spanish population.	Prostate Cancer Prostatic Dis	2016 Mar	Henr??quez-Hern??ndez LA	doi: 10.1038/pcan.2015.63
14570916	The Ku antigen-recombination signal-binding protein Jkappa complex binds to the nuclear factor-kappaB p50 promoter and acts as a positive regulator of p50 expression in human gastric cancer cells.	J Biol Chem	2004 Jan 2	Lim JW	-
19906305	Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines.	Breast Cancer Res	2009	Nolens G	doi: 10.1186/bcr2450
23349316	Castration therapy results in decreased Ku70 levels in prostate cancer.	Clin Cancer Res	2013 Mar 15	Al-Ubaidi FL	doi: 10.1158/1078-0432.CCR-12-2795
24382701	Comprehensive analyses of DNA repair pathways, smoking and bladder cancer risk in Los Angeles and Shanghai.	Int J Cancer	2014 Jul 15	Corral R	doi: 10.1002/ijc.28693
18487076	Oral cancer and genetic polymorphism of DNA double strand break gene Ku70 in Taiwan.	Oral Oncol	2008 Nov	Bau DT	doi: 10.1016/j.oraloncology.2008.02.008
17671430	Bin1 interacts with and restrains the DNA end-binding protein complex Ku.	Cell Cycle	2007 Aug 1	Ramalingam A	-
15905197	Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells.	Carcinogenesis	2005 Oct	Lee JC	-
15827325	Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation.	Mol Cancer Ther	2005 Apr	Ayene IS	-
24769731	Role of Ku70 in deubiquitination of Mcl-1 and suppression of apoptosis.	Cell Death Differ	2014 Jul	Wang B	doi: 10.1038/cdd.2014.42
22524845	Association between the Ku70-1310C/G promoter polymorphism and cancer risk: a meta-analysis.	Asian Pac J Cancer Prev	2012	Xu L	-
28153717	Ku70 inhibits gemcitabine-induced DNA damage and pancreatic cancer cell apoptosis.	Biochem Biophys Res Commun	2017 Mar 18	Ma J	doi: 10.1016/j.bbrc.2017.01.146
27384990	SIRT1 and LSD1 competitively regulate KU70 functions in DNA repair and mutation acquisition in cancer cells.	Oncotarget	2016 Aug 2	Roth M	doi: 10.18632/oncotarget.10328.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr22	41637758	Missense_Mutation	novel	R247H	0.39
BLCA	chr22	41646972	Missense_Mutation	rs776773263	P284S	0.1
BRCA	chr22	41647004	Missense_Mutation	novel	E294D	0.08
BRCA	chr22	41663700	Missense_Mutation	NA	T572M	0.13
BRCA	chr22	41653641	Silent	NA	V414V	0.23
BRCA	chr22	41636525	Missense_Mutation	rs765303000	R115Q	0.09
BRCA	chr22	41622035	Missense_Mutation	NA	E11Q	0.25
BRCA	chr22	41628195	Missense_Mutation	NA	E54K	0.22
BRCA	chr22	41636673	Missense_Mutation	NA	K164N	0.17
BRCA	chr22	41656900	Splice_Region	novel		0.18
CESC	chr22	41646894	Splice_Site	novel	X258_splice	0.28
CESC	chr22	41646905	Frame_Shift_Ins	novel	*L263Sfs6**	0.33
CESC	chr22	41656977	Missense_Mutation	novel	P456A	0.18
CESC	chr22	41653545	Silent	novel	F382F	0.25
COAD	chr22	41646968	Missense_Mutation	NA	K282N	0.35
COAD	chr22	41628150	Frame_Shift_Ins	NA	*L41Ffs3**	0.39
COAD	chr22	41653603	Frame_Shift_Del	NA	*R403Afs25**	0.35
COAD	chr22	41646960	Missense_Mutation	NA	A280S	0.45
COAD	chr22	41658287	Frame_Shift_Del	novel	*H486Pfs12**	0.12
COAD	chr22	41646971	Silent	novel	P283P	0.14
