EuRBPDB

Description

Ensembl ID: ENSG00000196433 (Gene tree)
Gene ID: 438
Gene Symbol: ASMT
Alias: HIOMT|ASMTY|HIOMTY
Full Name: acetylserotonin O-methyltransferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 47,627 bases
Position: chrX:1,595,455-1,643,081
Accession: 750
RBP type: canonical RBP
Summary: This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000370627	Methyltransf_31	PF13847.6	6.6e-07	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000381229	ASMT-201	1087	-	ENSP00000370627	345 (aa)	-	P46597
ENST00000509780	ASMT-205	510	-	-	- (aa)	-	-
ENST00000381241	ASMT-203	1388	-	ENSP00000370639	373 (aa)	-	P46597
ENST00000381233	ASMT-202	989	-	ENSP00000370631	298 (aa)	-	P46597
ENST00000432523	ASMT-204	442	-	ENSP00000392053	124 (aa)	-	I7HFW6

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00380	Tryptophan metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000196433	ASMT	100	56.647	ENSACAG00000005942	-	100	56.647	Anolis_carolinensis
ENSG00000196433	ASMT	90	54.054	ENSACAG00000005929	-	99	44.767	Anolis_carolinensis
ENSG00000196433	ASMT	100	70.435	ENSBTAG00000049541	ASMT	100	70.435	Bos_taurus
ENSG00000196433	ASMT	100	70.145	ENSCHIG00000006740	ASMT	100	70.145	Capra_hircus
ENSG00000196433	ASMT	90	97.297	ENSCATG00000029353	ASMT	100	86.957	Cercocebus_atys
ENSG00000196433	ASMT	100	72.174	ENSCLAG00000000340	ASMT	96	72.174	Chinchilla_lanigera
ENSG00000196433	ASMT	100	71.264	ENSEASG00005018698	ASMT	83	71.264	Equus_asinus_asinus
ENSG00000196433	ASMT	90	67.568	ENSECAG00000022808	ASMT	53	69.192	Equus_caballus
ENSG00000196433	ASMT	90	65.766	ENSLACG00000014340	ASMT	99	54.682	Latimeria_chalumnae
ENSG00000196433	ASMT	100	72.754	ENSMPUG00000001193	ASMT	100	72.754	Mustela_putorius_furo
ENSG00000196433	ASMT	88	86.239	ENSOGAG00000024834	ASMT	100	76.543	Otolemur_garnettii
ENSG00000196433	ASMT	93	97.516	ENSPPAG00000036526	ASMT	100	97.516	Pan_paniscus
ENSG00000196433	ASMT	100	98.261	ENSPTRG00000045230	ASMT	100	98.261	Pan_troglodytes
ENSG00000196433	ASMT	90	64.865	ENSPSIG00000002769	-	100	57.843	Pelodiscus_sinensis
ENSG00000196433	ASMT	99	51.906	ENSRNOG00000001324	Asmt	78	51.906	Rattus_norvegicus
ENSG00000196433	ASMT	100	90.435	ENSRROG00000007650	ASMT	100	90.435	Rhinopithecus_roxellana
ENSG00000196433	ASMT	100	75.362	ENSUMAG00000019039	ASMT	100	75.362	Ursus_maritimus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006412	translation	8397829.	TAS	Process
GO:0008171	O-methyltransferase activity	21873635.	IBA	Function
GO:0008172	S-methyltransferase activity	-	TAS	Function
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	21873635.	IBA	Function
GO:0017096	acetylserotonin O-methyltransferase activity	21873635.	IBA	Function
GO:0017096	acetylserotonin O-methyltransferase activity	22775292.	IDA	Function
GO:0019438	aromatic compound biosynthetic process	21873635.	IBA	Process
GO:0030187	melatonin biosynthetic process	21873635.	IBA	Process
GO:0030187	melatonin biosynthetic process	22775292.	IDA	Process
GO:0030187	melatonin biosynthetic process	-	IEA	Process
GO:0032259	methylation	-	IEA	Process
GO:0042802	identical protein binding	22775292.	IPI	Function
GO:0042803	protein homodimerization activity	22775292.	IPI	Function
GO:0046219	indolalkylamine biosynthetic process	-	TAS	Process