EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000196498 (Gene tree)
Gene ID: 9612
Gene Symbol: NCOR2
Alias: SMRT|SMRTE|TRAC-1|CTG26|TNRC14
Full Name: nuclear receptor corepressor 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 243,179 bases
Position: chr12:124,324,411-124,567,589
Accession: 7673
RBP type: non-canonical RBP
Summary: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
15525597	Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors.	J Mol Endocrinol	2004 Oct	Klinge CM	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000443451	NCOR2-211	951	-	-	- (aa)	-	-
ENST00000536195	NCOR2-222	452	-	-	- (aa)	-	-
ENST00000473999	NCOR2-218	1277	-	-	- (aa)	-	-
ENST00000413172	NCOR2-205	532	-	ENSP00000407357	132 (aa)	-	H7C2R5
ENST00000429285	NCOR2-208	8475	-	ENSP00000400281	2504 (aa)	-	C9J0Q5
ENST00000418829	NCOR2-206	563	-	ENSP00000391389	129 (aa)	-	H7BZU2
ENST00000404621	NCOR2-203	8520	-	ENSP00000384202	2458 (aa)	-	C9JE98
ENST00000405201	NCOR2-204	8533	-	ENSP00000384018	2514 (aa)	-	C9JFD3
ENST00000453428	NCOR2-214	674	-	ENSP00000400687	225 (aa)	-	H7C1J7
ENST00000461081	NCOR2-216	2910	-	-	- (aa)	-	-
ENST00000494460	NCOR2-221	339	-	-	- (aa)	-	-
ENST00000493859	NCOR2-220	557	-	-	- (aa)	-	-
ENST00000420698	NCOR2-207	1752	-	ENSP00000405367	493 (aa)	-	C9J330
ENST00000542927	NCOR2-224	828	-	ENSP00000443689	275 (aa)	-	H0YGK8
ENST00000440337	NCOR2-210	956	-	ENSP00000398963	134 (aa)	-	H7C184
ENST00000448614	NCOR2-213	582	-	ENSP00000408247	162 (aa)	-	C9JNV9
ENST00000542565	NCOR2-223	746	-	-	- (aa)	-	-
ENST00000458234	NCOR2-215	4675	-	ENSP00000402808	1451 (aa)	-	C9JQE8
ENST00000474079	NCOR2-219	321	-	-	- (aa)	-	-
ENST00000440187	NCOR2-209	467	-	ENSP00000396044	156 (aa)	-	H7C0P3
ENST00000404121	NCOR2-202	7175	-	ENSP00000385618	2062 (aa)	-	C9J7T7
ENST00000464377	NCOR2-217	499	-	-	- (aa)	-	-
ENST00000356219	NCOR2-201	7226	-	ENSP00000348551	2079 (aa)	-	Q9Y618
ENST00000448008	NCOR2-212	735	-	ENSP00000403034	245 (aa)	-	H7C1Y3

Gene Model

Click here to download ENSG00000196498's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04330	Notch signaling pathway	KEGG
hsa05169	Epstein-Barr virus infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000196498	Neoplasms	3.80520147097714E-5	17903305
ENSG00000196498	Neoplasms	4.9494767905779E-5	17903305
ENSG00000196498	Iron	7.2780000E-004	19880490
ENSG00000196498	Body Height	1.0840000E-005	-
ENSG00000196498	Body Height	6.8760000E-005	-
ENSG00000196498	Body Height	2.4520000E-005	-
ENSG00000196498	Platelet Function Tests	3.8094700E-005	-
ENSG00000196498	Cocaine-Related Disorders	5E-7	23958962
ENSG00000196498	Neuropsychological Tests	7E-6	19734545
ENSG00000196498	Antimetabolites	9E-6	23648065
ENSG00000196498	Antineoplastic Agents	9E-6	23648065

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000196498	rs12423712	12	124549387	?	Cognitive performance	19734545			EFO_0003926
ENSG00000196498	rs12582168	12	124409638	C	Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs)	23648065	[1.21-1.748]	1.454	GO_0097327\|GO_0097329
ENSG00000196498	rs150954431	12	124517777	?	Cocaine dependence	23958962			EFO_0002610
ENSG00000196498	rs73225423	12	124421378	T	Mosquito bite size	28199695	[0.031-0.074] unit increase	0.0522744	EFO_0008378
ENSG00000196498	rs2229840	12	124341916	?	Balding type 1	30595370			EFO_0007825
ENSG00000196498	rs1271309	12	124336159	A	Male-pattern baldness	30573740	[0.025-0.041] unit decrease	0.033054	EFO_0007825
ENSG00000196498	rs3741508	12	124328132	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000196498	rs1271309	12	124336159	A	Diastolic blood pressure	30224653	[0.14-0.22] mmHg decrease	0.1786	EFO_0006336
ENSG00000196498	rs12314162	12	124342130	?	Fat-free mass	30593698	[0.12-0.25] unit increase	0.18088	EFO_0004995
ENSG00000196498	rs12314162	12	124342130	?	Fat-free mass	30593698	[0.2-0.39] unit increase	0.29554	EFO_0004995
ENSG00000196498	rs12314162	12	124342130	?	Fat-free mass	30593698	[0.18-0.3] unit increase	0.24049	EFO_0004995
ENSG00000196498	rs7963151	12	124377180	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000196498's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000196498	NCOR2	100	94.929	ENSMUSG00000029478	Ncor2	100	96.774	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000118	histone deacetylase complex	21873635.	IBA	Component
GO:0000122	negative regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	12628926.18052923.19955185.20388878.	IMP	Process
GO:0000122	negative regulation of transcription by RNA polymerase II	-	TAS	Process
GO:0000790	nuclear chromatin	21873635.	IBA	Component
GO:0000790	nuclear chromatin	20388878.	IDA	Component
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0001012	RNA polymerase II regulatory region DNA binding	21873635.	IBA	Function
GO:0003682	chromatin binding	21873635.	IBA	Function
GO:0003714	transcription corepressor activity	21873635.	IBA	Function
GO:0003714	transcription corepressor activity	18052923.	IDA	Function
GO:0003714	transcription corepressor activity	12628926.20812024.	IMP	Function
GO:0005112	Notch binding	10713164.	IPI	Function
GO:0005515	protein binding	10395741.10713164.10809664.11013263.11739383.14985122.15016912.16129689.16924111.16980585.19786558.20195357.20467437.20543827.20812024.21258344.21475249.21624135.22230954.23518351.23752268.24268649.24449765.25303530.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	18052923.	IC	Component