COAD	chr22	41656923	Missense_Mutation	NA	P438S	0.24
COAD	chr22	41663782	Silent	rs369068201	L599L	0.2
COAD	chr22	41657020	Missense_Mutation	rs749612494	R470H	0.12
COAD	chr22	41637651	Silent	NA	F211F	0.12
COAD	chr22	41650838	Missense_Mutation	NA	H359R	0.19
COAD	chr22	41661346	Missense_Mutation	NA	A513V	0.45
COAD	chr22	41647069	Missense_Mutation	NA	T316I	0.14
ESCA	chr22	41661345	Missense_Mutation	rs61754572	A513T	0.28
ESCA	chr22	41637758	Missense_Mutation	novel	R247H	0.41
ESCA	chr22	41636234	Missense_Mutation	novel	Q106R	0.11
GBM	chr22	41637783	Frame_Shift_Ins	novel	*L256Vfs5**	0.45
GBM	chr22	41647065	Missense_Mutation	novel	D315N	0.47
HNSC	chr22	41628151	Frame_Shift_Del	novel	*L41Wfs17**	0.21
HNSC	chr22	41637718	Missense_Mutation	novel	E234Q	0.13
HNSC	chr22	41636120	Missense_Mutation	novel	Q68R	0.18
HNSC	chr22	41650857	Silent	rs201816814	S365S	0.12
KIRP	chr22	41664013	3'UTR	novel		0.33
KIRP	chr22	41663943	3'UTR	novel		0.39
LAML	chr22	41622073	Missense_Mutation	novel	N23K	0.05
LAML	chr22	41628150	Frame_Shift_Ins	NA	*L41Ffs3**	0.23
LAML	chr22	41663735	Missense_Mutation	novel	A584T	0.08	SAP
LIHC	chr22	41646962	Silent	NA	A280A	0.29
LIHC	chr22	41661388	Frame_Shift_Del	novel	*L528Ifs32**	0.24
LUAD	chr22	41661414	Missense_Mutation	novel	P536S	0.11
LUAD	chr22	41653683	Frame_Shift_Ins	novel	*P429Sfs35**	0.07
LUAD	chr22	41636771	Splice_Site	NA	X197_splice	0.21
LUAD	chr22	41646931	Missense_Mutation	NA	S270C	0.1
LUAD	chr22	41628179	Missense_Mutation	NA	M48I	0.42
LUAD	chr22	41663657	Missense_Mutation	novel	E558Q	0.33
LUAD	chr22	41653690	Missense_Mutation	novel	G431C	0.36
LUAD	chr22	41658265	Missense_Mutation	NA	E479Q	0.09
LUAD	chr22	41646915	Missense_Mutation	novel	K265E	0.27
LUSC	chr22	41663739	Missense_Mutation	novel	C585F	0.51	SAP
LUSC	chr22	41646986	Silent	novel	L288L	0.17
LUSC	chr22	41653687	Missense_Mutation	NA	P430A	0.06
LUSC	chr22	41646922	Missense_Mutation	rs369020045	I267T	0.19
LUSC	chr22	41646905	Silent	NA	L261L	0.04
LUSC	chr22	41636647	Missense_Mutation	NA	D156N	0.11
LUSC	chr22	41622064	Silent	NA	Q20Q	0.3
OV	chr22	41653653	Missense_Mutation	NA	E418D	0.22
OV	chr22	41647027	Missense_Mutation	NA	T302I	0.16
OV	chr22	41636770	Missense_Mutation	NA	G197R	0.16
OV	chr22	41663831	3'UTR	novel		0.25
OV	chr22	41663832	3'UTR	rs776304269		0.22
PAAD	chr22	41637673	Missense_Mutation	novel	D219Y	0.13
PRAD	chr22	41663700	Missense_Mutation	NA	T572M	0.22
PRAD	chr22	41646986	Silent	novel	L288L	0.35
PRAD	chr22	41628150	Frame_Shift_Ins	NA	*L41Ffs3**	0.51
PRAD	chr22	41636737	Missense_Mutation	novel	A186T	0.1
READ	chr22	41636678	Missense_Mutation	novel	I166T	0.39
READ	chr22	41656938	Missense_Mutation	novel	K443E	0.32
READ	chr22	41636764	Missense_Mutation	novel	D195Y	0.37
SARC	chr22	41622073	Silent	novel	N23N	0.41
SKCM	chr22	41663843	3'UTR	novel		0.5
SKCM	chr22	41663844	3'UTR	rs764989290		0.52
SKCM	chr22	41656978	Missense_Mutation	novel	P456L	0.22
SKCM	chr22	41636197	Missense_Mutation	NA	K94E	0.14
SKCM	chr22	41647028	Silent	novel	T302T	0.22