GO:0005634	nucleus	12628926.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016363	nuclear matrix	21328542.	IDA	Component
GO:0016604	nuclear body	16030140.	IDA	Component
GO:0017053	transcriptional repressor complex	21873635.	IBA	Component
GO:0017053	transcriptional repressor complex	11804585.	IDA	Component
GO:0019216	regulation of lipid metabolic process	-	TAS	Process
GO:0035257	nuclear hormone receptor binding	21873635.	IBA	Function
GO:0042826	histone deacetylase binding	21873635.	IBA	Function
GO:0042826	histone deacetylase binding	11804585.16924111.	IPI	Function
GO:0043565	sequence-specific DNA binding	21873635.	IBA	Function
GO:0045892	negative regulation of transcription, DNA-templated	20812024.	IMP	Process
GO:0047485	protein N-terminus binding	16893456.	IPI	Function
GO:0060766	negative regulation of androgen receptor signaling pathway	20812024.	IMP	Process
GO:0072365	regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter	19955185.	IMP	Process
GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA	20388878.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
14715875	Differential recruitment of coregulator proteins steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid receptors to the estrogen receptor-estrogen response element by beta-estradiol and 4-hydroxytamoxifen in human breast cancer.	J Clin Endocrinol Metab	2004 Jan	Fleming FJ	-
21143702	Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas.	Cancer Sci	2011 Feb	Campos B	doi: 10.1111/j.1349-7006.2010.01792.x
15319284	Expression of SMRTbeta promotes ligand-induced activation of mutated and wild-type retinoid receptors.	Blood	2004 Dec 15	Ct?? S	-
24971610	The SMRT coregulator enhances growth of estrogen receptor-α-positive breast cancer cells by promotion of cell cycle progression and inhibition of apoptosis.	Endocrinology	2014 Sep	Blackmore JK	doi: 10.1210/en.2014-1002
22695118	Altered corepressor SMRT expression and recruitment to target genes as a mechanism that change the response to androgens in prostate cancer progression.	Biochem Biophys Res Commun	2012 Jul 6	Godoy AS	doi: 10.1016/j.bbrc.2012.06.005
15802375	Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT.	Mol Endocrinol	2005 Jun	Keeton EK	-
19223455	Inhibition of MAPK-signaling pathway promotes the interaction of the corepressor SMRT with the human androgen receptor and mediates repression of prostate cancer cell growth in the presence of antiandrogens.	J Mol Endocrinol	2009 May	Eisold M	doi: 10.1677/JME-08-0084
23117886	SpliceArray profiling of breast cancer reveals a novel variant of NCOR2/SMRT that is associated with tamoxifen resistance and control of ERα transcriptional activity.	Cancer Res	2013 Jan 1	Zhang L	doi: 10.1158/0008-5472.CAN-12-2241
18546531	[Expression of ER alpha and SMRT in apoptosis of breast cancer cells induced by tamoxifen].	Zhejiang Da Xue Xue Bao Yi Xue Ban	2008 May	Zhao XH	-
15300237	Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells.	Oncogene	2004 Sep 2	Khanim FL	-
17902051	The prognostic significance of steroid receptor co-regulators in breast cancer: co-repressor NCOR2/SMRT is an independent indicator of poor outcome.	Breast Cancer Res Treat	2008 Aug	Green AR	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr12	124420003	Missense_Mutation	novel	Y479C	0.48
BLCA	chr12	124332374	Missense_Mutation	NA	K2283N	0.07
BLCA	chr12	124336891	Missense_Mutation	rs200307018	R1993C	0.35
BLCA	chr12	124336962	Frame_Shift_Del	novel	*S1964Lfs57**	0.6
BLCA	chr12	124473047	Missense_Mutation	rs768616938	R166W	0.21
BLCA	chr12	124341953	Missense_Mutation	novel	I1686M	0.09
BLCA	chr12	124340147	Missense_Mutation	NA	A1849V	0.36
BLCA	chr12	124400519	Frame_Shift_Del	novel	*Q599Sfs11**	0.44
BLCA	chr12	124336827	Missense_Mutation	rs762352790	S2014L	0.12
BLCA	chr12	124336859	Silent	rs377215571	H2003H	0.1
BLCA	chr12	124335564	Missense_Mutation	novel	T2062A	0.16
BLCA	chr12	124343157	Missense_Mutation	novel	S1595F	0.31
BLCA	chr12	124362189	Nonsense_Mutation	NA	Q1013*	0.25
BLCA	chr12	124483738	Nonsense_Mutation	NA	S90*	0.25
BLCA	chr12	124335280	Missense_Mutation	rs201214871	G2089D	0.38
BLCA	chr12	124354149	Missense_Mutation	NA	P1213S	0.63
BLCA	chr12	124495208	Missense_Mutation	rs374998878	T15I	0.17
BLCA	chr12	124378281	Missense_Mutation	rs772228038	S708L	0.36
BLCA	chr12	124335123	Splice_Site	novel	X2130_splice	0.04
BLCA	chr12	124426698	Missense_Mutation	novel	D418H	0.41
BRCA	chr12	124402541	Silent	NA	Q501Q	0.49
BRCA	chr12	124398162	Frame_Shift_Ins	novel	*S612Efs39**	0.24
BRCA	chr12	124340355	Missense_Mutation	novel	E1809D	0.65
BRCA	chr12	124332325	Nonsense_Mutation	NA	E2300*	0.18
BRCA	chr12	124426629	Missense_Mutation	novel	R441W	0.12
BRCA	chr12	124402424	Frame_Shift_Del	NA	*N540Kfs70**	0.2
BRCA	chr12	124419976	Missense_Mutation	NA	R488Q	0.18
BRCA	chr12	124350656	Missense_Mutation	rs373295499	R1259W	0.16
BRCA	chr12	124332407	Silent	NA	L2272L	0.29
BRCA	chr12	124378324	Missense_Mutation	novel	A694T	0.07
BRCA	chr12	124324783	3'UTR	novel		0.1
CESC	chr12	124336977	Missense_Mutation	rs774145486	S1964C	0.4
CESC	chr12	124327469	Missense_Mutation	NA	P2375S	0.12
CESC	chr12	124324546	3'UTR	novel		0.33
CESC	chr12	124348233	Missense_Mutation	novel	R1309H	0.21
CESC	chr12	124336774	Missense_Mutation	NA	E2032Q	0.2
CESC	chr12	124402406	Splice_Region	NA	L546L	0.14
CESC	chr12	124324783	3'UTR	novel		0.09
CESC	chr12	124430755	Silent	novel	L305L	0.4
CESC	chr12	124354879	Missense_Mutation	NA	V1148I	0.33
CESC	chr12	124363767	Missense_Mutation	rs748412865	P947L	0.21
CESC	chr12	124324982	3'UTR	rs184867915		0.29
CESC	chr12	124356656	Missense_Mutation	novel	S1076F	0.31
CESC	chr12	124337166	Missense_Mutation	novel	S1901F	0.41
CESC	chr12	124378364	Silent	novel	R680R	0.36
CHOL	chr12	124354923	Missense_Mutation	novel	L1133R	0.18
COAD	chr12	124340362	In_Frame_Del	NA	D1807_R1808del	0.29
COAD	chr12	124354839	Missense_Mutation	NA	L1161P	0.13
COAD	chr12	124372291	Silent	rs532518067	P846P	0.21
COAD	chr12	124326219	Silent	rs766761610	R2445R	0.35
COAD	chr12	124327440	Silent	rs375299131	D2384D	0.35
COAD	chr12	124348235	Silent	NA	K1308K	0.36
COAD	chr12	124326194	Missense_Mutation	NA	A2454T	0.49
COAD	chr12	124344728	Missense_Mutation	novel	V1528A	0.13
COAD	chr12	124333259	Missense_Mutation	rs749006415	T2209M	0.23
COAD	chr12	124336838	Silent	rs371641181	A2010A	0.27
COAD	chr12	124344702	Missense_Mutation	NA	R1537W	0.62
COAD	chr12	124362138	Missense_Mutation	rs536539471	A1030T	0.29
COAD	chr12	124347899	Missense_Mutation	rs562298385	R1333H	0.19
COAD	chr12	124356705	Frame_Shift_Del	rs771862790	*R1060Vfs3**	0.23
COAD	chr12	124402424	Silent	rs765176410	N540N	0.23
COAD	chr12	124344853	Silent	rs560814961	P1486P	0.32
COAD	chr12	124336761	Missense_Mutation	rs775458405	R2036H	0.05
COAD	chr12	124326363	Silent	rs536482449	G2397G	0.19
COAD	chr12	124473090	Frame_Shift_Del	NA	*S152Afs21**	0.21
COAD	chr12	124473131	Missense_Mutation	NA	D138Y	0.67
COAD	chr12	124325378	3'UTR	novel		0.89
COAD	chr12	124346710	Frame_Shift_Del	NA	L1405*	0.44
COAD	chr12	124372440	Missense_Mutation	novel	T797A	0.46
COAD	chr12	124372308	Frame_Shift_Del	novel	*E841Rfs123**	0.06
COAD	chr12	124378310	Silent	rs776612196	P698P	0.37
COAD	chr12	124362270	Frame_Shift_Del	NA	*R986Gfs77**	0.18
COAD	chr12	124486558	Missense_Mutation	novel	L39R	0.29
COAD	chr12	124342053	Missense_Mutation	rs774193502	R1653Q	0.13
COAD	chr12	124378369	Missense_Mutation	rs367654646	A679T	0.26
COAD	chr12	124457117	Frame_Shift_Del	NA	*Q251Rfs22**	0.24
COAD	chr12	124466207	Missense_Mutation	rs760665839	R224H	0.36
COAD	chr12	124327435	Missense_Mutation	rs552340226	R2386Q	0.6
COAD	chr12	124372159	Silent	rs780909563	A890A	0.43
COAD	chr12	124325435	Silent	NA	C2504C	0.56
COAD	chr12	124346741	Silent	rs771028465	T1394T	0.28
COAD	chr12	124363682	Frame_Shift_Del	NA	*I976Sfs87**	0.39
COAD	chr12	124347890	Missense_Mutation	NA	P1336L	0.47
COAD	chr12	124325378	3'UTR	novel		0.27
COAD	chr12	124344934	Silent	rs370364401	Y1459Y	0.34
COAD	chr12	124348255	Frame_Shift_Del	NA	*H1302Mfs12**	0.07
COAD	chr12	124362207	Missense_Mutation	NA	P1007S	0.61
COAD	chr12	124372135	Silent	rs200016013	G898G	0.57
COAD	chr12	124419991	Missense_Mutation	NA	V483A	0.08
COAD	chr12	124350675	Silent	rs748022862	P1252P	0.24
COAD	chr12	124430726	Missense_Mutation	NA	R315H	0.09
COAD	chr12	124346807	Silent	NA	R1372R	0.23
COAD	chr12	124363682	Frame_Shift_Del	NA	*I976Sfs87**	0.26
COAD	chr12	124343115	Missense_Mutation	rs767880178	S1609L	0.49
COAD	chr12	124363682	Frame_Shift_Del	NA	*I976Sfs87**	0.6
COAD	chr12	124378359	Missense_Mutation	NA	K682R	0.46
COAD	chr12	124327544	Missense_Mutation	novel	K2350E	0.06
COAD	chr12	124495247	Missense_Mutation	rs200569241	S2L	0.52
COAD	chr12	124335166	Missense_Mutation	novel	Q2127R	0.12
COAD	chr12	124430726	Missense_Mutation	NA	R315H	0.13
COAD	chr12	124483717	Missense_Mutation	NA	K97T	0.28
COAD	chr12	124348255	Frame_Shift_Del	NA	*H1302Mfs12**	0.43
COAD	chr12	124363682	Frame_Shift_Del	NA	*I976Sfs87**	0.39
COAD	chr12	124430727	Missense_Mutation	NA	R315C	0.21
COAD	chr12	124466215	Silent	rs755095650	S221S	0.31
COAD	chr12	124344702	Missense_Mutation	NA	R1537W	0.55
COAD	chr12	124356743	Frame_Shift_Del	NA	*P1047Lfs16**	0.43
COAD	chr12	124340119	Silent	rs200208502	S1858S	0.15
COAD	chr12	124363682	Frame_Shift_Del	NA	*I976Sfs87**	0.5
COAD	chr12	124344810	Missense_Mutation	NA	R1501C	0.41
COAD	chr12	124420037	Missense_Mutation	NA	L468I	0.18
COAD	chr12	124335529	Missense_Mutation	NA	E2073D	0.59
COAD	chr12	124346593	Missense_Mutation	rs766376384	R1444W	0.23
COAD	chr12	124355442	Missense_Mutation	NA	A1124V	0.18
COAD	chr12	124355520	Missense_Mutation	rs375804883	R1098H	0.31
DLBC	chr12	124335497	Missense_Mutation	rs201766557	R2084Q	0.17
ESCA	chr12	124378307	Silent	novel	V699V	0.14
ESCA	chr12	124350656	Missense_Mutation	rs373295499	R1259W	0.16
ESCA	chr12	124342003	Missense_Mutation	rs772634427	I1670V	0.5
ESCA	chr12	124336839	Missense_Mutation	rs757979246	A2010V	0.23
ESCA	chr12	124344757	Silent	rs551690182	S1518S	0.39
ESCA	chr12	124335210	Silent	rs747314164	S2112S	0.12
ESCA	chr12	124343095	Missense_Mutation	novel	R1616W	0.36
ESCA	chr12	124347850	Missense_Mutation	novel	H1349Q	0.35
ESCA	chr12	124333182	Missense_Mutation	novel	R2235G	0.17
ESCA	chr12	124362199	Silent	rs374201637	S1009S	0.29
ESCA	chr12	124335569	Missense_Mutation	novel	S2060I	0.6
GBM	chr12	124420015	Missense_Mutation	novel	K475R	0.16