SKCM	chr22	41637660	Silent	NA	S214S	0.23
SKCM	chr22	41647008	Missense_Mutation	NA	V296M	0.08
SKCM	chr22	41636638	Missense_Mutation	NA	L153F	0.17
STAD	chr22	41656902	Splice_Site	NA	X431_splice	0.11
STAD	chr22	41637612	Silent	NA	I198I	0.58
STAD	chr22	41663685	Missense_Mutation	novel	H567R	0.46
STAD	chr22	41636730	Silent	novel	A183A	0.56
STAD	chr22	41636523	Silent	NA	K114K	0.32
STAD	chr22	41658323	Missense_Mutation	NA	M498R	0.25
STAD	chr22	41628151	Frame_Shift_Del	novel	*L41Wfs17**	0.24
STAD	chr22	41663827	3'UTR	rs551060392		0.33
UCEC	chr22	41622019	Silent	novel	E5E	0.22
UCEC	chr22	41663830	3'UTR	novel		0.15
UCEC	chr22	41650777	Missense_Mutation	novel	R339W	0.04
UCEC	chr22	41621993	5'UTR	novel		0.47
UCEC	chr22	41663845	3'UTR	rs9653842		0.34
UCEC	chr22	41637636	Missense_Mutation	novel	K206N	0.05
UCEC	chr22	41663621	Splice_Site	NA	X546_splice	0.21
UCEC	chr22	41663688	Missense_Mutation	NA	I568T	0.37
UCEC	chr22	41636178	Missense_Mutation	novel	F87L	0.1
UCEC	chr22	41636156	Missense_Mutation	novel	R80Q	0.29
UCEC	chr22	41636570	Missense_Mutation	rs780415976	R130H	0.18
UCEC	chr22	41663633	Missense_Mutation	novel	S550P	0.23
UCEC	chr22	41637677	Missense_Mutation	novel	I220T	0.31
UCEC	chr22	41663829	3'UTR	rs376378849		0.15
UCEC	chr22	41636188	Missense_Mutation	rs373148769	E91K	0.35
UCEC	chr22	41653638	Silent	novel	L413L	0.55
UCEC	chr22	41663866	3'UTR	novel		0.32
UCEC	chr22	41647064	Missense_Mutation	novel	S314R	0.33
UCEC	chr22	41646981	Missense_Mutation	novel	K287Q	0.28
UCEC	chr22	41658274	Missense_Mutation	NA	V482M	0.41
UCEC	chr22	41663856	3'UTR	novel		0.36
UCEC	chr22	41646918	Missense_Mutation	NA	D266Y	0.2
UCEC	chr22	41663791	Silent	novel	A602A	0.29
UCEC	chr22	41653682	Missense_Mutation	novel	T428N	0.31
UCEC	chr22	41636227	Missense_Mutation	rs757018461	V104I	0.13
UCEC	chr22	41650864	Missense_Mutation	rs761413214	V368M	0.23
UCEC	chr22	41653597	Missense_Mutation	novel	Y400N	0.38
UCEC	chr22	41650755	Missense_Mutation	NA	K331N	0.46
UCEC	chr22	41650863	Silent	rs368334650	F367F	0.49
UCEC	chr22	41628226	Missense_Mutation	novel	I64T	0.45
UCEC	chr22	41650843	Missense_Mutation	novel	Y361H	0.21
UCEC	chr22	41628151	Frame_Shift_Del	novel	*L41Wfs17**	0.38
UCEC	chr22	41636528	Missense_Mutation	NA	I116S	0.23

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0625	0.21158
PCPG	DEL	0.3395	0.044123
THCA	DEL	0.1563	0.046486
THYM	DEL	0.065	0.063154
UCS	DEL	0.6071	0.0013619

Survival Analysis

Cancer	P-value	Q-value
THYM	0.017	Kaplan-Meier Survival Analysis
KIRC	0.0057	Kaplan-Meier Survival Analysis
ACC	0.00072	Kaplan-Meier Survival Analysis
LUSC	0.026	Kaplan-Meier Survival Analysis
PCPG	0.0057	Kaplan-Meier Survival Analysis
CESC	0.047	Kaplan-Meier Survival Analysis
READ	0.00064	Kaplan-Meier Survival Analysis
LAML	0.0022	Kaplan-Meier Survival Analysis
LIHC	0.00046	Kaplan-Meier Survival Analysis
DLBC	0.018	Kaplan-Meier Survival Analysis
LGG	0.04	Kaplan-Meier Survival Analysis
THCA	0.034	Kaplan-Meier Survival Analysis
LUAD	0.0084	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742