GBM	chr12	124343095	Missense_Mutation	novel	R1616W	0.46
GBM	chr12	124362135	Missense_Mutation	rs751853167	D1031N	0.14
GBM	chr12	124420032	Nonsense_Mutation	novel	Y469*	0.89
GBM	chr12	124334525	Nonsense_Mutation	novel	C2168*	0.76
GBM	chr12	124340119	Silent	rs200208502	S1858S	0.22
GBM	chr12	124340423	Missense_Mutation	novel	K1787Q	0.15
GBM	chr12	124342053	Missense_Mutation	rs774193502	R1653Q	0.27
GBM	chr12	124430649	Frame_Shift_Del	novel	*R341Afs54**	0.3
HNSC	chr12	124372501	Frame_Shift_Del	novel	*P770Rfs19**	0.25
HNSC	chr12	124398143	Missense_Mutation	novel	E618Q	0.29
HNSC	chr12	124374457	Missense_Mutation	rs376775457	H725R	0.67
HNSC	chr12	124354874	Silent	rs373530484	T1149T	0.2
HNSC	chr12	124335566	Missense_Mutation	novel	L2061P	0.22
HNSC	chr12	124372278	Silent	novel	L851L	0.17
HNSC	chr12	124426710	Missense_Mutation	novel	G414R	0.38
HNSC	chr12	124372134	Missense_Mutation	novel	G899W	0.22
HNSC	chr12	124372023	Missense_Mutation	rs147831485	R936W	0.29
HNSC	chr12	124372149	Missense_Mutation	novel	E894K	0.22
HNSC	chr12	124333136	Missense_Mutation	novel	E2250G	0.19
HNSC	chr12	124340137	Silent	novel	S1852S	0.57
HNSC	chr12	124348208	Silent	novel	R1317R	0.36
HNSC	chr12	124362130	Missense_Mutation	novel	K1032N	0.28
HNSC	chr12	124378320	Missense_Mutation	novel	A695V	0.22
HNSC	chr12	124378303	Nonsense_Mutation	novel	E701*	0.2
HNSC	chr12	124327568	Missense_Mutation	novel	I2342V	0.44
HNSC	chr12	124378281	Missense_Mutation	rs772228038	S708L	0.36
HNSC	chr12	124472976	Silent	novel	Q189Q	0.29
HNSC	chr12	124348252	Missense_Mutation	novel	E1303K	0.16
HNSC	chr12	124495232	Missense_Mutation	novel	P7L	0.14
HNSC	chr12	124449820	Missense_Mutation	novel	I270M	0.36
HNSC	chr12	124430702	Missense_Mutation	rs757613317	R323Q	0.13
HNSC	chr12	124335218	Nonsense_Mutation	novel	Q2110*	0.42
KIRC	chr12	124374448	Missense_Mutation	NA	G728E	0.42
KIRC	chr12	124355438	Silent	rs756684433	I1125I	0.29
KIRP	chr12	124362269	Missense_Mutation	novel	R986L	0.46
KIRP	chr12	124363745	Silent	NA	N954N	0.55
LAML	chr12	124335498	Missense_Mutation	rs371813927	R2084W	0.36
LAML	chr12	124385746	Missense_Mutation	novel	M673T	0.04
LGG	chr12	124335242	In_Frame_Ins	novel	P2101_H2102insTR	0.11
LGG	chr12	124340360	Missense_Mutation	rs375229118	R1808W	0.36
LGG	chr12	124342025	Silent	rs745529747	P1662P	0.28
LGG	chr12	124327502	Missense_Mutation	novel	A2364T	0.39
LGG	chr12	124333148	Missense_Mutation	novel	G2246V	0.13
LGG	chr12	124385754	Silent	novel	K670K	0.43
LGG	chr12	124466185	Silent	rs761420828	Y231Y	0.41
LGG	chr12	124325558	Silent	NA	P2463P	0.8
LGG	chr12	124333136	Frame_Shift_Ins	novel	*E2250Gfs49**	0.3
LIHC	chr12	124337151	Missense_Mutation	novel	P1906L	0.42
LIHC	chr12	124350722	Missense_Mutation	rs755508738	V1237I	0.3
LIHC	chr12	124350670	Missense_Mutation	novel	R1254H	0.26
LIHC	chr12	124402449	Missense_Mutation	NA	E532V	0.47
LIHC	chr12	124344798	Missense_Mutation	NA	E1505K	0.21
LIHC	chr12	124346615	Silent	rs779461576	T1436T	0.2
LIHC	chr12	124340407	Missense_Mutation	rs773108865	S1792F	0.08
LIHC	chr12	124354921	Missense_Mutation	novel	H1134Y	0.32
LIHC	chr12	124340325	Silent	rs780246024	T1819T	0.28
LIHC	chr12	124430644	Missense_Mutation	novel	K342N	0.51
LIHC	chr12	124350615	Frame_Shift_Ins	novel	*K1273Qfs9**	0.14
LIHC	chr12	124337173	Splice_Site	novel	X1896_splice	0.41
LIHC	chr12	124398154	Missense_Mutation	novel	R614H	0.1
LUAD	chr12	124343132	Silent	NA	H1603H	0.28
LUAD	chr12	124449835	Missense_Mutation	NA	Q265H	0.21
LUAD	chr12	124346614	Missense_Mutation	novel	P1437S	0.27
LUAD	chr12	124341824	Splice_Region	novel	R1729R	0.4
LUAD	chr12	124341825	Missense_Mutation	novel	R1729L	0.4
LUAD	chr12	124363766	Silent	rs779125633	P947P	0.08
LUAD	chr12	124372251	Missense_Mutation	novel	E860K	0.09
LUAD	chr12	124372058	Missense_Mutation	novel	D924G	0.15
LUAD	chr12	124398171	Missense_Mutation	novel	E608D	0.59
LUAD	chr12	124472969	Frame_Shift_Ins	novel	K192*	0.1
LUAD	chr12	124327466	Missense_Mutation	rs773013649	A2376T	0.12
LUAD	chr12	124473133	Splice_Site	novel	X138_splice	0.29
LUAD	chr12	124378337	Silent	NA	A689A	0.18
LUAD	chr12	124363775	Silent	novel	L944L	0.25
LUAD	chr12	124426700	Missense_Mutation	novel	A417V	0.09
LUAD	chr12	124398164	Missense_Mutation	novel	E611K	0.14
LUAD	chr12	124372538	Missense_Mutation	novel	Q764L	0.21
LUAD	chr12	124400653	Missense_Mutation	NA	S554L	0.22
LUAD	chr12	124341976	Silent	NA	L1679L	0.26
LUAD	chr12	124336826	Silent	novel	S2014S	0.39
LUAD	chr12	124378260	Missense_Mutation	NA	E715V	0.09
LUAD	chr12	124348249	Missense_Mutation	NA	T1304S	0.17
LUAD	chr12	124336840	Missense_Mutation	rs751521938	A2010P	0.17
LUAD	chr12	124327512	Silent	rs778552469	L2360L	0.31
LUAD	chr12	124333241	Missense_Mutation	NA	G2215V	0.62
LUAD	chr12	124355531	Silent	rs564573781	P1094P	0.35
LUAD	chr12	124341853	Silent	NA	L1720L	0.2
LUAD	chr12	124335260	Missense_Mutation	novel	E2096K	0.28
LUAD	chr12	124372371	Missense_Mutation	novel	P820A	0.36
LUAD	chr12	124372167	Nonsense_Mutation	NA	E888*	0.2
LUAD	chr12	124340049	Missense_Mutation	NA	G1882C	0.41
LUAD	chr12	124356651	Missense_Mutation	novel	A1078S	0.18
LUAD	chr12	124340011	Silent	NA	V1894V	0.29
LUAD	chr12	124372156	Silent	novel	L891L	0.07
LUAD	chr12	124466182	Missense_Mutation	NA	D232E	0.05
LUAD	chr12	124334521	Missense_Mutation	novel	V2170F	0.29
LUAD	chr12	124372571	Missense_Mutation	NA	S753C	0.38
LUAD	chr12	124378277	Silent	novel	G709G	0.15
LUSC	chr12	124354871	Missense_Mutation	NA	M1150I	0.27
LUSC	chr12	124354873	Missense_Mutation	NA	M1150L	0.27
LUSC	chr12	124344933	Missense_Mutation	novel	D1460N	0.44
LUSC	chr12	124372569	Missense_Mutation	novel	P754T	0.12
LUSC	chr12	124372566	Missense_Mutation	novel	H755D	0.1
LUSC	chr12	124355530	Missense_Mutation	rs199761768	V1095I	0.16
LUSC	chr12	124372092	Frame_Shift_Del	novel	*Q913Rfs51**	0.14
LUSC	chr12	124355523	Missense_Mutation	rs530717643	P1097L	0.14
LUSC	chr12	124356686	Missense_Mutation	NA	S1066F	0.47
LUSC	chr12	124327487	Missense_Mutation	NA	N2369D	0.32
LUSC	chr12	124363726	Silent	NA	L961L	0.06
LUSC	chr12	124495219	Silent	rs369322766	T11T	0.27
LUSC	chr12	124430701	Silent	novel	R323R	0.11
LUSC	chr12	124495193	Missense_Mutation	rs757710006	P20L	0.45
LUSC	chr12	124483643	Missense_Mutation	NA	P122S	0.28
LUSC	chr12	124372022	Missense_Mutation	novel	R936L	0.38
LUSC	chr12	124372356	Missense_Mutation	novel	E825K	0.4
LUSC	chr12	124355516	Silent	NA	P1099P	0.33
LUSC	chr12	124346581	Nonsense_Mutation	novel	E1448*	0.25
LUSC	chr12	124473010	Missense_Mutation	rs369807577	R178H	0.22
LUSC	chr12	124362167	Missense_Mutation	rs371445558	R1020Q	0.68
LUSC	chr12	124430680	Silent	NA	R330R	0.17
LUSC	chr12	124473005	Missense_Mutation	novel	D180N	0.19
LUSC	chr12	124483682	Silent	novel	R109R	0.21
OV	chr12	124495252	5'UTR	novel		1
OV	chr12	124400571	Silent	novel	R581R	0.06
OV	chr12	124372261	Silent	novel	G856G	0.71
OV	chr12	124378257	Missense_Mutation	novel	E716V	0.15
OV	chr12	124400637	Silent	rs759827085	D559D	0.32
OV	chr12	124350737	Missense_Mutation	novel	G1232R	0.27
OV	chr12	124341901	Missense_Mutation	novel	A1704P	0.14
OV	chr12	124378305	Frame_Shift_Ins	novel	*V700Afs10**	0.12
OV	chr12	124430761	Missense_Mutation	novel	D303E	0.09
OV	chr12	124327581	Missense_Mutation	NA	M2337I	0.47
OV	chr12	124350587	Missense_Mutation	novel	G1282S	0.33
OV	chr12	124350621	Nonsense_Mutation	novel	Y1270*	0.38
PAAD	chr12	124340639	Silent	novel	P1767P	0.27
PAAD	chr12	124342026	Missense_Mutation	rs769363112	P1662L	0.12
PAAD	chr12	124343177	Silent	rs571877591	T1588T	0.08
PAAD	chr12	124372084	Silent	rs546717361	S915S	0.2
PAAD	chr12	124400599	Missense_Mutation	novel	A572V	0.17
PAAD	chr12	124400640	Silent	rs542671777	N558N	0.16
PRAD	chr12	124340010	Silent	rs753066848	L1895L	0.31
PRAD	chr12	124340390	Nonsense_Mutation	NA	R1798*	0.26
PRAD	chr12	124473095	Frame_Shift_Ins	novel	*P150Sfs8**	0.3
PRAD	chr12	124327516	Missense_Mutation	rs199616664	P2359L	0.07
PRAD	chr12	124372290	Missense_Mutation	novel	A847T	0.31
PRAD	chr12	124343068	Missense_Mutation	NA	R1625C	0.36
PRAD	chr12	124346838	Missense_Mutation	novel	S1362F	0.7
PRAD	chr12	124372555	Silent	rs771509251	A758A	0.42
READ	chr12	124337136	Missense_Mutation	NA	P1911L	0.32
READ	chr12	124354112	Missense_Mutation	NA	Y1225C	0.52
READ	chr12	124343009	Silent	rs760461669	D1644D	0.48
READ	chr12	124400518	Frame_Shift_Ins	novel	*Q599Pfs13**	0.1
READ	chr12	124348255	Frame_Shift_Del	NA	*H1302Mfs12**	0.35
READ	chr12	124336827	Missense_Mutation	rs762352790	S2014L	0.38
SARC	chr12	124348228	Missense_Mutation	novel	Y1311N	0.09
SARC	chr12	124356675	Missense_Mutation	NA	P1070S	0.48
SARC	chr12	124344624	Missense_Mutation	novel	R1563W	0.68
SARC	chr12	124341878	Silent	novel	R1711R	0.32
SARC	chr12	124372421	Missense_Mutation	novel	T803I	0.18
SKCM	chr12	124340307	Silent	novel	P1825P	0.38
SKCM	chr12	124495173	Missense_Mutation	novel	P27T	0.42
SKCM	chr12	124495174	Silent	novel	Y26Y	0.41
SKCM	chr12	124362150	Missense_Mutation	novel	P1026S	0.17
SKCM	chr12	124334456	Silent	NA	A2191A	0.68
SKCM	chr12	124429677	Missense_Mutation	NA	S362F	0.25
SKCM	chr12	124385883	Silent	rs375563372	L627L	0.41
SKCM	chr12	124355505	Missense_Mutation	novel	S1103F	0.42
SKCM	chr12	124356751	Silent	NA	G1044G	0.45
SKCM	chr12	124346633	Silent	rs371027420	R1430R	0.3
SKCM	chr12	124348200	Missense_Mutation	rs537038342	R1320K	0.16
SKCM	chr12	124336998	Missense_Mutation	novel	L1957R	0.28
SKCM	chr12	124340331	Silent	novel	S1817S	0.18
SKCM	chr12	124355569	Missense_Mutation	NA	H1082Y	0.46
SKCM	chr12	124362274	Silent	NA	P984P	0.38
SKCM	chr12	124363769	Silent	NA	T946T	0.35
SKCM	chr12	124372094	Missense_Mutation	NA	P912L	0.22
SKCM	chr12	124430659	Silent	rs374059688	F337F	0.23
SKCM	chr12	124372475	Missense_Mutation	NA	P785L	0.43
SKCM	chr12	124354915	Missense_Mutation	NA	P1136S	0.57
SKCM	chr12	124336827	Missense_Mutation	rs762352790	S2014L	0.42
SKCM	chr12	124335266	Missense_Mutation	rs763944351	G2094S	0.25
SKCM	chr12	124340117	Missense_Mutation	novel	P1859L	0.19
SKCM	chr12	124372371	Missense_Mutation	NA	P820S	0.39
SKCM	chr12	124340111	Missense_Mutation	NA	S1861F	0.19
SKCM	chr12	124340083	Silent	NA	Q1870Q	0.22
SKCM	chr12	124430658	Missense_Mutation	NA	P338S	0.34
SKCM	chr12	124336763	Silent	NA	L2035L	0.34
SKCM	chr12	124340400	Silent	novel	S1794S	0.77
SKCM	chr12	124340401	Missense_Mutation	NA	S1794F	0.77
SKCM	chr12	124333215	Missense_Mutation	novel	P2224S	0.35
SKCM	chr12	124333216	Silent	novel	S2223S	0.38
SKCM	chr12	124449848	Missense_Mutation	NA	S261F	0.38
SKCM	chr12	124346598	Missense_Mutation	NA	A1442V	0.25
SKCM	chr12	124346596	Missense_Mutation	NA	P1443S	0.44
SKCM	chr12	124341936	Missense_Mutation	NA	S1692L	0.46
SKCM	chr12	124483701	Silent	novel	F102F	0.28
SKCM	chr12	124363691	Silent	NA	A972A	0.37
SKCM	chr12	124341939	Missense_Mutation	NA	T1691I	0.41
SKCM	chr12	124426654	Missense_Mutation	NA	W432C	0.51
SKCM	chr12	124340308	Missense_Mutation	NA	P1825L	0.24
SKCM	chr12	124336877	Silent	NA	K1997K	0.12
SKCM	chr12	124344857	Missense_Mutation	NA	P1485L	0.57
SKCM	chr12	124356667	Silent	NA	P1072P	0.75
SKCM	chr12	124495193	Missense_Mutation	rs757710006	P20L	0.41
SKCM	chr12	124495194	Missense_Mutation	novel	P20S	0.41
SKCM	chr12	124336787	Silent	novel	P2027P	0.34
SKCM	chr12	124466232	Missense_Mutation	novel	P216S	0.39
SKCM	chr12	124344859	Silent	novel	F1484F	1
SKCM	chr12	124372247	Missense_Mutation	novel	P861L	0.51
SKCM	chr12	124340744	Silent	NA	I1732I	0.3
SKCM	chr12	124363784	Silent	NA	R941R	0.11
SKCM	chr12	124340111	Missense_Mutation	NA	S1861F	0.38
SKCM	chr12	124340401	Missense_Mutation	NA	S1794F	0.33
SKCM	chr12	124350594	Silent	NA	S1279S	0.25
SKCM	chr12	124363767	Missense_Mutation	rs748412865	P947L	0.09
SKCM	chr12	124363768	Missense_Mutation	novel	P947S	0.09
SKCM	chr12	124385847	Silent	NA	R639R	0.28
SKCM	chr12	124372095	Missense_Mutation	NA	P912S	0.2
SKCM	chr12	124430737	Silent	NA	K311K	0.39
SKCM	chr12	124336762	Missense_Mutation	rs763480105	R2036C	0.26
SKCM	chr12	124336763	Silent	NA	L2035L	0.25
SKCM	chr12	124333231	Silent	NA	G2218G	0.24
SKCM	chr12	124426744	Silent	NA	A402A	0.18
SKCM	chr12	124378316	Silent	novel	F696F	0.28
SKCM	chr12	124402427	Silent	novel	E539E	0.43
STAD	chr12	124340101	Silent	NA	T1864T	0.2
STAD	chr12	124362262	Silent	rs552738969	D988D	0.64
STAD	chr12	124430624	Missense_Mutation	NA	R349H	0.29
STAD	chr12	124483594	Splice_Site	NA	X137_splice	0.43
STAD	chr12	124341833	Silent	rs375290289	A1726A	0.43
STAD	chr12	124466220	Missense_Mutation	novel	E220K	0.27
STAD	chr12	124341998	Silent	rs201769852	R1671R	0.17
STAD	chr12	124343081	Silent	NA	G1620G	0.13
STAD	chr12	124372218	Missense_Mutation	rs370196674	E871K	0.18
STAD	chr12	124363682	Frame_Shift_Del	NA	*I976Sfs87**	0.47
STAD	chr12	124340086	Silent	NA	Q1869Q	0.26
STAD	chr12	124486405	Intron	novel		0.32
STAD	chr12	124400519	Frame_Shift_Del	novel	*Q599Sfs11**	0.22
STAD	chr12	124342011	Missense_Mutation	NA	P1667L	0.33
STAD	chr12	124402458	Missense_Mutation	rs376669119	A529E	0.36
STAD	chr12	124356746	Missense_Mutation	novel	P1046L	0.3
STAD	chr12	124363682	Frame_Shift_Del	NA	*I976Sfs87**	0.41
STAD	chr12	124437982	Missense_Mutation	novel	R277Q	0.48
STAD	chr12	124354842	Frame_Shift_Del	novel	*K1160Sfs8**	0.21
STAD	chr12	124430726	Missense_Mutation	NA	R315H	0.43
STAD	chr12	124348182	Missense_Mutation	NA	S1326N	0.11
STAD	chr12	124350606	Silent	NA	G1275G	0.07
STAD	chr12	124398172	Missense_Mutation	NA	E608A	0.08
STAD	chr12	124400517	Missense_Mutation	NA	Q599H	0.09
STAD	chr12	124385782	Missense_Mutation	NA	N661S	0.52
STAD	chr12	124372291	Frame_Shift_Del	novel	*A847Rfs117**	0.44
STAD	chr12	124336963	Missense_Mutation	rs747426729	A1969T	0.15
STAD	chr12	124402503	Missense_Mutation	rs768882087	R514H	0.3
STAD	chr12	124348255	Frame_Shift_Del	NA	*H1302Mfs12**	0.35
STAD	chr12	124327594	Missense_Mutation	NA	A2333V	0.19
STAD	chr12	124340153	Missense_Mutation	rs753590635	R1847H	0.32
STAD	chr12	124483687	Missense_Mutation	novel	R107H	0.58
STAD	chr12	124430638	Silent	rs371011372	R344R	0.25
STAD	chr12	124400635	Missense_Mutation	NA	E560G	0.11
STAD	chr12	124378309	Missense_Mutation	rs771023965	V699M	0.34
STAD	chr12	124362269	Frame_Shift_Ins	rs746871841	*R986Pfs76**	0.38
STAD	chr12	124372209	Missense_Mutation	novel	P874A	0.14
STAD	chr12	124336841	Silent	rs757282329	P2009P	0.5
STAD	chr12	124426782	Missense_Mutation	NA	R390C	0.28
STAD	chr12	124378379	In_Frame_Del	novel	K675del	0.21
STAD	chr12	124466254	Silent	rs772776811	P208P	0.27
STAD	chr12	124333232	Missense_Mutation	novel	G2218D	0.17
STAD	chr12	124336894	Missense_Mutation	rs368518568	A1992T	0.14
STAD	chr12	124342000	Missense_Mutation	rs748517349	R1671C	0.31
STAD	chr12	124348238	Frame_Shift_Del	novel	*K1308Sfs6**	0.08
STAD	chr12	124356743	Frame_Shift_Del	NA	*P1047Lfs16**	0.42
STAD	chr12	124354883	Silent	novel	G1146G	0.28
STAD	chr12	124378258	Missense_Mutation	NA	E716Q	0.18
STAD	chr12	124466258	Missense_Mutation	rs776360455	P207L	0.41
STAD	chr12	124348178	Silent	novel	I1327I	0.27
STAD	chr12	124372561	Silent	novel	T756T	0.16
STAD	chr12	124466258	Missense_Mutation	rs776360455	P207L	0.58
STAD	chr12	124378354	Missense_Mutation	NA	K684E	0.33
STAD	chr12	124426682	Missense_Mutation	rs370836867	Y423C	0.25
STAD	chr12	124372554	Missense_Mutation	rs747451283	A759T	0.57
STAD	chr12	124340020	Silent	rs755595126	T1891T	0.38
STAD	chr12	124402544	Frame_Shift_Del	novel	*Q500Hfs110**	0.36
STAD	chr12	124402546	Frame_Shift_Del	novel	*Q500Afs22**	0.33
TGCT	chr12	124340649	Missense_Mutation	rs777397769	A1764V	0.14
THCA	chr12	124402547	Silent	NA	Q499Q	0.64
THCA	chr12	124343013	Missense_Mutation	NA	L1643Q	0.12
THCA	chr12	124340137	Silent	novel	S1852S	0.06
UCEC	chr12	124400539	Missense_Mutation	novel	S592N	0.23
UCEC	chr12	124356673	Silent	rs375879296	P1070P	0.35
UCEC	chr12	124355458	Missense_Mutation	NA	E1119K	0.45
UCEC	chr12	124483617	Silent	rs577563958	A130A	0.44
UCEC	chr12	124325288	3'UTR	rs370910056		0.16
UCEC	chr12	124327490	Missense_Mutation	novel	L2368M	0.14
UCEC	chr12	124330851	Missense_Mutation	rs761117621	G2318R	0.37
UCEC	chr12	124332391	Missense_Mutation	rs375952313	A2278T	0.37
UCEC	chr12	124343078	Silent	novel	V1621V	0.21
UCEC	chr12	124354091	Splice_Site	novel	X1231_splice	0.56
UCEC	chr12	124473005	Missense_Mutation	novel	D180N	0.38
UCEC	chr12	124332463	Missense_Mutation	NA	M2254V	0.41
UCEC	chr12	124348255	Frame_Shift_Del	NA	*H1302Mfs12**	0.46
UCEC	chr12	124402544	Frame_Shift_Del	novel	*Q500Hfs110**	0.16
UCEC	chr12	124402546	Frame_Shift_Del	novel	*Q500Afs22**	0.16
UCEC	chr12	124422537	Missense_Mutation	NA	K449N	0.31
UCEC	chr12	124355466	Missense_Mutation	novel	S1116I	0.62
UCEC	chr12	124385888	Splice_Site	novel	X626_splice	0.27
UCEC	chr12	124473009	Silent	rs757994990	R178R	0.13
UCEC	chr12	124324852	3'UTR	rs4459410		0.12
UCEC	chr12	124449813	Splice_Site	novel	X272_splice	0.41
UCEC	chr12	124378283	Silent	rs773430474	A707A	0.15
UCEC	chr12	124344798	Missense_Mutation	NA	E1505K	0.51
UCEC	chr12	124350671	Missense_Mutation	rs202111746	R1254C	0.23
UCEC	chr12	124378365	Missense_Mutation	rs373767918	R680Q	0.54
UCEC	chr12	124430768	Missense_Mutation	NA	R301H	0.42
UCEC	chr12	124486444	Missense_Mutation	NA	E77A	0.29
UCEC	chr12	124343153	Silent	rs377741543	P1596P	0.32
UCEC	chr12	124385848	Missense_Mutation	rs761858151	R639Q	0.35
UCEC	chr12	124449846	Missense_Mutation	novel	D262N	0.31
UCEC	chr12	124332346	Missense_Mutation	novel	T2293A	0.44
UCEC	chr12	124426782	Missense_Mutation	NA	R390C	0.29
UCEC	chr12	124356807	Intron	novel		0.29
UCEC	chr12	124330880	Missense_Mutation	rs756901061	T2308M	0.39
UCEC	chr12	124335483	Missense_Mutation	NA	G2089C	0.21
UCEC	chr12	124336890	Missense_Mutation	novel	R1993P	0.09
UCEC	chr12	124337047	Frame_Shift_Del	NA	*R1941Gfs41**	0.2
UCEC	chr12	124378325	Missense_Mutation	NA	E693D	0.26
UCEC	chr12	124336761	Missense_Mutation	rs775458405	R2036H	0.49
UCEC	chr12	124354140	Missense_Mutation	novel	R1216W	0.17
UCEC	chr12	124340149	Silent	NA	P1848P	0.23
UCEC	chr12	124342053	Missense_Mutation	rs774193502	R1653Q	0.14
UCEC	chr12	124344922	Silent	rs191598312	A1463A	0.21
UCEC	chr12	124350661	Missense_Mutation	rs780940395	R1257H	0.13
UCEC	chr12	124355522	Silent	rs368708782	P1097P	0.3
UCEC	chr12	124356771	Missense_Mutation	rs531931569	E1038K	0.15
UCEC	chr12	124372303	Silent	NA	E842E	0.28
UCEC	chr12	124385778	Silent	rs369119404	L662L	0.22
UCEC	chr12	124483651	Missense_Mutation	NA	R119Q	0.25
UCEC	chr12	124486431	Intron	novel		0.32
UCEC	chr12	124363682	Frame_Shift_Del	NA	*I976Sfs87**	0.52
UCEC	chr12	124333258	Silent	rs779695599	T2209T	0.16
UCEC	chr12	124335265	Missense_Mutation	novel	G2094D	0.5
UCEC	chr12	124325547	Missense_Mutation	rs200312114	R2467Q	0.14
UCEC	chr12	124335541	Missense_Mutation	novel	K2069N	0.25
UCEC	chr12	124340372	Missense_Mutation	rs201265970	R1804W	0.15
UCEC	chr12	124348212	Missense_Mutation	novel	G1316D	0.22
UCEC	chr12	124362220	Silent	rs747598845	P1002P	0.2
UCEC	chr12	124385862	Nonsense_Mutation	novel	W634*	0.29
UCEC	chr12	124344751	Frame_Shift_Ins	novel	*S1521Lfs12**	0.5
UCEC	chr12	124362270	Frame_Shift_Del	NA	*R986Gfs77**	0.58
UCEC	chr12	124342040	Frame_Shift_Del	novel	*N1658Tfs53**	0.43
UCEC	chr12	124363681	Frame_Shift_Ins	novel	*I976Hfs8**	0.22
UCEC	chr12	124335215	Missense_Mutation	rs746341430	P2111S	0.31
UCEC	chr12	124342036	Missense_Mutation	novel	P1659T	0.28
UCEC	chr12	124355478	Missense_Mutation	novel	A1112V	0.37
UCEC	chr12	124348255	Frame_Shift_Del	NA	*H1302Mfs12**	0.26
UCEC	chr12	124324574	3'UTR	novel		0.32
UCEC	chr12	124340648	Silent	rs755427580	A1764A	0.33
UCEC	chr12	124344915	Missense_Mutation	novel	T1466A	0.27
UCEC	chr12	124348233	Missense_Mutation	novel	R1309H	0.36
UCEC	chr12	124372079	Missense_Mutation	novel	S917F	0.53
UCEC	chr12	124378280	Silent	rs747952180	S708S	0.41
UCEC	chr12	124429633	Missense_Mutation	novel	D377N	0.38
UCEC	chr12	124466207	Missense_Mutation	rs760665839	R224H	0.33
UCEC	chr12	124363682	Frame_Shift_Del	NA	*I976Sfs87**	0.43
UCEC	chr12	124402451	In_Frame_Del	NA	K531del	0.18
UCEC	chr12	124344924	Missense_Mutation	rs373008881	A1463T	0.45
UCEC	chr12	124324648	3'UTR	novel		0.29
UCEC	chr12	124333269	Missense_Mutation	novel	P2206T	0.36
UCEC	chr12	124343009	Silent	rs760461669	D1644D	0.47
UCEC	chr12	124350629	Missense_Mutation	rs575622579	V1268I	0.46
UCEC	chr12	124385852	Missense_Mutation	NA	A638T	0.58
UCEC	chr12	124398154	Missense_Mutation	novel	R614H	0.4
UCEC	chr12	124363682	Frame_Shift_Del	NA	*I976Sfs87**	0.29
UCEC	chr12	124335606	Missense_Mutation	rs372303606	E2048K	0.37
UCEC	chr12	124343137	Missense_Mutation	novel	E1602K	0.33
UCEC	chr12	124354913	Silent	rs750952172	P1136P	0.4
UCEC	chr12	124430681	Missense_Mutation	NA	R330H	0.56
UCEC	chr12	124430681	Missense_Mutation	NA	R330H	0.1
UCEC	chr12	124337047	Frame_Shift_Del	NA	*R1941Gfs41**	0.5
UCEC	chr12	124344771	Missense_Mutation	NA	T1514A	0.36
UCEC	chr12	124325459	Silent	rs575349014	D2496D	0.28
UCEC	chr12	124340702	Silent	rs376629520	P1746P	0.35
UCEC	chr12	124402503	Missense_Mutation	rs768882087	R514H	0.41
UCEC	chr12	124344752	Frame_Shift_Del	novel	*G1520Afs22**	0.37
UCEC	chr12	124344752	Frame_Shift_Del	novel	*G1520Afs22**	0.5
UCEC	chr12	124333170	Missense_Mutation	novel	Y2239H	0.25
UCEC	chr12	124457122	Missense_Mutation	novel	G249V	0.35
UCEC	chr12	124344626	Missense_Mutation	novel	T1562M	0.26
UCEC	chr12	124348238	Frame_Shift_Del	novel	*K1308Sfs6**	0.31
UCEC	chr12	124356705	Frame_Shift_Del	rs771862790	*R1060Vfs3**	0.4
UCEC	chr12	124420040	Missense_Mutation	rs754030327	V467I	0.14
UCEC	chr12	124430679	Missense_Mutation	novel	E331K	0.46
UCEC	chr12	124324790	3'UTR	novel		0.39
UCEC	chr12	124362269	Frame_Shift_Ins	rs746871841	*R986Pfs76**	0.4
UCEC	chr12	124340642	Silent	novel	Q1766Q	0.41
UCEC	chr12	124355458	Missense_Mutation	NA	E1119K	0.35
UCEC	chr12	124372500	Missense_Mutation	rs201469143	G777R	0.47
UCEC	chr12	124457140	Missense_Mutation	rs754316117	R243Q	0.27
UCEC	chr12	124356742	Frame_Shift_Ins	novel	*C1048Lfs14**	0.38
UCEC	chr12	124483688	Missense_Mutation	novel	R107C	0.18
UCEC	chr12	124324968	3'UTR	novel		0.44
UCEC	chr12	124348255	Frame_Shift_Del	NA	*H1302Mfs12**	0.52
UCEC	chr12	124362136	Silent	rs757649266	A1030A	0.49
UCEC	chr12	124402436	Silent	rs758225706	P536P	0.44
UCEC	chr12	124378277	Silent	novel	G709G	0.46
UCEC	chr12	124324833	3'UTR	novel		0.3
UCEC	chr12	124344868	Silent	novel	G1481G	0.24
UCEC	chr12	124324783	3'UTR	novel		0.31
UCEC	chr12	124363682	Frame_Shift_Del	NA	*I976Sfs87**	0.31
UCEC	chr12	124495219	Silent	rs369322766	T11T	0.4
UCEC	chr12	124354879	Missense_Mutation	NA	V1148I	0.49
UCEC	chr12	124363682	Frame_Shift_Del	NA	*I976Sfs87**	0.37
UCEC	chr12	124486566	Splice_Region	rs371190775	D36D	0.47
UCEC	chr12	124332399	Missense_Mutation	novel	S2275I	0.13
UCEC	chr12	124372456	Silent	rs367877965	P791P	0.29
UCEC	chr12	124466287	Splice_Site	novel	X198_splice	0.11
UCEC	chr12	124335233	Missense_Mutation	novel	P2105S	0.31
UCEC	chr12	124429701	Missense_Mutation	novel	V354A	0.19
UCEC	chr12	124457105	Splice_Site	novel	X254_splice	0.26
UCEC	chr12	124354914	Missense_Mutation	rs766879930	P1136L	0.43
UCEC	chr12	124402458	Missense_Mutation	rs376669119	A529V	0.23
UCEC	chr12	124363682	Frame_Shift_Del	NA	*I976Sfs87**	0.5
UCEC	chr12	124419976	Missense_Mutation	NA	R488Q	0.39
UCEC	chr12	124340014	Silent	rs201611391	T1893T	0.34
UCEC	chr12	124343053	Silent	novel	L1630L	0.41
UCEC	chr12	124343144	Silent	novel	T1599T	0.38
UCEC	chr12	124362167	Frame_Shift_Ins	novel	*R1020Pfs42**	0.38
UCEC	chr12	124324980	3'UTR	novel		0.33
UCEC	chr12	124332352	Missense_Mutation	novel	L2291M	0.39
UCEC	chr12	124335239	Missense_Mutation	novel	L2103M	0.14
UCEC	chr12	124362220	Silent	rs747598845	P1002P	0.39
UCEC	chr12	124473083	Missense_Mutation	novel	P154T	0.29
UCEC	chr12	124333223	Missense_Mutation	novel	P2221H	0.3
UCEC	chr12	124356705	Frame_Shift_Del	rs771862790	*R1060Vfs3**	0.35
UCEC	chr12	124350732	Silent	NA	T1233T	0.33
UCEC	chr12	124332357	Missense_Mutation	NA	K2289T	0.48
UCEC	chr12	124343068	Missense_Mutation	NA	R1625C	0.35
UCEC	chr12	124325347	3'UTR	novel		0.27
UCEC	chr12	124385874	Silent	rs748585756	H630H	0.41
UCEC	chr12	124378352	Missense_Mutation	novel	K684N	0.29
UCEC	chr12	124348197	Missense_Mutation	novel	A1321V	0.47
UCEC	chr12	124430681	Missense_Mutation	NA	R330H	0.32
UCEC	chr12	124356705	Frame_Shift_Del	rs771862790	*R1060Vfs3**	0.39
UCEC	chr12	124334458	Missense_Mutation	novel	A2191T	0.64
UCEC	chr12	124362269	Frame_Shift_Ins	rs746871841	*R986Pfs76**	0.51
UCEC	chr12	124333255	Silent	rs747434424	S2210S	0.32
UCEC	chr12	124341825	Missense_Mutation	rs773550297	R1729Q	0.43
UCEC	chr12	124343194	Nonsense_Mutation	novel	R1583*	0.1
UCEC	chr12	124355530	Missense_Mutation	rs199761768	V1095I	0.4
UCEC	chr12	124385852	Missense_Mutation	NA	A638T	0.37
UCEC	chr12	124426749	Missense_Mutation	novel	D401N	0.24
UCEC	chr12	124466281	Silent	novel	Q199Q	0.43
UCEC	chr12	124483687	Missense_Mutation	novel	R107H	0.4
UCEC	chr12	124324783	3'UTR	novel		0.38
UCEC	chr12	124336880	Silent	rs538165631	A1996A	0.33
UCEC	chr12	124340086	Missense_Mutation	rs753261260	Q1869H	0.41
UCEC	chr12	124348177	Missense_Mutation	NA	E1328K	0.38
UCEC	chr12	124362138	Missense_Mutation	rs536539471	A1030T	0.27
UCEC	chr12	124426755	Silent	novel	L399L	0.29
UCEC	chr12	124473001	Missense_Mutation	novel	R181Q	0.42
UCEC	chr12	124356667	Silent	novel	P1072P	0.17
UCEC	chr12	124363682	Frame_Shift_Del	NA	*I976Sfs87**	0.29
UCEC	chr12	124473090	Frame_Shift_Del	NA	*S152Afs21**	0.21
UCS	chr12	124348274	Frame_Shift_Ins	novel	*R1295Sfs25**	0.12
UCS	chr12	124363682	Frame_Shift_Del	NA	*I976Sfs87**	0.43
UCS	chr12	124426710	Missense_Mutation	novel	G414R	0.36
UCS	chr12	124346594	Silent	rs754333875	P1443P	0.32
UVM	chr12	124402437	Frame_Shift_Del	novel	*K535Rfs74**	0.09

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.1639	6.3933e-07
CHOL	DEL	0.1944	0.067545
HNSC	DEL	0.0709	0.22646
LIHC	DEL	0.1324	2.3723e-05
LUAD	DEL	0.1434	0.0059643
LUSC	DEL	0.1118	0.038823
PAAD	DEL	0.163	0.0030251
PRAD	DEL	0.0711	0.024258
SKCM	DEL	0.1826	0.00079981
UCEC	DEL	0.0928	0.00053229
UCS	DEL	0.3214	0.033261

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0035	Kaplan-Meier Survival Analysis
SKCM	0.035	Kaplan-Meier Survival Analysis
LUSC	0.031	Kaplan-Meier Survival Analysis
BRCA	0.012	Kaplan-Meier Survival Analysis
COAD	0.013	Kaplan-Meier Survival Analysis
PAAD	0.019	Kaplan-Meier Survival Analysis
CESC	0.0065	Kaplan-Meier Survival Analysis
LAML	0.0019	Kaplan-Meier Survival Analysis
UCEC	0.034	Kaplan-Meier Survival Analysis
LIHC	0.049	Kaplan-Meier Survival Analysis
LGG	0.00053	Kaplan-Meier Survival Analysis
OV	0.002	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742